Mol Pharm -- Table of Contents (56 [4])

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October 1999; 56 (4)   [Index by Author] [Cover Caption]

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       Errata

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Articles:

Johanna B. Paukovits, Rosalia Rutter, Erika Ganglberger, Heidi I. Karlic, Brigitte Marian, and Walter R. Paukovits: The Hemoregulatory Peptide pEEDCK May Inhibit Stem Cell Proliferation via Hydropathic Binding to Antisense Sequence Motifs in Interleukin-11 and Other Growth Factors
Mol Pharmacol 1999 56: 665-674. [Abstract] [Full Text] [PDF]

Dong Jiang and David R. Sibley: Regulation of D₁ Dopamine Receptors with Mutations of Protein Kinase Phosphorylation Sites: Attenuation of the Rate of Agonist-Induced Desensitization
Mol Pharmacol 1999 56: 675-683. [Abstract] [Full Text] [PDF]

Elaine Kellett, I. Craig Carr, and Graeme Milligan: Regulation of G Protein Activation and Effector Modulation by Fusion Proteins between the Human 5-Hydroxytryptamine_1A Receptor and the $alpha$ Subunit of G_i1 $alpha$ : Differences in Receptor-Constitutive Activity Imparted by Single Amino Acid Substitutions in G_i1 $alpha$
Mol Pharmacol 1999 56: 684-692. [Abstract] [Full Text] [PDF]

Didier Saboulard, Lieve Naesens, Dominique Cahard, Antonio Salgado, Ranjith Pathirana, Sonsoles Velazquez, Christopher McGuigan, Erik De Clercq, and Jan Balzarini: Characterization of the Activation Pathway of Phosphoramidate Triester Prodrugs of Stavudine and Zidovudine
Mol Pharmacol 1999 56: 693-704. [Abstract] [Full Text] [PDF]

Joel Linden, Tami Thai, Heidi Figler, Xiaowei Jin, and Anna S. Robeva: Characterization of Human A_2B Adenosine Receptors: Radioligand Binding, Western Blotting, and Coupling to G_q in Human Embryonic Kidney 293 Cells and HMC-1 Mast Cells
Mol Pharmacol 1999 56: 705-713. [Abstract] [Full Text] [PDF]

Rémon A. M. H. Van Aubel, Jan B. Koenderink, Janny G. P. Peters, Carel H. Van Os, and Frans G. M. Russel: Mechanisms and Interaction of Vinblastine and Reduced Glutathione Transport in Membrane Vesicles by the Rabbit Multidrug Resistance Protein Mrp2 Expressed in Insect Cells
Mol Pharmacol 1999 56: 714-719. [Abstract] [Full Text] [PDF]

William R. Haines, Gonzalo E. Torres, Mark M. Voigt, and Terrance M. Egan: Properties of the Novel ATP-Gated Ionotropic Receptor Composed of the P2X₁ and P2X₅ Isoforms
Mol Pharmacol 1999 56: 720-727. [Abstract] [Full Text] [PDF]

Kazuto Nakamura and Mario Ascoli: A Dileucine-Based Motif in the C-Terminal Tail of the Lutropin/Choriogonadotropin Receptor Inhibits Endocytosis of the Agonist-Receptor Complex
Mol Pharmacol 1999 56: 728-736. [Abstract] [Full Text] [PDF]

Lech Kiedrowski: Elevated Extracellular K⁺ Concentrations Inhibit N-Methyl-D-Aspartate-Induced Ca²⁺ Influx and Excitotoxicity
Mol Pharmacol 1999 56: 737-743. [Abstract] [Full Text] [PDF]

Katrin B. Sandau, Dagmar Callsen, and Bernhard Brüne: Protection against Nitric Oxide-Induced Apoptosis in Rat Mesangial Cells Demands Mitogen-Activated Protein Kinases and Reduced Glutathione
Mol Pharmacol 1999 56: 744-751. [Abstract] [Full Text] [PDF]

Kendall D. W. Morris, Charles N. Moorefield, and Jahanshah Amin: Differential Modulation of the $gamma$ -Aminobutyric Acid Type C Receptor by Neuroactive Steroids
Mol Pharmacol 1999 56: 752-759. [Abstract] [Full Text] [PDF]

Henry P. Ciolino and Grace Chao Yeh: Inhibition of Aryl Hydrocarbon-Induced Cytochrome P-450 1A1 Enzyme Activity and CYP1A1 Expression by Resveratrol
Mol Pharmacol 1999 56: 760-767. [Abstract] [Full Text] [PDF]

Susan M. J. Dunn, Martin Davies, Anna Lisa Muntoni, and Jeremy J. Lambert: Mutagenesis of the Rat $alpha$ 1 Subunit of the $gamma$ -Aminobutyric Acid_A Receptor Reveals the Importance of Residue 101 in Determining the Allosteric Effects of Benzodiazepine Site Ligands
Mol Pharmacol 1999 56: 768-774. [Abstract] [Full Text] [PDF]

Xi-Ping Huang, Frederick E. Williams, Steven M. Peseckis, and William S. Messer, Jr.: Differential Modulation of Agonist Potency and Receptor Coupling by Mutations of Ser388Tyr and Thr389Pro at the Junction of Transmembrane Domain VI and the Third Extracellular Loop of Human M₁ Muscarinic Acetylcholine Receptors
Mol Pharmacol 1999 56: 775-783. [Abstract] [Full Text] [PDF]

Robert F. Casper, Monique Quesne, Ian M. Rogers, Takuhiko Shirota, André Jolivet, Edwin Milgrom, and Jean-François Savouret: Resveratrol Has Antagonist Activity on the Aryl Hydrocarbon Receptor: Implications for Prevention of Dioxin Toxicity
Mol Pharmacol 1999 56: 784-790. [Abstract] [Full Text] [PDF]

G. Ecker, M. Huber, D. Schmid, and P. Chiba: The Importance of a Nitrogen Atom in Modulators of Multidrug Resistance
Mol Pharmacol 1999 56: 791-796. [Abstract] [Full Text] [PDF]

Wim Vanden Berghe, Elisa Francesconi, Karolien De Bosscher, Michèle Resche-Rigon, and Guy Haegeman: Dissociated Glucocorticoids with Anti-Inflammatory Potential Repress Interleukin-6 Gene Expression by a Nuclear Factor- $kappa$ B-Dependent Mechanism
Mol Pharmacol 1999 56: 797-806. [Abstract] [Full Text] [PDF]

Don E. Griswold, Stephen A. Douglas, Lenox D. Martin, T. Gregg Davis, Laura Davis, Zhaohui Ao, Mark A. Luttmann, Mark Pullen, Ponnal Nambi, Douglas W. P. Hay, and Eliot H. Ohlstein: Endothelin B Receptor Modulates Inflammatory Pain and Cutaneous Inflammation
Mol Pharmacol 1999 56: 807-812. [Abstract] [Full Text] [PDF]

David C. Budd, R. A. John Challiss, Kenneth W. Young, and Andrew B. Tobin: Cross Talk Between m3-Muscarinic and $beta$ ₂-Adrenergic Receptors at the Level of Receptor Phosphorylation and Desensitization
Mol Pharmacol 1999 56: 813-823. [Abstract] [Full Text] [PDF]

László Virág, Gwen S. Scott, Péter Antal-Szalmás, Michael O'Connor, Hiroshi Ohshima, and Csaba Szabó: Requirement of Intracellular Calcium Mobilization for Peroxynitrite-Induced Poly(ADP-Ribose) Synthetase Activation and Cytotoxicity
Mol Pharmacol 1999 56: 824-833. [Abstract] [Full Text] [PDF]

Z. H. Song, Carole-Anne Slowey, Dow P. Hurst, and Patricia H. Reggio: The Difference between the CB₁ and CB₂ Cannabinoid Receptors at Position 5.46 Is Crucial for the Selectivity of WIN55212-2 for CB₂
Mol Pharmacol 1999 56: 834-840. [Abstract] [Full Text] [PDF]

Natalia F. Krynetskaia, Eugene Y. Krynetski, and William E. Evans: Human RNase H-Mediated RNA Cleavage from DNA-RNA Duplexes Is Inhibited by 6-Deoxythioguanosine Incorporation into DNA
Mol Pharmacol 1999 56: 841-848. [Abstract] [Full Text] [PDF]

Errata:

: Correction for vol. 56, p. 272
Mol Pharmacol 1999 56: 849. [Full Text] [PDF]

Cover Caption:

About the cover: Putative structure of a regulatory domain in the amino terminus of the N-methyl-D-aspartate (NMDA) receptorNR1 subunit. The left-hand schematic shows the proposed topologyof the NMDA receptor subunits with three membrane-spanning domains,a re-entrant loop, the agonist binding pocket formed by the S1-S2domains (with the agonist shown by a gray oval), and a large extracellularamino terminus that precedes S1. The positions of amino acid residuesthat may form binding sites for ifenprodil (green) and spermine(yellow) are shown by circles. The right-hand schematic is a projectedstructure of the bacterial leucine/isoleucine/valine binding protein(LIVBP). The putative secondary structure of the amino terminusof NR1 shows considerable similarity to that of LIVBP, and thisregion of NR1, which is termed the R1-R2 regulatory domain, isproposed to have a tertiary structure similar to LIVBP. From MasukoT, Kashiwagi K, Kuno T, Nguyen ND, Pahk AJ, Fukuchi J-I, IgarashiK and Williams K (1999) A regulatory domain (R1-R2) in the aminoterminus of the N-methyl-D-aspartate receptor: Effects of spermine,protons, and ifenprodil, and structural similarity to bacterialLIVBP. Mol Pharmacol 55:957-969.