Mol Pharm -- Table of Contents (59 [6])

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June 2001; 59 (6)   [Index by Author] [Cover Caption]

       Perspective

       Accelerated Communications

       Articles

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Perspective:

Richard M. Breyer: Prostaglandin EP₁ Receptor Subtype Selectivity Takes Shape
Mol Pharmacol 2001 59: 1357-1359. [Full Text] [PDF]

Accelerated Communications:

Jay P. McLaughlin and Charles Chavkin: Tyrosine Phosphorylation of the µ-Opioid Receptor Regulates Agonist Intrinsic Efficacy
Mol Pharmacol 2001 59: 1360-1368. [Abstract] [Full Text] [PDF]

Theresa A. Day, Fariborz Rakhshan, Dale G. Deutsch, and Eric L. Barker: Role of Fatty Acid Amide Hydrolase in the Transport of the Endogenous Cannabinoid Anandamide
Mol Pharmacol 2001 59: 1369-1375. [Abstract] [Full Text] [PDF]

Articles:

Volodymr Rybalchenko, Natalia Prevarskaya, Fabien Van Coppenolle, Guillaume Legrand, Loic Lemonnier, Xuefen Le Bourhis, and Roman Skryma: Verapamil Inhibits Proliferation of LNCaP Human Prostate Cancer Cells Influencing K⁺ Channel Gating
Mol Pharmacol 2001 59: 1376-1387. [Abstract] [Full Text] [PDF]

Iván P. Uray, Peter J. A. Davies, and László Fésüs: Pharmacological Separation of the Expression of Tissue Transglutaminase and Apoptosis after Chemotherapeutic Treatment of HepG2 Cells
Mol Pharmacol 2001 59: 1388-1394. [Abstract] [Full Text] [PDF]

Donna Bowen-Pidgeon, Giulio Innamorati, Hamid M. Sadeghi, and Mariel Birnbaumer: Arrestin Effects on Internalization of Vasopressin Receptors
Mol Pharmacol 2001 59: 1395-1401. [Abstract] [Full Text] [PDF]

K. I. Hirsch-Ernst, K. Schlaefer, D. Bauer, A. F. Heder, and G. F. Kahl: Repression of Phenobarbital-Dependent CYP2B1 mRNA Induction by Reactive Oxygen Species in Primary Rat Hepatocyte Cultures
Mol Pharmacol 2001 59: 1402-1409. [Abstract] [Full Text] [PDF]

Benedetta Barabino, Silvia Vailati, Milena Moretti, J. Michael McIntosh, Renato Longhi, Francesco Clementi, and Cecilia Gotti: An $alpha$ 4 $beta$ 4 Nicotinic Receptor Subtype Is Present in Chick Retina: Identification, Characterization and Pharmacological Comparison with the Transfected $alpha$ 4 $beta$ 4 and $alpha$ 6 $beta$ 4 Subtypes
Mol Pharmacol 2001 59: 1410-1417. [Abstract] [Full Text] [PDF]

Nikolaus Heveker, Michèle Tissot, Alain Thuret, Jens Schneider-Mergener, Marc Alizon, Monique Roch, and Stefano Marullo: Pharmacological Properties of Peptides Derived from Stromal Cell-Derived Factor 1: Study on Human Polymorphonuclear Cells
Mol Pharmacol 2001 59: 1418-1425. [Abstract] [Full Text] [PDF]

Robert J. Donati, Chandrashekhar Thukral, and Mark M. Rasenick: Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Results in a Redistribution of Gs $alpha$
Mol Pharmacol 2001 59: 1426-1432. [Abstract] [Full Text] [PDF]

Sylvie A. Terlouw, Rosalinde Masereeuw, Frans G. M. Russel, and David S. Miller: Nephrotoxicants Induce Endothelin Release and Signaling in Renal Proximal Tubules: Effect on Drug Efflux
Mol Pharmacol 2001 59: 1433-1440. [Abstract] [Full Text] [PDF]

George P. Dinos, Maria Michelinaki, and Dimitrios L. Kalpaxis: Insights into the Mechanism of Azithromycin Interaction with an Escherichia coli Functional Ribosomal Complex
Mol Pharmacol 2001 59: 1441-1445. [Abstract] [Full Text] [PDF]

Mark D. Ungrin, Marie-Claude Carrière, Danielle Denis, Sonia Lamontagne, Nicole Sawyer, Rino Stocco, Nathalie Tremblay, Kathleen M. Metters, and Mark Abramovitz: Key Structural Features of Prostaglandin E₂ and Prostanoid Analogs Involved in Binding and Activation of the Human EP₁ Prostanoid Receptor
Mol Pharmacol 2001 59: 1446-1456. [Abstract] [Full Text] [PDF]

Eiji Kinoshita, Hiroshi Maejima, Kaoru Yamaoka, Katsuhiro Konno, Nobufumi Kawai, Eisuke Shimizu, Sawana Yokote, Hitoshi Nakayama, and Issei Seyama: Novel Wasp Toxin Discriminates between Neuronal and Cardiac Sodium Channels
Mol Pharmacol 2001 59: 1457-1463. [Abstract] [Full Text] [PDF]

Birgit L. Coffman, William R. Kearney, Mitchell D. Green, Robert G. Lowery, and Thomas R. Tephly: Analysis of Opioid Binding to UDP-Glucuronosyltransferase 2B7 Fusion Proteins Using Nuclear Magnetic Resonance Spectroscopy
Mol Pharmacol 2001 59: 1464-1469. [Abstract] [Full Text] [PDF]

Erwin Sigel, Roland Baur, Roman Furtmueller, Rodolphe Razet, Robert H. Dodd, and Werner Sieghart: Differential Cross Talk of ROD Compounds with the Benzodiazepine Binding Site
Mol Pharmacol 2001 59: 1470-1477. [Abstract] [Full Text] [PDF]

Andrea Toell, Manuel Macias Gonzalez, Dagmar Ruf, Andreas Steinmeyer, Seiichi Ishizuka, and Carsten Carlberg: Different Molecular Mechanisms of Vitamin D₃ Receptor Antagonists
Mol Pharmacol 2001 59: 1478-1485. [Abstract] [Full Text] [PDF]

Hee-Jeong Im, Dmitri Smirnov, Tomoaki Yuhi, Shalini Raghavan, Jane E. Olsson, George E. Muscat, Peter Koopman, and Horace H. Loh: Transcriptional Modulation of Mouse µ-Opioid Receptor Distal Promoter Activity by Sox18
Mol Pharmacol 2001 59: 1486-1496. [Abstract] [Full Text] [PDF]

Robert Halmosi, Zoltan Berente, Erzsebet Osz, Kalman Toth, Peter Literati-Nagy, and Balazs Sumegi: Effect of Poly(ADP-Ribose) Polymerase Inhibitors on the Ischemia-Reperfusion-Induced Oxidative Cell Damage and Mitochondrial Metabolism in Langendorff Heart Perfusion System
Mol Pharmacol 2001 59: 1497-1505. [Abstract] [Full Text] [PDF]

Roberta Vezza, Joshua Rokach, and Garret A. FitzGerald: Prostaglandin F₂ Receptor-Dependent Regulation of Prostaglandin Transport
Mol Pharmacol 2001 59: 1506-1513. [Abstract] [Full Text] [PDF]

Martin J. Gallagher, David C. Chiara, and Jonathan B. Cohen: Interactions between 3-(Trifluoromethyl)-3-(m-[¹²⁵I]iodophenyl)diazirine and Tetracaine, Phencyclidine, or Histrionicotoxin in the Torpedo Species Nicotinic Acetylcholine Receptor Ion Channel
Mol Pharmacol 2001 59: 1514-1522. [Abstract] [Full Text] [PDF]

Derek A. McCulloch, Eve M. Lutz, Melanie S. Johnson, Derek N. Robertson, Chris J. MacKenzie, Pamela J. Holland, and Rory Mitchell: ADP-Ribosylation Factor-Dependent Phospholipase D Activation by VPAC Receptors and a PAC₁ Receptor Splice Variant
Mol Pharmacol 2001 59: 1523-1532. [Abstract] [Full Text] [PDF]

Alan M. Carruthers, Lynda A. Sellers, David W. Jenkins, Emma M. Jarvie, Wasyl Feniuk, and Patrick P. A. Humphrey: Adenosine A₁ Receptor-Mediated Inhibition of Protein Kinase A-Induced Calcitonin Gene-Related Peptide Release from Rat Trigeminal Neurons
Mol Pharmacol 2001 59: 1533-1541. [Abstract] [Full Text] [PDF]

João F. Mata, José M. García-Manteiga, M. Pilar Lostao, Sonia Fernández-Veledo, Elena Guillén-Gómez, Ignacio M. Larrayoz, Jorge Lloberas, F. Javier Casado, and Marçal Pastor-Anglada: Role of the Human Concentrative Nucleoside Transporter (hCNT1) In the Cytotoxic Action of 5[Prime]-Deoxy-5-fluorouridine, an Active Intermediate Metabolite of Capecitabine, a Novel Oral Anticancer Drug
Mol Pharmacol 2001 59: 1542-1548. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Molecular modeling and site-directed mutagenesis reveal differential binding of $alpha$ -methyl 5HT to the 5-HT_2Areceptor. Views (from the extracellular side of the receptor)of the transmembrane helices (represented as tubes), showing variousagonists (green) and all residues within a 3.5-Å sphere radiusof the agonist molecule in energy-minimized complexes after 100-psmolecular dynamics simulations. The top two panels show the simulatedbinding of 5-methyl-DMT and N- $omega$ -methyl-5HT. The bottom two panelsshow two views of the simulated binding of $alpha$ -Me-5HT to the 5-HT2Areceptor after two different molecular dynamics simulations (seeResults and Discussion for details). Color coding of ligand andreceptor atoms: red, O; green, N; cyan, H; white, C in the receptor;green: C in the ligand. Mol Pharmacol 58:877-886.