Mol Pharm -- Table of Contents (54 [2])

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August 1998; 54 (2)   [Index by Author] [Cover Caption]

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Wei-Jen Tang and James H. Hurley: Catalytic Mechanism and Regulation of Mammalian Adenylyl Cyclases
Mol Pharmacol 1998 54: 231-240. [Full Text] [PDF]

Articles:

Detlef Bönisch, Artur-Aron Weber, Michael Wittpoth, Michael Osinski, and Karsten Schrör: Antimitogenic Effects of Trapidil In Coronary Artery Smooth Muscle Cells by Direct Activation of Protein Kinase A
Mol Pharmacol 1998 54: 241-248. [Abstract] [Full Text] [PDF]

Chee Wai Fong, Daljit S. Bahia, Stephen Rees, and Graeme Milligan: Selective Activation of a Chimeric G_i1/G_s G Protein $alpha$ Subunit by the Human IP Prostanoid Receptor: Analysis Using Agonist Stimulation of High Affinity GTPase Activity and [³⁵S]Guanosine-5'-O-(3-thio)triphosphate Binding
Mol Pharmacol 1998 54: 249-257. [Abstract] [Full Text] [PDF]

Petra M. Schwarz, Birgit Gierten, Jean-Paul Boissel, and Ulrich Förstermann: Expressional Down-Regulation of Neuronal-Type Nitric Oxide Synthase I by Glucocorticoids in N1E-115 Neuroblastoma Cells
Mol Pharmacol 1998 54: 258-263. [Abstract] [Full Text] [PDF]

Valerie Boss, Xiaofei Wang, Lacie F. Koppelman, Kaiming Xu, and T. J. Murphy: Histamine Induces Nuclear Factor of Activated T Cell-Mediated Transcription and Cyclosporin A-Sensitive Interleukin-8 mRNA Expression in Human Umbilical Vein Endothelial Cells
Mol Pharmacol 1998 54: 264-272. [Abstract] [Full Text] [PDF]

Marion B. Sewer, Thomas B. Barclay, and Edward T. Morgan: Down-Regulation of Cytochrome P450 mRNAs and Proteins in Mice Lacking a Functional NOS2 Gene
Mol Pharmacol 1998 54: 273-279. [Abstract] [Full Text] [PDF]

Nouri Neamati, Abhijit Mazumder, Sanjay Sunder, Joshua M. Owen, Manju Tandon, J. William Lown, and Yves Pommier: Highly Potent Synthetic Polyamides, Bisdistamycins, and Lexitropsins as Inhibitors of Human Immunodeficiency Virus Type 1 Integrase
Mol Pharmacol 1998 54: 280-290. [Abstract] [Full Text] [PDF]

Michael D. Miller, Patrick D. Lamy, Michael D. Fuller, Andrew S. Mulato, Nicolas A. Margot, Tomas Cihlar, and Julie M. Cherrington: Human Immunodeficiency Virus Type 1 Reverse Transcriptase Expressing the K70E Mutation Exhibits a Decrease in Specific Activity and Processivity
Mol Pharmacol 1998 54: 291-297. [Abstract] [Full Text] [PDF]

Wanda R. Fields, Charles S. Morrow, Amanda J. Doss, Kathrin Sundberg, Bengt Jernström, and Alan J. Townsend: Overexpression of Stably Transfected Human Glutathione S-Transferase P1-1 Protects against DNA Damage by Benzo[a]pyrene Diol-Epoxide in Human T47D Cells
Mol Pharmacol 1998 54: 298-304. [Abstract] [Full Text] [PDF]

Romuald Lainé and Paul R. Ortiz de Montellano: Neuronal Nitric Oxide Synthase Isoforms $alpha$ and µ Are Closely Related Calpain-Sensitive Proteins
Mol Pharmacol 1998 54: 305-312. [Abstract] [Full Text] [PDF]

Hani Zaher, Pedro M. Fernandez-Salguero, John Letterio, M. Saeed Sheikh, Albert J. Fornace Jr., Anita B. Roberts, and Frank J. Gonzalez: The Involvement of Aryl Hydrocarbon Receptor in the Activation of Transforming Growth Factor- $beta$ and Apoptosis
Mol Pharmacol 1998 54: 313-321. [Abstract] [Full Text] [PDF]

Yingxian Xiao, Erin L. Meyer, Jessica M. Thompson, Alexander Surin, Jarda Wroblewski, and Kenneth J. Kellar: Rat $alpha$ 3/ $beta$ 4 Subtype of Neuronal Nicotinic Acetylcholine Receptor Stably Expressed in a Transfected Cell Line: Pharmacology of Ligand Binding and Function
Mol Pharmacol 1998 54: 322-333. [Abstract] [Full Text] [PDF]

Stefania D'Atri, Lucio Tentori, Pedro Miguel Lacal, Grazia Graziani, Elena Pagani, Elena Benincasa, Giovanna Zambruno, Enzo Bonmassar, and Josef Jiricny: Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis
Mol Pharmacol 1998 54: 334-341. [Abstract] [Full Text] [PDF]

Andreas E. Busch, Ulrich Karbach, Dagmar Miska, Valentin Gorboulev, Aida Akhoundova, Christopher Volk, Petra Arndt, Jochen C. Ulzheimer, Mark S. Sonders, Carmen Baumann, Siegfried Waldegger, Florian Lang, and Hermann Koepsell: Human Neurons Express the Polyspecific Cation Transporter hOCT2, Which Translocates Monoamine Neurotransmitters, Amantadine, and Memantine
Mol Pharmacol 1998 54: 342-352. [Abstract] [Full Text] [PDF]

Rudolfs K. Zalups, Lisa D. Parks, Vernon T. Cannon, and Delon W. Barfuss: Mechanisms of Action of 2,3-Dimercaptopropane-1-sulfonate and the Transport, Disposition, and Toxicity of Inorganic Mercury in Isolated Perfused Segments of Rabbit Proximal Tubules
Mol Pharmacol 1998 54: 353-363. [Abstract] [Full Text] [PDF]

Sandrine Silvente-Poirot, Chantal Escrieut, and Stephen A. Wank: Role of the Extracellular Domains of the Cholecystokinin Receptor in Agonist Binding
Mol Pharmacol 1998 54: 364-371. [Abstract] [Full Text] [PDF]

Baljit S. Khakh and Graeme Henderson: ATP Receptor-Mediated Enhancement of Fast Excitatory Neurotransmitter Release in the Brain
Mol Pharmacol 1998 54: 372-378. [Abstract] [Full Text] [PDF]

Glen L. Alberts, Jeffrey F. Pregenzer, and Wha Bin Im: Identification of Transmembrane Regions Critical for Ligand Binding to the Human D₃ Dopamine Receptor Using Various D₃/D₁ Transmembrane Chimeras
Mol Pharmacol 1998 54: 379-388. [Abstract] [Full Text] [PDF]

Ging Kuo Wang, Catherine Quan, and Sho-Ya Wang: Local Anesthetic Block of Batrachotoxin-Resistant Muscle Na⁺ Channels
Mol Pharmacol 1998 54: 389-396. [Abstract] [Full Text] [PDF]

Benson Chu, Alejandro M. Dopico, José R. Lemos, and Steven N. Treistman: Ethanol Potentiation of Calcium-Activated Potassium Channels Reconstituted into Planar Lipid Bilayers
Mol Pharmacol 1998 54: 397-406. [Abstract] [Full Text] [PDF]

Kathy G. Sutton, Chet Siok, Anthony Stea, Gerald W. Zamponi, Steven D. Heck, Robert A. Volkmann, Michael K. Ahlijanian, and Terry P. Snutch: Inhibition of Neuronal Calcium Channels by a Novel Peptide Spider Toxin, DW13.3
Mol Pharmacol 1998 54: 407-418. [Abstract] [Full Text] [PDF]

Igal Nevo, Tomer Avidor-Reiss, Rivka Levy, Michael Bayewitch, Eli Heldman, and Zvi Vogel: Regulation of Adenylyl Cyclase Isozymes on Acute and Chronic Activation of Inhibitory Receptors
Mol Pharmacol 1998 54: 419-426. [Abstract] [Full Text] [PDF]

László Hunyady, Hong Ji, Gowraganahalli Jagadeesh, Meng Zhang, Zsuzsanna Gáborik, Balázs Mihalik, and Kevin J. Catt: Dependence of AT₁ Angiotensin Receptor Function on Adjacent Asparagine Residues in the Seventh Transmembrane Helix
Mol Pharmacol 1998 54: 427-434. [Abstract] [Full Text] [PDF]

Brenda L. Wiens, Cole S. Nelson, and Kim A. Neve: Contribution of Serine Residues to Constitutive and Agonist-Induced Signaling via the D_2S Dopamine Receptor: Evidence for Multiple, Agonist-Specific Active Conformations
Mol Pharmacol 1998 54: 435-444. [Abstract] [Full Text] [PDF]

Oliver Werz, Dagmar Szellas, Margarete Henseler, and Dieter Steinhilber: Nonredox 5-Lipoxygenase Inhibitors Require Glutathione Peroxidase for Efficient Inhibition of 5-Lipoxygenase Activity
Mol Pharmacol 1998 54: 445-451. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Simultaneous monitoring of cytosolic and mitochondrial calcium transients in a cultured striatal neuron.The cell was loaded with calcium green-1N/AM to follow cytosoliccalcium (diffuse green signal) and with rhod-2/AM to follow mitochondrialcalcium (punctate red signal). Laser scanning confocal microscopywas used to measure changes in the two fluorescence signals afterdepolarization with KCl. The graph shows that with this stimulus,cytosolic calcium (green trace) rises rapidly and is followedby a latency of a few seconds caused by mitochondrial calciumaccumulation (red trace). From Peng T-I, Greenamyre JT (1998)Privileged access to mitochondria of calcium influx through N-methyl-D-aspartatereceptors. Mol Pharmacol 53:974-980.