Mol Pharm -- Table of Contents (56 [2])

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August 1999; 56 (2)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Barbara Malitschek, Claude Schweizer, Miranda Keir, Jakob Heid, Wolfgang Froestl, Johannes Mosbacher, Rainer Kuhn, Jeremy Henley, Cécile Joly, Jean-Phillippe Pin, Klemens Kaupmann, and Bernhard Bettler: ACCELERATED COMMUNICATION: The N-Terminal Domain of $gamma$ -Aminobutyric Acid_B Receptors Is Sufficient to Specify Agonist and Antagonist Binding
Mol Pharmacol 1999 56: 448-454. [Abstract] [Full Text] [PDF]

Articles:

Martin Feelisch, Peter Kotsonis, Jan Siebe, Bernd Clement, and Harald H. H. W. Schmidt: The Soluble Guanylyl Cyclase Inhibitor 1H-[1,2,4]Oxadiazolo[4,3,-a]quinoxalin-1-one Is a Nonselective Heme Protein Inhibitor of Nitric Oxide Synthase and Other Cytochrome P-450 Enzymes Involved in Nitric Oxide Donor Bioactivation
Mol Pharmacol 1999 56: 243-253. [Abstract] [Full Text] [PDF]

Yongquan Luo, Akinori Hattori, James Munoz, Zheng-Hong Qin, and George S. Roth: Intrastriatal Dopamine Injection Induces Apoptosis Through Oxidation-Involved Activation of Transcription Factors AP-1 and NF- $kappa$ B in Rats
Mol Pharmacol 1999 56: 254-264. [Abstract] [Full Text] [PDF]

Michelle L. Cunningham, Theresa M. Filtz, and T. Kendall Harden: Protein Kinase C-Promoted Inhibition of G $alpha$ ₁₁-Stimulated Phospholipase C- $beta$ Activity
Mol Pharmacol 1999 56: 265-271. [Abstract] [Full Text] [PDF]

Shiuan Chen, Kebin Wu, Di Zhang, Mark Sherman, Richard Knox, and Chung S. Yang: Molecular Characterization of Binding of Substrates and Inhibitors to DT-Diaphorase: Combined Approach Involving Site-Directed Mutagenesis, Inhibitor-Binding Analysis, and Computer Modeling
Mol Pharmacol 1999 56: 272-278. [Abstract] [Full Text] [PDF]

Martina Pfeffer, Erik Maronde, Carlos A. Molina, Horst-Werner Korf, and Jörg H. Stehle: Inducible Cyclic AMP Early Repressor Protein in Rat Pinealocytes: A Highly Sensitive Natural Reporter for Regulated Gene Transcription
Mol Pharmacol 1999 56: 279-289. [Abstract] [Full Text] [PDF]

Richard E. Middleton, Nina P. Strnad, and Jonathan B. Cohen: Photoaffinity Labeling the Torpedo Nicotinic Acetylcholine Receptor with [³H]Tetracaine, a Nondesensitizing Noncompetitive Antagonist
Mol Pharmacol 1999 56: 290-299. [Abstract] [Full Text] [PDF]

Martin J. Gallagher and Jonathan B. Cohen: Identification of Amino Acids of the Torpedo Nicotinic Acetylcholine Receptor Contributing to the Binding Site for the Noncompetitive Antagonist [³H]Tetracaine
Mol Pharmacol 1999 56: 300-307. [Abstract] [Full Text] [PDF]

Nathalie D'hahan, Hélène Jacquet, Christophe Moreau, Patrice Catty, and Michel Vivaudou: A Transmembrane Domain of the Sulfonylurea Receptor Mediates Activation of ATP-Sensitive K⁺ Channels by K⁺ Channel Openers
Mol Pharmacol 1999 56: 308-315. [Abstract] [Full Text] [PDF]

Luisa Iacovelli, Rossana Franchetti, Deborah Grisolia, and Antonio De Blasi: Selective Regulation of G Protein-Coupled Receptor-Mediated Signaling by G Protein-Coupled Receptor Kinase 2 in FRTL-5 Cells: Analysis of Thyrotropin, $alpha$ _1B-Adrenergic, and A₁ Adenosine Receptor-Mediated Responses
Mol Pharmacol 1999 56: 316-324. [Abstract] [Full Text] [PDF]

Stephen B. Phagoo, Stephen Poole, and L. M. Fredrik Leeb-Lundberg: Autoregulation of Bradykinin Receptors: Agonists in the Presence of Interleukin-1 $beta$ Shift the Repertoire of Receptor Subtypes from B2 to B1 in Human Lung Fibroblasts
Mol Pharmacol 1999 56: 325-333. [Abstract] [Full Text] [PDF]

Stephan Wnendt, Thomas Krüger, Elke Janocha, Dieter Hildebrandt, and Werner Englberger: Agonistic Effect of Buprenorphine in a Nociceptin/OFQ Receptor-Triggered Reporter Gene Assay
Mol Pharmacol 1999 56: 334-338. [Abstract] [Full Text] [PDF]

Huabao Xiong, Kiyofumi Yamada, Hussam Jourdi, Meiko Kawamura, Nobuyuki Takei, Daiken Han, Toshitaka Nabeshima, and Hiroyuki Nawa: Regulation of Nerve Growth Factor Release by Nitric Oxide through Cyclic GMP Pathway in Cortical Glial Cells
Mol Pharmacol 1999 56: 339-347. [Abstract] [Full Text] [PDF]

Roland Seifert, Ulrik Gether, Katharina Wenzel-Seifert, and Brian K. Kobilka: Effects of Guanine, Inosine, and Xanthine Nucleotides on $beta$ ₂-Adrenergic Receptor/G_s Interactions: Evidence for Multiple Receptor Conformations
Mol Pharmacol 1999 56: 348-358. [Abstract] [Full Text] [PDF]

James P. Basilion, Andrea R. Schievella, Erica Burns, Patrice Rioux, Jeffrey C. Olson, Brett P. Monia, Kristina M. Lemonidis, Vincent P. Stanton, Jr., and David E. Housman: Selective Killing of Cancer Cells Based on Loss of Heterozygosity and Normal Variation in the Human Genome: A New Paradigm for Anticancer Drug Therapy
Mol Pharmacol 1999 56: 359-369. [Abstract] [Full Text] [PDF]

Juliana Setyawan, Kazunori Koide, Thomas C. Diller, Mark E. Bunnage, Susan S. Taylor, K. C. Nicolaou, and Laurence L. Brunton: Inhibition of Protein Kinases by Balanol: Specificity within the Serine/Threonine Protein Kinase Subfamily
Mol Pharmacol 1999 56: 370-376. [Abstract] [Full Text] [PDF]

Åsa B. Gustafsson and Laurence L. Brunton: Differential and Selective Inhibition of Protein Kinase A and Protein Kinase C in Intact Cells by Balanol Congeners
Mol Pharmacol 1999 56: 377-382. [Abstract] [Full Text] [PDF]

Heike Gutmann, Gert Fricker, Jürgen Drewe, Michael Toeroek, and David S. Miller: Interactions of HIV Protease Inhibitors with ATP-Dependent Drug Export Proteins
Mol Pharmacol 1999 56: 383-389. [Abstract] [Full Text] [PDF]

Xinjian Lin and Stephen B. Howell: Effect of Loss of DNA Mismatch Repair on Development of Topotecan-, Gemcitabine-, and Paclitaxel-Resistant Variants after Exposure to Cisplatin
Mol Pharmacol 1999 56: 390-395. [Abstract] [Full Text] [PDF]

Ying-Xian Pan, Jin Xu, Elizabeth Bolan, Catherine Abbadie, Albert Chang, Amy Zuckerman, Grace Rossi, and Gavril W. Pasternak: Identification and Characterization of Three New Alternatively Spliced µ-Opioid Receptor Isoforms
Mol Pharmacol 1999 56: 396-403. [Abstract] [Full Text] [PDF]

Carla Nau, Sho-Ya Wang, Gary R. Strichartz, and Ging Kuo Wang: Point Mutations at N434 in D1-S6 of µ1 Na⁺ Channels Modulate Binding Affinity and Stereoselectivity of Local Anesthetic Enantiomers
Mol Pharmacol 1999 56: 404-413. [Abstract] [Full Text] [PDF]

Roderic G. Eckenhoff, Jonathan W. Tanner, and Jonas S. Johansson: Steric Hindrance Is Not Required for n-Alkanol Cutoff in Soluble Proteins
Mol Pharmacol 1999 56: 414-418. [Abstract] [Full Text] [PDF]

Frank Neuschäfer-Rube, Martin Oppermann, Ulrike Möller, Ulrike Böer, and Gerhard P. Püschel: Agonist-Induced Phosphorylation by G Protein-Coupled Receptor Kinases of the EP4 Receptor Carboxyl-Terminal Domain in an EP3/EP4 Prostaglandin E₂ Receptor Hybrid
Mol Pharmacol 1999 56: 419-428. [Abstract] [Full Text] [PDF]

Rodrigo A. Cunha, João O. Malva, and J. A. Ribeiro: Kainate Receptors Coupled to G_i/G_o Proteins in the Rat Hippocampus
Mol Pharmacol 1999 56: 429-433. [Abstract] [Full Text] [PDF]

Zhicheng Lin, Wenfei Wang, Theresa Kopajtic, Randal S. Revay, and George R. Uhl: Dopamine Transporter: Transmembrane Phenylalanine Mutations Can Selectively Influence Dopamine Uptake and Cocaine Analog Recognition
Mol Pharmacol 1999 56: 434-447. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Putative structure of a regulatory domain in the amino terminus of the N-methyl-D-aspartate (NMDA) receptorNR1 subunit. The left-hand schematic shows the proposed topologyof the NMDA receptor subunits with three membrane-spanning domains,a re-entrant loop, the agonist binding pocket formed by the S1-S2domains (with the agonist shown by a gray oval), and a large extracellularamino terminus that precedes S1. The positions of amino acid residuesthat may form binding sites for ifenprodil (green) and spermine(yellow) are shown by circles. The right-hand schematic is a projectedstructure of the bacterial leucine/isoleucine/valine binding protein(LIVBP). The putative secondary structure of the amino terminusof NR1 shows considerable similarity to that of LIVBP, and thisregion of NR1, which is termed the R1-R2 regulatory domain, isproposed to have a tertiary structure similar to LIVBP. From MasukoT, Kashiwagi K, Kuno T, Nguyen ND, Pahk AJ, Fukuchi J-I, IgarashiK and Williams K (1999) A regulatory domain (R1-R2) in the aminoterminus of the N-methyl-D-aspartate receptor: Effects of spermine,protons, and ifenprodil, and structural similarity to bacterialLIVBP. Mol Pharmacol 55:957-969.