Mol Pharm -- Table of Contents (57 [3])

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March 2000; 57 (3)   [Index by Author] [Cover Caption]

       Accelerated Communications

       Articles

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Accelerated Communications:

Alexey G. Mukhin, Daniela Gündisch, Andrew G. Horti, Andrei O. Koren, Gilles Tamagnan, Alane S. Kimes, Joann Chambers, D. Bruce Vaupel, Sarah L. King, Marina R. Picciotto, Robert B. Innis, and Edythe D. London: 5-Iodo-A-85380, an $alpha$ 4 $beta$ 2 Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors
Mol Pharmacol 2000 57: 642-649. [Abstract] [Full Text] [PDF]

Articles:

Thierry Galvez, Stephan Urwyler, Laurent Prézeau, Johannes Mosbacher, Cécile Joly, Barbara Malitschek, Jakob Heid, Isabelle Brabet, Wolfgang Froestl, Bernhard Bettler, Klemens Kaupmann, and Jean-Philippe Pin: Ca²⁺ Requirement for High-Affinity $gamma$ -Aminobutyric Acid (GABA) Binding at GABA_B Receptors: Involvement of Serine 269 of the GABA_BR1 Subunit
Mol Pharmacol 2000 57: 419-426. [Abstract] [Full Text] [PDF]

Huige Li and Ulrich Förstermann: Structure-Activity Relationship of Staurosporine Analogs in Regulating Expression of Endothelial Nitric-Oxide Synthase Gene
Mol Pharmacol 2000 57: 427-435. [Abstract] [Full Text] [PDF]

Ray A. Leppik, Anita Mynett, Sebastian Lazareno, and Nigel J. M. Birdsall: Allosteric Interactions between the Antagonist Prazosin and Amiloride Analogs at the Human $alpha$ _1A-Adrenergic Receptor
Mol Pharmacol 2000 57: 436-445. [Abstract] [Full Text] [PDF]

M. Li, J. C. Bermak, Z. W. Wang, and Q. Y. Zhou: Modulation of Dopamine D₂ Receptor Signaling by Actin-Binding Protein (ABP-280)
Mol Pharmacol 2000 57: 446-452. [Abstract] [Full Text] [PDF]

Ming-Biao Yin, Bin Guo, Udo Vanhoefer, Rami G. Azrak, Hans Minderman, Cheryl Frank, Carol Wrzosek, Harry K. Slocum, and Youcef M. Rustum: Characterization of Protein Kinase chk1 Essential for the Cell Cycle Checkpoint after Exposure of Human Head and Neck Carcinoma A253 Cells to a Novel Topoisomerase I Inhibitor BNP1350
Mol Pharmacol 2000 57: 453-459. [Abstract] [Full Text] [PDF]

Sharon L. Grant, Bernard Lassègue, Kathy K. Griendling, Masuko Ushio-Fukai, P. Reid Lyons, and R. Wayne Alexander: Specific Regulation of RGS2 Messenger RNA by Angiotensin II in Cultured Vascular Smooth Muscle Cells
Mol Pharmacol 2000 57: 460-467. [Abstract] [Full Text] [PDF]

Neville J. Butcher, Kenneth F. Ilett, and Rodney F. Minchin: Substrate-Dependent Regulation of Human Arylamine N-Acetyltransferase-1 in Cultured Cells
Mol Pharmacol 2000 57: 468-473. [Abstract] [Full Text] [PDF]

Berit X. Carlson, A. Christine Engblom, Uffe Kristiansen, Arne Schousboe, and Richard W. Olsen: A Single Glycine Residue at the Entrance to the First Membrane-Spanning Domain of the $gamma$ -Aminobutyric Acid Type A Receptor $beta$ ₂ Subunit Affects Allosteric Sensitivity to GABA and Anesthetics
Mol Pharmacol 2000 57: 474-484. [Abstract] [Full Text] [PDF]

Christopher M. Coulis, Chunja Lee, Violet Nardone, and Rebecca D. Prokipcak: Inhibition of c-myc Expression in Cells by Targeting an RNA-Protein Interaction Using Antisense Oligonucleotides
Mol Pharmacol 2000 57: 485-494. [Abstract] [Full Text] [PDF]

Lionel Mouledous, Christopher M. Topham, Christiane Moisand, Catherine Mollereau, and Jean-Claude Meunier: Functional Inactivation of the Nociceptin Receptor by Alanine Substitution of Glutamine 286 at the C Terminus of Transmembrane Segment VI: Evidence from a Site-Directed Mutagenesis Study of the ORL1 Receptor Transmembrane-Binding Domain
Mol Pharmacol 2000 57: 495-502. [Abstract] [Full Text] [PDF]

Katharine E. Pestell, Stephen M. Hobbs, Jenny C. Titley, Lloyd R. Kelland, and Michael I. Walton: Effect of p53 Status on Sensitivity to Platinum Complexes in a Human Ovarian Cancer Cell Line
Mol Pharmacol 2000 57: 503-511. [Abstract] [Full Text] [PDF]

David W. Pyatt, Yanzhu Yang, Brenda Mehos, Anh Le, Wayne Stillman, and Richard D. Irons: Hematotoxicity of the Chinese Herbal Medicine Tripterygium wilfordii Hook f in CD34-Positive Human Bone Marrow Cells
Mol Pharmacol 2000 57: 512-518. [Abstract] [Full Text] [PDF]

Michael D. Hlubek, Edward L. Stuenkel, Valery G. Krasnoperov, Alexander G. Petrenko, and Ronald W. Holz: Calcium-Independent Receptor for $alpha$ -Latrotoxin and Neurexin 1 $alpha$ Facilitate Toxin-Induced Channel Formation: Evidence That Channel Formation Results from Tethering of Toxin to Membrane
Mol Pharmacol 2000 57: 519-528. [Abstract] [Full Text] [PDF]

I. Imawati Budihardjo, Scott A. Boerner, Steven Eckdahl, Phyllis A. Svingen, Robert Rios, Matthew M. Ames, and Scott H. Kaufmann: Effect of 6-Aminonicotinamide and Other Protein Synthesis Inhibitors on Formation of Platinum-DNA Adducts and Cisplatin Sensitivity
Mol Pharmacol 2000 57: 529-538. [Abstract] [Full Text] [PDF]

Timothy M. Palmer and Gary L. Stiles: Identification of Threonine Residues Controlling the Agonist-Dependent Phosphorylation and Desensitization of the Rat A₃ Adenosine Receptor
Mol Pharmacol 2000 57: 539-545. [Abstract] [Full Text] [PDF]

Gail Ferguson, Kenneth R. Watterson, and Timothy M. Palmer: Subtype-Specific Kinetics of Inhibitory Adenosine Receptor Internalization Are Determined by Sensitivity to Phosphorylation by G Protein-Coupled Receptor Kinases
Mol Pharmacol 2000 57: 546-552. [Abstract] [Full Text] [PDF]

Cécile Combeau, Jean Provost, Frédérique Lancelin, Yann Tournoux, François Prod'homme, Frédéric Herman, François Lavelle, Jean Leboul, and Marc Vuilhorgne: RPR112378 and RPR115781: Two Representatives of a New Family of Microtubule Assembly Inhibitors
Mol Pharmacol 2000 57: 553-563. [Abstract] [Full Text] [PDF]

Ludwig Missiaen, Humbert DeSmedt, Geert Bultynck, Sara Vanlingen, Patrick Desmet, Geert Callewaert, and Jan B. Parys: Calmodulin Increases the Sensitivity of Type 3 Inositol-1,4,5-trisphosphate Receptors to Ca²⁺ Inhibition in Human Bronchial Mucosal Cells
Mol Pharmacol 2000 57: 564-567. [Abstract] [Full Text] [PDF]

Pascal Verdier-Pinard, Zhiqiang Wang, Arasambattu K. Mohanakrishnan, Mark Cushman, and Ernest Hamel: A Steroid Derivative with Paclitaxel-Like Effects on Tubulin Polymerization
Mol Pharmacol 2000 57: 568-575. [Abstract] [Full Text] [PDF]

Todd L. Anthony, Heddwen L. Brooks, Daniela Boassa, Sergey Leonov, Gina M. Yanochko, John W. Regan, and Andrea J. Yool: Cloned Human Aquaporin-1 Is a Cyclic GMP-Gated Ion Channel
Mol Pharmacol 2000 57: 576-588. [Abstract] [Full Text] [PDF]

Alexander Storch, Heike Blessing, Markus Bareiss, Sinje Jankowski, Zao Dung Ling, Paul Carvey, and Johannes Schwarz: Catechol-O-methyltransferase Inhibition Attenuates Levodopa Toxicity in Mesencephalic Dopamine Neurons
Mol Pharmacol 2000 57: 589-594. [Abstract] [Full Text] [PDF]

Christine T. Murphy, Andrew M. Riley, Steve J. Mills, Catherine J. Lindley, Barry V. L. Potter, and John Westwick: myo-Inositol 1,4,6-Trisphosphorothioate and myo-Inositol 1,3,6-Trisphosphorothioate: Partial Agonists with Very Low Intrinsic Activity at the Platelet myo-Inositol 1,4,5-Trisphosphate Receptor
Mol Pharmacol 2000 57: 595-601. [Abstract] [Full Text] [PDF]

Mette M. Rosenkilde and Thue W. Schwartz: Potency of Ligands Correlates with Affinity Measured against Agonist and Inverse Agonists but Not against Neutral Ligand in Constitutively Active Chemokine Receptor
Mol Pharmacol 2000 57: 602-609. [Abstract] [Full Text] [PDF]

Stephan Immenschuh, Vera Hinke, Norbert Katz, and Thomas Kietzmann: Transcriptional Induction of Heme Oxygenase-1 Gene Expression by Okadaic Acid in Primary Rat Hepatocyte Cultures
Mol Pharmacol 2000 57: 610-618. [Abstract] [Full Text] [PDF]

Ann-Sofie Johansson, Marianne Ridderström, and Bengt Mannervik: The Human Glutathione Transferase P1-1 Specific Inhibitor TER 117 Designed for Overcoming Cytostatic-Drug Resistance Is also a Strong Inhibitor of Glyoxalase I
Mol Pharmacol 2000 57: 619-624. [Abstract] [Full Text] [PDF]

Stéphanie Chauvin, Annette Bérault, Yannick Lerrant, Marcel Hibert, and Raymond Counis: Functional Importance of Transmembrane Helix 6 Trp²⁷⁹ and Exoloop 3 Val²⁹⁹ of Rat Gonadotropin-Releasing Hormone Receptor
Mol Pharmacol 2000 57: 625-633. [Abstract] [Full Text] [PDF]

Jerzy Madon, Bruno Hagenbuch, Lukas Landmann, Peter J. Meier, and Bruno Stieger: Transport Function and Hepatocellular Localization of mrp6 in Rat Liver
Mol Pharmacol 2000 57: 634-641. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Model for the activation of oxytocin receptors. The left panel shows a minimized structure of a constitutivelyactive mutant of the human oxytocin receptor. The right panelshows a model of the interaction between oxytocin and the wild-typereceptor, and for comparison the center panel shows a complexbetween oxytocin and inactive mutant of the receptor. Receptorsare depicted as helix ribbon bundles in cross-section throughthe surface membrane, with the intracellular surface at the topand the extracellular surface at the bottom. The solvent-accessiblesurfaces are represented by dot-clouds and predict that the activationprocess involves the opening of a solvent-exposed cytosolic crevice.From Fanelli F, Barbier P, Zanchetta D, de Benedetti PG and ChiniB (1999) Activation mechanism of human oxytocin receptor: A combinedstudy of experimental and computer-simulated mutagenesis. MolPharmacol 56:214-225.