Mol Pharm -- Table of Contents (56 [6])

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December 1999; 56 (6)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

       Errata

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Accelerated Communication:

Insa Gross, Andreas Toman, Ingo Uhde, Christina Schwanstecher, and Mathias Schwanstecher: ACCELERATED COMMUNICATION: Stoichiometry of Potassium Channel Opener Action
Mol Pharmacol 1999 56: 1370-1373. [Abstract] [Full Text] [PDF]

Articles:

Hans P. Koch, Michael P. Kavanaugh, Christopher S. Esslinger, Noah Zerangue, John M. Humphrey, Susan G. Amara, A. Richard Chamberlin, and Richard J. Bridges: Differentiation of Substrate and Nonsubstrate Inhibitors of the High-Affinity, Sodium-Dependent Glutamate Transporters
Mol Pharmacol 1999 56: 1095-1104. [Abstract] [Full Text] [PDF]

Paola Fiorani, James F. Amatruda, Alessandra Silvestri, Richard H. Butler, Mary-Ann Bjornsti, and Piero Benedetti: Domain Interactions Affecting Human DNA Topoisomerase I Catalysis and Camptothecin Sensitivity
Mol Pharmacol 1999 56: 1105-1115. [Abstract] [Full Text] [PDF]

Merrill M. Simpson, Juan A. Ballesteros, Victor Chiappa, Jiayun Chen, Makiko Suehiro, Deborah S. Hartman, Thierry Godel, Lenore A. Snyder, Thomas P. Sakmar, and Jonathan A. Javitch: Dopamine D4/D2 Receptor Selectivity Is Determined by A Divergent Aromatic Microdomain Contained within the Second, Third, and Seventh Membrane-Spanning Segments
Mol Pharmacol 1999 56: 1116-1126. [Abstract] [Full Text] [PDF]

Richard S. Pollenz, Nikos A. Davarinos, and Todd P. Shearer: Analysis of Aryl Hydrocarbon Receptor-Mediated Signaling during Physiological Hypoxia Reveals Lack of Competition for the Aryl Hydrocarbon Nuclear Translocator Transcription Factor
Mol Pharmacol 1999 56: 1127-1137. [Abstract] [Full Text] [PDF]

Louis S. Premkumar: Selective Potentiation of L-Type Calcium Channel Currents by Cocaine in Cardiac Myocytes
Mol Pharmacol 1999 56: 1138-1142. [Abstract] [Full Text] [PDF]

Xiaohua Xin, Nengyu Yang, and James E. Faber: Platelet-Derived Growth Factor Inhibits $alpha$ 1D-Adrenergic Receptor Expression in Vascular Smooth Muscle Cells In Vitro and Ex Vivo
Mol Pharmacol 1999 56: 1143-1151. [Abstract] [Full Text] [PDF]

Xiaohua Xin, Nengyu Yang, and James E. Faber: Platelet-Derived Growth Factor-BB Inhibits Rat $alpha$ 1D-Adrenergic Receptor Gene Expression in Vascular Smooth Muscle Cells by Inducing AP-2-Like Protein Binding to $alpha$ 1D Proximal Promoter Region
Mol Pharmacol 1999 56: 1152-1161. [Abstract] [Full Text] [PDF]

Harry P. de Koning and Simon M. Jarvis: Adenosine Transporters in Bloodstream Forms of Trypanosoma brucei brucei: Substrate Recognition Motifs and Affinity for Trypanocidal Drugs
Mol Pharmacol 1999 56: 1162-1170. [Abstract] [Full Text] [PDF]

Kevin J. Lynch, Edward Touma, Wende Niforatos, Karen L. Kage, Edward C. Burgard, Tim van Biesen, Elizabeth A. Kowaluk, and Michael F. Jarvis: Molecular and Functional Characterization of Human P2X₂ Receptors
Mol Pharmacol 1999 56: 1171-1181. [Abstract] [Full Text] [PDF]

Alison J. McLean, Nicola Bevan, Stephen Rees, and Graeme Milligan: Visualizing Differences in Ligand Regulation of Wild-Type and Constitutively Active Mutant $beta$ ₂-Adrenoceptor-Green Fluorescent Protein Fusion Proteins
Mol Pharmacol 1999 56: 1182-1191. [Abstract] [Full Text] [PDF]

Juan Carlos Gomora, Judith A. Enyeart, and John J. Enyeart: Mibefradil Potently Blocks ATP-Activated K⁺ Channels in Adrenal Cells
Mol Pharmacol 1999 56: 1192-1197. [Abstract] [Full Text] [PDF]

Melissa Runge-Morris, Wei Wu, and Thomas A. Kocarek: Regulation of Rat Hepatic Hydroxysteroid Sulfotransferase (SULT2-40/41) Gene Expression by Glucocorticoids: Evidence for a Dual Mechanism of Transcriptional Control
Mol Pharmacol 1999 56: 1198-1206. [Abstract] [Full Text] [PDF]

Rinat Nahum-Levy, Linda H. Fossom, Phil Skolnick, and Morris Benveniste: Putative Partial Agonist 1-Aminocyclopropanecarboxylic Acid Acts Concurrently as a Glycine-Site Agonist and a Glutamate-Site Antagonist at N-Methyl-D-aspartate Receptors
Mol Pharmacol 1999 56: 1207-1218. [Abstract] [Full Text] [PDF]

Zhe-Sheng Chen, Takeshi Kawabe, Mayumi Ono, Shunji Aoki, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Takeshi Uchiumi, Morimasa Wada, Michihiko Kuwano, and Shin-Ichi Akiyama: Effect of Multidrug Resistance-Reversing Agents on Transporting Activity of Human Canalicular Multispecific Organic Anion Transporter
Mol Pharmacol 1999 56: 1219-1228. [Abstract] [Full Text] [PDF]

Marion Blomenröhr, Anders Heding, Robin Sellar, Rob Leurs, Jan Bogerd, Karin A. Eidne, and Gary B. Willars: Pivotal Role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization
Mol Pharmacol 1999 56: 1229-1237. [Abstract] [Full Text] [PDF]

Thomas Weiser, Yusheng Qu, William A. Catterall, and Todd Scheuer: Differential Interaction of R-Mexiletine with the Local Anesthetic Receptor Site on Brain and Heart Sodium Channel $alpha$ -Subunits
Mol Pharmacol 1999 56: 1238-1244. [Abstract] [Full Text] [PDF]

Ann L. Gnagey, Margaret Seidenberg, and John Ellis: Site-Directed Mutagenesis Reveals Two Epitopes Involved in the Subtype Selectivity of the Allosteric Interactions of Gallamine at Muscarinic Acetylcholine Receptors
Mol Pharmacol 1999 56: 1245-1253. [Abstract] [Full Text] [PDF]

Valentin Gorboulev, Christopher Volk, Petra Arndt, Aida Akhoundova, and Hermann Koepsell: Selectivity of the Polyspecific Cation Transporter rOCT1 Is Changed by Mutation of Aspartate 475 to Glutamate
Mol Pharmacol 1999 56: 1254-1261. [Abstract] [Full Text] [PDF]

Pavel Kramata and Kathleen M. Downey: 9-(2-Phosphonylmethoxyethyl) Derivatives of Purine Nucleotide Analogs: A Comparison of Their Metabolism and Interaction with Cellular DNA Synthesis
Mol Pharmacol 1999 56: 1262-1270. [Abstract] [Full Text] [PDF]

Yi-Rong Chen, Guisheng Zhou, and Tse-Hua Tan: c-Jun N-Terminal Kinase Mediates Apoptotic Signaling Induced by N-(4-Hydroxyphenyl)retinamide
Mol Pharmacol 1999 56: 1271-1279. [Abstract] [Full Text] [PDF]

Maria G. Juarranz, Jean Van Rampelbergh, Philippe Gourlet, Philippe De Neef, Johnny Cnudde, Patrick Robberecht, and Magali Waelbroeck: Different Vasoactive Intestinal Polypeptide Receptor Domains Are Involved in the Selective Recognition of Two VPAC₂-Selective Ligands
Mol Pharmacol 1999 56: 1280-1287. [Abstract] [Full Text] [PDF]

Michael J. Zuscik, Michael T. Piascik, and Dianne M. Perez: Cloning, Cell-Type Specificity, and Regulatory Function of the Mouse $alpha$ _1B-Adrenergic Receptor Promoter
Mol Pharmacol 1999 56: 1288-1297. [Abstract] [Full Text] [PDF]

Maurizio Taglialatela, Anna Pannaccione, Silvana Iossa, Pasqualina Castaldo, and Lucio Annunziato: Modulation of the K⁺ Channels Encoded by the Human Ether-a-Gogo-Related Gene-1 (hERG1) by Nitric Oxide
Mol Pharmacol 1999 56: 1298-1308. [Abstract] [Full Text] [PDF]

F. Errington, E. Willmore, M. J. Tilby, L. Li, G. Li, W. Li, B. C. Baguley, and C. A. Austin: Murine Transgenic Cells Lacking DNA Topoisomerase II $beta$ Are Resistant to Acridines and Mitoxantrone: Analysis of Cytotoxicity and Cleavable Complex Formation
Mol Pharmacol 1999 56: 1309-1316. [Abstract] [Full Text] [PDF]

Shawn M. Heidel, Karrie Holston, Jeroen T.M. Buters, Frank J. Gonzalez, Colin R. Jefcoate, and Charles J. Czupyrynski: Bone Marrow Stromal Cell Cytochrome P4501B1 Is Required for Pre-B Cell Apoptosis Induced by 7,12-Dimethylbenz[a]anthracene
Mol Pharmacol 1999 56: 1317-1323. [Abstract] [Full Text] [PDF]

Nobuhiko Miura, Yoko Matsumoto, Shinichi Miyairi, Shoji Nishiyama, and Akira Naganuma: Protective Effects of Triterpene Compounds Against the Cytotoxicity of Cadmium in HepG2 Cells
Mol Pharmacol 1999 56: 1324-1328. [Abstract] [Full Text] [PDF]

Bryan Goodwin, Ecushla Hodgson, and Christopher Liddle: The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
Mol Pharmacol 1999 56: 1329-1339. [Abstract] [Full Text] [PDF]

Dale R. Grabowski, Katherine A. Holmes, Masako Aoyama, Ying Ye, Lisa A. Rybicki, Ronald M. Bukowski, Mahrukh K. Ganapathi, Ian D. Hickson, and Ram Ganapathi: Altered Drug Interaction and Regulation of Topoisomerase II $beta$ : Potential Mechanisms Governing Sensitivity of HL-60 Cells to Amsacrine and Etoposide
Mol Pharmacol 1999 56: 1340-1345. [Abstract] [Full Text] [PDF]

Helen M. Dodds and Laurent P. Rivory: The Mechanism for the Inhibition of Acetylcholinesterases by Irinotecan (CPT-11)
Mol Pharmacol 1999 56: 1346-1353. [Abstract] [Full Text] [PDF]

Jan Balzarini, Lieve Naesens, S. Aquaro, T. Knispel, C.-F. Perno, E. De Clercq, and C. Meier: Intracellular Metabolism of CycloSaligenyl 3'-Azido-2',3'-dideoxythymidine Monophosphate, a Prodrug of 3'-Azido-2',3'-dideoxythymidine (Zidovudine)
Mol Pharmacol 1999 56: 1354-1361. [Abstract] [Full Text] [PDF]

Michelle Glass and John K. Northup: Agonist Selective Regulation of G Proteins by Cannabinoid CB₁ and CB₂ Receptors
Mol Pharmacol 1999 56: 1362-1369. [Abstract] [Full Text] [PDF]

Errata:

: Correction for vol. 56, p. 737
Mol Pharmacol 1999 56: 1374. [Full Text] [PDF]

Cover Caption:

About the cover: Putative structure of a regulatory domain in the amino terminus of the N-methyl-D-aspartate (NMDA) receptorNR1 subunit. The left-hand schematic shows the proposed topologyof the NMDA receptor subunits with three membrane-spanning domains,a re-entrant loop, the agonist binding pocket formed by the S1-S2domains (with the agonist shown by a gray oval), and a large extracellularamino terminus that precedes S1. The positions of amino acid residuesthat may form binding sites for ifenprodil (green) and spermine(yellow) are shown by circles. The right-hand schematic is a projectedstructure of the bacterial leucine/isoleucine/valine binding protein(LIVBP). The putative secondary structure of the amino terminusof NR1 shows considerable similarity to that of LIVBP, and thisregion of NR1, which is termed the R1-R2 regulatory domain, isproposed to have a tertiary structure similar to LIVBP. From MasukoT, Kashiwagi K, Kuno T, Nguyen ND, Pahk AJ, Fukuchi J-I, IgarashiK and Williams K (1999) A regulatory domain (R1-R2) in the aminoterminus of the N-methyl-D-aspartate receptor: Effects of spermine,protons, and ifenprodil, and structural similarity to bacterialLIVBP. Mol Pharmacol 55:957-969.