Mol Pharm -- Table of Contents (54 [6])

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December 1998; 54 (6)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Roger D. Smith, László Hunyady, J. Alberto Olivares-Reyes, Balázs Mihalik, Suman Jayadev, and Kevin J. Catt: Agonist-Induced Phosphorylation of the Angiotensin AT_1a Receptor Is Localized to a Serine/Threonine-Rich Region of Its Cytoplasmic Tail
Mol Pharmacol 1998 54: 935-941. [Abstract] [Full Text] [PDF]

Rana Dajani, Alan M. Hood, and Michael W. H. Coughtrie: A Single Amino Acid, Glu146, Governs the Substrate Specificity of a Human Dopamine Sulfotransferase, SULT1A3
Mol Pharmacol 1998 54: 942-948. [Abstract] [Full Text] [PDF]

Sumita Chakrabarti, Lin Wang, Wei-Jen Tang, and Alan R. Gintzler: Chronic Morphine Augments Adenylyl Cyclase Phosphorylation: Relevance to Altered Signaling during Tolerance/Dependence
Mol Pharmacol 1998 54: 949-953. [Abstract] [Full Text] [PDF]

Articles:

Radosveta P. Koldamova, Iliya M. Lefterov, Marc T. DiSabella, and John S. Lazo: An Evolutionarily Conserved Cysteine Protease, Human Bleomycin Hydrolase, Binds to the Human Homologue of Ubiquitin-Conjugating Enzyme 9
Mol Pharmacol 1998 54: 954-961. [Abstract] [Full Text] [PDF]

Andreas Friebe, Florian Müllershausen, Albert Smolenski, Ulrich Walter, Günter Schultz, and Doris Koesling: YC-1 Potentiates Nitric Oxide- and Carbon Monoxide-Induced Cyclic GMP Effects in Human Platelets
Mol Pharmacol 1998 54: 962-967. [Abstract] [Full Text] [PDF]

Anny-Odile Colson, Jeffrey H. Perlman, Arti Jinsi-Parimoo, Daniel R. Nussenzveig, Roman Osman, and Marvin C. Gershengorn: A Hydrophobic Cluster between Transmembrane Helices 5 and 6 Constrains the Thyrotropin-Releasing Hormone Receptor in an Inactive Conformation
Mol Pharmacol 1998 54: 968-978. [Abstract] [Full Text] [PDF]

David J. Fischer, Károly Liliom, Zhong Guo, Nóra Nusser, Tamás Virág, Kimiko Murakami-Murofushi, Susumu Kobayashi, James R. Erickson, Guoping Sun, Duane D. Miller, and Gábor Tigyi: Naturally Occurring Analogs of Lysophosphatidic Acid Elicit Different Cellular Responses through Selective Activation of Multiple Receptor Subtypes
Mol Pharmacol 1998 54: 979-988. [Abstract] [Full Text] [PDF]

Gonzalo E. Torres, William R. Haines, Terrance M. Egan, and Mark M. Voigt: Co-Expression of P2X₁ and P2X₅ Receptor Subunits Reveals a Novel ATP-Gated Ion Channel
Mol Pharmacol 1998 54: 989-993. [Abstract] [Full Text] [PDF]

Sutapa Ray, Banasri Hazra, Bidyottam Mittra, Aditi Das, and Hemanta K. Majumder: Diospyrin, A Bisnaphthoquinone: A Novel Inhibitor of Type I DNA Topoisomerase of Leishmania donovani
Mol Pharmacol 1998 54: 994-999. [Abstract] [Full Text] [PDF]

Shawn M. Heidel, Charles J. Czuprynski, and Colin R. Jefcoate: Bone Marrow Stromal Cells Constitutively Express High Levels of Cytochrome P4501B1 that Metabolize 7,12-Dimethylbenz[a]anthracene
Mol Pharmacol 1998 54: 1000-1006. [Abstract] [Full Text] [PDF]

Trevor R. Walker, Sarah M. Moore, Mark F. Lawson, Reynold A. Panettieri Jr., and Edwin R. Chilvers: Platelet-Derived Growth Factor-BB and Thrombin Activate Phosphoinositide 3-Kinase and Protein Kinase B: Role in Mediating Airway Smooth Muscle Proliferation
Mol Pharmacol 1998 54: 1007-1015. [Abstract] [Full Text] [PDF]

Lawrence E. Cornett, F. Charles Hiller, Sandie E. Jacobi, Wenhui Cao, and Dennis W. McGraw: Identification of a Glucocorticoid Response Element in the Rat $beta$ ₂-Adrenergic Receptor Gene
Mol Pharmacol 1998 54: 1016-1023. [Abstract] [Full Text] [PDF]

Koichi Sakurai and Arthur I. Cederbaum: Oxidative Stress and Cytotoxicity Induced by Ferric-Nitrilotriacetate in HepG2 Cells That Express Cytochrome P450 2E1
Mol Pharmacol 1998 54: 1024-1035. [Abstract] [Full Text] [PDF]

Claudia Sissi, Loretta Bolgan, Stefano Moro, Giuseppe Zagotto, Christian Bailly, Ernesto Menta, Giovanni Capranico, and Manlio Palumbo: DNA-Binding Preferences of Bisantrene Analogues: Relevance to the Sequence Specificity of Drug-Mediated Topoisomerase II Poisoning
Mol Pharmacol 1998 54: 1036-1045. [Abstract] [Full Text] [PDF]

Yoshihisa Kitamura, Tadashi Kosaka, Jun-Ichi Kakimura, Yasuji Matsuoka, Yasuko Kohno, Yasuyuki Nomura, and Takashi Taniguchi: Protective Effects of the Antiparkinsonian Drugs Talipexole and Pramipexole against 1-Methyl-4-phenylpyridinium-Induced Apoptotic Death in Human Neuroblastoma SH-SY5Y Cells
Mol Pharmacol 1998 54: 1046-1054. [Abstract] [Full Text] [PDF]

Zhi-Gang Xiong, Ramin Raouf, Wei-Yang Lu, Lu-Yang Wang, Beverley A. Orser, Ellen M. Dudek, Michael D. Browning, and John F. MacDonald: Regulation of N-Methyl-D-Aspartate Receptor Function by Constitutively Active Protein Kinase C
Mol Pharmacol 1998 54: 1055-1063. [Abstract] [Full Text] [PDF]

Xianghua Pan, Stephen R. Ikeda, and Deborah L. Lewis: SR 141716A Acts as an Inverse Agonist to Increase Neuronal Voltage-Dependent Ca²⁺ Currents by Reversal of Tonic CB1 Cannabinoid Receptor Activity
Mol Pharmacol 1998 54: 1064-1072. [Abstract] [Full Text] [PDF]

Olivier Kassel, Fabien Schmidlin, Catherine Duvernelle, Frédéric de Blay, and Nelly Frossard: Up- and Down-Regulation by Glucocorticoids of the Constitutive Expression of the Mast Cell Growth Factor Stem Cell Factor by Human Lung Fibroblasts in Culture
Mol Pharmacol 1998 54: 1073-1079. [Abstract] [Full Text] [PDF]

Stefan I. McDonough and Bruce P. Bean: Mibefradil Inhibition of T-Type Calcium Channels in Cerebellar Purkinje Neurons
Mol Pharmacol 1998 54: 1080-1087. [Abstract] [Full Text] [PDF]

Thierry Wurch, Francis C. Colpaert, and Petrus J. Pauwels: Chimeric Receptor Analysis of the Ketanserin Binding Site in the Human 5-Hydroxytryptamine_1D Receptor: Importance of the Second Extracellular Loop and Fifth Transmembrane Domain in Antagonist Binding
Mol Pharmacol 1998 54: 1088-1096. [Abstract] [Full Text] [PDF]

Erwin Sigel, Martin T. Schaerer, Andreas Buhr, and Roland Baur: The Benzodiazepine Binding Pocket of Recombinant $alpha$ 1 $beta$ 2 $gamma$ 2 $gamma$ -Aminobutyric Acid_A Receptors: Relative Orientation of Ligands and Amino Acid Side Chains
Mol Pharmacol 1998 54: 1097-1105. [Abstract] [Full Text] [PDF]

Murat Oz, Michael T. Melia, Nikolai M. Soldatov, Darrell R. Abernethy, and Martin Morad: Functional Coupling of Human L-Type Ca²⁺ Channels and Angiotensin AT_1A Receptors Coexpressed in Xenopus laevis Oocytes: Involvement of the Carboxyl-Terminal Ca²⁺ Sensors
Mol Pharmacol 1998 54: 1106-1112. [Abstract] [Full Text] [PDF]

Erin G. Schuetz, Cynthia Brimer, and John D. Schuetz: Environmental Xenobiotics and the Antihormones Cyproterone Acetate and Spironolactone Use the Nuclear Hormone Pregnenolone X Receptor to Activate the CYP3A23 Hormone Response Element
Mol Pharmacol 1998 54: 1113-1117. [Abstract] [Full Text] [PDF]

R. Kyle Palmer, José L. Boyer, Joel B. Schachter, Robert A. Nicholas, and T. Kendall Harden: Agonist Action of Adenosine Triphosphates at the Human P2Y₁ Receptor
Mol Pharmacol 1998 54: 1118-1123. [Abstract] [Full Text] [PDF]

Ruud Zwart and Henk P. M. Vijverberg: Four Pharmacologically Distinct Subtypes of $alpha$ 4 $beta$ 2 Nicotinic Acetylcholine Receptor Expressed in Xenopus laevis Oocytes
Mol Pharmacol 1998 54: 1124-1131. [Abstract] [Full Text] [PDF]

Michael J. Parker, Avi Beck, and Charles W. Luetje: Neuronal Nicotinic Receptor $beta$ 2 and $beta$ 4 Subunits Confer Large Differences in Agonist Binding Affinity
Mol Pharmacol 1998 54: 1132-1139. [Abstract] [Full Text] [PDF]

David A. Fidock, Takashi Nomura, and Thomas E. Wellems: Cycloguanil and Its Parent Compound Proguanil Demonstrate Distinct Activities against Plasmodium falciparum Malaria Parasites Transformed with Human Dihydrofolate Reductase
Mol Pharmacol 1998 54: 1140-1147. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Simultaneous monitoring of cytosolic and mitochondrial calcium transients in a cultured striatal neuron.The cell was loaded with calcium green-1N/AM to follow cytosoliccalcium (diffuse green signal) and with rhod-2/AM to follow mitochondrialcalcium (punctate red signal). Laser scanning confocal microscopywas used to measure changes in the two fluorescence signals afterdepolarization with KCl. The graph shows that with this stimulus,cytosolic calcium (green trace) rises rapidly and is followedby a latency of a few seconds caused by mitochondrial calciumaccumulation (red trace). From Peng T-I and Greenamyre JT (1998)Privileged access to mitochondria of calcium influx through N-methyl-D-aspartatereceptors. Mol Pharmacol 53:974-980.