Mol Pharm -- Table of Contents (57 [4])

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April 2000; 57 (4)   [Index by Author] [Cover Caption]

       Minireview

       Accelerated Communication

       Editorial

       Articles

       Errata

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Minireview:

Alex Toker: Protein Kinases as Mediators of Phosphoinositide 3-Kinase Signaling
Mol Pharmacol 2000 57: 652-658. [Full Text] [PDF]

Accelerated Communication:

Michael L. Bayewitch, Igal Nevo, Tomer Avidor-Reiss, Rivka Levy, William F. Simonds, and Zvi Vogel: Alterations in Detergent Solubility of Heterotrimeric G Proteins after Chronic Activation of G_i/o-Coupled Receptors: Changes in Detergent Solubility Are in Correlation with Onset of Adenylyl Cyclase Superactivation
Mol Pharmacol 2000 57: 820-825. [Abstract] [Full Text] [PDF]

Michele Sallese, Stefania Mariggiò, Etrusca D'Urbano, Luisa Iacovelli, and Antonio De Blasi: Selective Regulation of Gq Signaling by G Protein-Coupled Receptor Kinase 2: Direct Interaction of Kinase N Terminus with Activated G $alpha$ q
Mol Pharmacol 2000 57: 826-831. [Abstract] [Full Text] [PDF]

Editorial:

Joan Heller Brown: Editorial
Mol Pharmacol 2000 57: 651. [Full Text] [PDF]

Articles:

Dan F. McCune, Stephanie E. Edelmann, Jennifer R. Olges, Ginell R. Post, Bruce A. Waldrop, David J. J. Waugh, Dianne M. Perez, and Michael T. Piascik: Regulation of the Cellular Localization and Signaling Properties of the $alpha$ _1B- and $alpha$ _1D-Adrenoceptors by Agonists and Inverse Agonists
Mol Pharmacol 2000 57: 659-666. [Abstract] [Full Text] [PDF]

Olga Zelenaia, Brian D. Schlag, Gordon E. Gochenauer, Raquelli Ganel, Wei Song, Jacqueline S. Beesley, Judith B. Grinspan, Jeffrey D. Rothstein, and Michael B. Robinson: Epidermal Growth Factor Receptor Agonists Increase Expression of Glutamate Transporter GLT-1 in Astrocytes through Pathways Dependent on Phosphatidylinositol 3-Kinase and Transcription Factor NF- $kappa$ B
Mol Pharmacol 2000 57: 667-678. [Abstract] [Full Text] [PDF]

Christophe Rousselle, Philippe Clair, Jeanne-Marie Lefauconnier, Michel Kaczorek, Jean-Michel Scherrmann, and Jamal Temsamani: New Advances in the Transport of Doxorubicin through the Blood-Brain Barrier by a Peptide Vector-Mediated Strategy
Mol Pharmacol 2000 57: 679-686. [Abstract] [Full Text] [PDF]

Jiefa Wang, Lei Wang, Jialin Zheng, Jodi L. Anderson, and Myron L. Toews: Identification of Distinct Carboxyl-Terminal Domains Mediating Internalization and Down-Regulation of the Hamster $alpha$ _1B- Adrenergic Receptor
Mol Pharmacol 2000 57: 687-694. [Abstract] [Full Text] [PDF]

Susan W. Tendian and William B. Parker: Interaction of Deoxyguanosine Nucleotide Analogs with Human Telomerase
Mol Pharmacol 2000 57: 695-699. [Abstract] [Full Text] [PDF]

Joy S. C. Chan, Jonathan W. M. Lee, Maurice K. C. Ho, and Yung H. Wong: Preactivation Permits Subsequent Stimulation of Phospholipase C by G_i-Coupled Receptors
Mol Pharmacol 2000 57: 700-708. [Abstract] [Full Text] [PDF]

Han Geuk Seo, Toru Nishinaka, and Chihiro Yabe-Nishimura: Nitric Oxide Up-Regulates Aldose Reductase Expression in Rat Vascular Smooth Muscle Cells: A Potential Role for Aldose Reductase in Vascular Remodeling
Mol Pharmacol 2000 57: 709-717. [Abstract] [Full Text] [PDF]

Dror Yahalom, Yitzhak Koch, Nurit Ben-Aroya, and Mati Fridkin: Hexapeptide and Cyclic Pentapeptide Endothelin Antagonists Directly Activate Pituitary Gonadotropin-Releasing Hormone Receptors
Mol Pharmacol 2000 57: 718-724. [Abstract] [Full Text] [PDF]

Graeme L. Fraser, Janna Holmgren, Paul B. S. Clarke, and Claes Wahlestedt: Antisense Inhibition of $delta$ -Opioid Receptor Gene Function In Vivo by Peptide Nucleic Acids
Mol Pharmacol 2000 57: 725-731. [Abstract] [Full Text] [PDF]

Alexandra S. Herr, Gabriele M. Wochnik, Marcus C. Rosenhagen, Florian Holsboer, and Theo Rein: Rifampicin Is Not an Activator of Glucocorticoid Receptor
Mol Pharmacol 2000 57: 732-737. [Abstract] [Full Text] [PDF]

Michael R. Nichols and Bruce H. Morimoto: Differential Inhibition of Multiple cAMP Phosphodiesterase Isozymes by Isoflavones and Tyrphostins
Mol Pharmacol 2000 57: 738-745. [Abstract] [Full Text] [PDF]

Man-Hee Rhee, Igal Nevo, Tomer Avidor-Reiss, Rivka Levy, and Zvi Vogel: Differential Superactivation of Adenylyl Cyclase Isozymes after Chronic Activation of the CB₁ Cannabinoid Receptor
Mol Pharmacol 2000 57: 746-752. [Abstract] [Full Text] [PDF]

Dong-Soon Im, Christopher E. Heise, Michael A. Harding, Susan R. George, Brian F. O'Dowd, Dan Theodorescu, and Kevin R. Lynch: Molecular Cloning and Characterization of a Lysophosphatidic Acid Receptor, Edg-7, Expressed in Prostate
Mol Pharmacol 2000 57: 753-759. [Abstract] [Full Text] [PDF]

Éva Bakos, Raymond Evers, Emese Sinkó, András Váradi, Piet Borst, and Balázs Sarkadi: Interactions of the Human Multidrug Resistance Proteins MRP1 and MRP2 with Organic Anions
Mol Pharmacol 2000 57: 760-768. [Abstract] [Full Text] [PDF]

G. Kevin Chen, Norman J. Lacayo, George E. Durán, Dalia Cohen, and Branimir I. Sikic: Loss of Cyclosporin and Azidopine Binding Are Associated with Altered ATPase Activity by a Mutant P-glycoprotein with Deleted Phe³³⁵
Mol Pharmacol 2000 57: 769-777. [Abstract] [Full Text] [PDF]

Ana Elorza, Susana Sarnago, and Federico Mayor, Jr.: Agonist-Dependent Modulation of G Protein-Coupled Receptor Kinase 2 by Mitogen-Activated Protein Kinases
Mol Pharmacol 2000 57: 778-783. [Abstract] [Full Text] [PDF]

Sandhiya Patel, Beatrice A. Keller, and L. Mark Fisher: Mutations at Arg486 and Glu571 in Human Topoisomerase II $alpha$ Confer Resistance to Amsacrine: Relevance for Antitumor Drug Resistance in Human Cells
Mol Pharmacol 2000 57: 784-791. [Abstract] [Full Text] [PDF]

Steven J. Chmura, Edwardine Nodzenski, Surender Kharbanda, Pramod Pandey, Jose Quintans, Donald W. Kufe, and Ralph R. Weichselbaum: Down-Regulation of Ceramide Production Abrogates Ionizing Radiation-Induced Cytochrome c Release and Apoptosis
Mol Pharmacol 2000 57: 792-796. [Abstract] [Full Text] [PDF]

Anne Talbodec, Nathalie Berkane, Virginie Blandin, Jean Philippe Breittmayer, Emile Ferrari, Christian Frelin, and Paul Vigne: Aspirin and Sodium Salicylate Inhibit Endothelin ETA Receptors by an Allosteric Type of Mechanism
Mol Pharmacol 2000 57: 797-804. [Abstract] [Full Text] [PDF]

José L. Boyer, Suzanne M. Delaney, Demetrio Villanueva, and T. Kendall Harden: A Molecularly Identified P2Y Receptor Simultaneously Activates Phospholipase C and Inhibits Adenylyl Cyclase and Is Nonselectively Activated by All Nucleoside Triphosphates
Mol Pharmacol 2000 57: 805-810. [Abstract] [Full Text] [PDF]

Jan Balzarini, Bart Degrève, Sigrid Hatse, Erik De Clercq, Michael Breuer, Magnus Johansson, Roger Huybrechts, and Anna Karlsson: The Multifunctional Deoxynucleoside Kinase of Insect Cells Is a Target for the Development of New Insecticides
Mol Pharmacol 2000 57: 811-819. [Abstract] [Full Text] [PDF]

Errata:

: Mol Pharmacol 2000 57: 832. [Full Text] [PDF]

Cover Caption:

About the cover: Model for the activation of oxytocin receptors. The left panel shows a minimized structure of a constitutivelyactive mutant of the human oxytocin receptor. The right panelshows a model of the interaction between oxytocin and the wild-typereceptor, and for comparison the center panel shows a complexbetween oxytocin and inactive mutant of the receptor. Receptorsare depicted as helix ribbon bundles in cross-section throughthe surface membrane, with the intracellular surface at the topand the extracellular surface at the bottom. The solvent-accessiblesurfaces are represented by dot-clouds and predict that the activationprocess involves the opening of a solvent-exposed cytosolic crevice.From Fanelli F, Barbier P, Zanchetta D, de Benedetti PG and ChiniB (1999) Activation mechanism of human oxytocin receptor: A combinedstudy of experimental and computer-simulated mutagenesis. MolPharmacol 56:214-225.