Mol Pharm -- Table of Contents (52 [4])

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October 1997; 52 (4)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

       Errata

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Accelerated Communication:

Rita Raddatz, Angelo Parini, and Stephen M. Lanier: Localization of the Imidazoline Binding Domain on Monoamine Oxidase B
Mol Pharmacol 1997 52: 549-553. [Abstract] [Full Text] [PDF]

Adrienne S. Gordon, Lina Yao, Zhi-Liang Wu, Imogen R. Coe, and Ivan Diamond: Ethanol Alters the Subcellular Localization of $delta$ - and $epsilon$ Protein Kinase C in NG108-15 Cells
Mol Pharmacol 1997 52: 554-559. [Abstract] [Full Text] [PDF]

Articles:

Maciej Baginski, Haluk Resat, and J. Andrew McCammon: Molecular Properties of Amphotericin B Membrane Channel: A Molecular Dynamics Simulation
Mol Pharmacol 1997 52: 560-570. [Abstract] [Full Text] [PDF]

Carmine M. Pariante, Bradley D. Pearce, Tracy L. Pisell, Michael J. Owens, and Andrew H. Miller: Steroid-Independent Translocation of the Glucocorticoid Receptor by the Antidepressant Desipramine
Mol Pharmacol 1997 52: 571-581. [Abstract] [Full Text] [PDF]

Ponnal Nambi, Mark Pullen, Jamie Kincaid, Parvathi Nuthulaganti, Nambi Aiyar, David P. Brooks, Miklos Gellai, and Chandrika Kumar: Identification and Characterization of a Novel Endothelin Receptor That Binds Both ET_A- and ET_B-Selective Ligands
Mol Pharmacol 1997 52: 582-589. [Abstract] [Full Text] [PDF]

Christopher J. Sinal and John R. Bend: Aryl Hydrocarbon Receptor-Dependent Induction of Cyp1a1 by Bilirubin in Mouse Hepatoma Hepa 1c1c7 Cells
Mol Pharmacol 1997 52: 590-599. [Abstract] [Full Text] [PDF]

Leslie A. Parsels, Richard C. Zellars, Tania L. Loney, Joshua D. Parsels, Michael F. Clarke, Audrea K. Merchant, Theodore S. Lawrence, and Jonathan Maybaum: Prevention of Fluorodeoxyuridine-Induced Cytotoxicity and DNA Damage in HT29 Colon Carcinoma Cells by Conditional Expression of Wild-Type p53 Phenotype
Mol Pharmacol 1997 52: 600-605. [Abstract] [Full Text] [PDF]

Zhiyi Zuo and Roger A. Johns: Inhalational Anesthetics Up-Regulate Constitutive and Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase Expression and Activity
Mol Pharmacol 1997 52: 606-612. [Abstract] [Full Text] [PDF]

Richard J. Kowalski, Paraskevi Giannakakou, Sarath P. Gunasekera, Ross E. Longley, Billy W. Day, and Ernest Hamel: The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells
Mol Pharmacol 1997 52: 613-622. [Abstract] [Full Text] [PDF]

Christian Waeber and Michael A. Moskowitz: 5-Hydroxytryptamine_1A and 5-Hydroxytryptamine_1B Receptors Stimulate [³⁵S]Guanosine-5 $'$ -O-(3-thio)triphosphate Binding to Rodent Brain Sections as Visualized by In Vitro Autoradiography
Mol Pharmacol 1997 52: 623-631. [Abstract] [Full Text] [PDF]

Timothy M. Palmer, Carol A. Harris, James Coote, and Gary L. Stiles: Induction of Multiple Effects on Adenylyl Cyclase Regulation by Chronic Activation of the Human A₃ Adenosine Receptor
Mol Pharmacol 1997 52: 632-640. [Abstract] [Full Text] [PDF]

José A. Rodríguez-Gómez, Marina Romero-Ramos, María L. Vizuete, José L. Venero, Josefina Cano, and Alberto Machado: Increased Activity and Expression of Tyrosine Hydroxylase in the Rat Substantia Nigra after Chronic Treatment with Nomifensine
Mol Pharmacol 1997 52: 641-647. [Abstract] [Full Text] [PDF]

Qi Chen and Arthur I. Cederbaum: Menadione Cytotoxicity to Hep G2 Cells and Protection by Activation of Nuclear Factor- $kappa$ B
Mol Pharmacol 1997 52: 648-657. [Abstract] [Full Text] [PDF]

Sandhiya Patel, Antje U. Sprung, Beatrice A. Keller, Victoria J. Heaton, and L. Mark Fisher: Identification of Yeast DNA Topoisomerase II Mutants Resistant to the Antitumor Drug Doxorubicin: Implications for the Mechanisms of Doxorubicin Action and Cytotoxicity
Mol Pharmacol 1997 52: 658-666. [Abstract] [Full Text] [PDF]

Alan Blankenship and Fumio Matsumura: 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Activation of a Protein Tyrosine Kinase, pp60^src, in Murine Hepatic Cytosol Using a Cell-Free System
Mol Pharmacol 1997 52: 667-675. [Abstract] [Full Text] [PDF]

Andreas Buhr, Martin T. Schaerer, Roland Baur, and Erwin Sigel: Residues at Positions 206 and 209 of the $alpha$ 1 Subunit of $gamma$ -Aminobutyric Acid_A Receptors Influence Affinities for Benzodiazepine Binding Site Ligands
Mol Pharmacol 1997 52: 676-682. [Abstract] [Full Text] [PDF]

Miduturu Srinivas, John C. Shryock, Donn M. Dennis, Stephen P. Baker, and Luiz Belardinelli: Differential A₁ Adenosine Receptor Reserve for Two Actions of Adenosine on Guinea Pig Atrial Myocytes
Mol Pharmacol 1997 52: 683-691. [Abstract] [Full Text] [PDF]

Thierry Pedron, Robert Girard, Kengo Inoue, Daniel Charon, and Richard Chaby: Lipopolysaccharide and the Glycoside Ring of Staurosporine Induce CD14 Expression on Bone Marrow Granulocytes by Different Mechanisms
Mol Pharmacol 1997 52: 692-700. [Abstract] [Full Text] [PDF]

Keiko Kashiwagi, Albert J. Pahk, Takashi Masuko, Kazuei Igarashi, and Keith Williams: Block and Modulation of N-Methyl-D-Aspartate Receptors by Polyamines and Protons: Role of Amino Acid Residues in the Transmembrane and Pore-Forming Regions of NR1 and NR2 Subunits
Mol Pharmacol 1997 52: 701-713. [Abstract] [Full Text] [PDF]

Janet L. Fisher, Jie Zhang, and Robert L. Macdonald: The Role of $alpha$ 1 and $alpha$ 6 Subtype Amino-Terminal Domains in Allosteric Regulation of $gamma$ -Aminobutyric Acid_a Receptors
Mol Pharmacol 1997 52: 714-724. [Abstract] [Full Text] [PDF]

Yoshiyuki Hirayama and H. Criss Hartzell: Effects of Protein Phosphatase and Kinase Inhibitors on Ca²⁺ and Cl Currents in Guinea Pig Ventricular Myocytes
Mol Pharmacol 1997 52: 725-734. [Abstract] [Full Text] [PDF]

Hiroyuki Ito, Norbert Klugbauer, and Franz Hofmann: Transfer of the High Affinity Dihydropyridine Sensitivity from L-Type To Non-L-Type Calcium Channel
Mol Pharmacol 1997 52: 735-740. [Abstract] [Full Text] [PDF]

C. T. Murphy, A. M. Riley, C. J. Lindley, D. J. Jenkins, J. Westwick, and B. V. L. Potter: Structural Analogues of D-myo-Inositol-1,4,5-trisphosphate and Adenophostin A: Recognition by Cerebellar and Platelet Inositol-1,4,5-trisphosphate Receptors
Mol Pharmacol 1997 52: 741-748. [Abstract] [Full Text] [PDF]

G. P. Vicent, M. C. Monteserín, A. S. Veleiro, G. Burton, C. P. Lantos, and M. D. Galigniana: 21-Hydroxy-6,19-oxidoprogesterone: A Novel Synthetic Steroid with Specific Antiglucocorticoid Properties in the Rat
Mol Pharmacol 1997 52: 749-753. [Abstract] [Full Text] [PDF]

Errata:

: Correction for Volume 52, p. 314
Mol Pharmacol 1997 52: 754. [Full Text] [PDF]

Cover Caption:

About the cover: Rapid agonist-induced sequestration of a GFP-tagged $beta$ 2-adrenergic receptor. A fusion protein was constructedthat consisted of the S65T mutant of green fluorescent protein(GFP) attached to the carboxyl terminus of the $beta$ 2-adrenergic receptor.The GFP tag did not interfere with ligand recognition, G proteincoupling or internalization. Left, when expressed in HEK 293 cells,receptor is distributed diffusely over the surface membrane. Right,5 min after exposure to 10 µM isoproterenol, receptors are internalizedwithin endosomal vesicular membranes. The left and right panelsare two different cells representative of control and agonist-treatedpopulations. From Barak, L. S., S. S. G. Ferguson, J. Zhang, C.Martenson, T. Meyer, and M. C. Caron. Internal trafficking andsurface mobility of a functionally intact $beta$ 2-adrenergic receptor-greenfluorescent protein conjugate. Mol. Pharmacol. 51:177-184(1997).