Mol Pharm -- Table of Contents (57 [2])

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February 2000; 57 (2)   [Index by Author] [Cover Caption]

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Heather A. Carlson and J. Andrew McCammon: Accommodating Protein Flexibility in Computational Drug Design
Mol Pharmacol 2000 57: 213-218. [Full Text] [PDF]

Articles:

Alexander Scheer, Tommaso Costa, Francesca Fanelli, Pier G. De Benedetti, Sakina Mhaouty-Kodja, Liliane Abuin, Monique Nenniger-Tosato, and Susanna Cotecchia: Mutational Analysis of the Highly Conserved Arginine within the Glu/Asp-Arg-Tyr Motif of the $alpha$ _1b-Adrenergic Receptor: Effects on Receptor Isomerization and Activation
Mol Pharmacol 2000 57: 219-231. [Abstract] [Full Text] [PDF]

Gerd Krause, Ricardo Hermosilla, Alexander Oksche, Claudia Rutz, Walter Rosenthal, and Ralf Schülein: Molecular and Conformational Features of a Transport-Relevant Domain in the C-Terminal Tail of the Vasopressin V₂ Receptor
Mol Pharmacol 2000 57: 232-242. [Abstract] [Full Text] [PDF]

Bogdan Vladu, Jan M. Woynarowski, Govindarajan Manikumar, Mansukhlal C. Wani, Monroe E. Wall, Daniel D. Von Hoff, and Randy M. Wadkins: 7- and 10-Substituted Camptothecins: Dependence of Topoisomerase I-DNA Cleavable Complex Formation and Stability on the 7- and 10-Substituents
Mol Pharmacol 2000 57: 243-251. [Abstract] [Full Text] [PDF]

Anish A. Konkar, Ying Zhai, and James G. Granneman: $beta$ 1-Adrenergic Receptors Mediate $beta$ 3-Adrenergic-Independent Effects of CGP 12177 in Brown Adipose Tissue
Mol Pharmacol 2000 57: 252-258. [Abstract] [Full Text] [PDF]

Kailash N. Pandey, Ravindra Kumar, Ming Li, and Huong Nguyen: Functional Domains and Expression of Truncated Atrial Natriuretic Peptide Receptor-A: The Carboxyl-Terminal Regions Direct the Receptor Internalization and Sequestration in COS-7 Cells
Mol Pharmacol 2000 57: 259-267. [Abstract] [Full Text] [PDF]

Annamaria De Luca, Fedele Natuzzi, Jean-Francois Desaphy, Gabriella Loni, Giovanni Lentini, Carlo Franchini, Vincenzo Tortorella, and Diana Conte Camerino: Molecular Determinants of Mexiletine Structure for Potent and Use-Dependent Block of Skeletal Muscle Sodium Channels
Mol Pharmacol 2000 57: 268-277. [Abstract] [Full Text] [PDF]

Gerald W. Dorn, II, Nicole M. Tepe, Guangyu Wu, Atsuko Yatani, and Stephen B. Liggett: Mechanisms of Impaired $beta$ -Adrenergic Receptor Signaling in G_q-Mediated Cardiac Hypertrophy and Ventricular Dysfunction
Mol Pharmacol 2000 57: 278-287. [Abstract] [Full Text] [PDF]

Christopher W. Vaughan, Mark Connor, Elena E. Bagley, and MacDonald J. Christie: Actions of Cannabinoids on Membrane Properties and Synaptic Transmission in Rat Periaqueductal Gray Neurons In Vitro
Mol Pharmacol 2000 57: 288-295. [Abstract] [Full Text] [PDF]

Susan E. Morgan, Rhonda S. Cadena, Susana C. Raimondi, and William T. Beck: Selection of Human Leukemic CEM Cells for Resistance to the DNA Topoisomerase II Catalytic Inhibitor ICRF-187 Results in Increased Levels of Topoisomerase II $alpha$ and Altered G₂/M Checkpoint and Apoptotic Responses
Mol Pharmacol 2000 57: 296-307. [Abstract] [Full Text] [PDF]

Matthias Braun and Frank Thévenod: Photoaffinity Labeling and Purification of ZG-16p, a High-Affinity Dihydropyridine Binding Protein of Rat Pancreatic Zymogen Granule Membranes that Regulates a K⁺-Selective Conductance
Mol Pharmacol 2000 57: 308-316. [Abstract] [Full Text] [PDF]

Rongbao Zhao, Feng Gao, Pi Jun Wang, and I. David Goldman: Role of the Amino Acid 45 Residue in Reduced Folate Carrier Function and Ion-Dependent Transport as Characterized by Site-Directed Mutagenesis
Mol Pharmacol 2000 57: 317-323. [Abstract] [Full Text] [PDF]

Aaron B. Coleman, Jamil Momand, and Susan E. Kane: Basic Fibroblast Growth Factor Sensitizes NIH 3T3 Cells to Apoptosis Induced by Cisplatin
Mol Pharmacol 2000 57: 324-333. [Abstract] [Full Text] [PDF]

Alexander I. Sobolevsky, Maria V. Yelshansky, and Boris I. Khodorov: Eosine-Induced Blockade of N-Methyl-D-aspartate Channels in Acutely Isolated Rat Hippocampal Neurons
Mol Pharmacol 2000 57: 334-341. [Abstract] [Full Text] [PDF]

Anthone W. Dunah, Yuehua Wang, Robert P. Yasuda, Kimihiko Kameyama, Richard L. Huganir, Barry B. Wolfe, and David G. Standaert: Alterations in Subunit Expression, Composition, and Phosphorylation of Striatal N-Methyl-D-Aspartate Glutamate Receptors in a Rat 6-Hydroxydopamine Model of Parkinson's Disease
Mol Pharmacol 2000 57: 342-352. [Abstract] [Full Text] [PDF]

Hiromichi Fujino, Dinesh Srinivasan, Kristen L. Pierce, and John W. Regan: Differential Regulation of Prostaglandin F₂ Receptor Isoforms by Protein Kinase C
Mol Pharmacol 2000 57: 353-358. [Abstract] [Full Text] [PDF]

Corinne Fantz, David Shaw, William Jennings, Antonia Forsthoefel, Maria Kitchens, Jason Phan, Wladek Minor, Lukasz Lebioda, Franklin G. Berger, and H. Trent Spencer: Drug-Resistant Variants of Escherichia coli Thymidylate Synthase: Effects of Substitutions at Pro-254
Mol Pharmacol 2000 57: 359-366. [Abstract] [Full Text] [PDF]

James P. Lees-Miller, Yanjun Duan, Guo Qi Teng, and Henry J. Duff: Molecular Determinant of High-Affinity Dofetilide Binding to HERG1 Expressed in Xenopus Oocytes: Involvement of S6 Sites
Mol Pharmacol 2000 57: 367-374. [Abstract] [Full Text] [PDF]

Marcus Quack and Carsten Carlberg: The Impact of Functional Vitamin D₃ Receptor Conformations on DNA-Dependent Vitamin D₃ Signaling
Mol Pharmacol 2000 57: 375-384. [Abstract] [Full Text] [PDF]

Sergei Maliartchouk, Yangbo Feng, Ljubica Ivanisevic, Thomas Debeir, A. Claudio Cuello, Kevin Burgess, and H. Uri Saragovi: A Designed Peptidomimetic Agonistic Ligand of TrkA Nerve Growth Factor Receptors
Mol Pharmacol 2000 57: 385-391. [Abstract] [Full Text] [PDF]

Katsushige Ono, Toshihiko Kaku, Naomasa Makita, Akira Kitabatake, and Makoto Arita: Selective Block of Late Currents in the $Delta$ KPQ Na⁺ Channel Mutant by Pilsicainide and Lidocaine with Distinct Mechanisms
Mol Pharmacol 2000 57: 392-400. [Abstract] [Full Text] [PDF]

Li-Na Wei, Xinli Hu, Jing Bi, and Horace Loh: Post-Transcriptional Regulation of Mouse $kappa$ -Opioid Receptor Expression
Mol Pharmacol 2000 57: 401-408. [Abstract] [Full Text] [PDF]

Pelayo Camps, Bernadette Cusack, William D. Mallender, Rachid El Achab, Jordi Morral, Diego Muñoz-Torrero, and Terrone L. Rosenberry: Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease
Mol Pharmacol 2000 57: 409-417. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Model for the activation of oxytocin receptors. The left panel shows a minimized structure of a constitutivelyactive mutant of the human oxytocin receptor. The right panelshows a model of the interaction between oxytocin and the wild-typereceptor, and for comparison the center panel shows a complexbetween oxytocin and inactive mutant of the receptor. Receptorsare depicted as helix ribbon bundles in cross-section throughthe surface membrane, with the intracellular surface at the topand the extracellular surface at the bottom. The solvent-accessiblesurfaces are represented by dot-clouds and predict that the activationprocess involves the opening of a solvent-exposed cytosolic crevice.From Fanelli F, Barbier P, Zanchetta D, de Benedetti PG and ChiniB (1999) Activation mechanism of human oxytocin receptor: A combinedstudy of experimental and computer-simulated mutagenesis. MolPharmacol 56:214-225.