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Other Issues:
January 2001; 59 (1)   [Index by Author]  [Cover Caption]
       Accelerated Communication
       Articles
       Errata
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Accelerated Communication:

Guillaume Drutel, Nina Peitsaro, Kaj Karlstedt, Kerstin Wieland, Martine J. Smit, Henk Timmerman, Pertti Panula, and Rob Leurs
Identification of Rat H3 Receptor Isoforms with Different Brain Expression and Signaling Properties
Mol Pharmacol 2001 59: 1-8. [Abstract] [Full Text] [PDF]  

Philip Wahl, Christian Foged, Søren Tullin, and Christian Thomsen
Iodo-Resiniferatoxin, a New Potent Vanilloid Receptor Antagonist
Mol Pharmacol 2001 59: 9-15. [Abstract] [Full Text] [PDF]  

Articles:

Mitsuhiro Fukao, Helen S. Mason, James L. Kenyon, Burton Horowitz, and Kathleen D. Keef
Regulation of BKca Channels Expressed in Human Embryonic Kidney 293 Cells by Epoxyeicosatrienoic Acid
Mol Pharmacol 2001 59: 16-23. [Abstract] [Full Text] [PDF]  

Damon R. Demady, Suree Jianmongkol, Jennifer L. Vuletich, Andrew T. Bender, and Yoichi Osawa
Agmatine Enhances the NADPH Oxidase Activity of Neuronal NO Synthase and Leads to Oxidative Inactivation of the Enzyme
Mol Pharmacol 2001 59: 24-29. [Abstract] [Full Text] [PDF]  

Ahmad B. Fawzi, Douglas Macdonald, Lawrence L. Benbow, April Smith-Torhan, Hongtao Zhang, Blair C. Weig, Ginny Ho, Deen Tulshian, Maurine E. Linder, and Michael P. Graziano
SCH-202676: An Allosteric Modulator of Both Agonist and Antagonist Binding to G Protein-Coupled Receptors
Mol Pharmacol 2001 59: 30-37. [Abstract] [Full Text] [PDF]  

Chih C. Chou and Benjamin Y. M. Yung
Increased Stability of Nucleophosmin/B23 in Anti-Apoptotic Effect of Ras during Serum Deprivation
Mol Pharmacol 2001 59: 38-45. [Abstract] [Full Text] [PDF]  

Carmelo Romano, Judith Kelvin Miller, Krzysztof Hyrc, Seta Dikranian, Steven Mennerick, Yutaka Takeuchi, Mark P. Goldberg, and Karen L. O'Malley
Covalent and Noncovalent Interactions Mediate Metabotropic Glutamate Receptor mGlu5 Dimerization
Mol Pharmacol 2001 59: 46-53. [Abstract] [Full Text] [PDF]  

Tomas C. Bellamy and John Garthwaite
"cAMP-Specific" Phosphodiesterase Contributes to cGMP Degradation in Cerebellar Cells Exposed to Nitric Oxide
Mol Pharmacol 2001 59: 54-61. [Abstract] [Full Text] [PDF]  

Lili Lu, Fabio Leonessa, Robert Clarke, and Irving W. Wainer
Competitive and Allosteric Interactions in Ligand Binding to P-glycoprotein as Observed on an Immobilized P-glycoprotein Liquid Chromatographic Stationary Phase
Mol Pharmacol 2001 59: 62-68. [Abstract] [Full Text] [PDF]  

Carleton B. Jones, Jane McIntosh, Hong Huang, Andrea Graytock, and Dale G. Hoyt
Regulation of Bleomycin-Induced DNA Breakage and Chromatin Structure in Lung Endothelial Cells by Integrins and Poly(ADP-Ribose) Polymerase
Mol Pharmacol 2001 59: 69-75. [Abstract] [Full Text] [PDF]  

Zhenhai Gao, Bing-Sheng Li, Yuan-Ji Day, and Joel Linden
A3 Adenosine Receptor Activation Triggers Phosphorylation of Protein Kinase B and Protects Rat Basophilic Leukemia 2H3 Mast Cells from Apoptosis
Mol Pharmacol 2001 59: 76-82. [Abstract] [Full Text] [PDF]  

Peter Pörzgen, Sang Ki Park, Jay Hirsh, Mark S. Sonders, and Susan G. Amara
The Antidepressant-Sensitive Dopamine Transporter in Drosophila melanogaster: A Primordial Carrier for Catecholamines
Mol Pharmacol 2001 59: 83-95. [Abstract] [Full Text] [PDF]  

C. Sissi, S. Moro, S. Richter, B. Gatto, E. Menta, S. Spinelli, A. P. Krapcho, F. Zunino, and M. Palumbo
DNA-Interactive Anticancer Aza-Anthrapyrazoles: Biophysical and Biochemical Studies Relevant to the Mechanism of Action
Mol Pharmacol 2001 59: 96-103. [Abstract] [Full Text] [PDF]  

Guadalupe Torrecillas, Maria del Carmen Boyano-Adánez, J. Medina, Trinidad Parra, Mercedes Griera, Susana López-Ongil, Eduardo Arilla, Manuel Rodríguez-Puyol, and Diego Rodríguez-Puyol
The Role of Hydrogen Peroxide in the Contractile Response to Angiotensin II
Mol Pharmacol 2001 59: 104-112. [Abstract] [Full Text] [PDF]  

R. Dayne Mayfield and Nancy R. Zahniser
Dopamine D2 Receptor Regulation of the Dopamine Transporter Expressed in Xenopus laevis Oocytes Is Voltage-Independent
Mol Pharmacol 2001 59: 113-121. [Abstract] [Full Text] [PDF]  

Jiesheng Kang, Lin Wang, Xiao-Liang Chen, David J. Triggle, and David Rampe
Interactions of a Series of Fluoroquinolone Antibacterial Drugs with the Human Cardiac K+ Channel HERG
Mol Pharmacol 2001 59: 122-126. [Abstract] [Full Text] [PDF]  

C. Herrera, V. Casadó, F. Ciruela, P. Schofield, J. Mallol, C. Lluis, and R. Franco
Adenosine A2B Receptors Behave as an Alternative Anchoring Protein for Cell Surface Adenosine Deaminase in Lymphocytes and Cultured Cells
Mol Pharmacol 2001 59: 127-134. [Abstract] [Full Text] [PDF]  

Ana M. Rodriguez-Lopez, Dia Xenaki, Tim O. B. Eden, John A. Hickman, and Christine M. Chresta
MDM2 Mediated Nuclear Exclusion of p53 Attenuates Etoposide-Induced Apoptosis in Neuroblastoma Cells
Mol Pharmacol 2001 59: 135-143. [Abstract] [Full Text] [PDF]  

Gordon Y. K. Ng, Sandrine Bertrand, Richard Sullivan, Nathalie Ethier, Jennifer Wang, Jim Yergey, Michel Belley, Laird Trimble, Kevin Bateman, Luanda Alder, Alison Smith, Ruth McKernan, Kathleen Metters, Gary P. O'Neill, Jean-Claude Lacaille, and Terence E. Hébert
gamma -Aminobutyric Acid Type B Receptors with Specific Heterodimer Composition and Postsynaptic Actions in Hippocampal Neurons Are Targets of Anticonvulsant Gabapentin Action
Mol Pharmacol 2001 59: 144-152. [Abstract] [Full Text] [PDF]  

Adrienne S. Gordon, Lina Yao, Zhan Jiang, C. Simone Fishburn, Sara Fuchs, and Ivan Diamond
Ethanol Acts Synergistically with a D2 Dopamine Agonist to Cause Translocation of Protein Kinase C
Mol Pharmacol 2001 59: 153-160. [Abstract] [Full Text] [PDF]  

Errata:

Correction for Volume 58, p. 1412
Mol Pharmacol 2001 59: 161. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: Molecular modeling and site-directed mutagenesis reveal differential binding of alpha -methyl 5HT to the 5-HT2A receptor. Views (from the extracellular side of the receptor) of the transmembrane helices (represented as tubes), showing various agonists (green) and all residues within a 3.5-Å sphere radius of the agonist molecule in energy-minimized complexes after 100-ps molecular dynamics simulations. The top two panels show the simulated binding of 5-methyl-DMT and N-omega -methyl-5HT. The bottom two panels show two views of the simulated binding of alpha -Me-5HT to the 5-HT2A receptor after two different molecular dynamics simulations (see Results and Discussion for details). Color coding of ligand and receptor atoms: red, O; green, N; cyan, H; white, C in the receptor; green: C in the ligand. Mol Pharmacol 58:877-886.



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