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August 2001; 60 (2)   [Index by Author]  [Cover Caption]
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Articles:

Guillermo Spitzmaul, James P. Dilger, and Cecilia Bouzat
The Noncompetitive Inhibitor Quinacrine Modifies the Desensitization Kinetics of Muscle Acetylcholine Receptors
Mol Pharmacol 2001 60: 235-243. [Abstract] [Full Text] [PDF]  

Kaichiro Kamiya, John S. Mitcheson, Kenji Yasui, Itsuo Kodama, and Michael C. Sanguinetti
Open Channel Block of HERG K+ Channels by Vesnarinone
Mol Pharmacol 2001 60: 244-253. [Abstract] [Full Text] [PDF]  

Jinming Song and Peter W. Melera
Transmembrane Domain (TM) 9 Represents a Novel Site in P-Glycoprotein That Affects Drug Resistance and Cooperates with TM6 to Mediate [125I]Iodoarylazidoprazosin Labeling
Mol Pharmacol 2001 60: 254-261. [Abstract] [Full Text] [PDF]  

Xinyu Zheng, Magnus Johansson, and Anna Karlsson
Bystander Effects of Cancer Cell Lines Transduced with the Multisubstrate Deoxyribonucleoside Kinase of Drosophila melanogaster and Synergistic Enhancement by Hydroxyurea
Mol Pharmacol 2001 60: 262-266. [Abstract] [Full Text] [PDF]  

Sven E. Boden, Stephan Schweizer, Thilo Bertsche, Martina Düfer, Gisela Drews, and Hasan Safayhi
Stimulation of Leukotriene Synthesis in Intact Polymorphonuclear Cells by the 5-Lipoxygenase Inhibitor 3-oxo-Tirucallic Acid
Mol Pharmacol 2001 60: 267-273. [Abstract] [Full Text] [PDF]  

Benjamin P. Davidson, Satish C. Dogra, and Brian K. May
The Antiglucocorticoid RU486 Inhibits Phenobarbital Induction of the Chicken CYP2H1 Gene in Primary Hepatocytes
Mol Pharmacol 2001 60: 274-281. [Abstract] [Full Text] [PDF]  

L. G. Weigl and W. Schreibmayer
G Protein-Gated Inwardly Rectifying Potassium Channels Are Targets for Volatile Anesthetics
Mol Pharmacol 2001 60: 282-289. [Abstract] [Full Text] [PDF]  

Hayley M. McDaid and Susan Band Horwitz
Selective Potentiation of Paclitaxel (Taxol)-Induced Cell Death by Mitogen-Activated Protein Kinase Kinase Inhibition in Human Cancer Cell Lines
Mol Pharmacol 2001 60: 290-301. [Abstract] [Full Text] [PDF]  

Jie Liu, Hua Chen, David S. Miller, Joseph E. Saavedra, Larry K. Keefer, David R. Johnson, Curtis D. Klaassen, and Michael P. Waalkes
Overexpression of Glutathione S-Transferase II and Multidrug Resistance Transport Proteins Is Associated with Acquired Tolerance to Inorganic Arsenic
Mol Pharmacol 2001 60: 302-309. [Abstract] [Full Text] [PDF]  

Baichun Yang, LeRae Graham, Serguei Dikalov, Ronald P. Mason, John R. Falck, James K. Liao, and Darryl C. Zeldin
Overexpression of Cytochrome P450 CYP2J2 Protects against Hypoxia-Reoxygenation Injury in Cultured Bovine Aortic Endothelial Cells
Mol Pharmacol 2001 60: 310-320. [Abstract] [Full Text] [PDF]  

Jonathon M. Willets, R. A. John Challiss, Eamonn Kelly, and Stefan R. Nahorski
G Protein-Coupled Receptor Kinases 3 and 6 Use Different Pathways to Desensitize the Endogenous M3 Muscarinic Acetylcholine Receptor in Human SH-SY5Y Cells
Mol Pharmacol 2001 60: 321-330. [Abstract] [Full Text] [PDF]  

Dmitri Smirnov, Hee-Jeong Im, and Horace H. Loh
delta -Opioid Receptor Gene: Effect of Sp1 Factor on Transcriptional Regulation in Vivo
Mol Pharmacol 2001 60: 331-340. [Abstract] [Full Text] [PDF]  

David Fenard, Gerard Lambeau, Thomas Maurin, Jean-Claude Lefebvre, and Alain Doglio
A Peptide Derived from Bee Venom-Secreted Phospholipase A2 Inhibits Replication of T-Cell Tropic HIV-1 Strains via Interaction with the CXCR4 Chemokine Receptor
Mol Pharmacol 2001 60: 341-347. [Abstract] [Full Text] [PDF]  

Horng-Huei Liou, Wen Lin, Houng-Chi Liou, Tur-Fu Huang, and Wen-Mei Fu
Modulation of Protein Kinase A Activation by Fibronectin Matrix Proteins at Developing Neuromuscular Synapses in Xenopus laevis Cell Cultures
Mol Pharmacol 2001 60: 348-354. [Abstract] [Full Text] [PDF]  

Randy M. Wadkins, Christopher L. Morton, James K. Weeks, LaGora Oliver, Monika Wierdl, Mary K. Danks, and Philip M. Potter
Structural Constraints Affect the Metabolism of 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by Carboxylesterases
Mol Pharmacol 2001 60: 355-362. [Abstract] [Full Text] [PDF]  

Sandrine Faivre, Karine Régnauld, Erik Bruyneel, Quang-Dé Nguyen, Marc Mareel, Shahin Emami, and Christian Gespach
Suppression of Cellular Invasion by Activated G-Protein Subunits Galpha o, Galpha i1, Galpha i2, and Galpha i3 and Sequestration of Gbeta gamma
Mol Pharmacol 2001 60: 363-372. [Abstract] [Full Text] [PDF]  

Kim A. Neve, Medhane G. Cumbay, Kimberly R. Thompson, Rui Yang, David C. Buck, Val J. Watts, Curtiss J. DuRand, and Martha M. Teeter
Modeling and Mutational Analysis of a Putative Sodium-Binding Pocket on the Dopamine D2 Receptor
Mol Pharmacol 2001 60: 373-381. [Abstract] [Full Text] [PDF]  

Leslie J. Dickmann, Allan E. Rettie, M. Byron Kneller, Richard B. Kim, Alastair J. J. Wood, C. Michael Stein, Grant R. Wilkinson, and Ute I. Schwarz
Identification and Functional Characterization of a New CYP2C9 Variant (CYP2C9*5) Expressed among African Americans
Mol Pharmacol 2001 60: 382-387. [Abstract] [Full Text] [PDF]  

Xiang-Dong Lei, Brett Chapman, and Oliver Hankinson
Loss of CYP1A1 Messenger RNA Expression Due to Nonsense-Mediated Decay
Mol Pharmacol 2001 60: 388-393. [Abstract] [Full Text] [PDF]  

Kulbhushan Tikoo, Serrine S. Lau, and Terrence J. Monks
Histone H3 Phosphorylation Is Coupled to Poly-(ADP-Ribosylation) during Reactive Oxygen Species-Induced Cell Death in Renal Proximal Tubular Epithelial Cells
Mol Pharmacol 2001 60: 394-402. [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway"
Mol Pharmacol 2001 60: 403. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: 4-Phenylimidazole docked into the active site of the CYP2B models. A, CYP2B4. B, CYP2B5. C, the interaction between the B'-C loop and helix I in CYP2B5. D, CYP2B1. The heme is shown in red. 4-Phenylimidazole is shown in yellow with the nitrogen in blue pointing to the heme iron. Mol Pharmacol 59:475-484.



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