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July 1997; 52 (1)   [Index by Author]  [Cover Caption]
       ASPET Meeting Report
       Minireview
       Accelerated Communication
       Articles
       Errata
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ASPET Meeting Report:

Palmer Taylor, Elliott M. Ross, Paul C. Sternweis, Richard R. Neubig, and J. Andrew McCammon
Colloquium on Signaling and Molecular Structure in Pharmacology (La Jolla, California, March 11-12, 1997)
Mol Pharmacol 1997 52: 1-5. [Full Text] [PDF]  

Minireview:

Georgi Gegelashvili and Arne Schousboe
High Affinity Glutamate Transporters: Regulation of Expression and Activity
Mol Pharmacol 1997 52: 6-15. [Abstract] [Full Text] [PDF]  

Accelerated Communication:

Ichiro Aramori, Junko Zenkoh, Noriyuki Morikawa, Masayuki Asano, Chie Hatori, Hiroe Sawai, Hiroshi Kayakiri, Shigeki Satoh, Takayuki Inoue, Yoshito Abe, Yuki Sawada, Tsuyoshi Mizutani, Noriaki Inamura, Kunio Nakahara, Hitoshi Kojo, Teruo Oku, and Yoshitada Notsu
Nonpeptide Mimic of Bradykinin with Long-Acting Properties at the Bradykinin B2 Receptor
Mol Pharmacol 1997 52: 16-20. [Abstract] [Full Text] [PDF]  

Articles:

Hamid M. Sadeghi, Giulio Innamorati, Mirabelle Dagarag, and Mariel Birnbaumer
Palmitoylation of the V2 Vasopressin Receptor
Mol Pharmacol 1997 52: 21-29. [Abstract] [Full Text] [PDF]  

Zhi-Wei Lai, Claudia Hundeiker, Ernst Gleichmann, and Charlotte Esser
Cytokine Gene Expression during Ontogeny in Murine Thymus on Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Mol Pharmacol 1997 52: 30-37. [Abstract] [Full Text] [PDF]  

Rachel C. Tsu, Maurice K.C. Ho, Lisa Y. Yung, Sushma Joshi, and Yung H. Wong
Role of Amino- and Carboxyl-Terminal Regions of Galpha z in the Recognition of Gi-Coupled Receptors
Mol Pharmacol 1997 52: 38-45. [Abstract] [Full Text] [PDF]  

Kathleen A. O'Leary, Huan-Chen Li, Prabha A. Ram, Patricia McQuiddy, David J. Waxman, and Charles B. Kasper
Thyroid Regulation of NADPH:Cytochrome P450 Oxidoreductase: Identification of a Thyroid-Responsive Element in the 5'-Flank of the Oxidoreductase Gene
Mol Pharmacol 1997 52: 46-53. [Abstract] [Full Text] [PDF]  

C. Renard, O. Chappey, M.-P. Wautier, M. Nagashima, E. Lundh, J. Morser, L. Zhao, A.-M. Schmidt, J.-M. Scherrmann, and J.-L. Wautier
Recombinant Advanced Glycation End Product Receptor Pharmacokinetics in Normal and Diabetic Rats
Mol Pharmacol 1997 52: 54-62. [Abstract] [Full Text] [PDF]  

Vladimir M. Pisarev, Suk-Hee Lee, Michele C. Connelly, and Arnold Fridland
Intracellular Metabolism and Action of Acyclic Nucleoside Phosphonates on DNA Replication
Mol Pharmacol 1997 52: 63-68. [Abstract] [Full Text] [PDF]  

Mirjana Fogel-Petrovic, Debora L. Kramer, Slavoljub Vujcic, John Miller, Jim S. Mcmanis, Raymond J. Bergeron, and Carl W. Porter
Structural Basis for Differential Induction of Spermidine/Spermine N1-Acetyltransferase Activity by Novel Spermine Analogs
Mol Pharmacol 1997 52: 69-74. [Abstract] [Full Text] [PDF]  

Kevin R. Lynch, Darrin W. Hopper, Steven J. Carlisle, John G. Catalano, Ming Zhang, and Timothy L. Macdonald
Structure/Activity Relationships in Lysophosphatidic Acid: The 2-Hydroxyl Moiety
Mol Pharmacol 1997 52: 75-81. [Abstract] [Full Text] [PDF]  

Monica Valenti, Wilberto Nieves-Neira, Glenda Kohlhagen, Kurt W. Kohn, Monroe E. Wall, Mansukh C. Wani, and Yves Pommier
Novel 7-Alkyl Methylenedioxy-Camptothecin Derivatives Exhibit Increased Cytotoxicity and Induce Persistent Cleavable Complexes Both with Purified Mammalian Topoisomerase I and in Human Colon Carcinoma SW620 Cells
Mol Pharmacol 1997 52: 82-87. [Abstract] [Full Text] [PDF]  

Carlos H. Pedemonte, Thomas A. Pressley, Angel R. Cinelli, and Mustafa F. Lokhandwala
Stimulation of Protein Kinase C Rapidly Reduces Intracellular Na+ Concentration via Activation of the Na+ Pump in OK Cells
Mol Pharmacol 1997 52: 88-97. [Abstract] [Full Text] [PDF]  

José A. Esté, Dominique Schols, Karen De Vreese, Kristel Van Laethem, Anne-Mieke Vandamme, Jan Desmyter, and Erik De Clercq
Development of Resistance of Human Immunodeficiency Virus Type 1 to Dextran Sulfate Associated with the Emergence of Specific Mutations in the Envelope gp120 Glycoprotein
Mol Pharmacol 1997 52: 98-104. [Abstract] [Full Text] [PDF]  

Sumita Chakrabarti, Wanling Yang, Ping-Yee Law, and Horace H. Loh
The µ-Opioid Receptor Down-Regulates Differently from the delta -Opioid Receptor: Requirement of a High Affinity Receptor/G Protein Complex Formation
Mol Pharmacol 1997 52: 105-113. [Abstract] [Full Text] [PDF]  

Korwyn L. Williams, Joseph B. Tucker, Geoffrey White, David S. Weiss, James A. Ferrendelli, Douglas F. Covey, James E. Krause, and Steven M. Rothman
Lactone Modulation of the gamma -Aminobutyric Acid A Receptor: Evidence for a Positive Modulatory Site
Mol Pharmacol 1997 52: 114-119. [Abstract] [Full Text] [PDF]  

Sandrine Sagan, Jean-Claude Beaujouan, Yvette Torrens, Monique Saffroy, Gérard Chassaing, Jacques Glowinski, and Solange Lavielle
High Affinity Binding of [3H]Propionyl-[Met(O2)11]Substance P(7-11), a Tritiated Septide-Like Peptide, in Chinese Hamster Ovary Cells Expressing Human Neurokinin-1 Receptors and in Rat Submandibular Glands
Mol Pharmacol 1997 52: 120-127. [Abstract] [Full Text] [PDF]  

Hitoshi Hashimoto, Nobuya Ogawa, Nami Hagihara, Kyohei Yamamoto, Kumiko Imanishi, Hiroyuki Nogi, Akiko Nishino, Takashi Fujita, Toshio Matsuda, Shigekazu Nagata, and Akemichi Baba
Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-Activating Polypeptide Receptor Chimeras Reveal Domains That Determine Specificity of Vasoactive Intestinal Polypeptide Binding and Activation
Mol Pharmacol 1997 52: 128-135. [Abstract] [Full Text] [PDF]  

Susan Ingram, Tim J. Wilding, Ed W. McCleskey, and John T. Williams
Efficacy and Kinetics of Opioid Action on Acutely Dissociated Neurons
Mol Pharmacol 1997 52: 136-143. [Abstract] [Full Text] [PDF]  

Andrejs M. Krumins and Roger Barber
The Stability of the Agonist beta 2-Adrenergic Receptor-Gs Complex: Evidence for Agonist-Specific States
Mol Pharmacol 1997 52: 144-154. [Abstract] [Full Text] [PDF]  

Amy J. Galpin, John D. Schuetz, Eric Masson, Yuri Yanishevski, Timothy W. Synold, Julio C. Barredo, Ching-Hon Pui, Mary V. Relling, and William E. Evans
Differences in Folylpolyglutamate Synthetase and Dihydrofolate Reductase Expression in Human B-Lineage versus T-Lineage Leukemic Lymphoblasts: Mechanisms for Lineage Differences in Methotrexate Polyglutamylation and Cytotoxicity
Mol Pharmacol 1997 52: 155-163. [Abstract] [Full Text] [PDF]  

Paola M. C. Lembo, Mohammad H. Ghahremani, Stephen J. Morris, and Paul R. Albert
A Conserved Threonine Residue in the Second Intracellular Loop of the 5-Hydroxytryptamine 1A Receptor Directs Signaling Specificity
Mol Pharmacol 1997 52: 164-171. [Abstract] [Full Text] [PDF]  

Jan Jakubík and Esam E. El-Fakahany
Positive Cooperativity of Acetylcholine and Other Agonists with Allosteric Ligands on Muscarinic Acetylcholine Receptors
Mol Pharmacol 1997 52: 172-179. [Abstract] [Full Text] [PDF]  

Errata:

Correction for Volume 51, p. 139
Mol Pharmacol 1997 52: 180. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: Rapid agonist-induced sequestration of a GFP-tagged beta 2-adrenergic receptor. A fusion protein was constructed that consisted of the S65T mutant of green fluorescent protein (GFP) attached to the carboxyl terminus of the beta 2-adrenergic receptor. The GFP tag did not interfere with ligand recognition, G protein coupling or internalization. Left, when expressed in HEK 293 cells, receptor is distributed diffusely over the surface membrane. Right, 5 min after exposure to 10 µM isoproterenol, receptors are internalized within endosomal vesicular membranes. The left and right panels are two different cells representative of control and agonist-treated populations. From Barak, L. S., S. S. G. Ferguson, J. Zhang, C. Martenson, T. Meyer, and M. C. Caron. Internal trafficking and surface mobility of a functionally intact beta 2-adrenergic receptor-green fluorescent protein conjugate. Mol. Pharmacol. 51:177-184 (1997).



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