Mol Pharm -- Table of Contents (54 [1])

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July 1998; 54 (1) [Index by Author] [Cover Caption]

Articles

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Articles:

Mari Yonemoto, Toshihiko Satoh, Hiroharu Arakawa, Ikuko Suzuki-Takahashi, Yoshiaki Monden, Tsutomu Kodera, Kenji Tanaka, Tetsuya Aoyama, Yoshikazu Iwasawa, Toshio Kamei, Susumu Nishimura, and Koji Tomimoto: J-104,871, a Novel Farnesyltransferase Inhibitor, Blocks Ras Farnesylation In Vivo in a Farnesyl Pyrophosphate-Competitive Manner
Mol Pharmacol 1998 54: 1-7. [Abstract] [Full Text] [PDF]

Jacqueline Loeper, Bénédicte Louérat-Oriou, Catherine Duport, and Denis Pompon: Yeast Expressed Cytochrome P450 2D6 (CYP2D6) Exposed on the External Face of Plasma Membrane Is Functionally Competent
Mol Pharmacol 1998 54: 8-13. [Abstract] [Full Text] [PDF]

Zhongwei Li, Vidita A. Vaidya, John D. Alvaro, Philip A. Iredale, Richard Hsu, Ginger Hoffman, Laura Fitzgerald, Patricia K. Curran, Curtis A. Machida, Peter H. Fishman, and Ronald S. Duman: Protein Kinase C-Mediated Down-Regulation of $beta$ ₁-Adrenergic Receptor Gene Expression in Rat C6 Glioma Cells
Mol Pharmacol 1998 54: 14-21. [Abstract] [Full Text] [PDF]

Benjamin D. Humphreys, Caterina Virginio, Annmarie Surprenant, Janet Rice, and George R. Dubyak: Isoquinolines as Antagonists of the P2X₇ Nucleotide Receptor: High Selectivity for the Human versus Rat Receptor Homologues
Mol Pharmacol 1998 54: 22-32. [Abstract] [Full Text] [PDF]

Ruth M. McKernan, Sophie Farrar, Ian Collins, Frances Emms, Ayodeji Asuni, Kathleen Quirk, and Howard Broughton: Photoaffinity Labeling of the Benzodiazepine Binding Site of $alpha$ 1 $beta$ 3 $gamma$ 2 $gamma$ -Aminobutyric Acid_A Receptors with Flunitrazepam Identifies a Subset of Ligands that Interact Directly with His102 of the $alpha$ Subunit and Predicts Orientation of These within the Benzodiazepine Pharmacophore
Mol Pharmacol 1998 54: 33-43. [Abstract] [Full Text] [PDF]

Mei Liang, Margaret G. Eason, Elizabeth A. Jewell-Motz, Mark A. Williams, Cheryl T. Theiss, Gerald W. Dorn II, and Stephen B. Liggett: Phosphorylation and Functional Desensitization of the $alpha$ _2A-Adrenergic Receptor by Protein Kinase C
Mol Pharmacol 1998 54: 44-49. [Abstract] [Full Text] [PDF]

Glenda Kohlhagen, Kenneth D. Paull, Mark Cushman, Pamela Nagafuji, and Yves Pommier: Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison
Mol Pharmacol 1998 54: 50-58. [Abstract] [Full Text] [PDF]

Kechun Tang, Hongjiang Wu, Sushil K. Mahata, and Daniel T. O'Connor: A Crucial Role for the Mitogen-Activated Protein Kinase Pathway in Nicotinic Cholinergic Signaling to Secretory Protein Transcription in Pheochromocytoma Cells
Mol Pharmacol 1998 54: 59-69. [Abstract] [Full Text] [PDF]

Mohamed Machwate, Sevgi B. Rodan, Gideon A. Rodan, and Shun-Ichi Harada: Sphingosine Kinase Mediates Cyclic AMP Suppression of Apoptosis in Rat Periosteal Cells
Mol Pharmacol 1998 54: 70-77. [Abstract] [Full Text] [PDF]

E. Willmore, A. J. Frank, K. Padget, M. J. Tilby, and C. A. Austin: Etoposide Targets Topoisomerase II $alpha$ and II $beta$ in Leukemic Cells: Isoform-Specific Cleavable Complexes Visualized and Quantified In Situ by a Novel Immunofluorescence Technique
Mol Pharmacol 1998 54: 78-85. [Abstract] [Full Text] [PDF]

Raimo Pohjanvirta, Judy M. Y. Wong, Wei Li, Patricia A. Harper, Jouko Tuomisto, and Allan B. Okey: Point Mutation in Intron Sequence Causes Altered Carboxyl-Terminal Structure in the Aryl Hydrocarbon Receptor of the Most 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Resistant Rat Strain
Mol Pharmacol 1998 54: 86-93. [Abstract] [Full Text] [PDF]

Kelly A. Berg, Saul Maayani, Joseph Goldfarb, Clare Scaramellini, Paul Leff, and William P. Clarke: Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus
Mol Pharmacol 1998 54: 94-104. [Abstract] [Full Text] [PDF]

Tomas Barkhem, Bo Carlsson, Yvonne Nilsson, Eva Enmark, Jan-Åke Gustafsson, and Stefan Nilsson: Differential Response of Estrogen Receptor $alpha$ and Estrogen Receptor $beta$ to Partial Estrogen Agonists/Antagonists
Mol Pharmacol 1998 54: 105-112. [Abstract] [Full Text] [PDF]

Maurizio Taglialatela, Anna Pannaccione, Pasqualina Castaldo, Giovanna Giorgio, Zhengfeng Zhou, Craig T. January, Arturo Genovese, Gianni Marone, and Lucio Annunziato: Molecular Basis for the Lack of HERG K⁺ Channel Block-Related Cardiotoxicity by the H₁ Receptor Blocker Cetirizine Compared with Other Second-Generation Antihistamines
Mol Pharmacol 1998 54: 113-121. [Abstract] [Full Text] [PDF]

Karnam S. Murthy and Gabriel M. Makhlouf: Regulation of Adenylyl Cyclase Type V/VI in Smooth Muscle: Interplay of Inhibitory G Protein and Ca²⁺ Influx
Mol Pharmacol 1998 54: 122-128. [Abstract] [Full Text] [PDF]

Françoise Hervé, Giulia Caron, Jean-Claude Duché, Patrick Gaillard, Noorsaadah Abd. Rahman, Anna Tsantili-Kakoulidou, Pierre-Alain Carrupt, Philippe d'Athis, Jean-Paul Tillement, and Bernard Testa: Ligand Specificity of the Genetic Variants of Human $alpha$ ₁-Acid Glycoprotein: Generation of a Three-Dimensional Quantitative Structure-Activity Relationship Model for Drug Binding to the A Variant
Mol Pharmacol 1998 54: 129-138. [Abstract] [Full Text] [PDF]

Christian Tränkle, Elisabeth Mies-Klomfass, Mario H. Botero Cid, Ulrike Holzgrabe, and Klaus Mohr: Identification of a [³H]Ligand for the Common Allosteric Site of Muscarinic Acetylcholine M₂ Receptors
Mol Pharmacol 1998 54: 139-145. [Abstract] [Full Text] [PDF]

Cecilia Bouzat, Ana M. Roccamo, Ingrid Garbus, and F. J. Barrantes: Mutations at Lipid-Exposed Residues of the Acetylcholine Receptor Affect Its Gating Kinetics
Mol Pharmacol 1998 54: 146-153. [Abstract] [Full Text] [PDF]

Helgi B. Schiöth, Philip Yook, Ruta Muceniece, Jarl E. S. Wikberg, and Michael Szardenings: Chimeric Melanocortin MC1 and MC3 Receptors: Identification of Domains Participating in Binding of Melanocyte-Stimulating Hormone Peptides
Mol Pharmacol 1998 54: 154-161. [Abstract] [Full Text] [PDF]

Mónica Longobardo, Eva Delpón, Ricardo Caballero, Juan Tamargo, and Carmen Valenzuela: Structural Determinants of Potency and Stereoselective Block of hKv1.5 Channels Induced by Local Anesthetics
Mol Pharmacol 1998 54: 162-169. [Abstract] [Full Text] [PDF]

Patrick G. Bray, Mathirut Mungthin, Robert G. Ridley, and Stephen A. Ward: Access to Hematin: The Basis of Chloroquine Resistance
Mol Pharmacol 1998 54: 170-179. [Abstract] [Full Text] [PDF]

William S. Edgemond, Cecilia J. Hillard, J. R. Falck, Christopher S. Kearn, and William B. Campbell: Human Platelets and Polymorphonuclear Leukocytes Synthesize Oxygenated Derivatives of Arachidonylethanolamide (Anandamide): Their Affinities for Cannabinoid Receptors and Pathways of Inactivation
Mol Pharmacol 1998 54: 180-188. [Abstract] [Full Text] [PDF]

Robert J. Vandenberg, Ann D. Mitrovic, and Graham A. R. Johnston: Molecular Basis for Differential Inhibition of Glutamate Transporter Subtypes by Zinc Ions
Mol Pharmacol 1998 54: 189-196. [Abstract] [Full Text] [PDF]

Domenico Tricarico, Sabata Pierno, Rosanna Mallamaci, Giovanni Siro Brigiani, Raffaele Capriulo, Giuseppe Santoro, and Diana Conte Camerino: The Biophysical and Pharmacological Characteristics of Skeletal Muscle ATP-Sensitive K⁺ Channels Are Modified in K⁺-Depleted Rat, an Animal Model of Hypokalemic Periodic Paralysis
Mol Pharmacol 1998 54: 197-206. [Abstract] [Full Text] [PDF]

Astrid Schrammel, Silvia Pfeiffer, Kurt Schmidt, Doris Koesling, and Bernd Mayer: Activation of Soluble Guanylyl Cyclase by the Nitrovasodilator 3-Morpholinosydnonimine Involves Formation of S-Nitrosoglutathione
Mol Pharmacol 1998 54: 207-212. [Abstract] [Full Text] [PDF]

Paola Perego, Franco Zunino, Nives Carenini, Fernando Giuliani, Silvano Spinelli, and Stephen B. Howell: Sensitivity to Cisplatin and Platinum-Containing Compounds of Schizosaccharomyces pombe Rad Mutants
Mol Pharmacol 1998 54: 213-219. [Abstract] [Full Text] [PDF]

Joseph J. Salata, Nancy K. Jurkiewicz, Jixin Wang, Ben E. Evans, Heidi T. Orme, and Michael C. Sanguinetti: A Novel Benzodiazepine that Activates Cardiac Slow Delayed Rectifier K⁺ Currents
Mol Pharmacol 1998 54: 220-230. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Simultaneous monitoring of cytosolic and mitochondrial calcium transients in a cultured striatal neuron.The cell was loaded with calcium green-1N/AM to follow cytosoliccalcium (diffuse green signal) and with rhod-2/AM to follow mitochondrialcalcium (punctate red signal). Laser scanning confocal microscopywas used to measure changes in the two fluorescence signals afterdepolarization with KCl. The graph shows that with this stimulus,cytosolic calcium (green trace) rises rapidly and is followedby a latency of a few seconds caused by mitochondrial calciumaccumulation (red trace). From Peng T-I, Greenamyre JT (1998)Privileged access to mitochondria of calcium influx through N-methyl-D-aspartatereceptors. Mol Pharmacol 54:974-980.