Mol Pharm -- Table of Contents (58 [6])

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December 2000; 58 (6)   [Index by Author] [Cover Caption]

       Minireview

       Perspectives

       Accelerated Communications

       Articles

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Minireview:

James J. A. Contos, Isao Ishii, and Jerold Chun: Lysophosphatidic Acid Receptors
Mol Pharmacol 2000 58: 1188-1196. [Abstract] [Full Text] [PDF]

Perspectives:

Morley D. Hollenberg: Receptor Binding and Agonist Efficacy: New Insights from Mutants of the Thrombin Protease-Activated Receptor-1 (PAR-1)
Mol Pharmacol 2000 58: 1175-1177. [Full Text] [PDF]

Brian D. Blackhart, Lily Ruslim-Litrus, Chin-Chun Lu, Veronica L. Alves, Willy Teng, Robert M. Scarborough, Elwood E. Reynolds, and Donna Oksenberg: Extracellular Mutations of Protease-Activated Receptor-1 Result in Differential Activation by Thrombin and Thrombin Receptor Agonist Peptide
Mol Pharmacol 2000 58: 1178-1187. [Abstract] [Full Text] [PDF]

Accelerated Communications:

Christelle Thibault, Chaoqiang Lai, Norbert Wilke, Bao Duong, M. Foster Olive, Sajida Rahman, Helin Dong, Clyde W. Hodge, David J. Lockhart, and Michael F. Miles: Expression Profiling of Neural Cells Reveals Specific Patterns of Ethanol-Responsive Gene Expression
Mol Pharmacol 2000 58: 1593-1600. [Abstract] [Full Text] [PDF]

Hans-Peter Nothacker, Zhiwei Wang, Yuhong Zhu, Rainer K. Reinscheid, Steven H. S. Lin, and Olivier Civelli: Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist
Mol Pharmacol 2000 58: 1601-1608. [Abstract] [Full Text] [PDF]

Mohamed Ouzzine, Laurence Antonio, Brian Burchell, Patrick Netter, Sylvie Fournel-Gigleux, and Jacques Magdalou: Importance of Histidine Residues for the Function of the Human Liver UDP-Glucuronosyltransferase UGT1A6: Evidence for the Catalytic Role of Histidine 370
Mol Pharmacol 2000 58: 1609-1615. [Abstract] [Full Text] [PDF]

Articles:

Lisa A. Palmer, Benjamin Gaston, and Roger A. Johns: Normoxic Stabilization of Hypoxia-Inducible Factor-1 Expression and Activity: Redox-Dependent Effect of Nitrogen Oxides
Mol Pharmacol 2000 58: 1197-1203. [Abstract] [Full Text] [PDF]

Eva C. Ihle and Doris K. Patneau: Modulation of $alpha$ -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Desensitization by Extracellular Protons
Mol Pharmacol 2000 58: 1204-1212. [Abstract] [Full Text] [PDF]

Carl Sims, Jason Chiu, and Robert D. Harvey: Tyrosine Phosphatase Inhibitors Selectively Antagonize $beta$ -Adrenergic Receptor-Dependent Regulation of Cardiac Ion Channels
Mol Pharmacol 2000 58: 1213-1221. [Abstract] [Full Text] [PDF]

Xinjian Lin, Krishna Ramamurthi, Misako Mishima, Akira Kondo, and Stephen B. Howell: p53 Interacts with the DNA Mismatch Repair System to Modulate the Cytotoxicity and Mutagenicity of Hydrogen Peroxide
Mol Pharmacol 2000 58: 1222-1229. [Abstract] [Full Text] [PDF]

Chris Watson, Grace Chen, Paul Irving, James Way, Wen-Ji Chen, and Terry Kenakin: The Use of Stimulus-Biased Assay Systems to Detect Agonist-Specific Receptor Active States: Implications for the Trafficking of Receptor Stimulus by Agonists
Mol Pharmacol 2000 58: 1230-1238. [Abstract] [Full Text] [PDF]

Yannick Morel, Xavier Coumoul, Antoine Nalpas, and Robert Barouki: Nuclear Factor I/CCAAT Box Transcription Factor trans-Activating Domain Is a Negative Sensor of Cellular Stress
Mol Pharmacol 2000 58: 1239-1246. [Abstract] [Full Text] [PDF]

Bruce Ladenheim, Irina N. Krasnova, Xiaolin Deng, Jonathan M. Oyler, Aldo Polettini, Timothy H. Moran, Marilyn A. Huestis, and Jean Lud Cadet: Methamphetamine-Induced Neurotoxicity Is Attenuated in Transgenic Mice with a Null Mutation for Interleukin-6
Mol Pharmacol 2000 58: 1247-1256. [Abstract] [Full Text] [PDF]

Fujiko Tsukahara, Toshimasa Yoshioka, and Takamura Muraki: Molecular and Functional Characterization of HSC54, a Novel Variant of Human Heat-Shock Cognate Protein 70
Mol Pharmacol 2000 58: 1257-1263. [Abstract] [Full Text] [PDF]

Gregory H. Hockerman, Nejmi Dilmac, Todd Scheuer, and William A. Catterall: Molecular Determinants of Diltiazem Block in Domains IIIS6 and IVS6 of L-type Ca²⁺ Channels
Mol Pharmacol 2000 58: 1264-1270. [Abstract] [Full Text] [PDF]

Hitoshi Morikawa, Olivier J. Manzoni, John C. Crabbe, and John T. Williams: Regulation of Central Synaptic Transmission by 5-HT_1B Auto- and Heteroreceptors
Mol Pharmacol 2000 58: 1271-1278. [Abstract] [Full Text] [PDF]

Snehal Desai, Heather April, Chinwe Nwaneshiudu, and Barrie Ashby: Comparison of Agonist-Induced Internalization of the Human EP2 and EP4 Prostaglandin Receptors: Role of the Carboxyl Terminus in EP4 Receptor Sequestration
Mol Pharmacol 2000 58: 1279-1286. [Abstract] [Full Text] [PDF]

Xiao-Kui Li, Monica Motwani, William Tong, William Bornmann, and Gary K. Schwartz: Huanglian, A Chinese Herbal Extract, Inhibits Cell Growth by Suppressing the Expression of Cyclin B1 and Inhibiting CDC2 Kinase Activity in Human Cancer Cells
Mol Pharmacol 2000 58: 1287-1293. [Abstract] [Full Text] [PDF]

Rainer Hammermann, Maria Donata Messeri Dreißig, Jutta Mössner, Margarita Fuhrmann, Liberato Berrino, Manfred Göthert, and Kurt Racké: Nuclear Factor- $kappa$ B Mediates Simultaneous Induction of Inducible Nitric-Oxide Synthase and Up-Regulation of the Cationic Amino Acid Transporter CAT-2B in Rat Alveolar Macrophages
Mol Pharmacol 2000 58: 1294-1302. [Abstract] [Full Text] [PDF]

Li Q. Ren, Daniel K. Garrett, Marie Syapin, and Peter J. Syapin: Differential Fibronectin Expression in Activated C6 Glial Cells Treated with Ethanol
Mol Pharmacol 2000 58: 1303-1309. [Abstract] [Full Text] [PDF]

Frank S. Menniti, Bertrand L. Chenard, Mary B. Collins, Mary F. Ducat, Mark L. Elliott, Frank E. Ewing, Jianhua I. Huang, Kristin A. Kelly, John T. Lazzaro, Martin J. Pagnozzi, James L. Weeks, Willard M. Welch, and W. Frost White: Characterization of the Binding Site for a Novel Class of Noncompetitive $alpha$ -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonists
Mol Pharmacol 2000 58: 1310-1317. [Abstract] [Full Text] [PDF]

Frank Reimann, Fiona M. Gribble, and Frances M. Ashcroft: Differential Response of K_ATP Channels Containing SUR2A or SUR2B Subunits to Nucleotides and Pinacidil
Mol Pharmacol 2000 58: 1318-1325. [Abstract] [Full Text] [PDF]

Bart Degrève, Robert Esnouf, Erik De Clercq, and Jan Balzarini: Selective Abolishment of Pyrimidine Nucleoside Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase by Mutation of Alanine-167 to Tyrosine
Mol Pharmacol 2000 58: 1326-1332. [Abstract] [Full Text] [PDF]

Andreas H. Wagner, Robert Krzesz, Dingcheng Gao, Christian Schroeder, Marco Cattaruzza, and Markus Hecker: Decoy Oligodeoxynucleotide Characterization of Transcription Factors Controlling Endothelin-B Receptor Expression in Vascular Smooth Muscle Cells
Mol Pharmacol 2000 58: 1333-1340. [Abstract] [Full Text] [PDF]

Julie Marill, Thierry Cresteil, Michel Lanotte, and Guy G. Chabot: Identification of Human Cytochrome P450s Involved in the Formation of All-trans-Retinoic Acid Principal Metabolites
Mol Pharmacol 2000 58: 1341-1348. [Abstract] [Full Text] [PDF]

Margot W. Beukers, Hans den Dulk, Erica W. van Tilburg, Jaap Brouwer, and Adriaan P. Ijzerman: Why Are A_2B Receptors Low-Affinity Adenosine Receptors? Mutation of Asn273 to Tyr Increases Affinity of Human A_2B Receptor for 2-(1-Hexynyl)adenosine
Mol Pharmacol 2000 58: 1349-1356. [Abstract] [Full Text] [PDF]

David S. Miller, Stephanie N. Nobmann, Heike Gutmann, Michael Toeroek, Juergen Drewe, and Gert Fricker: Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy
Mol Pharmacol 2000 58: 1357-1367. [Abstract] [Full Text] [PDF]

Jie Wu, Noritaka Kamimura, Teruko Takeo, Sechiko Suga, Makoto Wakui, Takayuki Maruyama, and Katsuhiko Mikoshiba: 2-Aminoethoxydiphenyl Borate Modulates Kinetics of Intracellular Ca²⁺ Signals Mediated by Inositol 1,4,5-Trisphosphate-Sensitive Ca²⁺ Stores in Single Pancreatic Acinar Cells of Mouse
Mol Pharmacol 2000 58: 1368-1374. [Abstract] [Full Text] [PDF]

Yongchang Chang, Douglas F. Covey, and David S. Weiss: Correlation of the Apparent Affinities and Efficacies of $gamma$ -Aminobutyric Acid_C Receptor Agonists
Mol Pharmacol 2000 58: 1375-1380. [Abstract] [Full Text] [PDF]

Roya Poosti, Laure di Malta, Didier Gagne, Nicole Bernad, Jean-Claude Galleyrand, Chantal Escrieut, Sandrine Silvente-Poirot, Daniel Fourmy, and Jean Martinez: The Third Intracellular Loop of the Rat and Mouse Cholecystokinin-A Receptors Is Responsible for Different Patterns of Gene Activation
Mol Pharmacol 2000 58: 1381-1388. [Abstract] [Full Text] [PDF]

Renate Gnad, Klaus Aktories, Bernd Kaina, and Gerhard Fritz: Inhibition of Protein Isoprenylation Impairs Rho-Regulated Early Cellular Response to Genotoxic Stress
Mol Pharmacol 2000 58: 1389-1397. [Abstract] [Full Text] [PDF]

Wen-Chun Hung, Hui-Chiu Chang, Mei-Ren Pan, Te-Hsiu Lee, and Lea-Yea Chuang: Induction of p27^KIP1 as a Mechanism Underlying NS398-Induced Growth Inhibition in Human Lung Cancer Cells
Mol Pharmacol 2000 58: 1398-1403. [Abstract] [Full Text] [PDF]

Maria Syringas, François Janin, Sana Mezghanni, Bruno Giros, Jean Costentin, and Jean-Jacques Bonnet: Structural Domains of Chimeric Dopamine-Noradrenaline Human Transporters Involved in the Na⁺- and Cl-Dependence of Dopamine Transport
Mol Pharmacol 2000 58: 1404-1411. [Abstract] [Full Text] [PDF]

David A. Hall: Modeling the Functional Effects of Allosteric Modulators at Pharmacological Receptors: An Extension of the Two-State Model of Receptor Activation
Mol Pharmacol 2000 58: 1412-1423. [Abstract] [Full Text] [PDF]

Xi-Qin Ding, Rammohan V. Rao, Susan M. Kuntz, Eileen L. Holicky, and Laurence J. Miller: Impaired Resensitization and Recycling of the Cholecystokinin Receptor by Co-expression of its Second Intracellular Loop
Mol Pharmacol 2000 58: 1424-1433. [Abstract] [Full Text] [PDF]

Marina I. Strakhova, Scott C. Harvey, Christine M. Cook, James M. Cook, and Phil Skolnick: A Single Amino Acid Residue on the $alpha$ ₅ Subunit (Ile215) Is Essential for Ligand Selectivity at $alpha$ ₅ $beta$ ₃ $gamma$ ₂ $gamma$ -Aminobutyric Acid_A Receptors
Mol Pharmacol 2000 58: 1434-1440. [Abstract] [Full Text] [PDF]

Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Jean-Michel Fabre, Patrick Maurel, and Marie-José Vilarem: Dexamethasone Enhances Constitutive Androstane Receptor Expression in Human Hepatocytes: Consequences on Cytochrome P450 Gene Regulation
Mol Pharmacol 2000 58: 1441-1450. [Abstract] [Full Text] [PDF]

John Ellis and Margaret Seidenberg: Interactions of Alcuronium, TMB-8, and Other Allosteric Ligands with Muscarinic Acetylcholine Receptors: Studies with Chimeric Receptors
Mol Pharmacol 2000 58: 1451-1460. [Abstract] [Full Text] [PDF]

Virginie Blandin, Paul Vigne, Jean Philippe Breittmayer, and Christian Frelin: Allosteric Inhibition of Endothelin ETA Receptors by 3,5-Dibromosalicylic Acid
Mol Pharmacol 2000 58: 1461-1469. [Abstract] [Full Text] [PDF]

Åsa B. Gustafsson and Laurence L. Brunton: $beta$ -Adrenergic Stimulation of Rat Cardiac Fibroblasts Enhances Induction of Nitric-Oxide Synthase by Interleukin-1 $beta$ via Message Stabilization
Mol Pharmacol 2000 58: 1470-1478. [Abstract] [Full Text] [PDF]

Ching-Chow Chen, Jun-Jie Chen, and Chian-Ying Chou: Protein Kinase C $alpha$ but not p44/42 Mitogen-Activated Protein Kinase, p38, or c-Jun NH₂-Terminal Kinase Is Required for Intercellular Adhesion Molecule-1 Expression Mediated by Interleukin-1 $beta$ : Involvement of Sequential Activation of Tyrosine Kinase, Nuclear Factor- $kappa$ B-Inducing Kinase, and I $kappa$ B Kinase 2
Mol Pharmacol 2000 58: 1479-1489. [Abstract] [Full Text] [PDF]

Richard V. Benya, Takashi Kusui, Tatsuro Katsuno, Takaharu Tsuda, Samuel A. Mantey, James F. Battey, and Robert T. Jensen: Glycosylation of the Gastrin-Releasing Peptide Receptor and Its Effect on Expression, G Protein Coupling, and Receptor Modulatory Processes
Mol Pharmacol 2000 58: 1490-1501. [Abstract] [Full Text] [PDF]

Edward C. Burgard, Wende Niforatos, Tim van Biesen, Kevin J. Lynch, Karen L. Kage, Edward Touma, Elizabeth A. Kowaluk, and Michael F. Jarvis: Competitive Antagonism of Recombinant P2X_2/3 Receptors by 2',3'-O-(2,4,6-Trinitrophenyl) Adenosine 5'-Triphosphate (TNP-ATP)
Mol Pharmacol 2000 58: 1502-1510. [Abstract] [Full Text] [PDF]

Victor L. Schuster, Shigekazu Itoh, Steven W. Andrews, Robert M. Burk, June Chen, Karen M. Kedzie, Daniel W. Gil, and David F. Woodward: Synthetic Modification of Prostaglandin F₂ Indicates Different Structural Determinants for Binding to the Prostaglandin F Receptor Versus the Prostaglandin Transporter
Mol Pharmacol 2000 58: 1511-1516. [Abstract] [Full Text] [PDF]

Steven L. Levine, John R. Petrulis, Allison Dubil, and Gary H. Perdew: A Tetratricopeptide Repeat Half-Site in the Aryl Hydrocarbon Receptor Is Important for DNA Binding and trans-Activation Potential
Mol Pharmacol 2000 58: 1517-1524. [Abstract] [Full Text] [PDF]

Marc Leng, Daniel Locker, Marie-Josèphe Giraud-Panis, Annie Schwartz, Francesco P. Intini, Giovanni Natile, Claudio Pisano, Angelina Boccarelli, Domenico Giordano, and Mauro Coluccia: Replacement of an NH₃ by an Iminoether in Transplatin Makes an Antitumor Drug from an Inactive Compound
Mol Pharmacol 2000 58: 1525-1535. [Abstract] [Full Text] [PDF]

Zang Hee Lee, Kyubum Kwack, Kyung Keun Kim, Sang Ho Lee, and Hong-Hee Kim: Activation of c-Jun N-Terminal Kinase and Activator Protein 1 by Receptor Activator of Nuclear Factor $kappa$ B
Mol Pharmacol 2000 58: 1536-1545. [Abstract] [Full Text] [PDF]

Morgana Henaff, Stéphane N. Hatem, and Jean-Jacques Mercadier: Low Catecholamine Concentrations Protect Adult Rat Ventricular Myocytes against Apoptosis through cAMP-Dependent Extracellular Signal-Regulated Kinase Activation
Mol Pharmacol 2000 58: 1546-1553. [Abstract] [Full Text] [PDF]

Takahiro Moriya, Kazumasa Horikawa, Masashi Akiyama, and Shigenobu Shibata: Correlative Association between N-Methyl-D-Aspartate Receptor-Mediated Expression of Period Genes in the Suprachiasmatic Nucleus and Phase Shifts in Behavior with Photic Entrainment of Clock in Hamsters
Mol Pharmacol 2000 58: 1554-1562. [Abstract] [Full Text] [PDF]

Hiroshi Okumura, Zhe-Sheng Chen, Magoichi Sakou, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Masaharu Komatsu, Ryuji Ikeda, Hikokazu Suzuki, Kosaku Hirota, Takashi Aikou, and Shin-Ichi Akiyama: Reversal of P-Glycoprotein and Multidrug-Resistance Protein-Mediated Drug Resistance in KB Cells by 5-O-Benzoylated Taxinine K
Mol Pharmacol 2000 58: 1563-1569. [Abstract] [Full Text] [PDF]

Seksiri Arttamangkul, Veronica Alvarez-Maubecin, Gerald Thomas, John T. Williams, and David K. Grandy: Binding and Internalization of Fluorescent Opioid Peptide Conjugates in Living Cells
Mol Pharmacol 2000 58: 1570-1580. [Abstract] [Full Text] [PDF]

Zhicheng Lin, Wenfei Wang, and George R. Uhl: Dopamine Transporter Tryptophan Mutants Highlight Candidate Dopamine- and Cocaine-Selective Domains
Mol Pharmacol 2000 58: 1581-1592. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Model of the receptor-G protein complex. The G protein heterotrimer is an $alpha$ _t/ $alpha$ _i1 chimera complexed with $beta$ _t $gamma$ _t(Lambright et al., 1996). The receptor model is the MII rhodopsinmodel (Pogozheva et al., 1997). Positioning of the heterotrimerrelative to the receptor is based on the model in Bourne (1997).The GTPase domain of the $alpha$ -subunit is light blue. The helicaldomain of the $alpha$ -subunit is pink. The GDP is yellow. Switch I isdark blue, switch II is green, and switch III is magenta. The $alpha$ 2/ $beta$ 4 loop is yellow, the $alpha$ 3/ $beta$ 5 loop is orange, and the $alpha$ 4/ $beta$ 6loop is red. The carboxyl terminus (labeled C) of the $alpha$ -subunitis magenta. Selected regions of secondary structure in the $alpha$ -subunit,including the amino-terminal $alpha$ -helix ( $alpha$ N), are indicated. The $beta$ -strands of the $beta$ -subunit are orange, and the amino-terminalhelix and connecting loops are yellow. the $gamma$ -subunit is white.Receptor helices are numbered, and those connected to each otherby an intracellular loop are the same color. These figures weredrawn using MidasPlus, developed by the Computer Graphics Laboratoryat the University of California at San Francisco. From GrishnaG and Berlot CH (2000) A surface-exposed region of G_s inwhich substitutions decrease receptor-mediated activation andincrease receptor affinity. Mol Pharmacol 57:1081-1092.