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Other Issues:
July 2001; 60 (1)   [Index by Author]  [Cover Caption]
       Minireview
       Perspectives
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       Errata
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Minireview:

Juan A. Ballesteros, Lei Shi, and Jonathan A. Javitch
Structural Mimicry in G Protein-Coupled Receptors: Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors
Mol Pharmacol 2001 60: 1-19. [Abstract] [Full Text] [PDF]  

Perspectives:

Charles Chavkin, Jay P. McLaughlin, and Jeremy P. Celver
Regulation of Opioid Receptor Function by Chronic Agonist Exposure: Constitutive Activity and Desensitization
Mol Pharmacol 2001 60: 20-25. [Full Text] [PDF]  

Articles:

Alexander C. Zambon, Laurence L. Brunton, Kim E. Barrett, Richard J. Hughes, Brian Torres, and Paul A. Insel
Cloning, Expression, Signaling Mechanisms, and Membrane Targeting of P2Y11 Receptors in Madin Darby Canine Kidney Cells
Mol Pharmacol 2001 60: 26-35. [Abstract] [Full Text] [PDF]  

M. Machwate, S. Harada, C. T. Leu, G. Seedor, M. Labelle, M. Gallant, S. Hutchins, N. Lachance, N. Sawyer, D. Slipetz, K. M. Metters, S. B. Rodan, R. Young, and G. A. Rodan
Prostaglandin Receptor EP4 Mediates the Bone Anabolic Effects of PGE2
Mol Pharmacol 2001 60: 36-41. [Abstract] [Full Text] [PDF]  

Valerie Turquier, Laurent Yon, Luca Grumolato, David Alexandre, Alain Fournier, Hubert Vaudry, and Youssef Anouar
Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Secretoneurin Release and Secretogranin II Gene Transcription in Bovine Adrenochromaffin Cells through Multiple Signaling Pathways and Increased Binding of Pre-Existing Activator Protein-1-Like Transcription Factors
Mol Pharmacol 2001 60: 42-52. [Abstract] [Full Text] [PDF]  

Jing-Gen Liu and Paul L. Prather
Chronic Exposure to µ-Opioid Agonists Produces Constitutive Activation of µ-Opioid Receptors in Direct Proportion to the Efficacy of the Agonist Used for Pretreatment
Mol Pharmacol 2001 60: 53-62. [Abstract] [Full Text] [PDF]  

Soma Rakhit, Susan Pyne, and Nigel J. Pyne
Nerve Growth Factor Stimulation of p42/p44 Mitogen-Activated Protein Kinase in PC12 Cells: Role of Gi/o, G Protein-Coupled Receptor Kinase 2, beta -Arrestin I, and Endocytic Processing
Mol Pharmacol 2001 60: 63-70. [Abstract] [Full Text] [PDF]  

Michael M. Francis, Elaine Y. Cheng, Gregory A. Weiland, and Robert E. Oswald
Specific Activation of the alpha 7 Nicotinic Acetylcholine Receptor by a Quaternary Analog of Cocaine
Mol Pharmacol 2001 60: 71-79. [Abstract] [Full Text] [PDF]  

Raphaël Courjaret and Bruno Lapied
Complex Intracellular Messenger Pathways Regulate One Type of Neuronal alpha -Bungarotoxin-Resistant Nicotinic Acetylcholine Receptors Expressed in Insect Neurosecretory Cells (Dorsal Unpaired Median Neurons)
Mol Pharmacol 2001 60: 80-91. [Abstract] [Full Text] [PDF]  

James N. Oak, Natalie Lavine, and Hubert H. M. Van Tol
Dopamine D4 and D2L Receptor Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Dependent on trans-Activation of the Platelet-Derived Growth Factor Receptor
Mol Pharmacol 2001 60: 92-103. [Abstract] [Full Text] [PDF]  

Donald J. Gruol, Josh Bernd, Alba E. Phippard, Iwao Ojima, and Ralph J. Bernacki
The Use of a Novel Taxane-Based P-Glycoprotein Inhibitor to Identify Mutations That Alter the Interaction of the Protein with Paclitaxel
Mol Pharmacol 2001 60: 104-113. [Abstract] [Full Text] [PDF]  

John J. Enyeart, Lin Xu, Juan Carlos Gomora, and Judith A. Enyeart
Reciprocal Modulation of Voltage-Gated and Background K+ Channels Mediated by Nucleotides and Corticotropin
Mol Pharmacol 2001 60: 114-123. [Abstract] [Full Text] [PDF]  

Mathieu Goumain, Thierry Voisin, Anne-Marie Lorinet, Robert Ducroc, Annick Tsocas, Claude Rozé, Patricia Rouet-Benzineb, Herbert Herzog, Ambikaipakan Balasubramaniam, and Marc Laburthe
The Peptide YY-Preferring Receptor Mediating Inhibition of Small Intestinal Secretion Is a Peripheral Y2 Receptor: Pharmacological Evidence and Molecular Cloning
Mol Pharmacol 2001 60: 124-134. [Abstract] [Full Text] [PDF]  

Camilla Svensson and Katarina Lundberg
Immune-Specific Up-Regulation of Adseverin Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Mol Pharmacol 2001 60: 135-142. [Abstract] [Full Text] [PDF]  

Chunrong Yu, Shujie Wang, Paul Dent, and Steven Grant
Sequence-Dependent Potentiation of Paclitaxel-Mediated Apoptosis in Human Leukemia Cells by Inhibitors of the Mitogen-Activated Protein Kinase Kinase/Mitogen-Activated Protein Kinase Pathway
Mol Pharmacol 2001 60: 143-154. [Abstract] [Full Text] [PDF]  

Christopher S. Breivogel, Graeme Griffin, Vincenzo Di Marzo, and Billy R. Martin
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
Mol Pharmacol 2001 60: 155-163. [Abstract] [Full Text] [PDF]  

Sigrid Hatse, Katrien Princen, Lars-Ole Gerlach, Gary Bridger, Geoffrey Henson, Erik De Clercq, Thue W. Schwartz, and Dominique Schols
Mutation of Asp171 and Asp262 of the Chemokine Receptor CXCR4 Impairs Its Coreceptor Function for Human Immunodeficiency Virus-1 Entry and Abrogates the Antagonistic Activity of AMD3100
Mol Pharmacol 2001 60: 164-173. [Abstract] [Full Text] [PDF]  

Annamaria Biroccio, Barbara Benassi, Sarah Amodei, Chiara Gabellini, Donatella Del Bufalo, and Gabriella Zupi
C-Myc Down-Regulation Increases Susceptibility to Cisplatin through Reactive Oxygen Species-Mediated Apoptosis in M14 Human Melanoma Cells
Mol Pharmacol 2001 60: 174-182. [Abstract] [Full Text] [PDF]  

Dominik Oliver, Jost Ludwig, Ellen Reisinger, Werner Zoellner, J. Peter Ruppersberg, and Bernd Fakler
Memantine Inhibits Efferent Cholinergic Transmission in the Cochlea by Blocking Nicotinic Acetylcholine Receptors of Outer Hair Cells
Mol Pharmacol 2001 60: 183-189. [Abstract] [Full Text] [PDF]  

Annette Hambrock, Cornelia Löffler-Walz, Ulrich Russ, Ulf Lange, and Ulrich Quast
Characterization of a Mutant Sulfonylurea Receptor SUR2B with High Affinity for Sulfonylureas and Openers: Differences in the Coupling to Kir6.x Subtypes
Mol Pharmacol 2001 60: 190-199. [Abstract] [Full Text] [PDF]  

E. C. Aromataris, G. Y. Rychkov, B. Bennetts, B. P. Hughes, A. H. Bretag, and M. L. Roberts
Fast and Slow Gating of CLC-1: Differential Effects of 2-(4-Chlorophenoxy) Propionic Acid and Dominant Negative Mutations
Mol Pharmacol 2001 60: 200-208. [Abstract] [Full Text] [PDF]  

Luc Ferrari, Ning Peng, James R. Halpert, and Edward T. Morgan
Role of Nitric Oxide in Down-Regulation of CYP2B1 Protein, but Not RNA, in Primary Cultures of Rat Hepatocytes
Mol Pharmacol 2001 60: 209-216. [Abstract] [Full Text] [PDF]  

Rong Yu, Vidya Hebbar, Daniel W. Kim, Sandhya Mandlekar, John M. Pezzuto, and Ah-Ng Tony Kong
Resveratrol Inhibits Phorbol Ester and UV-Induced Activator Protein 1 Activation by Interfering with Mitogen-Activated Protein Kinase Pathways
Mol Pharmacol 2001 60: 217-224. [Abstract] [Full Text] [PDF]  

Vivian K. Ngan, Krista Bellman, Bridget T. Hill, Leslie Wilson, and Mary Ann Jordan
Mechanism of Mitotic Block and Inhibition of Cell Proliferation by the Semisynthetic Vinca Alkaloids Vinorelbine and Its Newer Derivative Vinflunine
Mol Pharmacol 2001 60: 225-232. [Abstract] [Full Text] [PDF]  

Errata:

Correction to "High-intensity p38 kinase activity is critical for p21cip1 induction and the antiproliferative function of Gi protein-coupled receptors"
Mol Pharmacol 2001 60: 233. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: 4-Phenylimidazole docked into the active site of the CYP2B models. A, CYP2B4. B, CYP2B5. C, the interaction between the B'-C loop and helix I in CYP2B5. D, CYP2B1. The heme is shown in red. 4-Phenylimidazole is shown in yellow with the nitrogen in blue pointing to the heme iron. Mol Pharmacol 59:475-484.



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