Mol Pharm -- Table of Contents (59 [2])

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February 2001; 59 (2)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

       Errata

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Accelerated Communication:

Stewart Barker, Noorafza Q. Khan, Elizabeth G. Wood, and Roger Corder: Effect of an Antisense Oligodeoxynucleotide to Endothelin-Converting Enzyme-1c (ECE-1c) on ECE-1c mRNA, ECE-1 Protein and Endothelin-1 Synthesis in Bovine Pulmonary Artery Smooth Muscle Cells
Mol Pharmacol 2001 59: 163-169. [Abstract] [Full Text] [PDF]

Articles:

Peter J. A. Davies, Stacey A. Berry, Gregory L. Shipley, Robert H. Eckel, Nathalie Hennuyer, Diane L. Crombie, Kathleen M. Ogilvie, Julia Peinado-Onsurbe, Catherine Fievet, Mark D. Leibowitz, Richard A. Heyman, and Johan Auwerx: Metabolic Effects of Rexinoids: Tissue-Specific Regulation of Lipoprotein Lipase Activity
Mol Pharmacol 2001 59: 170-176. [Abstract] [Full Text] [PDF]

Bernhard Sperker, Céline Tomkiewicz, Oliver Burk, Robert Barouki, and Heyo K. Kroemer: Regulation of Human $beta$ -Glucuronidase by A23187 and Thapsigargin in the Hepatoma Cell Line HepG2
Mol Pharmacol 2001 59: 177-182. [Abstract] [Full Text] [PDF]

Sterling N. Wright: Irreversible Block of Human Heart (hH1) Sodium Channels by the Plant Alkaloid Lappaconitine
Mol Pharmacol 2001 59: 183-192. [Abstract] [Full Text] [PDF]

Alfred A. Reszka, Judit Halasy-Nagy, and Gideon A. Rodan: Nitrogen-Bisphosphonates Block Retinoblastoma Phosphorylation and Cell Growth by Inhibiting the Cholesterol Biosynthetic Pathway in a Keratinocyte Model for Esophageal Irritation
Mol Pharmacol 2001 59: 193-202. [Abstract] [Full Text] [PDF]

Susan E. Morgan and William T. Beck: Role of an Inverted CCAAT Element in Human Topoisomerase II $alpha$ Gene Expression in ICRF-187-Sensitive and -Resistant CEM Leukemic Cells
Mol Pharmacol 2001 59: 203-211. [Abstract] [Full Text] [PDF]

Nansheng Chen, Jihong Ren, Lynn A. Raymond, and Timothy H. Murphy: Changes in Agonist Concentration Dependence That Are a Function of Duration of Exposure Suggest N-Methyl-D-aspartate Receptor Nonsaturation during Synaptic Stimulation
Mol Pharmacol 2001 59: 212-219. [Abstract] [Full Text] [PDF]

Kurt Schmidt, Astrid Schrammel, Doris Koesling, and Bernd Mayer: Molecular Mechanisms Involved in the Synergistic Activation of Soluble Guanylyl Cyclase by YC-1 and Nitric Oxide in Endothelial Cells
Mol Pharmacol 2001 59: 220-224. [Abstract] [Full Text] [PDF]

Yongge Liu, Guifen Ren, Brian O'Rourke, Eduardo Marbán, and Jegatheesan Seharaseyon: Pharmacological Comparison of Native Mitochondrial K_ATP Channels with Molecularly Defined Surface K_ATP Channels
Mol Pharmacol 2001 59: 225-230. [Abstract] [Full Text] [PDF]

Veli-Pekka Korhonen, Kirsi Niiranen, Maria Halmekytö, Marko Pietilä, Paula Diegelman, Jyrki J. Parkkinen, Terho Eloranta, Carl W. Porter, Leena Alhonen, and Juhani Jänne: Spermine Deficiency Resulting from Targeted Disruption of the Spermine Synthase Gene in Embryonic Stem Cells Leads to Enhanced Sensitivity to Antiproliferative Drugs
Mol Pharmacol 2001 59: 231-238. [Abstract] [Full Text] [PDF]

Zsuzsanna Gáborik, Márta Szaszák, László Szidonya, Borbála Balla, Sándor Paku, Kevin J. Catt, Adrian J. L. Clark, and László Hunyady: $beta$ -Arrestin- and Dynamin-Dependent Endocytosis of the AT₁ Angiotensin Receptor
Mol Pharmacol 2001 59: 239-247. [Abstract] [Full Text] [PDF]

Michael Lee and Young Jin Jeon: Paclitaxel-Induced Immune Suppression Is Associated with NF- $kappa$ B Activation Via Conventional PKC Isotypes in Lipopolysaccharide-Stimulated 70Z/3 Pre-B Lymphocyte Tumor Cells
Mol Pharmacol 2001 59: 248-253. [Abstract] [Full Text] [PDF]

Shine-Gwo Shiah, Shuang-En Chuang, and Min-Liang Kuo: Involvement of Asp-Glu-Val-Asp-Directed, Caspase-Mediated Mitogen-Activated Protein Kinase Kinase 1 Cleavage, c-Jun N-Terminal Kinase Activation, and Subsequent Bcl-2 Phosphorylation for Paclitaxel-Induced Apoptosis in HL-60 Cells
Mol Pharmacol 2001 59: 254-262. [Abstract] [Full Text] [PDF]

David Siegel, Adil Anwar, Shannon L. Winski, Jadwiga K. Kepa, Kathryn L. Zolman, and David Ross: Rapid Polyubiquitination and Proteasomal Degradation of a Mutant Form of NAD(P)H:Quinone Oxidoreductase 1
Mol Pharmacol 2001 59: 263-268. [Abstract] [Full Text] [PDF]

Michael E. O'Leary: Inhibition of Human Ether-A-Go-Go Potassium Channels by Cocaine
Mol Pharmacol 2001 59: 269-277. [Abstract] [Full Text] [PDF]

Kouichi Yoshinari, Tatsuya Sueyoshi, Rick Moore, and Masahiko Negishi: Nuclear Receptor CAR as a Regulatory Factor for the Sexually Dimorphic Induction of CYP2B1 Gene by Phenobarbital in Rat Livers
Mol Pharmacol 2001 59: 278-284. [Abstract] [Full Text] [PDF]

Bart Degrève, Robert Esnouf, Erik De Clercq, and Jan Balzarini: Mutation of Gln125 to Asn Selectively Abolishes the Thymidylate Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase
Mol Pharmacol 2001 59: 285-293. [Abstract] [Full Text] [PDF]

Markus W. Hollmann, Kathrin S. Wieczorek, Andreas Berger, and Marcel E. Durieux: Local Anesthetic Inhibition of G Protein-Coupled Receptor Signaling by Interference with G $alpha$ _q Protein Function
Mol Pharmacol 2001 59: 294-301. [Abstract] [Full Text] [PDF]

Koren K. Mann, Stefan Doerre, Jennifer J. Schlezinger, David H. Sherr, and Shafat Quadri: The Role of NF- $kappa$ B as a Survival Factor in Environmental Chemical-Induced Pre-B Cell Apoptosis
Mol Pharmacol 2001 59: 302-309. [Abstract] [Full Text] [PDF]

Ben Gardner, Zhi Fang Liu, Dong Jiang, and David R. Sibley: The Role of Phosphorylation/Dephosphorylation in Agonist-Induced Desensitization of D₁ Dopamine Receptor Function: Evidence for a Novel Pathway for Receptor Dephosphorylation
Mol Pharmacol 2001 59: 310-321. [Abstract] [Full Text] [PDF]

Marta Letizia Hribal, Rossella D'Alfonso, Barbara Giovannone, Davide Lauro, Yong Yu Liu, Patrizia Borboni, Massimo Federici, Renato Lauro, and Giorgio Sesti: The Sulfonylurea Glimepiride Regulates Intracellular Routing of the Insulin-Receptor Complexes through Their Interaction with Specific Protein Kinase C Isoforms
Mol Pharmacol 2001 59: 322-330. [Abstract] [Full Text] [PDF]

Isabelle Limon-Boulez, Rachel Bouet-Alard, Tom W. Gettys, Stephen M. Lanier, Jean-Paul Maltier, and Chantal Legrand: Partial Agonist Clonidine Mediates $alpha$ ₂-AR Subtypes Specific Regulation of cAMP Accumulation in Adenylyl Cyclase II Transfected DDT1-MF2 Cells
Mol Pharmacol 2001 59: 331-338. [Abstract] [Full Text] [PDF]

Guangqing Xiao, Juan Wang, Tonje Tangen, and Kathleen M. Giacomini: A Novel Proton-Dependent Nucleoside Transporter, CeCNT3, from Caenorhabditis elegans
Mol Pharmacol 2001 59: 339-348. [Abstract] [Full Text] [PDF]

Anna Lorenzen, Christina Stannek, Heidrun Lang, Viktor Andrianov, Ivars Kalvinsh, and Ulrich Schwabe: Characterization of a G Protein-Coupled Receptor for Nicotinic Acid
Mol Pharmacol 2001 59: 349-357. [Abstract] [Full Text] [PDF]

Rikiya Ohashi, Ikumi Tamai, Jun-ichi Nezu, Hiroko Nikaido, Noriyoshi Hashimoto, Asuka Oku, Yoshimichi Sai, Miyuki Shimane, and Akira Tsuji: Molecular and Physiological Evidence for Multifunctionality of Carnitine/Organic Cation Transporter OCTN2
Mol Pharmacol 2001 59: 358-366. [Abstract] [Full Text] [PDF]

Eugene Y. Krynetski, Natalia F. Krynetskaia, Amy E. Gallo, K. Gopal Murti, and William E. Evans: A Novel Protein Complex Distinct from Mismatch Repair Binds Thioguanylated DNA
Mol Pharmacol 2001 59: 367-374. [Abstract] [Full Text] [PDF]

D. Alex Groarke, Tomas Drmota, Daljit S. Bahia, Nicholas A. Evans, Shelagh Wilson, and Graeme Milligan: Analysis of the C-Terminal Tail of the Rat Thyrotropin-Releasing Hormone Receptor-1 in Interactions and Cointernalization with $beta$ -Arrestin 1-Green Fluorescent Protein
Mol Pharmacol 2001 59: 375-385. [Abstract] [Full Text] [PDF]

Tammy L. Domanski, Csaba Finta, James R. Halpert, and Peter G. Zaphiropoulos: cDNA Cloning and Initial Characterization of CYP3A43, a Novel Human Cytochrome P450
Mol Pharmacol 2001 59: 386-392. [Abstract] [Full Text] [PDF]

Pia Lautala, Ismo Ulmanen, and Jyrki Taskinen: Molecular Mechanisms Controlling the Rate and Specificity of Catechol O-Methylation by Human Soluble Catechol O-Methyltransferase
Mol Pharmacol 2001 59: 393-402. [Abstract] [Full Text] [PDF]

Errata:

: Correction to "Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters"
Mol Pharmacol 2001 59: 403. [Full Text] [PDF]

Cover Caption:

About the cover: Molecular modeling and site-directed mutagenesis reveal differential binding of $alpha$ -methyl 5HT to the 5-HT_2Areceptor. Views (from the extracellular side of the receptor)of the transmembrane helices (represented as tubes), showing variousagonists (green) and all residues within a 3.5-Å sphere radiusof the agonist molecule in energy-minimized complexes after 100-psmolecular dynamics simulations. The top two panels show the simulatedbinding of 5-methyl-DMT and N- $omega$ -methyl-5HT. The bottom two panelsshow two views of the simulated binding of $alpha$ -Me-5HT to the 5-HT2Areceptor after two different molecular dynamics simulations (seeResults and Discussion for details). Color coding of ligand andreceptor atoms: red, O; green, N; cyan, H; white, C in the receptor;green: C in the ligand. Mol Pharmacol 58:877-886.