Mol Pharm -- Table of Contents (57 [1])

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January 2000; 57 (1)   [Index by Author] [Cover Caption]

       Editorial

       Accelerated Communications

       Articles

       Errata

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Editorial:

Joan Heller Brown: Editorial
Mol Pharmacol 2000 57: 1. [Full Text] [PDF]

Accelerated Communications:

Lawrence W. Fitzgerald, Timothy C. Burn, Barry S. Brown, John P. Patterson, Martha H. Corjay, Patricia A. Valentine, Jung-Hui Sun, John R. Link, Ilgar Abbaszade, Jeannine M. Hollis, Brian L. Largent, Paul R. Hartig, Gregory F. Hollis, Paul C. Meunier, Albert J. Robichaud, and David W. Robertson: ACCELERATED COMMUNICATION: Possible Role of Valvular Serotonin 5-HT_2B Receptors in the Cardiopathy Associated with Fenfluramine
Mol Pharmacol 2000 57: 75-81. [Abstract] [Full Text] [PDF]

Articles:

Graeme W. Carlile, Ruth M. E. Chalmers-Redman, Nadine A. Tatton, Amanda Pong, Katherine L.B. Borden, and William G. Tatton: Reduced Apoptosis after Nerve Growth Factor and Serum Withdrawal: Conversion of Tetrameric Glyceraldehyde-3-Phosphate Dehydrogenase to a Dimer
Mol Pharmacol 2000 57: 2-12. [Abstract] [Full Text] [PDF]

Sejal M. Mody, Maurice K. C. Ho, Sushma A. Joshi, and Yung H. Wong: Incorporation of G $alpha$ _z-Specific Sequence at the Carboxyl Terminus Increases the Promiscuity of G $alpha$ ₁₆ toward G_i-Coupled Receptors
Mol Pharmacol 2000 57: 13-23. [Abstract] [Full Text] [PDF]

Valerie Lecureur, Daxi Sun, Philip Hargrove, Erin G. Schuetz, Richard B. Kim, Lu-Bin Lan, and John D. Schuetz: Cloning and Expression of Murine Sister of P-Glycoprotein Reveals a More Discriminating Transporter Than MDR1/P-Glycoprotein
Mol Pharmacol 2000 57: 24-35. [Abstract] [Full Text] [PDF]

Chien-Huang Lin, Sheng-Yuan Sheu, Horng-Mo Lee, Yuan-Soon Ho, Wen-Sen Lee, Wun-Chang Ko, and Joen-Rong Sheu: Involvement of Protein Kinase C- $gamma$ in IL-1 $beta$ -Induced Cyclooxygenase-2 Expression in Human Pulmonary Epithelial Cells
Mol Pharmacol 2000 57: 36-43. [Abstract] [Full Text] [PDF]

Christine Saunders and Lee E. Limbird: Microtubule-Dependent Regulation of $alpha$ _2B Adrenergic Receptors in Polarized MDCKII Cells Requires the Third Intracellular Loop but Not G Protein Coupling
Mol Pharmacol 2000 57: 44-52. [Abstract] [Full Text] [PDF]

Thomas McMahon, Reid Andersen, Pamela Metten, John C. Crabbe, and Robert O. Messing: Protein Kinase C $epsilon$ Mediates Up-Regulation of N-Type Calcium Channels by Ethanol
Mol Pharmacol 2000 57: 53-58. [Abstract] [Full Text] [PDF]

Rosalinde Masereeuw, Sylvie A. Terlouw, Rémon A. M. H. van Aubel, Frans G. M. Russel, and David S. Miller: Endothelin B Receptor-Mediated Regulation of ATP-Driven Drug Secretion in Renal Proximal Tubule
Mol Pharmacol 2000 57: 59-67. [Abstract] [Full Text] [PDF]

Ellen I. Closs, Jan-Stefan Scheld, Masoumeh Sharafi, and Ulrich Förstermann: Substrate Supply for Nitric-Oxide Synthase in Macrophages and Endothelial Cells: Role of Cationic Amino Acid Transporters
Mol Pharmacol 2000 57: 68-74. [Abstract] [Full Text] [PDF]

Scott E. Heid, Richard S. Pollenz, and Hollie I. Swanson: Role of Heat Shock Protein 90 Dissociation in Mediating Agonist-Induced Activation of the Aryl Hydrocarbon Receptor
Mol Pharmacol 2000 57: 82-92. [Abstract] [Full Text] [PDF]

Vijayakumar Muppala, Chun-Shien Lin, and Ying-Hue Lee: The Role of HNF-1 $alpha$ in Controlling Hepatic Catalase Activity
Mol Pharmacol 2000 57: 93-100. [Abstract] [Full Text] [PDF]

Toshihisa Nagatomo, Craig T. January, and Jonathan C. Makielski: Preferential Block of Late Sodium Current in the LQT3 $Delta$ KPQ Mutant by the Class I_C Antiarrhythmic Flecainide
Mol Pharmacol 2000 57: 101-107. [Abstract] [Full Text] [PDF]

Hiroshi Ueda and Makoto Inoue: In Vivo Signal Transduction of Nociceptive Response by Kyotorphin (Tyrosine-Arginine) through G $alpha$ _i- and Inositol Trisphosphate-Mediated Ca²⁺ Influx
Mol Pharmacol 2000 57: 108-115. [Abstract] [Full Text] [PDF]

Dirk Daelemans, Dominique Schols, Myriam Witvrouw, Christophe Pannecouque, Sigrid Hatse, Sonia van Dooren, François Hamy, Thomas Klimkait, Erik de Clercq, and Anne-Mieke VanDamme: A Second Target for the Peptoid Tat/Transactivation Response Element Inhibitor CGP64222: Inhibition of Human Immunodeficiency Virus Replication by Blocking CXC-Chemokine Receptor 4-Mediated Virus Entry
Mol Pharmacol 2000 57: 116-124. [Abstract] [Full Text] [PDF]

Grace Chen, James Way, Susan Armour, Chris Watson, Ken Queen, Channa K. Jayawickreme, Wen-Ji Chen, and Terry Kenakin: Use of Constitutive G Protein-Coupled Receptor Activity for Drug Discovery
Mol Pharmacol 2000 57: 125-134. [Abstract] [Full Text] [PDF]

Chung-Chin Kuo, Ron-Chi Huang, and Bih-Show Lou: Inhibition of Na⁺ Current by Diphenhydramine and Other Diphenyl Compounds: Molecular Determinants of Selective Binding to the Inactivated Channels
Mol Pharmacol 2000 57: 135-143. [Abstract] [Full Text] [PDF]

John A. Schetz, Peter S. Benjamin, and David R. Sibley: Nonconserved Residues in the Second Transmembrane-Spanning Domain of the D₄ Dopamine Receptor Are Molecular Determinants of D₄-Selective Pharmacology
Mol Pharmacol 2000 57: 144-152. [Abstract] [Full Text] [PDF]

Ben-Kuen Chen, Hui-Chung Kung, Tein-Yi Tsai, and Wen-Chang Chang: Essential Role of Mitogen-Activated Protein Kinase Pathway and c-Jun Induction in Epidermal Growth Factor-Induced Gene Expression of Human 12-Lipoxygenase
Mol Pharmacol 2000 57: 153-161. [Abstract] [Full Text] [PDF]

Somnath Mukhopadhyay, Helen H. McIntosh, Devin B. Houston, and Allyn C. Howlett: The CB₁ Cannabinoid Receptor Juxtamembrane C-Terminal Peptide Confers Activation to Specific G proteins in Brain
Mol Pharmacol 2000 57: 162-170. [Abstract] [Full Text] [PDF]

Dana B. Fathy, Donald J. Kyle, and L. M. Fredrik Leeb-Lundberg: High-Affinity Binding of Peptide Agonists to the Human B1 Bradykinin Receptor Depends on Interaction between the Peptide N-Terminal L-Lysine and the Fourth Extracellular Domain of the Receptor
Mol Pharmacol 2000 57: 171-179. [Abstract] [Full Text] [PDF]

Pascal Verdier-Pinard, John A. Kepler, George R. Pettit, and Ernest Hamel: Sustained Intracellular Retention of Dolastatin 10 Causes Its Potent Antimitotic Activity
Mol Pharmacol 2000 57: 180-187. [Abstract] [Full Text] [PDF]

Erin G. Schuetz, Diane R. Umbenhauer, Kazuto Yasuda, Cynthia Brimer, Lan Nguyen, Mary V. Relling, John D. Schuetz, and Alfred H. Schinkel: Altered Expression of Hepatic Cytochromes P-450 in Mice Deficient in One or More mdr1 Genes
Mol Pharmacol 2000 57: 188-197. [Abstract] [Full Text] [PDF]

Caterina Ambrosio, Paola Molinari, Susanna Cotecchia, and Tommaso Costa: Catechol-Binding Serines of $beta$ ₂-Adrenergic Receptors Control the Equilibrium between Active and Inactive Receptor States
Mol Pharmacol 2000 57: 198-210. [Abstract] [Full Text] [PDF]

Errata:

: Mol Pharmacol 2000 57: 211. [Full Text] [PDF]

Cover Caption:

About the cover: Model for the activation of oxytocin receptors. The left panel shows a minimized structure of a constitutivelyactive mutant of the human oxytocin receptor. The right panelshows a model of the interaction between oxytocin and the wild-typereceptor, and for comparison the center panel shows a complexbetween oxytocin and inactive mutant of the receptor. Receptorsare depicted as helix ribbon bundles in cross-section throughthe surface membrane, with the intracellular surface at the topand the extracellular surface at the bottom. The solvent-accessiblesurfaces are represented by dot-clouds and predict that the activationprocess involves the opening of a solvent-exposed cytosolic crevice.From Fanelli F, Barbier P, Zanchetta D, de Benedetti PG and ChiniB (1999) Activation mechanism of human oxytocin receptor: A combinedstudy of experimental and computer-simulated mutagenesis. MolPharmacol 56:214-225.