Mol Pharm -- Table of Contents (60 [4])

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October 2001; 60 (4)   [Index by Author] [Cover Caption]

       Perspective

       Accelerated Communications

       Articles

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Perspective:

J. David Port and Michael R. Bristow: $beta$ -Adrenergic Receptors, Transgenic Mice, and Pharmacological Model Systems
Mol Pharmacol 2001 60: 629-631. [Full Text] [PDF]

Accelerated Communications:

M. Rodriguez, P. Beauverger, I. Naime, H. Rique, C. Ouvry, S. Souchaud, S. Dromaint, N. Nagel, T. Suply, V. Audinot, J. A. Boutin, and J. P. Galizzi: Cloning and Molecular Characterization of the Novel Human Melanin-Concentrating Hormone Receptor MCH2
Mol Pharmacol 2001 60: 632-639. [Abstract] [Full Text] [PDF]

Nicolas Boute, Karine Pernet, and Tarik Issad: Monitoring the Activation State of the Insulin Receptor Using Bioluminescence Resonance Energy Transfer
Mol Pharmacol 2001 60: 640-645. [Abstract] [Full Text] [PDF]

Articles:

Yassine Amrani, Alaina J. Ammit, and Reynold A. Panettieri, Jr.: Tumor Necrosis Factor Receptor (TNFR) 1, but Not TNFR2, Mediates Tumor Necrosis Factor- $alpha$ -Induced Interleukin-6 and RANTES in Human Airway Smooth Muscle Cells: Role of p38 and p42/44 Mitogen-Activated Protein Kinases
Mol Pharmacol 2001 60: 646-655. [Abstract] [Full Text] [PDF]

Masanori Yoshizumi, Koichiro Tsuchiya, Kazuyoshi Kirima, Moe Kyaw, Yuki Suzaki, and Toshiaki Tamaki: Quercetin Inhibits Shc- and Phosphatidylinositol 3-Kinase-Mediated c-Jun N-Terminal Kinase Activation by Angiotensin II in Cultured Rat Aortic Smooth Muscle Cells
Mol Pharmacol 2001 60: 656-665. [Abstract] [Full Text] [PDF]

Thierry Wurch, Junko Okuda, and Petrus J. Pauwels: Reciprocal Modulation of $alpha$ _2A-Adrenoceptor and G_o Protein States as Determined by Carboxy-Terminal Mutagenesis of a G_o Protein
Mol Pharmacol 2001 60: 666-673. [Abstract] [Full Text] [PDF]

Jin-Ming Yang, Andrew D. Vassil, and William N. Hait: Activation of Phospholipase C Induces the Expression of the Multidrug Resistance (MDR1) Gene through the Raf-MAPK Pathway
Mol Pharmacol 2001 60: 674-680. [Abstract] [Full Text] [PDF]

Christoph Handschin, Michael Podvinec, Renate Looser, Remo Amherd, and Urs A. Meyer: Multiple Enhancer Units Mediate Drug Induction of CYP2H1 by Xenobiotic-Sensing Orphan Nuclear Receptor Chicken Xenobiotic Receptor
Mol Pharmacol 2001 60: 681-689. [Abstract] [Full Text] [PDF]

Juan F. López-Giménez, María Villazón, José Brea, M. Isabel Loza, José M. Palacios, Guadalupe Mengod, and M. Teresa Vilaró: Multiple Conformations of Native and Recombinant Human 5-Hydroxytryptamine_2A Receptors Are Labeled by Agonists and Discriminated by Antagonists
Mol Pharmacol 2001 60: 690-699. [Abstract] [Full Text] [PDF]

Yi Zuo, Gary L. Aistrup, William Marszalec, Alison Gillespie, Laura E. Chavez-Noriega, Jay Z. Yeh, and Toshio Narahashi: Dual Action of n-Alcohols on Neuronal Nicotinic Acetylcholine Receptors
Mol Pharmacol 2001 60: 700-711. [Abstract] [Full Text] [PDF]

Stefan Engelhardt, Yvonne Grimmer, Guo-Huang Fan, and Martin J. Lohse: Constitutive Activity of the Human $beta$ ₁-Adrenergic Receptor in $beta$ ₁-Receptor Transgenic Mice
Mol Pharmacol 2001 60: 712-717. [Abstract] [Full Text] [PDF]

Eugen Brailoiu, Michael D. Miyamoto, and Nae J. Dun: Nicotinic Acid Adenine Dinucleotide Phosphate Enhances Quantal Neurosecretion at the Frog Neuromuscular Junction: Possible Action on Synaptic Vesicles in the Releasable Pool
Mol Pharmacol 2001 60: 718-724. [Abstract] [Full Text] [PDF]

Jeffrey L. Krajewski, Ian M. Dickerson, and Lincoln T. Potter: Site-Directed Mutagenesis of m1-Toxin1: Two Amino Acids Responsible for Stable Toxin Binding to M₁ Muscarinic Receptors
Mol Pharmacol 2001 60: 725-731. [Abstract] [Full Text] [PDF]

Steven Mennerick, Chun-Min Zeng, Ann Benz, Weixing Shen, Yukitoshi Izumi, Alex S. Evers, Douglas F. Covey, and Charles F. Zorumski: Effects on $gamma$ -Aminobutyric Acid (GABA)_A Receptors of a Neuroactive Steroid That Negatively Modulates Glutamate Neurotransmission and Augments GABA Neurotransmission
Mol Pharmacol 2001 60: 732-741. [Abstract] [Full Text] [PDF]

Andres A. Caro and Arthur I. Cederbaum: Synergistic Toxicity of Iron and Arachidonic Acid in HepG2 Cells Overexpressing CYP2E1
Mol Pharmacol 2001 60: 742-752. [Abstract] [Full Text] [PDF]

L. J. MacVinish, Y. Guo, A.K. Dixon, R. D. Murrell-Lagnado, and A. W. Cuthbert: XE991 Reveals Differences in K⁺ Channels Regulating Chloride Secretion in Murine Airway and Colonic Epithelium
Mol Pharmacol 2001 60: 753-760. [Abstract] [Full Text] [PDF]

Alena Krej $c$ í and Stanislav Tu $c$ ek: Changes of Cooperativity between N-Methylscopolamine and Allosteric Modulators Alcuronium and Gallamine Induced by Mutations of External Loops of Muscarinic M₃ Receptors
Mol Pharmacol 2001 60: 761-767. [Abstract] [Full Text] [PDF]

Shankung Lin, Huey-Chung Huang, Li-Li Chen, Chun-Chung Lee, and Tze-Sing Huang: GL331 Induces Down-Regulation of Cyclin D1 Expression via Enhanced Proteolysis and Repressed Transcription
Mol Pharmacol 2001 60: 768-775. [Abstract] [Full Text] [PDF]

David J. Fischer, Nora Nusser, Tamas Virag, Kazuaki Yokoyama, De-an Wang, Daniel L. Baker, Debra Bautista, Abby L. Parrill, and Gabor Tigyi: Short-Chain Phosphatidates Are Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors
Mol Pharmacol 2001 60: 776-784. [Abstract] [Full Text] [PDF]

Mats Ljungman and Michelle T. Paulsen: The Cyclin-Dependent Kinase Inhibitor Roscovitine Inhibits RNA Synthesis and Triggers Nuclear Accumulation of p53 That Is Unmodified at Ser15 and Lys382
Mol Pharmacol 2001 60: 785-789. [Abstract] [Full Text] [PDF]

Ingobert Wenningmann and James P. Dilger: The Kinetics of Inhibition of Nicotinic Acetylcholine Receptors by (+)-Tubocurarine and Pancuronium
Mol Pharmacol 2001 60: 790-796. [Abstract] [Full Text] [PDF]

Deeptankar Demazumder and James P. Dilger: The Kinetics of Competitive Antagonism by Cisatracurium of Embryonic and Adult Nicotinic Acetylcholine Receptors
Mol Pharmacol 2001 60: 797-807. [Abstract] [Full Text] [PDF]

Paolo Calabresi, Emilia Saulle, Girolama A. Marfia, Diego Centonze, Roseann Mulloy, Barbara Picconi, Robert A. Hipskind, François Conquet, and Giorgio Bernardi: Activation of Metabotropic Glutamate Receptor Subtype 1/Protein Kinase C/Mitogen-Activated Protein Kinase Pathway Is Required for Postischemic Long-Term Potentiation in the Striatum
Mol Pharmacol 2001 60: 808-815. [Abstract] [Full Text] [PDF]

Graciela Piñeyro, Mounia Azzi, André De Léan, Peter Schiller, and Michel Bouvier: Short-Term Inverse-Agonist Treatment Induces Reciprocal Changes in $delta$ -Opioid Agonist and Inverse-Agonist Binding Capacity
Mol Pharmacol 2001 60: 816-827. [Abstract] [Full Text] [PDF]

Andrew J. Burgess, Sandra Pavey, Robyn Warrener, Lisa-Jane K. Hunter, Terrence J. Piva, Elizabeth A. Musgrove, Nicholas Saunders, Peter G. Parsons, and Brian G. Gabrielli: Up-Regulation of p21^WAF1/CIP1 by Histone Deacetylase Inhibitors Reduces Their Cytotoxicity
Mol Pharmacol 2001 60: 828-837. [Abstract] [Full Text] [PDF]

Lydie Guermonprez, Claire Ducrocq, and Yvette Morot Gaudry-Talarmain: Inhibition of Acetylcholine Synthesis and Tyrosine Nitration Induced by Peroxynitrite Are Differentially Prevented by Antioxidants
Mol Pharmacol 2001 60: 838-846. [Abstract] [Full Text] [PDF]

Myung-Ae Bae, Jae-Eun Pie, and Byoung J. Song: Acetaminophen Induces Apoptosis of C6 Glioma Cells by Activating the c-Jun NH₂-Terminal Protein Kinase-Related Cell Death Pathway
Mol Pharmacol 2001 60: 847-856. [Abstract] [Full Text] [PDF]

Xuechu Zhen, Jie Zhang, Gerard P. Johnson, and Eitan Friedman: D₄ Dopamine Receptor Differentially Regulates Akt/Nuclear Factor- $kappa$ B and Extracellular Signal-Regulated Kinase Pathways in D₄MN9D Cells
Mol Pharmacol 2001 60: 857-864. [Abstract] [Full Text] [PDF]

Takahiro Kimura, Kaoru Yamaoka, Eiji Kinoshita, Hiroshi Maejima, Tsunetsugu Yuki, Masuhide Yakehiro, and Issei Seyama: Novel Site on Sodium Channel $alpha$ -Subunit Responsible for the Differential Sensitivity of Grayanotoxin in Skeletal and Cardiac Muscle
Mol Pharmacol 2001 60: 865-872. [Abstract] [Full Text] [PDF]

Martina Düfer, Peter Krippeit-Drews, Nicolas Lembert, Lars-Åke Idahl, and Gisela Drews: Diabetogenic Effect of Cyclosporin A Is Mediated by Interference with Mitochondrial Function of Pancreatic B-Cells
Mol Pharmacol 2001 60: 873-879. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: 4-Phenylimidazole docked into the active site of the CYP2B models. A, CYP2B4. B, CYP2B5. C, the interactionbetween the B'-C loop and helix I in CYP2B5. D, CYP2B1. The hemeis shown in red. 4-Phenylimidazole is shown in yellow with thenitrogen in blue pointing to the heme iron. Mol Pharmacol 59:475-484.