Mol Pharm -- Table of Contents (58 [3])

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September 2000; 58 (3)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Mansoureh Eghbali, Peter W. Gage, and Bryndis Birnir: Pentobarbital Modulates $gamma$ -Aminobutyric Acid-Activated Single-Channel Conductance in Rat Cultured Hippocampal Neurons
Mol Pharmacol 2000 58: 463-469. [Abstract] [Full Text] [PDF]

Articles:

John G. DeLuca, Thomas W. Doebber, Linda J. Kelly, Ramon K. Kemp, Sylvain Molon-Noblot, Soumya P. Sahoo, John Ventre, Margaret S. Wu, Jeffrey M. Peters, Frank J. Gonzalez, and David E. Moller: Evidence for Peroxisome Proliferator-Activated Receptor (PPAR) $alpha$ -Independent Peroxisome Proliferation: Effects of PPAR $gamma$ / $delta$ -Specific Agonists in PPAR $alpha$ -Null Mice
Mol Pharmacol 2000 58: 470-476. [Abstract] [Full Text] [PDF]

Gunnar Schulte and Bertil B. Fredholm: Human Adenosine A₁, A_2A, A_2B, and A₃ Receptors Expressed in Chinese Hamster Ovary Cells All Mediate the Phosphorylation of Extracellular-Regulated Kinase 1/2
Mol Pharmacol 2000 58: 477-482. [Abstract] [Full Text] [PDF]

Seong Yong Kim, Hiroshi Adachi, Ja Seok Koo, and Anton M. Jetten: Induction of the Cytochrome P450 Gene CYP26 during Mucous Cell Differentiation of Normal Human Tracheobronchial Epithelial Cells
Mol Pharmacol 2000 58: 483-490. [Abstract] [Full Text] [PDF]

Regina Alemany, Britta Sichelschmidt, Dagmar Meyer zu Heringdorf, Holger Lass, Chris J. van Koppen, and Karl H. Jakobs: Stimulation of Sphingosine-1-phosphate Formation by the P2Y₂ Receptor in HL-60 Cells: Ca²⁺ Requirement and Implication in Receptor-Mediated Ca²⁺ Mobilization, but Not MAP Kinase Activation
Mol Pharmacol 2000 58: 491-497. [Abstract] [Full Text] [PDF]

Michael Pusch, Antonella Liantonio, Lara Bertorello, Alessio Accardi, Annamaria De Luca, Sabata Pierno, Vincenzo Tortorella, and Diana Conte Camerino: Pharmacological Characterization of Chloride Channels Belonging to the ClC Family by the Use of Chiral Clofibric Acid Derivatives
Mol Pharmacol 2000 58: 498-507. [Abstract] [Full Text] [PDF]

Shi-Yong Sun, Ping Yue, Roshantha A. S. Chandraratna, Yohannes Tesfaigzi, Waun K. Hong, and Reuben Lotan: Dual Mechanisms of Action of the Retinoid CD437: Nuclear Retinoic Acid Receptor-Mediated Suppression of Squamous Differentiation and Receptor-Independent Induction of Apoptosis in UMSCC22B Human Head and Neck Squamous Cell Carcinoma Cells
Mol Pharmacol 2000 58: 508-514. [Abstract] [Full Text] [PDF]

Shafat A. Quadri, Ariful N. Qadri, Mark E. Hahn, Koren K. Mann, and David H. Sherr: The Bioflavonoid Galangin Blocks Aryl Hydrocarbon Receptor Activation and Polycyclic Aromatic Hydrocarbon-Induced Pre-B Cell Apoptosis
Mol Pharmacol 2000 58: 515-525. [Abstract] [Full Text] [PDF]

Babita Madan, Sanjay Batra, and Balaram Ghosh: 2'-Hydroxychalcone Inhibits Nuclear Factor- $kappa$ B and Blocks Tumor Necrosis Factor- $alpha$ - and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells
Mol Pharmacol 2000 58: 526-534. [Abstract] [Full Text] [PDF]

Yunjo Soh, Kyu-Shik Jeong, Insong James Lee, Myung-Ae Bae, Yong-Chul Kim, and Byoung J. Song: Selective Activation of the c-Jun N-Terminal Protein Kinase Pathway during 4-Hydroxynonenal-Induced Apoptosis of PC12 Cells
Mol Pharmacol 2000 58: 535-541. [Abstract] [Full Text] [PDF]

Veronique De Berardinis, Claude Moulis, Michele Maurice, Philippe Beaune, Dominique Pessayre, Denis Pompon, and Jacqueline Loeper: Human Microsomal Epoxide Hydrolase Is the Target of Germander-Induced Autoantibodies on the Surface of Human Hepatocytes
Mol Pharmacol 2000 58: 542-551. [Abstract] [Full Text] [PDF]

Henry M. Sarau, Jeffrey L. Mooney, Dulcie B. Schmidt, James J. Foley, Peter T. Buckley, Giuseppe A. M. Giardina, Da Y. Wang, Jonathan A. Lee, and Douglas W. P. Hay: Evidence That the Proposed Novel Human "Neurokinin-4" Receptor Is Pharmacologically Similar to the Human Neurokinin-3 Receptor but Is Not of Human Origin
Mol Pharmacol 2000 58: 552-559. [Abstract] [Full Text] [PDF]

Sandhiya Patel, Elen Jazrawi, Andrew M. Creighton, Caroline A. Austin, and L. Mark Fisher: Probing the Interaction of the Cytotoxic Bisdioxopiperazine ICRF-193 with the Closed Enzyme Clamp of Human Topoisomerase II $alpha$
Mol Pharmacol 2000 58: 560-568. [Abstract] [Full Text] [PDF]

Hyeseon Cho, Tohru Kozasa, Kenneth Takekoshi, Jean De Gunzburg, and John H. Kehrl: RGS14, a GTPase-Activating Protein for Gi $alpha$ , Attenuates Gi $alpha$ - and G13 $alpha$ -Mediated Signaling Pathways
Mol Pharmacol 2000 58: 569-576. [Abstract] [Full Text] [PDF]

Paul G. Richards, Martin K. Johnson, and David E. Ray: Identification of Acylpeptide Hydrolase as a Sensitive Site for Reaction with Organophosphorus Compounds and a Potential Target for Cognitive Enhancing Drugs
Mol Pharmacol 2000 58: 577-583. [Abstract] [Full Text] [PDF]

Franck Delaunay, Katarina Pettersson, Michel Tujague, and Jan-Åke Gustafsson: Functional Differences between the Amino-Terminal Domains of Estrogen Receptors $alpha$ and $beta$
Mol Pharmacol 2000 58: 584-590. [Abstract] [Full Text] [PDF]

Alan D. Wickenden, Weifeng Yu, Anrou Zou, Tim Jegla, and P. Kay Wagoner: Retigabine, A Novel Anti-Convulsant, Enhances Activation of KCNQ2/Q3 Potassium Channels
Mol Pharmacol 2000 58: 591-600. [Abstract] [Full Text] [PDF]

Robert E. Carroll, Denis Ostrovskiy, Sean Lee, Alexey Danilkovich, and Richard V. Benya: Characterization of Gastrin-Releasing Peptide and Its Receptor Aberrantly Expressed by Human Colon Cancer Cell Lines
Mol Pharmacol 2000 58: 601-607. [Abstract] [Full Text] [PDF]

Albrecht Piiper, Ralph Gebhardt, Bernd Kronenberger, Claudio D. Giannini, Robert Elez, and Stefan Zeuzem: Pertussis Toxin Inhibits Cholecystokinin- and Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Activation by Disinhibition of the cAMP Signaling Pathway and Inhibition of c-Raf-1
Mol Pharmacol 2000 58: 608-613. [Abstract] [Full Text] [PDF]

Sean D. Donevan and R. Tyler McCabe: Conantokin G Is an NR2B-Selective Competitive Antagonist of N-Methyl-D-aspartate Receptors
Mol Pharmacol 2000 58: 614-623. [Abstract] [Full Text] [PDF]

Catherine Martin, Georgina Berridge, Christopher F. Higgins, Prakash Mistry, Peter Charlton, and Richard Callaghan: Communication between Multiple Drug Binding Sites on P-glycoprotein
Mol Pharmacol 2000 58: 624-632. [Abstract] [Full Text] [PDF]

Hyun Jin Choi, Yeon Joo Jang, Hyo Jung Kim, and Onyou Hwang: Tetrahydrobiopterin Is Released from and Causes Preferential Death of Catecholaminergic Cells by Oxidative Stress
Mol Pharmacol 2000 58: 633-640. [Abstract] [Full Text] [PDF]

Wim Pluymers, Nouri Neamati, Christophe Pannecouque, Valery Fikkert, Christophe Marchand, Terrence R. Burke, Jr., Yves Pommier, Dominique Schols, Erik De Clercq, Zeger Debyser, and Myriam Witvrouw: Viral Entry as the Primary Target for the Anti-HIV Activity of Chicoric Acid and Its Tetra-Acetyl Esters
Mol Pharmacol 2000 58: 641-648. [Abstract] [Full Text] [PDF]

Adrienne Adams, J. Mitchell Guss, Charles A. Collyer, William A. Denny, Arungundrum S. Prakash, and Laurence P. G. Wakelin: Acridinecarboxamide Topoisomerase Poisons: Structural and Kinetic Studies of the DNA Complexes of 5-Substituted 9-Amino-(N-(2-dimethylamino)ethyl)acridine-4-Carboxamides
Mol Pharmacol 2000 58: 649-658. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Model of the receptor-G protein complex. The G protein heterotrimer is an $alpha$ _t/ $alpha$ _i1 chimera complexed with $beta$ _t $gamma$ _t(Lambright et al., 1996). The receptor model is the MII rhodopsinmodel (Pogozheva et al., 1997). Positioning of the heterotrimerrelative to the receptor is based on the model in Bourne (1997).The GTPase domain of the $alpha$ -subunit is light blue. The helicaldomain of the $alpha$ -subunit is pink. The GDP is yellow. Switch I isdark blue, switch II is green, and switch III is magenta. The $alpha$ 2/ $beta$ 4 loop is yellow, the $alpha$ 3/ $beta$ 5 loop is orange, and the $alpha$ 4/ $beta$ 6loop is red. The carboxyl terminus (labeled C) of the $alpha$ -subunitis magenta. Selected regions of secondary structure in the $alpha$ -subunit,including the amino-terminal $alpha$ -helix ( $alpha$ N), are indicated. The $beta$ -strands of the $beta$ -subunit are orange, and the amino-terminalhelix and connecting loops are yellow. the $gamma$ -subunit is white.Receptor helices are numbered, and those connected to each otherby an intracellular loop are the same color. These figures weredrawn using MidasPlus, developed by the Computer Graphics Laboratoryat the University of California at San Francisco. From GrishnaG and Berlot CH (2000) A surface-exposed region of G_s inwhich substitutions decrease receptor-mediated activation andincrease receptor affinity. Mol Pharmacol 57:1081-1092.