Mol Pharm -- Table of Contents (56 [1])

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July 1999; 56 (1) [Index by Author] [Cover Caption]

Articles

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Articles:

Dirk Gründemann, Gernot Liebich, Nicholas Kiefer, Sandra Köster, and Edgar Schömig: Selective Substrates for Non-Neuronal Monoamine Transporters
Mol Pharmacol 1999 56: 1-10. [Abstract] [Full Text] [PDF]

Silvia Vailati, Wolfgang Hanke, Andreea Bejan, Benedetta Barabino, Renato Longhi, Barbara Balestra, Milena Moretti, Francesco Clementi, and Cecilia Gotti: Functional $alpha$ 6-Containing Nicotinic Receptors Are Present in Chick Retina
Mol Pharmacol 1999 56: 11-19. [Abstract] [Full Text] [PDF]

Kamila Neplechová, Olga Nováková, Abraha Habtemariam, Beth Watchman, Peter J. Sadler, and Viktor Brabec: DNA Interactions of New Antitumor Aminophosphine Platinum(II) Complexes
Mol Pharmacol 1999 56: 20-30. [Abstract] [Full Text] [PDF]

Tao Xie, Shu-Leong Ho, and David Ramsden: Characterization and Implications of Estrogenic Down-Regulation of Human Catechol-O-Methyltransferase Gene Transcription
Mol Pharmacol 1999 56: 31-38. [Abstract] [Full Text] [PDF]

Guo-Huang Fan, Ling-Zhi Wang, Hao-Chun Qiu, Lan Ma, and Gang Pei: Inhibition of Calcium/Calmodulin-Dependent Protein Kinase II in Rat Hippocampus Attenuates Morphine Tolerance and Dependence
Mol Pharmacol 1999 56: 39-45. [Abstract] [Full Text] [PDF]

T. Kietzmann, K. I. Hirsch-Ernst, G. F. Kahl, and K. Jungermann: Mimicry in Primary Rat Hepatocyte Cultures of the In Vivo Perivenous Induction by Phenobarbital of Cytochrome P-450 2B1 mRNA: Role of Epidermal Growth Factor and Perivenous Oxygen Tension
Mol Pharmacol 1999 56: 46-53. [Abstract] [Full Text] [PDF]

P. Bonaventure, L. Umans, M. H. M. Bakker, P. Cras, X. Langlois, W. H. M. L. Luyten, A. A. H. P. Megens, L. Serneels, F. Van Leuven, and J. E. Leysen: Humanization of Mouse 5-Hydroxytryptamine_1B Receptor Gene by Homologous Recombination: In Vitro and In Vivo Characterization
Mol Pharmacol 1999 56: 54-67. [Abstract] [Full Text] [PDF]

Rongbao Zhao, Iraida G. Sharina, and I. David Goldman: Pattern of Mutations that Results in Loss of Reduced Folate Carrier Function under Antifolate Selective Pressure Augmented by Chemical Mutagenesis
Mol Pharmacol 1999 56: 68-76. [Abstract] [Full Text] [PDF]

Fulvio Guano, Philippe Pourquier, Stella Tinelli, Monica Binaschi, Mario Bigioni, Fabio Animati, Stefano Manzini, Franco Zunino, Glenda Kohlhagen, Yves Pommier, and Giovanni Capranico: Topoisomerase Poisoning Activity of Novel Disaccharide Anthracyclines
Mol Pharmacol 1999 56: 77-84. [Abstract] [Full Text] [PDF]

Jeff L. Weiner, Thomas V. Dunwiddie, and C. Fernando Valenzuela: Ethanol Inhibition of Synaptically Evoked Kainate Responses in Rat Hippocampal CA3 Pyramidal Neurons
Mol Pharmacol 1999 56: 85-90. [Abstract] [Full Text] [PDF]

Maria J. Moreno-Aliaga and Fumio Matsumura: Endrin Inhibits Adipocyte Differentiation by Selectively Altering Expression Pattern of CCAAT/Enhancer Binding Protein- $alpha$ in 3T3-L1 Cells
Mol Pharmacol 1999 56: 91-101. [Abstract] [Full Text] [PDF]

Jia-Ran Gurr, Da-Tian Bau, Fount Liu, Shugene Lynn, and Kun-Yan Jan: Dithiothreitol Enhances Arsenic Trioxide-Induced Apoptosis in NB4 Cells
Mol Pharmacol 1999 56: 102-109. [Abstract] [Full Text] [PDF]

Cyrille Sur, Sophie J. Farrar, Julie Kerby, Paul J. Whiting, John R. Atack, and Ruth M. McKernan: Preferential Coassembly of $alpha$ 4 and $delta$ Subunits of the $gamma$ -Aminobutyric Acid_A Receptor in Rat Thalamus
Mol Pharmacol 1999 56: 110-115. [Abstract] [Full Text] [PDF]

Santhini Ramasamy, Grant R. Drummond, Joon Ahn, Michal Storek, Jan Pohl, Sampath Parthasarathy, and David G. Harrison: Modulation of Expression of Endothelial Nitric Oxide Synthase by Nordihydroguaiaretic Acid, a Phenolic Antioxidant in Cultured Endothelial Cells
Mol Pharmacol 1999 56: 116-123. [Abstract] [Full Text] [PDF]

Illarion V. Turko, Stephen A. Ballard, Sharron H. Francis, and Jackie D. Corbin: Inhibition of Cyclic GMP-Binding Cyclic GMP-Specific Phosphodiesterase (Type 5) by Sildenafil and Related Compounds
Mol Pharmacol 1999 56: 124-130. [Abstract] [Full Text] [PDF]

Helena L. Benford, Julie C. Frith, Seppo Auriola, Jukka Mönkkönen, and Michael J. Rogers: Farnesol and Geranylgeraniol Prevent Activation of Caspases by Aminobisphosphonates: Biochemical Evidence for Two Distinct Pharmacological Classes of Bisphosphonate Drugs
Mol Pharmacol 1999 56: 131-140. [Abstract] [Full Text] [PDF]

Philippe Frit, Yvan Canitrot, Catherine Muller, Nicolas Foray, Patrick Calsou, Elisabetta Marangoni, Jean Bourhis, and Bernard Salles: Cross-Resistance to Ionizing Radiation in a Murine Leukemic Cell Line Resistant to cis-Dichlorodiammineplatinum(II): Role of Ku Autoantigen
Mol Pharmacol 1999 56: 141-146. [Abstract] [Full Text] [PDF]

Q. Q. Pu and W. R. Bezwoda: Induction of Alkylator (Melphalan) Resistance in HL60 Cells Is Accompanied by Increased Levels of Topoisomerase II Expression and Function
Mol Pharmacol 1999 56: 147-153. [Abstract] [Full Text] [PDF]

John D. Altman, Anne U. Trendelenburg, Leigh MacMillan, Dan Bernstein, Lee Limbird, Klaus Starke, Brian K. Kobilka, and Lutz Hein: Abnormal Regulation of the Sympathetic Nervous System in $alpha$ _2A-Adrenergic Receptor Knockout Mice
Mol Pharmacol 1999 56: 154-161. [Abstract] [Full Text] [PDF]

Youssef Anouar, Hyeon-Woo Lee, and Lee E. Eiden: Both Inducible and Constitutive Activator Protein-1-Like Transcription Factors Are Used for Transcriptional Activation of the Galanin Gene by Different First and Second Messenger Pathways
Mol Pharmacol 1999 56: 162-169. [Abstract] [Full Text] [PDF]

Peng Wang, Ping Wu, Kathleen M. Ohleth, Robert W. Egan, and M. Motasim Billah: Phosphodiesterase 4B2 Is the Predominant Phosphodiesterase Species and Undergoes Differential Regulation of Gene Expression in Human Monocytes and Neutrophils
Mol Pharmacol 1999 56: 170-174. [Abstract] [Full Text] [PDF]

Søren G.F. Rasmussen, Anne D. Jensen, George Liapakis, Pejman Ghanouni, Jonathan A. Javitch, and Ulrik Gether: Mutation of a Highly Conserved Aspartic Acid in the $beta$ ₂ Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6
Mol Pharmacol 1999 56: 175-184. [Abstract] [Full Text] [PDF]

Scott Pollack, Lisa Young, James Bilsland, Neil Wilkie, Semantha Ellis, Franz Hefti, Howard Broughton, and Sarah Harper: The Staurosporine-Like Compound L-753,000 (NB-506) Potentiates the Neurotrophic Effects of Neurotrophin-3 by Acting Selectively at the TrkA Receptor
Mol Pharmacol 1999 56: 185-195. [Abstract] [Full Text] [PDF]

Matthias Walther, Hermann-Georg Holzhütter, Ralf Jürgen Kuban, Rainer Wiesner, Jörg Rathmann, and Hartmut Kühn: The Inhibition of Mammalian 15-Lipoxygenases by the Anti-Inflammatory Drug Ebselen: Dual-Type Mechanism Involving Covalent Linkage and Alteration of the Iron Ligand Sphere
Mol Pharmacol 1999 56: 196-203. [Abstract] [Full Text] [PDF]

Sandra Liekens, Daria Leali, Johan Neyts, Robert Esnouf, Marco Rusnati, Patrizia Dell'Era, Prabhat C. Maudgal, Erik De Clercq, and Marco Presta: Modulation of Fibroblast Growth Factor-2 Receptor Binding, Signaling, and Mitogenic Activity by Heparin-Mimicking Polysulfonated Compounds
Mol Pharmacol 1999 56: 204-213. [Abstract] [Full Text] [PDF]

Francesca Fanelli, Pascaline Barbier, Deborah Zanchetta, Pier G. de Benedetti, and Bice Chini: Activation Mechanism of Human Oxytocin Receptor: A Combined Study of Experimental and Computer-Simulated Mutagenesis
Mol Pharmacol 1999 56: 214-225. [Abstract] [Full Text] [PDF]

Nadège Terrier, Etienne Benoit, Claire Senay, Françoise Lapicque, Anna Radominska-Pandya, Jacques Magdalou, and Sylvie Fournel-Gigleux: Human and Rat Liver UDP-Glucuronosyltransferases Are Targets of Ketoprofen Acylglucuronide
Mol Pharmacol 1999 56: 226-234. [Abstract] [Full Text] [PDF]

George Christopoulos, Katie J. Perry, Maria Morfis, Nanda Tilakaratne, Yongyi Gao, Neil J. Fraser, Martin J. Main, Steven M. Foord, and Patrick M. Sexton: Multiple Amylin Receptors Arise from Receptor Activity-Modifying Protein Interaction with the Calcitonin Receptor Gene Product
Mol Pharmacol 1999 56: 235-242. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Putative structure of a regulatory domain in the amino terminus of the N-methyl-D-aspartate (NMDA) receptorNR1 subunit. The left-hand schematic shows the proposed topologyof the NMDA receptor subunits with three membrane-spanning domains,a re-entrant loop, the agonist binding pocket formed by the S1-S2domains (with the agonist shown by a gray oval), and a large extracellularamino terminus that precedes S1. The positions of amino acid residuesthat may form binding sites for ifenprodil (green) and spermine(yellow) are shown by circles. The right-hand schematic is a projectedstructure of the bacterial leucine/isoleucine/valine binding protein(LIVBP). The putative secondary structure of the amino terminusof NR1 shows considerable similarity to that of LIVBP, and thisregion of NR1, which is termed the R1-R2 regulatory domain, isproposed to have a tertiary structure similar to LIVBP. From MasukoT, Kashiwagi K, Kuno T, Nguyen ND, Pahk AJ, Fukuchi J-I, IgarashiK and Williams K (1999) A regulatory domain (R1-R2) in the aminoterminus of the N-methyl-D-aspartate receptor: Effects of spermine,protons, and ifenprodil, and structural similarity to bacterialLIVBP. Mol Pharmacol 55:957-969.