Mol Pharm -- Table of Contents (54 [5])

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November 1998; 54 (5)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Faton Agani and Gregg L. Semenza: Mersalyl Is a Novel Inducer of Vascular Endothelial Growth Factor Gene Expression and Hypoxia-Inducible Factor 1 Activity
Mol Pharmacol 1998 54: 749-754. [Abstract] [Full Text] [PDF]

Articles:

Alexander Alexandrov, Susanne Keffel, Mark Goepel, and Martin C. Michel: Stimulation of $alpha$ _1A-Adrenoceptors in Rat-1 Cells Inhibits Extracellular Signal-Regulated Kinase by Activating p38 Mitogen-Activated Protein Kinase
Mol Pharmacol 1998 54: 755-760. [Abstract] [Full Text] [PDF]

Linda J. Olson, Begonia Y. Ho, L. William Cashdollar, and James G. Drewett: Functionally Active Catalytic Domain Is Essential for Guanylyl Cyclase-Linked Receptor Mediated Inhibition of Human Aldosterone Synthesis
Mol Pharmacol 1998 54: 761-769. [Abstract] [Full Text] [PDF]

Jan M. Woynarowski, William G. Chapman, Cheryl Napier, Maryanne C. S. Herzig, and Paul Juniewicz: Sequence- and Region-Specificity of Oxaliplatin Adducts in Naked and Cellular DNA
Mol Pharmacol 1998 54: 770-777. [Abstract] [Full Text] [PDF]

Arno D. J. Maus, Edna F. R. Pereira, Peter I. Karachunski, Robert M. Horton, Duraiswamy Navaneetham, Kevin Macklin, Wellington S. Cortes, Edson X. Albuquerque, and Bianca M. Conti-Fine: Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors
Mol Pharmacol 1998 54: 779-788. [Abstract] [Full Text] [PDF]

Marcel Leist, Christiane Volbracht, Eugenio Fava, and Pierluigi Nicotera: 1-Methyl-4-Phenylpyridinium Induces Autocrine Excitotoxicity, Protease Activation, and Neuronal Apoptosis
Mol Pharmacol 1998 54: 789-801. [Abstract] [Full Text] [PDF]

M. Alvarez, R. Robey, V. Sandor, K. Nishiyama, Y. Matsumoto, K. Paull, S. Bates, and T. Fojo: Using the National Cancer Institute Anticancer Drug Screen to Assess the Effect of MRP Expression on Drug Sensitivity Profiles
Mol Pharmacol 1998 54: 802-814. [Abstract] [Full Text] [PDF]

Hajime Hosoi, Michael B. Dilling, Linda N. Liu, Mary K. Danks, Takuma Shikata, Aleksander Sekulic, Robert T. Abraham, John C. Lawrence Jr., and Peter J. Houghton: Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells
Mol Pharmacol 1998 54: 815-824. [Abstract] [Full Text] [PDF]

Paul B. Brake, Leying Zhang, and Colin R. Jefcoate: Aryl Hydrocarbon Receptor Regulation of Cytochrome P4501B1 in Rat Mammary Fibroblasts: Evidence for Transcriptional Repression by Glucocorticoids
Mol Pharmacol 1998 54: 825-833. [Abstract] [Full Text] [PDF]

Cristina Sánchez, Ismael Galve-Roperh, Daniel Rueda, and Manuel Guzmán: Involvement of Sphingomyelin Hydrolysis and the Mitogen-Activated Protein Kinase Cascade in the $Delta$ ⁹-Tetrahydrocannabinol-Induced Stimulation of Glucose Metabolism in Primary Astrocytes
Mol Pharmacol 1998 54: 834-843. [Abstract] [Full Text] [PDF]

W. David Jarvis, Frank A. Fornari Jr., Robert M. Tombes, Ravi K. Erukulla, Robert Bittman, Gary K. Schwartz, Paul Dent, and Steven Grant: Evidence for Involvement of Mitogen-Activated Protein Kinase, Rather than Stress-Activated Protein Kinase, in Potentiation of 1- $beta$ -D-Arabinofuranosylcytosine-Induced Apoptosis by Interruption of Protein Kinase C Signaling
Mol Pharmacol 1998 54: 844-856. [Abstract] [Full Text] [PDF]

Michael Bläker, Yong Ren, Michelle C. Gordon, Jean E. Hsu, Martin Beinborn, and Alan S. Kopin: Mutations within the Cholecystokinin-B/Gastrin Receptor Ligand `Pocket' Interconvert the Functions of Nonpeptide Agonists and Antagonists
Mol Pharmacol 1998 54: 857-863. [Abstract] [Full Text] [PDF]

William R. Baumbach, Tikva A. Carrick, Mark H. Pausch, Brendan Bingham, Danielle Carmignac, Iain C. A. F. Robinson, Richard Houghten, C. Mark Eppler, Laura A. Price, and John R. Zysk: A Linear Hexapeptide Somatostatin Antagonist Blocks Somatostatin Activity In Vitro and Influences Growth Hormone Release in Rats
Mol Pharmacol 1998 54: 864-873. [Abstract] [Full Text] [PDF]

Kelly E. Gridley, Pattie S. Green, and James W. Simpkins: A Novel, Synergistic Interaction Between 17 $beta$ -Estradiol and Glutathione in the Protection of Neurons against $beta$ -Amyloid 25-35-Induced Toxicity In Vitro
Mol Pharmacol 1998 54: 874-880. [Abstract] [Full Text] [PDF]

Songzhu An, Thieu Bleu, Yuhua Zheng, and Edward J. Goetzl: Recombinant Human G Protein-Coupled Lysophosphatidic Acid Receptors Mediate Intracellular Calcium Mobilization
Mol Pharmacol 1998 54: 881-888. [Abstract] [Full Text] [PDF]

Barbara Y. Williams, Stéphane B. Dion, and Agnes Schonbrunn: Role of Receptor and Protein Kinase C Activation in the Internalization of the Gastrin-Releasing Peptide Receptor
Mol Pharmacol 1998 54: 889-898. [Abstract] [Full Text] [PDF]

Jan Jakubík and Tatsuya Haga: Effects of an Agonist, Allosteric Modulator, and Antagonist on Guanosine- $gamma$ -[³⁵S]thiotriphosphate Binding to Liposomes with Varying Muscarinic Receptor/G_o Protein Stoichiometry
Mol Pharmacol 1998 54: 899-906. [Abstract] [Full Text] [PDF]

Sigrid Hatse, Erik De Clercq, and Jan Balzarini: Enhanced 9-(2-Phosphonylmethoxyethyl)adenine Secretion by a Specific, Indomethacin-Sensitive Efflux Pump in a Mutant 9-(2-Phosphonylmethoxyethyl)adenine-Resistant Human Erythroleukemia K562 Cell Line
Mol Pharmacol 1998 54: 907-917. [Abstract] [Full Text] [PDF]

Slobodan M. Todorovic, Murali Prakriya, Yasunori M. Nakashima, Kent R. Nilsson, Mingchen Han, Charles F. Zorumski, Douglas F. Covey, and Christopher J. Lingle: Enantioselective Blockade of T-type Ca²⁺ Current in Adult Rat Sensory Neurons by a Steroid That Lacks $gamma$ -Aminobutyric Acid-Modulatory Activity
Mol Pharmacol 1998 54: 918-927. [Abstract] [Full Text] [PDF]

Cyrille Sur, Kathleen Quirk, Deborah Dewar, John Atack, and Ruth McKernan: Rat and Human Hippocampal $alpha$ 5 Subunit-Containing $gamma$ -Aminobutyric Acid_A Receptors Have $alpha$ 5 $beta$ 3 $gamma$ 2 Pharmacological Characteristics
Mol Pharmacol 1998 54: 928-933. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Simultaneous monitoring of cytosolic and mitochondrial calcium transients in a cultured striatal neuron.The cell was loaded with calcium green-1N/AM to follow cytosoliccalcium (diffuse green signal) and with rhod-2/AM to follow mitochondrialcalcium (punctate red signal). Laser scanning confocal microscopywas used to measure changes in the two fluorescence signals afterdepolarization with KCl. The graph shows that with this stimulus,cytosolic calcium (green trace) rises rapidly and is followedby a latency of a few seconds caused by mitochondrial calciumaccumulation (red trace). From Peng T-I, Greenamyre JT (1998)Privileged access to mitochondria of calcium influx through N-methyl-D-aspartatereceptors. Mol Pharmacol 53:974-980.