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November 1997; 52 (5)   [Index by Author]  [Cover Caption]
       Minireview
       Accelerated Communication
       Articles
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Minireview:

Craig Montell
New Light on TRP and TRPL
Mol Pharmacol 1997 52: 755-763. [Abstract] [Full Text] [PDF]  

Accelerated Communication:

Akira Hirasawa, Tatsuo Sugawara, Takeo Awaji, Keiko Tsumaya, Hiroshi Ito, and Gozoh Tsujimoto
Subtype-Specific Differences in Subcellular Localization of alpha 1-Adrenoceptors: Chlorethylclonidine Preferentially Alkylates the Accessible Cell Surface alpha 1-Adrenoceptors Irrespective of the Subtype
Mol Pharmacol 1997 52: 764-770. [Abstract] [Full Text] [PDF]  

Articles:

Peter Cherepanov, José A. Esté, Robert F. Rando, Joshua O. Ojwang, Gunther Reekmans, Robert Steinfeld, Guido David, Erik De Clercq, and Zeger Debyser
Mode of Interaction of G-Quartets with the Integrase of Human Immunodeficiency Virus Type 1
Mol Pharmacol 1997 52: 771-780. [Abstract] [Full Text] [PDF]  

Xiaofei Wang, Georg Nickenig, and T. J. Murphy
The Vascular Smooth Muscle Type I Angiotensin II Receptor mRNA Is Destabilized by Cyclic AMP-Elevating Agents
Mol Pharmacol 1997 52: 781-787. [Abstract] [Full Text] [PDF]  

Francisco Ciruela, Carles Saura, Enric I. Canela, Josefa Mallol, Carmen Lluís, and Rafael Franco
Ligand-Induced Phosphorylation, Clustering, and Desensitization of A1 Adenosine Receptors
Mol Pharmacol 1997 52: 788-797. [Abstract] [Full Text] [PDF]  

Lan Li, Michael J. Keating, William Plunkett, and Li-Ying Yang
Fludarabine-Mediated Repair Inhibition of Cisplatin-Induced DNA Lesions in Human Chronic Myelogenous Leukemia-Blast Crisis K562 Cells: Induction of Synergistic Cytotoxicity Independent of Reversal of Apoptosis Resistance
Mol Pharmacol 1997 52: 798-806. [Abstract] [Full Text] [PDF]  

Michael T. Greenwood, Nedim Hukovic, Ujendra Kumar, Rosemarie Panetta, Siv A. Hjorth, Coimbatore B. Srikant, and Yogesh C. Patel
Ligand Binding Pocket of the Human Somatostatin Receptor 5: Mutational Analysis of the Extracellular Domains
Mol Pharmacol 1997 52: 807-814. [Abstract] [Full Text] [PDF]  

Zhong-Ping Chen, Areti Malapetsa, Angela McQuillan, Daniela Marcantonio, Vanessa Bello, Gérard Mohr, Joanna Remack, Thomas P. Brent, and Lawrence C. Panasci
Evidence for Nucleotide Excision Repair as a Modifying Factor of O6-Methylguanine-DNA Methyltransferase-Mediated Innate Chloroethylnitrosourea Resistance in Human Tumor Cell Lines
Mol Pharmacol 1997 52: 815-820. [Abstract] [Full Text] [PDF]  

Hideyuki Murakoshi, Gongyi Shi, Robert H. Scannevin, and James S. Trimmer
Phosphorylation of the Kv2.1 K+ Channel Alters Voltage-Dependent Activation
Mol Pharmacol 1997 52: 821-828. [Abstract] [Full Text] [PDF]  

Gillian M. Greig, Donna A. Francis, Jean-Pierre Falgueyret, Marc Ouellet, M. David Percival, Patrick Roy, Christopher Bayly, Joseph A. Mancini, and Gary P. O'Neill
The Interaction of Arginine 106 of Human Prostaglandin G/H Synthase-2 with Inhibitors Is Not a Universal Component of Inhibition Mediated by Nonsteroidal Anti-inflammatory Drugs
Mol Pharmacol 1997 52: 829-838. [Abstract] [Full Text] [PDF]  

Brian B. Hasinoff, Andrew M. Creighton, Hanna Kozlowska, Padmakumari Thampatty, William P. Allan, and Jack C. Yalowich
Mitindomide Is a Catalytic Inhibitor of DNA Topoisomerase II That Acts at the Bisdioxopiperazine Binding Site
Mol Pharmacol 1997 52: 839-845. [Abstract] [Full Text] [PDF]  

John A. Auchampach, Xiaowei Jin, Tina C. Wan, George H. Caughey, and Joel Linden
Canine Mast Cell Adenosine Receptors: Cloning and Expression of the A3 Receptor and Evidence that Degranulation Is Mediated by the A2B Receptor
Mol Pharmacol 1997 52: 846-860. [Abstract] [Full Text] [PDF]  

Inga Everts, Carmen Villmann, and Michael Hollmann
N-Glycosylation Is Not a Prerequisite for Glutamate Receptor Function but Is Essential for Lectin Modulation
Mol Pharmacol 1997 52: 861-873. [Abstract] [Full Text] [PDF]  

Peter B. Wingrove, Sally A. Thompson, Keith A. Wafford, and Paul J. Whiting
Key Amino Acids in the gamma  Subunit of the gamma -Aminobutyric AcidA Receptor that Determine Ligand Binding and Modulation at the Benzodiazepine Site
Mol Pharmacol 1997 52: 874-881. [Abstract] [Full Text] [PDF]  

Ryszard Olinski, Pawel Jaruga, Marek Foksinski, Karol Bialkowski, and Jerzy Tujakowski
Epirubicin-Induced Oxidative DNA Damage and Evidence for Its Repair in Lymphocytes of Cancer Patients Who Are Undergoing Chemotherapy
Mol Pharmacol 1997 52: 882-885. [Abstract] [Full Text] [PDF]  

Ruud Zwart and Henk P. M. Vijverberg
Potentiation and Inhibition of Neuronal Nicotinic Receptors by Atropine: Competitive and Noncompetitive Effects
Mol Pharmacol 1997 52: 886-895. [Abstract] [Full Text] [PDF]  

Nirmala Yabaluri and Fedor Medzihradsky
Down-regulation of µ-Opioid Receptor by Full but Not Partial Agonists Is Independent of G Protein Coupling
Mol Pharmacol 1997 52: 896-902. [Abstract] [Full Text] [PDF]  

Zhi-Hao Chen, Olufunmilayo I. Olopade, and Todd M. Savarese
Expression of Methylthioadenosine Phosphorylase cDNA in p16-, MTAP- Malignant Cells: Restoration of Methylthioadenosine Phosphorylase-Dependent Salvage Pathways and Alterations of Sensitivity to Inhibitors of Purine de novo Synthesis
Mol Pharmacol 1997 52: 903-911. [Abstract] [Full Text] [PDF]  

Zhi Zhong, Henry Connor, Robert F. Stachlewitz, Moritz von Frankenberg, Ronald P. Mason, John J. Lemasters, and Ronald G. Thurman
Role of Free Radicals in Primary Nonfunction of Marginal Fatty Grafts from Rats Treated Acutely with Ethanol
Mol Pharmacol 1997 52: 912-919. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: Rapid agonist-induced sequestration of a GFP-tagged beta 2-adrenergic receptor. A fusion protein was constructed that consisted of the S65T mutant of green fluorescent protein (GFP) attached to the carboxyl terminus of the beta 2-adrenergic receptor. The GFP tag did not interfere with ligand recognition, G protein coupling or internalization. Left, when expressed in HEK 293 cells, receptor is distributed diffusely over the surface membrane. Right, 5 min after exposure to 10 µM isoproterenol, receptors are internalized within endosomal vesicular membranes. The left and right panels are two different cells representative of control and agonist-treated populations. From Barak, L. S., S. S. G. Ferguson, J. Zhang, C. Martenson, T. Meyer, and M. C. Caron. Internal trafficking and surface mobility of a functionally intact beta 2-adrenergic receptor-green fluorescent protein conjugate. Mol. Pharmacol. 51:177-184 (1997).



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