Mol Pharm -- Table of Contents (57 [6])

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June 2000; 57 (6)   [Index by Author] [Cover Caption]

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       Errata

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Articles:

Galina Grishina and Catherine H. Berlot: A Surface-Exposed Region of G_s in Which Substitutions Decrease Receptor-Mediated Activation and Increase Receptor Affinity
Mol Pharmacol 2000 57: 1081-1092. [Abstract] [Full Text] [PDF]

Masanari Itokawa, Zhicheng Lin, Ning-Sheng Cai, Cindy Wu, Shigeo Kitayama, Jia-Bei Wang, and George R. Uhl: Dopamine Transporter Transmembrane Domain Polar Mutants: $Delta$ G and $Delta$ $Delta$ G Values Implicate Regions Important for Transporter Functions
Mol Pharmacol 2000 57: 1093-1103. [Abstract] [Full Text] [PDF]

Alexander Oksche, Gregor Boese, Angelika Horstmeyer, Jens Furkert, Michael Beyermann, Michael Bienert, and Walter Rosenthal: Late Endosomal/Lysosomal Targeting and Lack of Recycling of the Ligand-Occupied Endothelin B Receptor
Mol Pharmacol 2000 57: 1104-1113. [Abstract] [Full Text] [PDF]

Hong Dang, Pamela M. England, S. Sarah Farivar, Dennis A. Dougherty, and Henry A. Lester: Probing the Role of a Conserved M1 Proline Residue in 5-Hydroxytryptamine₃ Receptor Gating
Mol Pharmacol 2000 57: 1114-1122. [Abstract] [Full Text] [PDF]

El-Bdaoui Haddad, Alison J. Fox, Jonathan Rousell, Gillian Burgess, Peter McIntyre, Peter J. Barnes, and K. Fan Chung: Post-Transcriptional Regulation of Bradykinin B1 and B2 Receptor Gene Expression in Human Lung Fibroblasts by Tumor Necrosis Factor- $alpha$ : Modulation by Dexamethasone
Mol Pharmacol 2000 57: 1123-1131. [Abstract] [Full Text] [PDF]

Reginald Brys, Katty Josson, Maria Paola Castelli, Mirek Jurzak, Peter Lijnen, Walter Gommeren, and Josée E. Leysen: Reconstitution of the Human 5-HT_1D Receptor-G-Protein Coupling: Evidence for Constitutive Activity and Multiple Receptor Conformations
Mol Pharmacol 2000 57: 1132-1141. [Abstract] [Full Text] [PDF]

Hugues Greney, Philippe Ronde, Céline Magnier, Françoise Maranca, Carla Rascente, Wilma Quaglia, Mario Giannella, Maria Pigini, Livio Brasili, Claire Lugnier, Pascal Bousquet, and Monique Dontenwill: Coupling of I₁ Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline
Mol Pharmacol 2000 57: 1142-1151. [Abstract] [Full Text] [PDF]

Evert L. de Beer, Antonio E. Bottone, Jolanda van der Velden, and Emile E. Voest: Doxorubicin Impairs Crossbridge Turnover Kinetics in Skinned Cardiac Trabeculae after Acute and Chronic Treatment
Mol Pharmacol 2000 57: 1152-1157. [Abstract] [Full Text] [PDF]

Yannick Morel, Isabelle de Waziers, and Robert Barouki: A Repressive Cross-Regulation between Catalytic and Promoter Activities of the CYP1A1 and CYP2E1 Genes: Role of H₂O₂
Mol Pharmacol 2000 57: 1158-1164. [Abstract] [Full Text] [PDF]

Elisa Bofill-Cardona, Nina Vartian, Christian Nanoff, Michael Freissmuth, and Stefan Boehm: Two Different Signaling Mechanisms Involved in the Excitation of Rat Sympathetic Neurons by Uridine Nucleotides
Mol Pharmacol 2000 57: 1165-1172. [Abstract] [Full Text] [PDF]

Je-Seong Won, Jin-Koo Lee, Dong-Keun Song, Sung-Oh Huh, Jun-Sub Jung, Yung-Hi Kim, Mi-Ran Choi, and Hong-Won Suh: Cycloheximide Increases Proenkephalin and Tyrosine Hydroxylase Gene Expression in Rat Adrenal Medulla
Mol Pharmacol 2000 57: 1173-1181. [Abstract] [Full Text] [PDF]

Saula Ravasi, Valérie Capra, Maurizio Mezzetti, Simonetta Nicosia, and G. Enrico Rovati: A Kinetic Binding Study to Evaluate the Pharmacological Profile of a Specific Leukotriene C₄ Binding Site Not Coupled to Contraction in Human Lung Parenchyma
Mol Pharmacol 2000 57: 1182-1189. [Abstract] [Full Text] [PDF]

Xinkang Wang, Xiang Li, Dulcie B. Schmidt, James J. Foley, Frank C. Barone, Robert S. Ames, and Henry M. Sarau: Identification and Molecular Characterization of Rat CXCR3: Receptor Expression and Interferon-Inducible Protein-10 Binding Are Increased in Focal Stroke
Mol Pharmacol 2000 57: 1190-1198. [Abstract] [Full Text] [PDF]

Michael J. Beckstead, Jeff L. Weiner, Edmond I. Eger, II, Diane H. Gong, and S. John Mihic: Glycine and $gamma$ -Aminobutyric Acid_A Receptor Function Is Enhanced by Inhaled Drugs of Abuse
Mol Pharmacol 2000 57: 1199-1205. [Abstract] [Full Text] [PDF]

Michaela Herdick, Yvonne Bury, Marcus Quack, Milan R. Uskokovic, Patsie Polly, and Carsten Carlberg: Response Element and Coactivator-Mediated Conformational Change of the Vitamin D₃ Receptor Permits Sensitive Interaction with Agonists
Mol Pharmacol 2000 57: 1206-1217. [Abstract] [Full Text] [PDF]

Hong-Sheng Wang, Barry S. Brown, David McKinnon, and Ira S. Cohen: Molecular Basis for Differential Sensitivity of KCNQ and I_Ks Channels to the Cognitive Enhancer XE991
Mol Pharmacol 2000 57: 1218-1223. [Abstract] [Full Text] [PDF]

Jürgen E. Gschwend, William R. Fair, and C. Thomas Powell: Bryostatin 1 Induces Prolonged Activation of Extracellular Regulated Protein Kinases in and Apoptosis of LNCaP Human Prostate Cancer Cells Overexpressing Protein Kinase C $alpha$
Mol Pharmacol 2000 57: 1224-1234. [Abstract] [Full Text] [PDF]

Yutaka Hirata, Norimichi Nakahata, and Yasushi Ohizumi: Identification of a 97-kDa Mastoparan-Binding Protein Involving in Ca²⁺ Release from Skeletal Muscle Sarcoplasmic Reticulum
Mol Pharmacol 2000 57: 1235-1242. [Abstract] [Full Text] [PDF]

Daniel Kraut, Heather Goff, Reetesh K. Pai, Natilie A. Hosea, Israel Silman, Joel L. Sussman, Palmer Taylor, and Judith G. Voet: Inactivation Studies of Acetylcholinesterase with Phenylmethylsulfonyl Fluoride
Mol Pharmacol 2000 57: 1243-1248. [Abstract] [Full Text] [PDF]

Lucinda J. Steward, Frank G. Boess, Joy A. Steele, Dan Liu, Norris Wong, and Ian L. Martin: Importance of Phenylalanine 107 in Agonist Recognition by the 5-Hydroxytryptamine_3A Receptor
Mol Pharmacol 2000 57: 1249-1255. [Abstract] [Full Text] [PDF]

Fiona M. Gribble, Frank Reimann, Rebecca Ashfield, and Frances M. Ashcroft: Nucleotide Modulation of Pinacidil Stimulation of the Cloned K_ATP Channel Kir6.2/SUR2A
Mol Pharmacol 2000 57: 1256-1261. [Abstract] [Full Text] [PDF]

Paolo Follesa, Mariangela Serra, Elisabetta Cagetti, Maria Giuseppina Pisu, Stefania Porta, Stefania Floris, Federico Massa, Enrico Sanna, and Giovanni Biggio: Allopregnanolone Synthesis in Cerebellar Granule Cells: Roles in Regulation of GABA_A Receptor Expression and Function during Progesterone Treatment and Withdrawal
Mol Pharmacol 2000 57: 1262-1270. [Abstract] [Full Text] [PDF]

Errata:

: Correction for Volume 57, p. 188
Mol Pharmacol 2000 57: 1271. [Full Text] [PDF]

Cover Caption:

About the cover: Model for the activation of oxytocin receptors. The left panel shows a minimized structure of a constitutivelyactive mutant of the human oxytocin receptor. The right panelshows a model of the interaction between oxytocin and the wild-typereceptor, and for comparison the center panel shows a complexbetween oxytocin and inactive mutant of the receptor. Receptorsare depicted as helix ribbon bundles in cross-section throughthe surface membrane, with the intracellular surface at the topand the extracellular surface at the bottom. The solvent-accessiblesurfaces are represented by dot-clouds and predict that the activationprocess involves the opening of a solvent-exposed cytosolic crevice.From Fanelli F, Barbier P, Zanchetta D, de Benedetti PG and ChiniB (1999) Activation mechanism of human oxytocin receptor: A combinedstudy of experimental and computer-simulated mutagenesis. MolPharmacol 56:214-225.