Mol Pharm -- Table of Contents (58 [5])

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November 2000; 58 (5)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

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Accelerated Communication:

Jesus A. Olivares-Reyes, Suman Jayadev, László Hunyady, Kevin J. Catt, and Roger D. Smith: Homologous and Heterologous Phosphorylation of the AT₂ Angiotensin Receptor by Protein Kinase C
Mol Pharmacol 2000 58: 1156-1161. [Abstract] [Full Text] [PDF]

Anita Seibold, Bruce Williams, Zai-Feng Huang, Jackie Friedman, Robert H. Moore, Brian J. Knoll, and Richard B. Clark: Localization of the Sites Mediating Desensitization of the $beta$ ₂-Adrenergic Receptor by the GRK Pathway
Mol Pharmacol 2000 58: 1162-1173. [Abstract] [Full Text] [PDF]

Articles:

David A. Shapiro, Kurt Kristiansen, Wesley K. Kroeze, and Bryan L. Roth: Differential Modes of Agonist Binding to 5-Hydroxytryptamine_2A Serotonin Receptors Revealed by Mutation and Molecular Modeling of Conserved Residues in Transmembrane Region 5
Mol Pharmacol 2000 58: 877-886. [Abstract] [Full Text] [PDF]

Ying-Ying Zhou, Dongmei Yang, Wei-Zhong Zhu, Sheng-Jun Zhang, Ding-Ji Wang, Dan K. Rohrer, Eric Devic, Brian K. Kobilka, Edward G. Lakatta, Heping Cheng, and Rui-Ping Xiao: Spontaneous Activation of $beta$ ₂- but Not $beta$ ₁-Adrenoceptors Expressed in Cardiac Myocytes from $beta$ ₁ $beta$ ₂ Double Knockout Mice
Mol Pharmacol 2000 58: 887-894. [Abstract] [Full Text] [PDF]

Isao Ishii, James J. A. Contos, Nobuyuki Fukushima, and Jerold Chun: Functional Comparisons of the Lysophosphatidic Acid Receptors, LP_A1/VZG-1/EDG-2, LP_A2/EDG-4, and LP_A3/EDG-7 in Neuronal Cell Lines Using a Retrovirus Expression System
Mol Pharmacol 2000 58: 895-902. [Abstract] [Full Text] [PDF]

Igor Feoktistov, Anna E. Goldstein, and Italo Biaggioni: Cyclic AMP and Protein Kinase A Stimulate Cdc42: Role of A₂ Adenosine Receptors in Human Mast Cells
Mol Pharmacol 2000 58: 903-910. [Abstract] [Full Text] [PDF]

Yan W. Asmann, Maoqing Dong, Subhas Ganguli, Elizabeth M. Hadac, and Laurence J. Miller: Structural Insights into the Amino-Terminus of the Secretin Receptor: I. Status of Cysteine and Cystine Residues
Mol Pharmacol 2000 58: 911-919. [Abstract] [Full Text] [PDF]

Jan M. Woynarowski, Sandrine Faivre, Maryanne C.S. Herzig, Brenda Arnett, William G. Chapman, Alex V. Trevino, Eric Raymond, Stephen G. Chaney, Alexandra Vaisman, Maria Varchenko, and Paul E. Juniewicz: Oxaliplatin-Induced Damage of Cellular DNA
Mol Pharmacol 2000 58: 920-927. [Abstract] [Full Text] [PDF]

Jan Balzarini, Stefano Aquaro, Tina Knispel, Chiara Rampazzo, Vera Bianchi, Carlo-Federico Perno, Erik De Clercq, and Chris Meier: Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine Monophosphate: Efficient Intracellular Delivery of d4TMP
Mol Pharmacol 2000 58: 928-935. [Abstract] [Full Text] [PDF]

Taka-aki Koshimizu, Fredrick Van Goor, Anderson On-Lam Wong, Akito Tanoue, Gozoh Tsujimoto, and Stanko S. Stojilkovic: Characterization of Calcium Signaling by Purinergic Receptor-Channels Expressed in Excitable Cells
Mol Pharmacol 2000 58: 936-945. [Abstract] [Full Text] [PDF]

Karen L. Abbott, James R. Loss, II, Aaron M. Robida, and T. J. Murphy: Evidence That G $alpha$ _q-Coupled Receptor-Induced Interleukin-6 mRNA in Vascular Smooth Muscle Cells Involves the Nuclear Factor of Activated T Cells
Mol Pharmacol 2000 58: 946-953. [Abstract] [Full Text] [PDF]

Katharina Wenzel-Seifert and Roland Seifert: Molecular Analysis of $beta$ ₂-Adrenoceptor Coupling to G_s-, G_i-, and G_q-Proteins
Mol Pharmacol 2000 58: 954-966. [Abstract] [Full Text] [PDF]

Josefa León, Manuel Macías, Germaine Escames, Encarna Camacho, Huda Khaldy, Miguel Martín, Antonio Espinosa, Miguel A. Gallo, and Darío Acuña-Castroviejo: Structure-Related Inhibition of Calmodulin-Dependent Neuronal Nitric-Oxide Synthase Activity by Melatonin and Synthetic Kynurenines
Mol Pharmacol 2000 58: 967-975. [Abstract] [Full Text] [PDF]

Conrad P. Hodgkinson, Matthew C. Wright, and Alan J. Paine: Fibronectin-Mediated Hepatocyte Shape Change Reprograms Cytochrome P450 2C11 Gene Expression via an Integrin-Signaled Induction of Ribonuclease Activity
Mol Pharmacol 2000 58: 976-981. [Abstract] [Full Text] [PDF]

Barry R. O'Keefe, Shilpa R. Shenoy, Dong Xie, Wentao Zhang, Jeffrey M. Muschik, Michael J. Currens, Irwin Chaiken, and Michael R. Boyd: Analysis of the Interaction between the HIV-Inactivating Protein Cyanovirin-N and Soluble Forms of the Envelope Glycoproteins gp120 and gp41
Mol Pharmacol 2000 58: 982-992. [Abstract] [Full Text] [PDF]

Maurice K.C. Ho and Yung H. Wong: The Amino Terminus of G $alpha$ _z is Required for Receptor Recognition, Whereas its $alpha$ 4/ $beta$ 6 Loop Is Essential for Inhibition of Adenylyl Cyclase
Mol Pharmacol 2000 58: 993-1000. [Abstract] [Full Text] [PDF]

Gui Gao and Q. Ping Dou: G₁ Phase-Dependent Expression of Bcl-2 mRNA and Protein Correlates with Chemoresistance of Human Cancer Cells
Mol Pharmacol 2000 58: 1001-1010. [Abstract] [Full Text] [PDF]

Masami Yoshimura, Peter H. Wu, Paula L. Hoffman, and Boris Tabakoff: Overexpression of Type 7 Adenylyl Cyclase in the Mouse Brain Enhances Acute and Chronic Actions of Morphine
Mol Pharmacol 2000 58: 1011-1016. [Abstract] [Full Text] [PDF]

Keon Wook Kang, Ji Hwa Ryu, and Sang Geon Kim: The Essential Role of Phosphatidylinositol 3-Kinase and of p38 Mitogen-Activated Protein Kinase Activation in the Antioxidant Response Element-Mediated rGSTA2 Induction by Decreased Glutathione in H4IIE Hepatoma Cells
Mol Pharmacol 2000 58: 1017-1025. [Abstract] [Full Text] [PDF]

Rainer Boer, Wolf-Rüdiger Ulrich, Thomas Klein, Berit Mirau, Sabine Haas, and Ilka Baur: The Inhibitory Potency and Selectivity of Arginine Substrate Site Nitric-Oxide Synthase Inhibitors Is Solely Determined by Their Affinity toward the Different Isoenzymes
Mol Pharmacol 2000 58: 1026-1034. [Abstract] [Full Text] [PDF]

Jeppe Wegener Tams, Rikke Malene Jørgensen, Arne Holm, and Jan Fahrenkrug: Creation of a Selective Antagonist and Agonist of the Rat VPAC₁ Receptor Using a Combinatorial Approach with Vasoactive Intestinal Peptide 6-23 as Template
Mol Pharmacol 2000 58: 1035-1041. [Abstract] [Full Text] [PDF]

Adrian Newman-Tancredi, Valérie Audinot, Celia Moreira, Laurence Verrièle, and Mark J. Millan: Inverse Agonism and Constitutive Activity as Functional Correlates of Serotonin h5-HT_1B Receptor/G-Protein Stoichiometry
Mol Pharmacol 2000 58: 1042-1049. [Abstract] [Full Text] [PDF]

Jun Guo, Yalan Wu, Wenbo Zhang, Jing Zhao, Lakshmi A. Devi, Gang Pei, and Lan Ma: Identification of G Protein-Coupled Receptor Kinase 2 Phosphorylation Sites Responsible for Agonist-Stimulated $delta$ -Opioid Receptor Phosphorylation
Mol Pharmacol 2000 58: 1050-1056. [Abstract] [Full Text] [PDF]

Yuh-Chi Kuo, Nai-Shian Yang, Cheng-Jen Chou, Lie-Chwen Lin, and Wei-Jern Tsai: Regulation of Cell Proliferation, Gene Expression, Production of Cytokines, and Cell Cycle Progression in Primary Human T Lymphocytes by Piperlactam S Isolated from Piper kadsura
Mol Pharmacol 2000 58: 1057-1066. [Abstract] [Full Text] [PDF]

Yvonne Bury, Andreas Steinmeyer, and Carsten Carlberg: Structure Activity Relationship of Carboxylic Ester Antagonists of the Vitamin D₃ Receptor
Mol Pharmacol 2000 58: 1067-1074. [Abstract] [Full Text] [PDF]

Yolande Cordeaux, Stephen J. Briddon, Anne E. Megson, Jacqui McDonnell, John M. Dickenson, and Stephen J. Hill: Influence of Receptor Number on Functional Responses Elicited by Agonists Acting at the Human Adenosine A₁ Receptor: Evidence for Signaling Pathway-Dependent Changes in Agonist Potency and Relative Intrinsic Activity
Mol Pharmacol 2000 58: 1075-1084. [Abstract] [Full Text] [PDF]

Anne Remaury, Rita Raddatz, Catherine Ordener, Sandra Savic, Jean C. Shih, Kevin Chen, Isabelle Seif, Edward De Maeyer, Stephen M. Lanier, and Angelo Parini: Analysis of the Pharmacological and Molecular Heterogeneity of I₂-Imidazoline-Binding Proteins using Monoamine Oxidase-Deficient Mouse Models
Mol Pharmacol 2000 58: 1085-1090. [Abstract] [Full Text] [PDF]

Ray A. Leppik and Nigel J. M. Birdsall: Agonist Binding and Function at the Human $alpha$ _2A-Adrenoceptor: Allosteric Modulation by Amilorides
Mol Pharmacol 2000 58: 1091-1099. [Abstract] [Full Text] [PDF]

Myriam Witvrouw, Valery Fikkert, Wim Pluymers, Barry Matthews, Karen Mardel, Dominique Schols, John Raff, Zeger Debyser, Erik De Clercq, George Holan, and Christophe Pannecouque: Polyanionic (i.e., Polysulfonate) Dendrimers Can Inhibit the Replication of Human Immunodeficiency Virus by Interfering with Both Virus Adsorption and Later Steps (Reverse Transcriptase/Integrase) in the Virus Replicative Cycle
Mol Pharmacol 2000 58: 1100-1108. [Abstract] [Full Text] [PDF]

Ling Li, Ginger E. Dutschman, Elizabeth A. Gullen, Eisaku Tsujii, Susan P. Grill, Yongseok Choi, Chung K. Chu, and Yung-chi Cheng: Metabolism and Mode of Inhibition of Varicella-Zoster Virus by L- $beta$ -5-Bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil Is Dependent on Viral Thymidine Kinase
Mol Pharmacol 2000 58: 1109-1114. [Abstract] [Full Text] [PDF]

Agnese Secondo, Maurizio Taglialatela, Mauro Cataldi, Giovanna Giorgio, Monica Valore, Gianfranco Di Renzo, and Lucio Annunziato: Pharmacological Blockade of ERG K⁺ Channels and Ca²⁺ Influx through Store-Operated Channels Exerts Opposite Effects on Intracellular Ca²⁺ Oscillations in Pituitary GH₃ Cells
Mol Pharmacol 2000 58: 1115-1128. [Abstract] [Full Text] [PDF]

Daniel B. Williams and Myles H. Akabas: Benzodiazepines Induce a Conformational Change in the Region of the $gamma$ -Aminobutyric Acid Type A Receptor $alpha$ ₁-Subunit M3 Membrane-Spanning Segment
Mol Pharmacol 2000 58: 1129-1136. [Abstract] [Full Text] [PDF]

Gaétan Thibault: Sodium Dodecyl Sulfate-Stable Complexes of Echistatin and RGD-Dependent Integrins: A Novel Approach to Study Integrins
Mol Pharmacol 2000 58: 1137-1145. [Abstract] [Full Text] [PDF]

Swee Y. Sharp, Lloyd R. Kelland, Melanie R. Valenti, Lisa A. Brunton, Steve Hobbs, and Paul Workman: Establishment of an Isogenic Human Colon Tumor Model for NQO1 Gene Expression: Application to Investigate the Role of DT-Diaphorase in Bioreductive Drug Activation In Vitro and In Vivo
Mol Pharmacol 2000 58: 1146-1155. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Model of the receptor-G protein complex. The G protein heterotrimer is an $alpha$ _t/ $alpha$ _i1 chimera complexed with $beta$ _t $gamma$ _t(Lambright et al., 1996). The receptor model is the MII rhodopsinmodel (Pogozheva et al., 1997). Positioning of the heterotrimerrelative to the receptor is based on the model in Bourne (1997).The GTPase domain of the $alpha$ -subunit is light blue. The helicaldomain of the $alpha$ -subunit is pink. The GDP is yellow. Switch I isdark blue, switch II is green, and switch III is magenta. The $alpha$ 2/ $beta$ 4 loop is yellow, the $alpha$ 3/ $beta$ 5 loop is orange, and the $alpha$ 4/ $beta$ 6loop is red. The carboxyl terminus (labeled C) of the $alpha$ -subunitis magenta. Selected regions of secondary structure in the $alpha$ -subunit,including the amino-terminal $alpha$ -helix ( $alpha$ N), are indicated. The $beta$ -strands of the $beta$ -subunit are orange, and the amino-terminalhelix and connecting loops are yellow. the $gamma$ -subunit is white.Receptor helices are numbered, and those connected to each otherby an intracellular loop are the same color. These figures weredrawn using MidasPlus, developed by the Computer Graphics Laboratoryat the University of California at San Francisco. From GrishnaG and Berlot CH (2000) A surface-exposed region of G_s inwhich substitutions decrease receptor-mediated activation andincrease receptor affinity. Mol Pharmacol 57:1081-1092.