Mol Pharm -- Table of Contents (58 [2])

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August 2000; 58 (2)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Daniel Palmer and Donald H. Maurice: Dual Expression and Differential Regulation of Phosphodiesterase 3A and Phosphodiesterase 3B in Human Vascular Smooth Muscle: Implications for Phosphodiesterase 3 Inhibition in Human Cardiovascular Tissues
Mol Pharmacol 2000 58: 247-252. [Abstract] [Full Text] [PDF]

Martin J. Main, Jennifer E. Cryan, Joe R. B. Dupere, Brian Cox, Jeffrey J. Clare, and Stephen A. Burbidge: Modulation of KCNQ2/3 Potassium Channels by the Novel Anticonvulsant Retigabine
Mol Pharmacol 2000 58: 253-262. [Abstract] [Full Text] [PDF]

Birgitte Holst, Christian E. Elling, and Thue W. Schwartz: Partial Agonism through a Zinc-Ion Switch Constructed between Transmembrane Domains III and VII in the Tachykinin NK₁ Receptor
Mol Pharmacol 2000 58: 263-270. [Abstract] [Full Text] [PDF]

Articles:

Ken Nakamura, Vytautas P. Bindokas, Jeremy D. Marks, David A. Wright, David M. Frim, Richard J. Miller, and Un Jung Kang: The Selective Toxicity of 1-Methyl-4-phenylpyridinium to Dopaminergic Neurons: The Role of Mitochondrial Complex I and Reactive Oxygen Species Revisited
Mol Pharmacol 2000 58: 271-278. [Abstract] [Full Text] [PDF]

Cheng-Chung Tsao, Julie Foley, Sherry J. Coulter, Robert Maronpot, Darryl C. Zeldin, and Joyce A. Goldstein: CYP2C40, a Unique Arachidonic Acid 16-Hydroxylase, Is the Major CYP2C in Murine Intestinal Tract
Mol Pharmacol 2000 58: 279-287. [Abstract] [Full Text] [PDF]

Jesús H. de León, Kostas P. Vatsis, and Wendell W. Weber: Characterization of Naturally Occurring and Recombinant Human N-Acetyltransferase Variants Encoded by NAT1*
Mol Pharmacol 2000 58: 288-299. [Abstract] [Full Text] [PDF]

Barbara Balestra, Silvia Vailati, Milena Moretti, Wolfang Hanke, Francesco Clementi, and Cecilia Gotti: Chick Optic Lobe Contains a Developmentally Regulated $alpha$ 2 $alpha$ 5 $beta$ 2 Nicotinic Receptor Subtype
Mol Pharmacol 2000 58: 300-311. [Abstract] [Full Text] [PDF]

Sergio Kaiser and Susan Wonnacott: $alpha$ -Bungarotoxin-Sensitive Nicotinic Receptors Indirectly Modulate [³H]Dopamine Release in Rat Striatal Slices via Glutamate Release
Mol Pharmacol 2000 58: 312-318. [Abstract] [Full Text] [PDF]

Richard P. Metz, Diana J. Auyeung, Fay K. Kessler, and Joseph K. Ritter: Involvement of Hepatocyte Nuclear Factor 1 in the Regulation of the UDP-Glucuronosyltransferase 1A7 (UGT1A7) Gene in Rat Hepatocytes
Mol Pharmacol 2000 58: 319-327. [Abstract] [Full Text] [PDF]

Thomas Koch, Thomas Kroslak, Marco Averbeck, Peter Mayer, Helmut Schröder, Evelyn Raulf, and Volker Höllt: Allelic Variation S268P of the Human µ-Opioid Receptor Affects Both Desensitization and G Protein Coupling
Mol Pharmacol 2000 58: 328-334. [Abstract] [Full Text] [PDF]

Liqiong Li, Peter J. Meier, and Nazzareno Ballatori: Oatp2 Mediates Bidirectional Organic Solute Transport: A Role for Intracellular Glutathione
Mol Pharmacol 2000 58: 335-340. [Abstract] [Full Text] [PDF]

Ken Paradiso, Kimberley Sabey, Alex S. Evers, Charles F. Zorumski, Douglas F. Covey, and Joe Henry Steinbach: Steroid Inhibition of Rat Neuronal Nicotinic $alpha$ 4 $beta$ 2 Receptors Expressed in HEK 293 Cells
Mol Pharmacol 2000 58: 341-351. [Abstract] [Full Text] [PDF]

Emmanuel Hermans, Ruth Saunders, Julie V. Selkirk, Rajendra Mistry, Stefan R. Nahorski, and R. A. John Challiss: Complex Involvement of Pertussis Toxin-Sensitive G Proteins in the Regulation of Type 1 $alpha$ Metabotropic Glutamate Receptor Signaling in Baby Hamster Kidney Cells
Mol Pharmacol 2000 58: 352-360. [Abstract] [Full Text] [PDF]

Jean-Marc Pascussi, Lionel Drocourt, Jean-Michel Fabre, Patrick Maurel, and Marie-José Vilarem: Dexamethasone Induces Pregnane X Receptor and Retinoid X Receptor- $alpha$ Expression in Human Hepatocytes: Synergistic Increase of CYP3A4 Induction by Pregnane X Receptor Activators
Mol Pharmacol 2000 58: 361-372. [Abstract] [Full Text] [PDF]

Alfredo Mijares, Diane Lebesgue, Gerd Wallukat, and Johan Hoebeke: From Agonist To Antagonist: Fab Fragments of an Agonist-Like Monoclonal Anti- $beta$ ₂-Adrenoceptor Antibody Behave as Antagonists
Mol Pharmacol 2000 58: 373-379. [Abstract] [Full Text] [PDF]

James G. Karras, Robert A. McKay, Nicholas M. Dean, and Brett P. Monia: Deletion of Individual Exons and Induction of Soluble Murine Interleukin-5 Receptor- $alpha$ Chain Expression through Antisense Oligonucleotide-Mediated Redirection of Pre-mRNA Splicing
Mol Pharmacol 2000 58: 380-387. [Abstract] [Full Text] [PDF]

Ping-Yee Law, Laurie J. Erickson, Rachid El-Kouhen, Lee Dicker, Jonathan Solberg, Wei Wang, Emilee Miller, Amy L. Burd, and Horace H. Loh: Receptor Density and Recycling Affect the Rate of Agonist-Induced Desensitization of µ-Opioid Receptor
Mol Pharmacol 2000 58: 388-398. [Abstract] [Full Text] [PDF]

Michael Bläker, Yong Ren, Lakshmi Seshadri, Edward W. McBride, Martin Beinborn, and Alan S. Kopin: CCK-B/Gastrin Receptor Transmembrane Domain Mutations Selectively Alter Synthetic Agonist Efficacy without Affecting the Activity of Endogenous Peptides
Mol Pharmacol 2000 58: 399-406. [Abstract] [Full Text] [PDF]

George McAllister, Josephine A. Stanton, Kamran Salim, Emma J. Handford, and Margaret S. Beer: Edg2 Receptor Functionality: Gi $alpha$ 1 Coexpression and Fusion Protein Studies
Mol Pharmacol 2000 58: 407-412. [Abstract] [Full Text] [PDF]

Soma Rakhit, Susan Pyne, and Nigel J. Pyne: The Platelet-Derived Growth Factor Receptor Stimulation of p42/p44 Mitogen-Activated Protein Kinase in Airway Smooth Muscle Involves a G-Protein-Mediated Tyrosine Phosphorylation of Gab1
Mol Pharmacol 2000 58: 413-420. [Abstract] [Full Text] [PDF]

Bruce R. Williams, Roger Barber, and Richard B. Clark: Kinetic Analysis of Agonist-Induced Down-Regulation of the $beta$ ₂-Adrenergic Receptor in BEAS-2B Cells Reveals High- and Low-Affinity Components
Mol Pharmacol 2000 58: 421-430. [Abstract] [Full Text] [PDF]

Rong Yu, Sandhya Mandlekar, and A.-N. Tony Kong: Molecular Mechanisms of Butylated Hydroxylanisole-Induced Toxicity: Induction of Apoptosis through Direct Release of Cytochrome c
Mol Pharmacol 2000 58: 431-437. [Abstract] [Full Text] [PDF]

Patricia A. Stevens, Nicola Bevan, Stephen Rees, and Graeme Milligan: Resolution of Inverse Agonist-Induced Up-Regulation from Constitutive Activity of Mutants of the $alpha$ _1b-Adrenoceptor
Mol Pharmacol 2000 58: 438-448. [Abstract] [Full Text] [PDF]

Herbert M. Himmel, Dagmar Meyer zu Heringdorf, Eva Graf, Dobromir Dobrev, Ariane Kortner, Stephan Schüler, Karl H. Jakobs, and Ursula Ravens: Evidence for Edg-3 Receptor-Mediated Activation of I_K.ACh by Sphingosine-1-Phosphate in Human Atrial Cardiomyocytes
Mol Pharmacol 2000 58: 449-454. [Abstract] [Full Text] [PDF]

Susan E. Senogles: The D2s Dopamine Receptor Stimulates Phospholipase D Activity: A Novel Signaling Pathway for Dopamine
Mol Pharmacol 2000 58: 455-462. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Model of the receptor-G protein complex. The G protein heterotrimer is an $alpha$ _t/ $alpha$ _i1 chimera complexed with $beta$ _t $gamma$ _t(Lambright et al., 1996). The receptor model is the MII rhodopsinmodel (Pogozheva et al., 1997). Positioning of the heterotrimerrelative to the receptor is based on the model in Bourne (1997).The GTPase domain of the $alpha$ -subunit is light blue. The helicaldomain of the $alpha$ -subunit is pink. The GDP is yellow. Switch I isdark blue, switch II is green, and switch III is magenta. The $alpha$ 2/ $beta$ 4 loop is yellow, the $alpha$ 3/ $beta$ 5 loop is orange, and the $alpha$ 4/ $beta$ 6loop is red. The carboxyl terminus (labeled C) of the $alpha$ -subunitis magenta. Selected regions of secondary structure in the $alpha$ -subunit,including the amino-terminal $alpha$ -helix ( $alpha$ N), are indicated. The $beta$ -strands of the $beta$ -subunit are orange, and the amino-terminalhelix and connecting loops are yellow. the $gamma$ -subunit is white.Receptor helices are numbered, and those connected to each otherby an intracellular loop are the same color. These figures weredrawn using MidasPlus, developed by the Computer Graphics Laboratoryat the University of California at San Francisco. From GrishnaG and Berlot CH (2000) A surface-exposed region of G_s inwhich substitutions decrease receptor-mediated activation andincrease receptor affinity. Mol Pharmacol 57:1081-1092.