Mol Pharm -- Table of Contents (54 [4])

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October 1998; 54 (4)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Lankupalle D. Jayanthi, Subramaniam Apparsundaram, M. Denise Malone, Eric Ward, David M. Miller, Mark Eppler, and Randy D. Blakely: The Caenorhabditis elegans Gene T23G5.5 Encodes an Antidepressant- and Cocaine-Sensitive Dopamine Transporter
Mol Pharmacol 1998 54: 601-609. [Abstract] [Full Text] [PDF]

Roderic G. Eckenhoff: Do Specific or Nonspecific Interactions with Proteins Underlie Inhalational Anesthetic Action?
Mol Pharmacol 1998 54: 610-615. [Abstract] [Full Text] [PDF]

Articles:

Masafumi Isogaya, Yoko Yamagiwa, Shigeo Fujita, Yoshiyuki Sugimoto, Taku Nagao, and Hitoshi Kurose: Identification of a Key Amino Acid of the $beta$ ₂-Adrenergic Receptor for High Affinity Binding of Salmeterol
Mol Pharmacol 1998 54: 616-622. [Abstract] [Full Text] [PDF]

Tzipora Shoshani, Shudong Zhang, Saibal Dey, Ira Pastan, and Michael M. Gottesman: Analysis of Random Recombination between Human MDR1 and Mouse Mdr1a cDNA in a pHaMDR-Dihydrofolate Reductase Bicistronic Expression System
Mol Pharmacol 1998 54: 623-630. [Abstract] [Full Text] [PDF]

Fraser P. Coxon, Helena L. Benford, R. Graham G. Russell, and Michael J. Rogers: Protein Synthesis Is Required for Caspase Activation and Induction of Apoptosis by Bisphosphonate Drugs
Mol Pharmacol 1998 54: 631-638. [Abstract] [Full Text] [PDF]

C. David Weaver, John G. Partridge, Tom L. Yao, J. Michael Moates, Mark A. Magnuson, and Todd A. Verdoorn: Activation of Glycine and Glutamate Receptors Increases Intracellular Calcium in Cells Derived from the Endocrine Pancreas
Mol Pharmacol 1998 54: 639-646. [Abstract] [Full Text] [PDF]

Christian P. Strassburg, Nghia Nguyen, Michael P. Manns, and Robert H. Tukey: Polymorphic Expression of the UDP-Glucuronosyltransferase UGT1A Gene Locus in Human Gastric Epithelium
Mol Pharmacol 1998 54: 647-654. [Abstract] [Full Text] [PDF]

Sumita Chakrabarti, Mildred Rivera, Shui-Zhong Yan, Wei-Jen Tang, and Alan R. Gintzler: Chronic Morphine Augments G/G_s Stimulation of Adenylyl Cyclase: Relevance to Opioid Tolerance
Mol Pharmacol 1998 54: 655-662. [Abstract] [Full Text] [PDF]

Siobhan T. Harkin, Gerald M. Cohen, and Andreas Gescher: Modulation of Apoptosis in Rat Thymocytes by Analogs of Staurosporine: Lack of Direct Association with Inhibition of Protein Kinase C
Mol Pharmacol 1998 54: 663-670. [Abstract] [Full Text] [PDF]

Hollie I. Swanson and Jun-Hau Yang: The Aryl Hydrocarbon Receptor Interacts with Transcription Factor IIB
Mol Pharmacol 1998 54: 671-677. [Abstract] [Full Text] [PDF]

M. A. Mena, Viviana Davila, Joanna Bogaluvsky, and David Sulzer: A Synergistic Neurotrophic Response to l-Dihydroxyphenylalanine and Nerve Growth Factor
Mol Pharmacol 1998 54: 678-686. [Abstract] [Full Text] [PDF]

James G. Granneman, Ying Zhai, Zhengxian Zhu, Michael J. Bannon, Scott A. Burchett, Carl J. Schmidt, Rodrigo Andrade, and James Cooper: Molecular Characterization of Human and Rat RGS 9L, a Novel Splice Variant Enriched in Dopamine Target Regions, and Chromosomal Localization of the RGS 9 Gene
Mol Pharmacol 1998 54: 687-694. [Abstract] [Full Text] [PDF]

Christophe Chouabe, Milou-Daniel Drici, Georges Romey, Jacques Barhanin, and Michel Lazdunski: HERG and KvLQT1/IsK, the Cardiac K⁺ Channels Involved in Long QT Syndromes, Are Targets for Calcium Channel Blockers
Mol Pharmacol 1998 54: 695-703. [Abstract] [Full Text] [PDF]

Abraham Kovoor, Jeremy P. Celver, Albert Wu, and Charles Chavkin: Agonist Induced Homologous Desensitization of µ-Opioid Receptors Mediated by G Protein-Coupled Receptor Kinases Is Dependent on Agonist Efficacy
Mol Pharmacol 1998 54: 704-711. [Abstract] [Full Text] [PDF]

Chung-Chin Kuo: A Common Anticonvulsant Binding Site for Phenytoin, Carbamazepine, and Lamotrigine in Neuronal Na⁺ Channels
Mol Pharmacol 1998 54: 712-721. [Abstract] [Full Text] [PDF]

Arimatti Jutila, Marjatta Rytömaa, and Paavo K. J. Kinnunen: Detachment of Cytochrome c by Cationic Drugs from Membranes Containing Acidic Phospholipids: Comparison of Lidocaine, Propranolol, and Gentamycin
Mol Pharmacol 1998 54: 722-732. [Abstract] [Full Text] [PDF]

Sterling N. Wright, Sho-Ya Wang, and Ging Kuo Wang: Lysine Point Mutations in Na⁺ Channel D4-S6 Reduce Inactivated Channel Block by Local Anesthetics
Mol Pharmacol 1998 54: 733-739. [Abstract] [Full Text] [PDF]

Hwei-Ming Peng and Minor J. Coon: Regulation of Rabbit Cytochrome P450 2E1 Expression in HepG2 Cells by Insulin and Thyroid Hormone
Mol Pharmacol 1998 54: 740-747. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Simultaneous monitoring of cytosolic and mitochondrial calcium transients in a cultured striatal neuron.The cell was loaded with calcium green-1N/AM to follow cytosoliccalcium (diffuse green signal) and with rhod-2/AM to follow mitochondrialcalcium (punctate red signal). Laser scanning confocal microscopywas used to measure changes in the two fluorescence signals afterdepolarization with KCl. The graph shows that with this stimulus,cytosolic calcium (green trace) rises rapidly and is followedby a latency of a few seconds caused by mitochondrial calciumaccumulation (red trace). From Peng T-I, Greenamyre JT (1998)Privileged access to mitochondria of calcium influx through N-methyl-D-aspartatereceptors. Mol Pharmacol 53:974-980.