Mol Pharm -- Table of Contents (56 [5])

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November 1999; 56 (5)   [Index by Author] [Cover Caption]

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Minireview:

Üzen Savas, Keith J. Griffin, and Eric F. Johnson: MINIREVIEW: Molecular Mechanisms of Cytochrome P-450 Induction by Xenobiotics: An Expanded Role for Nuclear Hormone Receptors
Mol Pharmacol 1999 56: 851-857. [Full Text] [PDF]

Articles:

Olivier Rossier, Liliane Abuin, Francesca Fanelli, Amedeo Leonardi, and Susanna Cotecchia: Inverse Agonism and Neutral Antagonism at $alpha$ _1a- and $alpha$ _1b-Adrenergic Receptor Subtypes
Mol Pharmacol 1999 56: 858-866. [Abstract] [Full Text] [PDF]

Véronique Mansat-De Mas, Christine Bezombes, Anne Quillet-Mary, Ali Bettaïeb, Aurélie De Thonel D'orgeix, Guy Laurent, and Jean-Pierre Jaffrézou: Implication of Radical Oxygen Species in Ceramide Generation, c-Jun N-Terminal Kinase Activation and Apoptosis Induced by Daunorubicin
Mol Pharmacol 1999 56: 867-874. [Abstract] [Full Text] [PDF]

Masafumi Isogaya, Yoshiyuki Sugimoto, Ryuji Tanimura, Rie Tanaka, Hideo Kikkawa, Taku Nagao, and Hitoshi Kurose: Binding Pockets of the $beta$ ₁- and $beta$ ₂-Adrenergic Receptors for Subtype-Selective Agonists
Mol Pharmacol 1999 56: 875-885. [Abstract] [Full Text] [PDF]

Z. David Luo, Yibin Wang, Guy Werlen, Shelley Camp, Kenneth R. Chien, and Palmer Taylor: Calcineurin Enhances Acetylcholinesterase mRNA Stability during C2-C12 Muscle Cell Differentiation
Mol Pharmacol 1999 56: 886-894. [Abstract] [Full Text] [PDF]

Gregor Zimmermann, Dongmei Zhou, and Ronald Taussig: Activating Mutation of Adenylyl Cyclase Reverses its Inhibition by G Proteins
Mol Pharmacol 1999 56: 895-901. [Abstract] [Full Text] [PDF]

Shin Hee Yoon, Tak-Man Lo, Horace H. Loh, and Stanley A. Thayer: $delta$ -Opioid-Induced Liberation of G $beta$ $gamma$ Mobilizes Ca²⁺ Stores in NG108-15 Cells
Mol Pharmacol 1999 56: 902-908. [Abstract] [Full Text] [PDF]

Helene M. Zuurmond, Jutta Hessling, Klaus Blüml, Martin Lohse, and Adriaan P. Ijzerman: Study of Interaction between Agonists and Asn293 in Helix VI of Human $beta$ ₂-Adrenergic Receptor
Mol Pharmacol 1999 56: 909-916. [Abstract] [Full Text] [PDF]

Norio Sakai, Lara M. Tolbert, and Ronald S. Duman: Identification and Functional Analysis of Novel cAMP Response Element Binding Protein Splice Variants Lacking the Basic/Leucine Zipper Domain
Mol Pharmacol 1999 56: 917-925. [Abstract] [Full Text] [PDF]

Siu K. Lo, Arshad Rahman, Ning Xu, Ming Yuan Zhou, Pablito Nagpala, Howard A. Jaffe, and Asrar B. Malik: Neutrophil Inhibitory Factor Abrogates Neutrophil Adhesion by Blockade of CD11a and CD11b $beta$ ₂ Integrins
Mol Pharmacol 1999 56: 926-932. [Abstract] [Full Text] [PDF]

Jigany M. Carsi, Helene H. Valentine, and Lincoln T. Potter: m2-Toxin: A Selective Ligand for M2 Muscarinic Receptors
Mol Pharmacol 1999 56: 933-937. [Abstract] [Full Text] [PDF]

Akio Ishida, Toshiyuki Sasaguri, Yoshikazu Miwa, Chiya Kosaka, Yoji Taba, and Takeo Abumiya: Tumor Suppressor p53 But Not cGMP Mediates NO-Induced Expression of p21^{Waf1/Cip1/Sdi1} in Vascular Smooth Muscle Cells
Mol Pharmacol 1999 56: 938-946. [Abstract] [Full Text] [PDF]

Zhongzhen Nie, Yun Mei, Renae L. Malek, Adriana Marcuzzi, Norman H. Lee, and Vickram Ramkumar: A Role of p75 in NGF-Mediated Down-Regulation of the A_2A Adenosine Receptors in PC12 Cells
Mol Pharmacol 1999 56: 947-954. [Abstract] [Full Text] [PDF]

Ulrich Russ, Annette Hambrock, Ferruh Artunc, Cornelia Löffler-Walz, Yoshiyuki Horio, Yoshihisa Kurachi, and Ulrich Quast: Coexpression with the Inward Rectifier K⁺ Channel Kir6.1 Increases the Affinity of the Vascular Sulfonylurea Receptor SUR2B for Glibenclamide
Mol Pharmacol 1999 56: 955-961. [Abstract] [Full Text] [PDF]

Christian Tränkle, Oliver Weyand, Alexandra Schröter, and Klaus Mohr: Using a Radioalloster to Test Predictions of the Cooperativity Model for Gallamine Binding to the Allosteric Site of Muscarinic Acetylcholine M₂ Receptors
Mol Pharmacol 1999 56: 962-965. [Abstract] [Full Text] [PDF]

Jianguo Fan and Joseph R. Bertino: Modulation of Cisplatinum Cytotoxicity by p53: Effect of p53-Mediated Apoptosis and DNA Repair
Mol Pharmacol 1999 56: 966-972. [Abstract] [Full Text] [PDF]

Ron Stoop, Sarah Thomas, François Rassendren, Eric Kawashima, Gary Buell, Annmarie Surprenant, and R. Alan North: Contribution of Individual Subunits to the Multimeric P2X₂ Receptor: Estimates based on Methanethiosulfonate Block at T336C
Mol Pharmacol 1999 56: 973-981. [Abstract] [Full Text] [PDF]

Jay S. Hanas, Justin S. Rodgers, John A. Bantle, and Yong-Gang Cheng: Lead Inhibition of DNA-Binding Mechanism of Cys₂His₂ Zinc Finger Proteins
Mol Pharmacol 1999 56: 982-988. [Abstract] [Full Text] [PDF]

Guoping Cai, Hakan Gurdal, Candyce Smith, Hoau-Yan Wang, and Eitan Friedman: Inverse Agonist Properties of Dopaminergic Antagonists at the D_1A Dopamine Receptor: Uncoupling of the D_1A Dopamine Receptor from G_s Protein
Mol Pharmacol 1999 56: 989-996. [Abstract] [Full Text] [PDF]

Yi Zhou, Michael M. Gottesman, and Ira Pastan: Domain Exchangeability between the Multidrug Transporter (MDR1) and Phosphatidylcholine Flippase (MDR2)
Mol Pharmacol 1999 56: 997-1004. [Abstract] [Full Text] [PDF]

Susan M. Wade, William K. Lim, Keng-Li Lan, Duane A. Chung, Masakatsu Nanamori, and Richard R. Neubig: G_i Activator Region of $alpha$ _2A-Adrenergic Receptors: Distinct Basic Residues Mediate G_i versus G_s Activation
Mol Pharmacol 1999 56: 1005-1013. [Abstract] [Full Text] [PDF]

Florian Roka, Lena Brydon, Maria Waldhoer, A. Donny Strosberg, Michael Freissmuth, Ralf Jockers, and Christian Nanoff: Tight Association of the Human Mel_1a-Melatonin Receptor and G_i: Precoupling and Constitutive Activity
Mol Pharmacol 1999 56: 1014-1024. [Abstract] [Full Text] [PDF]

Didier Cussac, Adrian Newman-Tancredi, Valerie Pasteau, and Mark J. Millan: Human Dopamine D₃ Receptors Mediate Mitogen-Activated Protein Kinase Activation Via a Phosphatidylinositol 3-Kinase and an Atypical Protein Kinase C-Dependent Mechanism
Mol Pharmacol 1999 56: 1025-1030. [Abstract] [Full Text] [PDF]

Stuart D. C. Ward, Carol A. M. Curtis, and Edward C. Hulme: Alanine-Scanning Mutagenesis of Transmembrane Domain 6 of the M₁ Muscarinic Acetylcholine Receptor Suggests that Tyr381 Plays Key Roles in Receptor Function
Mol Pharmacol 1999 56: 1031-1041. [Abstract] [Full Text] [PDF]

Sofia Kallia-Raftopoulos and Dimitrios L. Kalpaxis: Slow Sequential Conformational Changes in Escherichia coli Ribosomes Induced by Lincomycin: Kinetic Evidence
Mol Pharmacol 1999 56: 1042-1046. [Abstract] [Full Text] [PDF]

Christian Pifl and Ernst A. Singer: Ion Dependence of Carrier-Mediated Release in Dopamine or Norepinephrine Transporter-Transfected Cells Questions the Hypothesis of Facilitated Exchange Diffusion
Mol Pharmacol 1999 56: 1047-1054. [Abstract] [Full Text] [PDF]

Marc E. Surette, Eric Krump, Serge Picard, and Pierre Borgeat: Activation of Leukotriene Synthesis in Human Neutrophils by Exogenous Arachidonic Acid: Inhibition by Adenosine A_2a Receptor Agonists and Crucial Role of Autocrine Activation by Leukotriene B₄
Mol Pharmacol 1999 56: 1055-1062. [Abstract] [Full Text] [PDF]

Maria E. Kitchens, Antonia M. Forsthoefel, Karen W. Barbour, H. Trent Spencer, and Franklin G. Berger: Mechanisms of Acquired Resistance to Thymidylate Synthase Inhibitors: The Role of Enzyme Stability
Mol Pharmacol 1999 56: 1063-1070. [Abstract] [Full Text] [PDF]

Kelly D. Karpa, Michael S. Lidow, Mary T. Pickering, Robert Levenson, and Clare Bergson: N-linked Glycosylation Is Required for Plasma Membrane Localization of D5, but Not D1, Dopamine Receptors in Transfected Mammalian Cells
Mol Pharmacol 1999 56: 1071-1078. [Abstract] [Full Text] [PDF]

Alastair G. Stewart, Trudi Harris, Darren J. Fernandes, Leslie C. Schachte, Valentina Koutsoubos, Elizabeth Guida, Claire E. Ravenhall, Peter Vadiveloo, and John W. Wilson: $beta$ 2-Adrenergic Receptor Agonists and cAMP Arrest Human Cultured Airway Smooth Muscle Cells in the G₁ Phase of the Cell Cycle: Role of Proteasome Degradation of Cyclin D1
Mol Pharmacol 1999 56: 1079-1086. [Abstract] [Full Text] [PDF]

Vladimir V. Koltchine, Suzanne E. Finn, Andrew Jenkins, Natalia Nikolaeva, Audrey Lin, and Neil L. Harrison: Agonist Gating and Isoflurane Potentiation in the Human $gamma$ -Aminobutyric Acid Type A Receptor Determined by the Volume of a Second Transmembrane Domain Residue
Mol Pharmacol 1999 56: 1087-1093. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Putative structure of a regulatory domain in the amino terminus of the N-methyl-D-aspartate (NMDA) receptorNR1 subunit. The left-hand schematic shows the proposed topologyof the NMDA receptor subunits with three membrane-spanning domains,a re-entrant loop, the agonist binding pocket formed by the S1-S2domains (with the agonist shown by a gray oval), and a large extracellularamino terminus that precedes S1. The positions of amino acid residuesthat may form binding sites for ifenprodil (green) and spermine(yellow) are shown by circles. The right-hand schematic is a projectedstructure of the bacterial leucine/isoleucine/valine binding protein(LIVBP). The putative secondary structure of the amino terminusof NR1 shows considerable similarity to that of LIVBP, and thisregion of NR1, which is termed the R1-R2 regulatory domain, isproposed to have a tertiary structure similar to LIVBP. From MasukoT, Kashiwagi K, Kuno T, Nguyen ND, Pahk AJ, Fukuchi J-I, IgarashiK and Williams K (1999) A regulatory domain (R1-R2) in the aminoterminus of the N-methyl-D-aspartate receptor: Effects of spermine,protons, and ifenprodil, and structural similarity to bacterialLIVBP. Mol Pharmacol 55:957-969.