Mol Pharm -- Table of Contents (52 [3])

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September 1997; 52 (3)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Suke Wang, Tanaz Hashemi, Chaogang He, Catherine Strader, and Marvin Bayne: Molecular Cloning and Pharmacological Characterization of a New Galanin Receptor Subtype
Mol Pharmacol 1997 52: 337-343. [Abstract] [Full Text] [PDF]

Articles:

Brenda D. Stride, Caroline E. Grant, Douglas W. Loe, David R. Hipfner, Susan P. C. Cole, and Roger G. Deeley: Pharmacological Characterization of the Murine and Human Orthologs of Multidrug-Resistance Protein in Transfected Human Embryonic Kidney Cells
Mol Pharmacol 1997 52: 344-353. [Abstract] [Full Text] [PDF]

Zdenka Balcarová, Mauro Coluccia, Giovanni Natile, and Viktor Brabec: DNA Modifications by Antitumor trans-[PtCl₂(E-Iminoether)₂]
Mol Pharmacol 1997 52: 354-361. [Abstract] [Full Text] [PDF]

Deanna L. Kroetz, Linn M. Huse, Anneli Thuresson, and Mark P. Grillo: Developmentally Regulated Expression of the CYP4A Genes in the Spontaneously Hypertensive Rat Kidney
Mol Pharmacol 1997 52: 362-372. [Abstract] [Full Text] [PDF]

Michael S. Orr, Nicole C. Watson, Sujatha Sundaram, Joyce K. Randolph, Pramod T. Jain, and David A. Gewirtz: Ionizing Radiation and Teniposide Increase p21^waf1/cip1 and Promote Rb Dephosphorylation but Fail to Suppress E2F Activity in MCF-7 Breast Tumor Cells
Mol Pharmacol 1997 52: 373-379. [Abstract] [Full Text] [PDF]

Riikka Mäkelä, Mikko Uusi-Oukari, Gregg E. Homanics, Joseph J. Quinlan, Leonard L. Firestone, William Wisden, and Esa R. Korpi: Cerebellar $gamma$ -Aminobutyric Acid Type A Receptors: Pharmacological Subtypes Revealed by Mutant Mouse Lines
Mol Pharmacol 1997 52: 380-388. [Abstract] [Full Text] [PDF]

Agapios Sachinidis, Stefan Seewald, Petra Epping, Claudia Seul, Yon Ko, and Hans Vetter: The Growth-Promoting Effect of Low-Density Lipoprotein May Be Mediated by a Pertussis Toxin-Sensitive Mitogen-Activated Protein Kinase Pathway
Mol Pharmacol 1997 52: 389-397. [Abstract] [Full Text]

Guim Kwon, Jeanette R. Hill, John A. Corbett, and Michael L. McDaniel: Effects of Aspirin on Nitric Oxide Formation and De Novo Protein Synthesis by RINm5F Cells and Rat Islets
Mol Pharmacol 1997 52: 398-405. [Abstract] [Full Text] [PDF]

Alan M. Carruthers, R. A. John Challiss, Rajendra Mistry, Ruth Saunders, Christian Thomsen, and Stefan R. Nahorski: Enhanced Type 1 $alpha$ Metabotropic Glutamate Receptor-Stimulated Phosphoinositide Signaling after Pertussis Toxin Treatment
Mol Pharmacol 1997 52: 406-414. [Abstract] [Full Text] [PDF]

Shengli Lu, Horace H. Loh, and Li-Na Wei: Studies of Dual Promoters of Mouse $kappa$ -Opioid Receptor Gene
Mol Pharmacol 1997 52: 415-420. [Abstract] [Full Text] [PDF]

Rodney E. Shackelford, Paul B. Alford, Yan Xue, Sheau-Fung Thai, Dolph O. Adams, and Salvatore Pizzo: Aspirin Inhibits Tumor Necrosis Factor- $alpha$ Gene Expression in Murine Tissue Macrophages
Mol Pharmacol 1997 52: 421-429. [Abstract] [Full Text] [PDF]

Seong-Hun Kim, Young-Kyung Kim, Sung-Jin Jeong, Christian Haass, Young-Hoon Kim, and Yoo-Hun Suh: Enhanced Release of Secreted Form of Alzheimer's Amyloid Precursor Protein from PC12 Cells by Nicotine
Mol Pharmacol 1997 52: 430-436. [Abstract] [Full Text] [PDF]

Dan L. Wood, Dulal Panda, Todd R. Wiernicki, Leslie Wilson, Mary Ann Jordan, and Jai Pal Singh: Inhibition of Mitosis and Microtubule Function through Direct Tubulin Binding by a Novel Antiproliferative Naphthopyran LY290181
Mol Pharmacol 1997 52: 437-444. [Abstract] [Full Text] [PDF]

Patrick C. N. Rensen, Raymond M. Schiffelers, A. Jenny Versluis, Martin K. Bijsterbosch, Marly E. M. J. Van Kuijk-Meuwissen, and Theo J. C. Van Berkel: Human Recombinant Apolipoprotein E-Enriched Liposomes Can Mimic Low-Density Lipoproteins as Carriers for the Site-Specific Delivery of Antitumor Agents
Mol Pharmacol 1997 52: 445-455. [Abstract] [Full Text] [PDF]

Zhongzhen Nie, Yun Mei, and Vickram Ramkumar: Short Term Desensitization of the A₁ Adenosine Receptors in DDT₁MF-2 Cells
Mol Pharmacol 1997 52: 456-464. [Abstract] [Full Text] [PDF]

Yu-Li Lin and Jen-Kun Lin: ( $-$ )-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor- $kappa$ B
Mol Pharmacol 1997 52: 465-472. [Abstract] [Full Text] [PDF]

K. E. J. Dickinson, C. C. Bryson, R. B. Cohen, L. Rogers, D. W. Green, and K. S. Atwal: Nucleotide Regulation and Characteristics of Potassium Channel Opener Binding to Skeletal Muscle Membranes
Mol Pharmacol 1997 52: 473-481. [Abstract] [Full Text] [PDF]

Najah Abi-Gerges, Thomas Eschenhagen, Leif Hove-Madsen, Rodolphe Fischmeister, and Pierre-François Mery: Methylene Blue Is a Muscarinic Antagonist in Cardiac Myocytes
Mol Pharmacol 1997 52: 482-490. [Abstract] [Full Text] [PDF]

Jiahui Zhang, Luiz Belardinelli, Kenneth A. Jacobson, Deborah H. Otero, and Stephen P. Baker: Persistent Activation by and Receptor Reserve for an Irreversible A₁-Adenosine Receptor Agonist in DDT₁ MF-2 Cells and in Guinea Pig Heart
Mol Pharmacol 1997 52: 491-498. [Abstract] [Full Text] [PDF]

Qiaoling Jiang, Danping Guo, Brian X. Lee, A. Michiel Van Rhee, Yong-Chul Kim, Robert A. Nicholas, Joel B. Schachter, T. Kendall Harden, and Kenneth A. Jacobson: A Mutational Analysis of Residues Essential for Ligand Recognition at the Human P2Y₁ Receptor
Mol Pharmacol 1997 52: 499-507. [Abstract] [Full Text] [PDF]

Susan W. Robinson and Marc G. Caron: Selective Inhibition of Adenylyl Cyclase Type V by the Dopamine D₃ Receptor
Mol Pharmacol 1997 52: 508-514. [Abstract] [Full Text] [PDF]

Frank G. Boess, Frederick J. Monsma, Jr., Valerie Meyer, Catherine Zwingelstein, and Andrew J. Sleight: Interaction of Tryptamine and Ergoline Compounds with Threonine 196 in the Ligand Binding Site of the 5-Hydroxytryptamine₆ Receptor
Mol Pharmacol 1997 52: 515-523. [Abstract] [Full Text] [PDF]

Murali Gopalakrishnan, Eduardo J. Molinari, and James P. Sullivan: Regulation of Human $alpha$ 4 $beta$ 2 Neuronal Nicotinic Acetylcholine Receptors by Cholinergic Channel Ligands and Second Messenger Pathways
Mol Pharmacol 1997 52: 524-534. [Abstract] [Full Text] [PDF]

Min-Liang Kuo, Yat-Pang Chau, Jyh-Horng Wang, and Pei-Jung Lin: The Role of Src Kinase in the Potentiation by Ethanol of Cytokine- and Endotoxin-Mediated Nitric Oxide Synthase Expression in Rat Hepatocytes
Mol Pharmacol 1997 52: 535-541. [Abstract] [Full Text] [PDF]

Anthony H. Taylor, Zouhair F. Stephan, Ronald E. Steele, and Norman C. W. Wong: Beneficial Effects of a Novel Thyromimetic on Lipoprotein Metabolism
Mol Pharmacol 1997 52: 542-547. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Rapid agonist-induced sequestration of a GFP-tagged $beta$ 2-adrenergic receptor. A fusion protein was constructedthat consisted of the S65T mutant of green fluorescent protein(GFP) attached to the carboxyl terminus of the $beta$ 2-adrenergic receptor.The GFP tag did not interfere with ligand recognition, G proteincoupling or internalization. Left, when expressed in HEK 293 cells,receptor is distributed diffusely over the surface membrane. Right,5 min after exposure to 10 µM isoproterenol, receptors are internalizedwithin endosomal vesicular membranes. The left and right panelsare two different cells representative of control and agonist-treatedpopulations. From Barak, L. S., S. S. G. Ferguson, J. Zhang, C.Martenson, T. Meyer, and M. C. Caron. Internal trafficking andsurface mobility of a functionally intact $beta$ 2-adrenergic receptor-greenfluorescent protein conjugate. Mol. Pharmacol. 51:177-184(1997).