Mol Pharm -- Table of Contents (58 [1])

Receive this page by email each issue: [Sign up for eTOCs]

Other Issues:
July 2000; 58 (1)   [Index by Author] [Cover Caption]

       Articles

       Errata

Find articles in this issue containing these words:
[Search ALL Issues]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Victor V. Bartsevich and R. L. Juliano: Regulation of the MDR1 Gene by Transcriptional Repressors Selected Using Peptide Combinatorial Libraries
Mol Pharmacol 2000 58: 1-10. [Abstract] [Full Text] [PDF]

Joe Henry Steinbach, John Bracamontes, Li Yu, Pengnian Zhang, and Douglas F. Covey: Subunit-Specific Action of an Anticonvulsant Thiobutyrolactone on Recombinant Glycine Receptors Involves a Residue in the M2 Membrane-Spanning Region
Mol Pharmacol 2000 58: 11-17. [Abstract] [Full Text] [PDF]

Frédérique Scamps, Stéphan Vigues, Sophie Restituito, Brice Campo, Anne Roig, Pierre Charnet, and Jean Valmier: Sarco-Endoplasmic ATPase Blocker 2,5-Di(tert-butyl)-1,4-benzohydroquinone Inhibits N-, P-, and Q- but Not T-, L-, or R-Type Calcium Currents in Central and Peripheral Neurons
Mol Pharmacol 2000 58: 18-26. [Abstract] [Full Text] [PDF]

Nozomi Niitsu, Takashi Kasukabe, Akihiro Yokoyama, Junko Okabe-Kado, Yuri Yamamoto-Yamaguchi, Masanori Umeda, and Yoshio Honma: Anticancer Derivative of Butyric Acid (Pivalyloxymethyl Butyrate) Specifically Potentiates the Cytotoxicity of Doxorubicin and Daunorubicin through the Suppression of Microsomal Glycosidic Activity
Mol Pharmacol 2000 58: 27-36. [Abstract] [Full Text] [PDF]

Tony Kwan, Helen Loughrey, Martine Brault, Samantha Gruenheid, Ina L. Urbatsch, Alan E. Senior, and Philippe Gros: Functional Analysis of a Tryptophan-Less P-glycoprotein: A Tool for Tryptophan Insertion and Fluorescence Spectroscopy
Mol Pharmacol 2000 58: 37-47. [Abstract] [Full Text] [PDF]

Janice M. Huss and Charles B. Kasper: Two-Stage Glucocorticoid Induction of CYP3A23 through Both the Glucocorticoid and Pregnane X Receptors
Mol Pharmacol 2000 58: 48-57. [Abstract] [Full Text] [PDF]

Mario D. Galigniana, Guillermo P. Vicent, Graciela Piwien-Pilipuk, Gerardo Burton, and Carlos P. Lantos: Mechanism of Action of the Potent Sodium-Retaining Steroid 11,19-Oxidoprogesterone
Mol Pharmacol 2000 58: 58-70. [Abstract] [Full Text] [PDF]

Tatiana Syrovets, Berthold Büchele, Erk Gedig, Joseph R. Slupsky, and Thomas Simmet: Acetyl-Boswellic Acids Are Novel Catalytic Inhibitors of Human Topoisomerases I and II $alpha$
Mol Pharmacol 2000 58: 71-81. [Abstract] [Full Text] [PDF]

Lin-Hua Jiang, Amanda B. Mackenzie, R. Alan North, and Annmarie Surprenant: Brilliant Blue G Selectively Blocks ATP-Gated Rat P2X₇ Receptors
Mol Pharmacol 2000 58: 82-88. [Abstract] [Full Text] [PDF]

Qing Li, Greg Lamb, and Robert H. Tukey: Characterization of the UDP-Glucuronosyltransferase 1A Locus in Lagomorphs: Evidence for Duplication of the UGT1A6 Gene
Mol Pharmacol 2000 58: 89-97. [Abstract] [Full Text] [PDF]

Slobodan M. Todorovic, Edward Perez-Reyes, and Christopher J. Lingle: Anticonvulsants But Not General Anesthetics Have Differential Blocking Effects on Different T-Type Current Variants
Mol Pharmacol 2000 58: 98-108. [Abstract] [Full Text] [PDF]

Michael M. Francis, Raymond W. Vazquez, Roger L. Papke, and Robert E. Oswald: Subtype-Selective Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Cocaine Is Determined by the $alpha$ 4 and $beta$ 4 Subunits
Mol Pharmacol 2000 58: 109-119. [Abstract] [Full Text] [PDF]

Samuel P. Lee, Brian F. O'Dowd, Gordon Y.K. Ng, George Varghese, Huda Akil, Alfred Mansour, Tuan Nguyen, and Susan R. George: Inhibition of Cell Surface Expression by Mutant Receptors Demonstrates that D2 Dopamine Receptors Exist as Oligomers in the Cell
Mol Pharmacol 2000 58: 120-128. [Abstract] [Full Text] [PDF]

Karin R. Aubrey, Ann D. Mitrovic, and Robert J. Vandenberg: Molecular Basis for Proton Regulation of Glycine Transport by Glycine Transporter Subtype 1b
Mol Pharmacol 2000 58: 129-135. [Abstract] [Full Text] [PDF]

Sylvie Claeysen, Michèle Sebben, Carine Bécamel, Richard M. Eglen, Robin D. Clark, Joël Bockaert, and Aline Dumuis: Pharmacological Properties of 5-Hydroxytryptamine₄ Receptor Antagonists on Constitutively Active Wild-Type and Mutated Receptors
Mol Pharmacol 2000 58: 136-144. [Abstract] [Full Text] [PDF]

Lisa J. McCawley, Shunan Li, Mario Benavidez, Jennifer Halbleib, Elizabeth V. Wattenberg, and Laurie G. Hudson: Elevation of Intracellular cAMP Inhibits Growth Factor-Mediated Matrix Metalloproteinase-9 Induction and Keratinocyte Migration
Mol Pharmacol 2000 58: 145-151. [Abstract] [Full Text] [PDF]

J. Kevin Kerzee and Kenneth S. Ramos: Activation of c-Ha-ras by Benzo(a)pyrene in Vascular Smooth Muscle Cells Involves Redox Stress and Aryl Hydrocarbon Receptor
Mol Pharmacol 2000 58: 152-158. [Abstract] [Full Text] [PDF]

Florence Noble, Maria Szücs, Brigitte Kieffer, and Bernard P. Roques: Overexpression of Dynamin Is Induced by Chronic Stimulation of µ- but Not $delta$ -Opioid Receptors: Relationships with µ-Related Morphine Dependence
Mol Pharmacol 2000 58: 159-166. [Abstract] [Full Text] [PDF]

Lilliam A. Rosario, Miechelle L. O'Brien, Colin J. Henderson, C. Roland Wolf, and Kenneth D. Tew: Cellular Response to a Glutathione S-Transferase P1-1 Activated Prodrug
Mol Pharmacol 2000 58: 167-174. [Abstract] [Full Text] [PDF]

Karen Allman, Karen M. Page, Carol A.M. Curtis, and Edward C. Hulme: Scanning Mutagenesis Identifies Amino Acid Side Chains in Transmembrane Domain 5 of the M₁ Muscarinic Receptor that Participate in Binding the Acetyl Methyl Group of Acetylcholine
Mol Pharmacol 2000 58: 175-184. [Abstract] [Full Text] [PDF]

Cristina Rodríguez, Véronique Noé, Agatha Cabrero, Carlos J. Ciudad, and Juan C. Laguna: Differences in the Formation of PPAR $alpha$ -RXR/acoPPRE Complexes between Responsive and Nonresponsive Species upon Fibrate Administration
Mol Pharmacol 2000 58: 185-193. [Abstract] [Full Text] [PDF]

Sebastian Lazareno, Angela Popham, and Nigel J. M. Birdsall: Allosteric Interactions of Staurosporine and Other Indolocarbazoles with N-[methyl-³H]Scopolamine and Acetylcholine at Muscarinic Receptor Subtypes: Identification of a Second Allosteric Site
Mol Pharmacol 2000 58: 194-207. [Abstract] [Full Text] [PDF]

Dominic P. Williams, Munir Pirmohamed, Dean J. Naisbitt, Jack P. Uetrecht, and Brian K. Park: Induction of Metabolism-Dependent and -Independent Neutrophil Apoptosis by Clozapine
Mol Pharmacol 2000 58: 207-216. [Abstract] [Full Text] [PDF]

Douglas Macdonald, Nicholas Murgolo, Rumin Zhang, James P. Durkin, Xiaorui Yao, Catherine D. Strader, and Michael P. Graziano: Molecular Characterization of the Melanin-Concentrating Hormone/Receptor Complex: Identification of Critical Residues Involved in Binding and Activation
Mol Pharmacol 2000 58: 217-225. [Abstract] [Full Text] [PDF]

Maria R. Mazzoni, Simone Taddei, Laura Giusti, Paolo Rovero, Claudia Galoppini, Annamaria D'Ursi, Stefania Albrizio, Antonio Triolo, Ettore Novellino, Giovanni Greco, Antonio Lucacchini, and Heidi E. Hamm: A G $alpha$ _s Carboxyl-Terminal Peptide Prevents G_s Activation by the A_2A Adenosine Receptor
Mol Pharmacol 2000 58: 226-236. [Abstract] [Full Text] [PDF]

Yassine Amrani, Aili L. Lazaar, Rebecca Hoffman, Kunjalata Amin, Samir Ousmer, and Reynold A. Panettieri, Jr.: Activation of p55 Tumor Necrosis Factor- $alpha$ Receptor-1 Coupled to Tumor Necrosis Factor Receptor-Associated Factor 2 Stimulates Intercellular Adhesion Molecule-1 Expression by Modulating a Thapsigargin-Sensitive Pathway in Human Tracheal Smooth Muscle Cells
Mol Pharmacol 2000 58: 237-245. [Abstract] [Full Text] [PDF]

Errata:

: Mol Pharmacol 2000 58: 246. [Full Text] [PDF]

Cover Caption:

About the cover: Model of the receptor-G protein complex. The G protein heterotrimer is an $alpha$ _t/ $alpha$ _i1 chimera complexed with $beta$ _t $gamma$ _t(Lambright et al., 1996). The receptor model is the MII rhodopsinmodel (Pogozheva et al., 1997). Positioning of the heterotrimerrelative to the receptor is based on the model in Bourne (1997).The GTPase domain of the $alpha$ -subunit is light blue. The helicaldomain of the $alpha$ -subunit is pink. The GDP is yellow. Switch I isdark blue, switch II is green, and switch III is magenta. The $alpha$ 2/ $beta$ 4 loop is yellow, the $alpha$ 3/ $beta$ 5 loop is orange, and the $alpha$ 4/ $beta$ 6loop is red. The carboxyl terminus (labeled C) of the $alpha$ -subunitis magenta. Selected regions of secondary structure in the $alpha$ -subunit,including the amino-terminal $alpha$ -helix ( $alpha$ N), are indicated. The $beta$ -strands of the $beta$ -subunit are orange, and the amino-terminalhelix and connecting loops are yellow. the $gamma$ -subunit is white.Receptor helices are numbered, and those connected to each otherby an intracellular loop are the same color. These figures weredrawn using MidasPlus, developed by the Computer Graphics Laboratoryat the University of California at San Francisco. From GrishnaG and Berlot CH (2000) A surface-exposed region of G_s inwhich substitutions decrease receptor-mediated activation andincrease receptor affinity. Mol Pharmacol 57:1081-1092.