Mol Pharm -- Table of Contents (52 [6])

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December 1997; 52 (6)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Robert B. Crawford, Michael P. Holsapple, and Norbert E. Kaminski: Leukocyte Activation Induces Aryl Hydrocarbon Receptor Up-Regulation, DNA Binding, and Increased Cyp1a1 Expression in the Absence of Exogenous Ligand
Mol Pharmacol 1997 52: 921-927. [Abstract] [Full Text] [PDF]

José L. Boyer, Gary L. Waldo, and T. Kendall Harden: Molecular Cloning and Expression of an Avian G Protein-Coupled P2Y Receptor
Mol Pharmacol 1997 52: 928-934. [Abstract] [Full Text] [PDF]

Articles:

W. David Jarvis, Frank A. Fornari Jr., Kelly L. Auer, Alex J. Freemerman, Eva Szabo, Michael J. Birrer, Charlene R. Johnson, Suzanne E. Barbour, Paul Dent, and Steven Grant: Coordinate Regulation of Stress- and Mitogen-Activated Protein Kinases in the Apoptotic Actions of Ceramide and Sphingosine
Mol Pharmacol 1997 52: 935-947. [Abstract] [Full Text] [PDF]

Julie K. Horton, Kuntebommanahalli N. Thimmaiah, Guillermo A. Altenberg, Ariel F. Castro, Glen S. Germain, G. Krishne Gowda, and Peter J. Houghton: Characterization of a Novel Bisacridone and Comparison with PSC 833 as a Potent and Poorly Reversible Modulator of P-Glycoprotein
Mol Pharmacol 1997 52: 948-957. [Abstract] [Full Text] [PDF]

Roman A. McLellan, Mikael Oscarson, Anna-Karin Alexandrie, Janeric Seidegård, David A. Price Evans, Agneta Rannug, and Magnus Ingelman-Sundberg: Characterization of a Human Glutathione S-Transferase µ Cluster Containing a Duplicated GSTM1 Gene that Causes Ultrarapid Enzyme Activity
Mol Pharmacol 1997 52: 958-965. [Abstract] [Full Text] [PDF]

Jonathan Rousell, El-Bdaoui Haddad, Mark A. Lindsay, and Peter J. Barnes: Regulation of m2 Muscarinic Receptor Gene Expression by Platelet-Derived Growth Factor: Involvement of Extracellular Signal-Regulated Protein Kinases in the Down-Regulation Process
Mol Pharmacol 1997 52: 966-973. [Abstract] [Full Text] [PDF]

C. M. Bral and K. S. Ramos: Identification of Benzo[a]pyrene-Inducible Cis-Acting Elements Within c-Ha-ras Transcriptional Regulatory Sequences
Mol Pharmacol 1997 52: 974-982. [Abstract] [Full Text] [PDF]

Charles E. Spivak, Carol L. Beglan, Brian K. Seidleck, Laura D. Hirshbein, Carrie J. Blaschak, George R. Uhl, and Christopher K. Surratt: Naloxone Activation of µ-Opioid Receptors Mutated at a Histidine Residue Lining the Opioid Binding Cavity
Mol Pharmacol 1997 52: 983-992. [Abstract] [Full Text] [PDF]

Hermann Ammer and Rüdiger Schulz: Enhanced Stimulatory Adenylyl Cyclase Signaling during Opioid Dependence Is Associated with a Reduction in Palmitoylated G_s
Mol Pharmacol 1997 52: 993-999. [Abstract] [Full Text] [PDF]

Shujie Wang, Julie A. Vrana, Tina M. Bartimole, Alex J. Freemerman, W. David Jarvis, Lora B. Kramer, Geoffrey Krystal, Paul Dent, and Steven Grant: Agents that Down-Regulate or Inhibit Protein Kinase C Circumvent Resistance to 1- $beta$ -D-Arabinofuranosylcytosine-Induced Apoptosis in Human Leukemia Cells that Overexpress Bcl-2
Mol Pharmacol 1997 52: 1000-1009. [Abstract] [Full Text] [PDF]

Fengming Liu, Teresa Nesbitt, Marc K. Drezner, Peter A. Friedman, and Frank A. Gesek: Proximal Nephron Na⁺/H⁺ Exchange Is Regulated by $alpha$ _1A- and $alpha$ _1B-Adrenergic Receptor Subtypes
Mol Pharmacol 1997 52: 1010-1018. [Abstract] [Full Text] [PDF]

Bin Gao, Jianping Chen, Carl Johnson, and George Kunos: Both the Cyclic AMP Response Element and the Activator Protein 2 Binding Site Mediate Basal and Cyclic AMP-Induced Transcription from the Dominant Promoter of the Rat $alpha$ _1B-Adrenergic Receptor Gene in DDT₁MF-2 Cells
Mol Pharmacol 1997 52: 1019-1026. [Abstract] [Full Text] [PDF]

Jialin Zheng, Peijin Zhang, and Terry D. Hexum: Neuropeptide Y Inhibits Chromaffin Cell Nicotinic Receptor-Stimulated Tyrosine Hydroxylase Activity through a Receptor-Linked G Protein-Mediated Process
Mol Pharmacol 1997 52: 1027-1033. [Abstract] [Full Text] [PDF]

Mikael Oscarson, Mats Hidestrand, Inger Johansson, and Magnus Ingelman-Sundberg: A Combination of Mutations in the CYP2D6*17 (CYP2D6Z) Allele Causes Alterations in Enzyme Function
Mol Pharmacol 1997 52: 1034-1040. [Abstract] [Full Text] [PDF]

Nouri Neamati, Huixiao Hong, Sanjay Sunder, George W. A. Milne, and Yves Pommier: Potent Inhibitors of Human Immunodeficiency Virus Type 1 Integrase: Identification of a Novel Four-Point Pharmacophore and Tetracyclines as Novel Inhibitors
Mol Pharmacol 1997 52: 1041-1055. [Abstract] [Full Text] [PDF]

Etienne Sibille, Zoltan Sarnyai, Daniel Benjamin, Judit Gal, Harriet Baker, and Miklos Toth: Antisense Inhibition of 5-Hydroxytryptamine_2a Receptor Induces an Antidepressant-Like Effect in Mice
Mol Pharmacol 1997 52: 1056-1063. [Abstract] [Full Text] [PDF]

Hakan Gurdal, Tammy M. Seasholtz, Hoau-Yan Wang, R. Dale Brown, Mark D. Johnson, and Eitan Friedman: Role of G_q or G_o Proteins in $alpha$ ₁-Adrenoceptor Subtype-Mediated Responses in Fischer 344 Rat Aorta
Mol Pharmacol 1997 52: 1064-1070. [Abstract] [Full Text] [PDF]

Ren-Xue Wang and Lee E. Limbird: Distribution of mRNA Encoding Three $alpha$ ₂-Adrenergic Receptor Subtypes in the Developing Mouse Embryo Suggests a Role for the $alpha$ _2A Subtype in Apoptosis
Mol Pharmacol 1997 52: 1071-1080. [Abstract] [Full Text] [PDF]

Jinjie Jiang, Sandra J. Jordan, David P. Barr, Michael R. Gunther, Hiroshi Maeda, and Ronald P. Mason: In Vivo Production of Nitric Oxide in Rats after Administration of Hydroxyurea
Mol Pharmacol 1997 52: 1081-1086. [Abstract] [Full Text] [PDF]

Walter K. Vogel, David M. Sheehan, and Michael I. Schimerlik: Site-Directed Mutagenesis on the m2 Muscarinic Acetylcholine Receptor: The Significance of Tyr403 in the Binding of Agonists and Functional Coupling
Mol Pharmacol 1997 52: 1087-1094. [Abstract] [Full Text] [PDF]

Stefan I. McDonough, Richard A. Lampe, Richard A. Keith, and Bruce P. Bean: Voltage-Dependent Inhibition of N- and P-Type Calcium Channels by the Peptide Toxin $omega$ -Grammotoxin-SIA
Mol Pharmacol 1997 52: 1095-1104. [Abstract] [Full Text] [PDF]

Helge Eilers, Eric Schaeffer, Philip E. Bickler, and John R. Forsayeth: Functional Deactivation of the Major Neuronal Nicotinic Receptor Caused by Nicotine and a Protein Kinase C-Dependent Mechanism
Mol Pharmacol 1997 52: 1105-1112. [Abstract] [Full Text] [PDF]

Mijeong Park-Chung, Fong-Sen Wu, Robert H. Purdy, Andrew A. Malayev, Terrell T. Gibbs, and David H. Farb: Distinct Sites for Inverse Modulation of N-Methyl-D-Aspartate Receptors by Sulfated Steroids
Mol Pharmacol 1997 52: 1113-1123. [Abstract] [Full Text] [PDF]

Christine Dettbarn and Philip Palade: Ca²⁺ Feedback on "Quantal" Ca²⁺ Release Involving Ryanodine Receptors
Mol Pharmacol 1997 52: 1124-1130. [Abstract] [Full Text] [PDF]

Gildas Loussouarn, Flavien Charpentier, Raha Mohammad-Panah, Karl Kunzelmann, Isabelle Baró, and Denis Escande: KvLQT1 Potassium Channel but Not IsK Is the Molecular Target for trans-6-Cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethyl-chromane
Mol Pharmacol 1997 52: 1131-1136. [Abstract] [Full Text] [PDF]

Laura B. Kozell and Kim A. Neve: Constitutive Activity of a Chimeric D₂/D₁ Dopamine Receptor
Mol Pharmacol 1997 52: 1137-1149. [Abstract] [Full Text] [PDF]

Bjarke Ebert, Sally A. Thompson, Koralia Saounatsou, Ruth McKernan, Povl Krogsgaard-Larsen, and Keith A. Wafford: Differences in Agonist/Antagonist Binding Affinity and Receptor Transduction Using Recombinant Human $gamma$ -Aminobutyric Acid Type A Receptors
Mol Pharmacol 1997 52: 1150-1156. [Abstract] [Full Text] [PDF]

Dirk Daelemans, Jose A. Esté, Myriam Witvrouw, Christophe Pannecouque, Heidi Jonckheere, Stefano Aquaro, Carlo-Federico Perno, Erik De Clercq, and Anne-Mieke Vandamme: S-Adenosylhomocysteine Hydrolase Inhibitors Interfere with the Replication of Human Immunodeficiency Virus Type 1 through Inhibition of the LTR Transactivation
Mol Pharmacol 1997 52: 1157-1163. [Abstract] [Full Text] [PDF]

Wen-Ji Chen, Susan Armour, James Way, Grace Chen, Chris Watson, Paul Irving, Jeff Cobb, Sue Kadwell, Kevin Beaumont, Tom Rimele, and Terry Kenakin: Expression Cloning and Receptor Pharmacology of Human Calcitonin Receptors from MCF-7 Cells and Their Relationship to Amylin Receptors
Mol Pharmacol 1997 52: 1164-1175. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Rapid agonist-induced sequestration of a GFP-tagged $beta$ 2-adrenergic receptor. A fusion protein was constructedthat consisted of the S65T mutant of green fluorescent protein(GFP) attached to the carboxyl terminus of the $beta$ 2-adrenergic receptor.The GFP tag did not interfere with ligand recognition, G proteincoupling or internalization. Left, when expressed in HEK 293 cells,receptor is distributed diffusely over the surface membrane. Right,5 min after exposure to 10 µM isoproterenol, receptors are internalizedwithin endosomal vesicular membranes. The left and right panelsare two different cells representative of control and agonist-treatedpopulations. From Barak, L. S., S. S. G. Ferguson, J. Zhang, C.Martenson, T. Meyer, and M. C. Caron. Internal trafficking andsurface mobility of a functionally intact $beta$ 2-adrenergic receptor-greenfluorescent protein conjugate. Mol. Pharmacol. 51:177-184(1997).