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April 2002; 61 (4)   [Index by Author]  [Cover Caption]
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Minireview:

Marcelo G. Kazanietz
Novel "Nonkinase" Phorbol Ester Receptors: The C1 Domain Connection
Mol Pharmacol 2002 61: 759-767. [Abstract] [Full Text] [PDF]  

Perspective:

Ross D. Feldman
Deactivation of Vasodilator Responses by GRK2 Overexpression: A Mechanism or the Mechanism for Hypertension?
Mol Pharmacol 2002 61: 707-709. [Full Text] [PDF]  

Articles:

Chaohua Yan, Ye Liang, Karen D. Nylander, Judith Wong, Rena M. Rudavsky, H. Uri Saragovi, and Nina Felice Schor
p75-Nerve Growth Factor as an Antiapoptotic Complex: Independence versus Cooperativity in Protection from Enediyne Chemotherapeutic Agents
Mol Pharmacol 2002 61: 710-719. [Abstract] [Full Text] [PDF]  

John S. Lazo, Kaoru Nemoto, Katharine E. Pestell, Kathleen Cooley, Eileen C. Southwick, Douglas A. Mitchell, William Furey, Rick Gussio, Daniel W. Zaharevitz, Beomjun Joo, and Peter Wipf
Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors.
Mol Pharmacol 2002 61: 720-728. [Abstract] [Full Text] [PDF]  

Hiroshi Uchino, Yoshikatsu Kanai, Do Kyung Kim, Michael F. Wempe, Arthit Chairoungdua, Emiko Morimoto, M. W. Anders, and Hitoshi Endou
Transport of Amino Acid-Related Compounds Mediated by L-Type Amino Acid Transporter 1 (LAT1): Insights Into the Mechanisms of Substrate Recognition
Mol Pharmacol 2002 61: 729-737. [Abstract] [Full Text] [PDF]  

Takemitsu Furuchi, Gi-Wook Hwang, and Akira Naganuma
Overexpression of the Ubiquitin-Conjugating Enzyme Cdc34 Confers Resistance to Methylmercury in Saccharomyces cerevisiae
Mol Pharmacol 2002 61: 738-741. [Abstract] [Full Text] [PDF]  

Jiaxi Wu, Ming-biao Yin, Gunnar Hapke, Károly Tóth, and Youcef M. Rustum
Induction of Biphasic DNA Double Strand Breaks and Activation of Multiple Repair Protein Complexes by DNA Topoisomerase I Drug 7-Ethyl-10-hydroxy-camptothecin
Mol Pharmacol 2002 61: 742-748. [Abstract] [Full Text] [PDF]  

Andrea D. Eckhart, Tohru Ozaki, Hendrik Tevaearai, Howard A. Rockman, and Walter J. Koch
Vascular-Targeted Overexpression of G Protein-Coupled Receptor Kinase-2 in Transgenic Mice Attenuates beta -Adrenergic Receptor Signaling and Increases Resting Blood Pressure
Mol Pharmacol 2002 61: 749-758. [Abstract] [Full Text] [PDF]  

Alice C. Holloway, Hongwei Qian, Luisa Pipolo, James Ziogas, Shin-ichiro Miura, Sadashiva Karnik, Bridget R. Southwell, Michael J. Lew, and Walter G. Thomas
Side-Chain Substitutions within Angiotensin II Reveal Different Requirements for Signaling, Internalization, and Phosphorylation of Type 1A Angiotensin Receptors
Mol Pharmacol 2002 61: 768-777. [Abstract] [Full Text] [PDF]  

Seong Who Kim, So Yeon Park, and Onyou Hwang
Up-Regulation of Tryptophan Hydroxylase Expression and Serotonin Synthesis by Sertraline
Mol Pharmacol 2002 61: 778-785. [Abstract] [Full Text] [PDF]  

Mounia Alaoui-El-Azher, Yongzheng Wu, Nathalie Havet, Alain Israël, Alain Lilienbaum, and Lhousseine Touqui
Arachidonic Acid Differentially Affects Basal and Lipopolysaccharide-Induced sPLA2-IIA Expression in Alveolar Macrophages through NF-kappa B and PPAR-gamma -Dependent Pathways
Mol Pharmacol 2002 61: 786-794. [Abstract] [Full Text] [PDF]  

Françoise Raffalli-Mathieu, Tina Glisovic, Yaacov Ben-David, and Matti A. Lang
Heterogeneous Nuclear Ribonucleoprotein A1 and Regulation of the Xenobiotic-Inducible Gene Cyp2a5
Mol Pharmacol 2002 61: 795-799. [Abstract] [Full Text] [PDF]  

Christine Börner, Volker Höllt, and Jürgen Kraus
Involvement of Activator Protein-1 in Transcriptional Regulation of the Human µ-Opioid Receptor Gene
Mol Pharmacol 2002 61: 800-805. [Abstract] [Full Text] [PDF]  

John N. Mason, Laura B. Kozell, and Kim A. Neve
Regulation of Dopamine D1 Receptor Trafficking by Protein Kinase A-Dependent Phosphorylation
Mol Pharmacol 2002 61: 806-816. [Abstract] [Full Text] [PDF]  

Sinead M. Miggin and B. Therese Kinsella
Regulation of Extracellular Signal-Regulated Kinase Cascades by alpha - and beta -Isoforms of the Human Thromboxane A2 Receptor
Mol Pharmacol 2002 61: 817-831. [Abstract] [Full Text] [PDF]  

Grace L. Guo, Jeff Staudinger, Kenichiro Ogura, and Curtis D. Klaassen
Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16alpha -carbonitrile Is via Interaction with Pregnane X Receptor
Mol Pharmacol 2002 61: 832-839. [Abstract] [Full Text] [PDF]  

Lorraine M. King, Jixiang Ma, Supawon Srettabunjong, Joan Graves, J. Alyce Bradbury, Leping Li, Martin Spiecker, James K. Liao, Harvey Mohrenweiser, and Darryl C. Zeldin
Cloning of CYP2J2 Gene and Identification of Functional Polymorphisms
Mol Pharmacol 2002 61: 840-852. [Abstract] [Full Text] [PDF]  

Oscar Briz, Maria Angeles Serrano, Noemi Rebollo, Bruno Hagenbuch, Peter J. Meier, Hermann Koepsell, and Jose J.G. Marin
Carriers Involved in Targeting the Cytostatic Bile Acid-Cisplatin Derivatives cis-Diammine-chloro-cholylglycinate-platinum(II) and cis-Diammine-bisursodeoxycholate-platinum(II) toward Liver Cells
Mol Pharmacol 2002 61: 853-860. [Abstract] [Full Text] [PDF]  

Sally-Anne Thompson, Peter B. Wingrove, Linda Connelly, Paul J. Whiting, and Keith A. Wafford
Tracazolate Reveals a Novel Type of Allosteric Interaction with Recombinant gamma -Aminobutyric AcidA Receptors
Mol Pharmacol 2002 61: 861-869. [Abstract] [Full Text] [PDF]  

Ilaria Tommasini, Piero Sestili, and Orazio Cantoni
Delayed Formation of Hydrogen Peroxide Mediates the Lethal Response Evoked by Peroxynitrite in U937 Cells
Mol Pharmacol 2002 61: 870-878. [Abstract] [Full Text] [PDF]  

Mi Ran Kang and In Kwon Chung
Down-Regulation of DNA Topoisomerase IIalpha in Human Colorectal Carcinoma Cells Resistant to a Protoberberine Alkaloid, Berberrubine
Mol Pharmacol 2002 61: 879-884. [Abstract] [Full Text] [PDF]  

Zhicheng Lin and George R. Uhl
Dopamine Transporter Mutants with Cocaine Resistance and Normal Dopamine Uptake Provide Targets for Cocaine Antagonism
Mol Pharmacol 2002 61: 885-891. [Abstract] [Full Text] [PDF]  

R. C. Zangar, A. L. Kimzey, J. R. Okita, D. S. Wunschel, R. J. Edwards, H. Kim, and R. T. Okita
Cytochrome P450 3A Conjugation to Ubiquitin in a Process Distinct from Classical Ubiquitination Pathway
Mol Pharmacol 2002 61: 892-904. [Abstract] [Full Text] [PDF]  

Hong-Ling Li, David Hadid, and David S. Ragsdale
The Batrachotoxin Receptor on the Voltage-Gated Sodium Channel is Guarded by the Channel Activation Gate
Mol Pharmacol 2002 61: 905-912. [Abstract] [Full Text] [PDF]  

Susan I. V. Judge, Jay Z. Yeh, James E. Goolsby, Mervyn J. Monteiro, and Christopher T. Bever, Jr.
Determinants of 4-Aminopyridine Sensitivity in a Human Brain Kv1.4 K+ Channel: Phenylalanine Substitutions in Leucine Heptad Repeat Region Stabilize Channel Closed State
Mol Pharmacol 2002 61: 913-920. [Abstract] [Full Text] [PDF]  

James F. Otto, Matthew M. Kimball, and Karen S. Wilcox
Effects of the Anticonvulsant Retigabine on Cultured Cortical Neurons: Changes in Electroresponsive Properties and Synaptic Transmission
Mol Pharmacol 2002 61: 921-927. [Abstract] [Full Text] [PDF]  

Seok Choi, Se-Yeon Jung, Yoo-Seung Ko, Seong-Ryong Koh, Hyewhon Rhim, and Seung-Yeol Nah
Functional Expression of a Novel Ginsenoside Rf Binding Protein from Rat Brain mRNA in Xenopus laevis Oocytes
Mol Pharmacol 2002 61: 928-935. [Abstract] [Full Text] [PDF]  

Matthew J. Gage, Stanley G. Rane, Gregory H. Hockerman, and Thomas J. Smith
The Virally Encoded Fungal Toxin KP4 Specifically Blocks L-Type Voltage-Gated Calcium Channels
Mol Pharmacol 2002 61: 936-944. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: Three-dimensional molecular representation of the distribution of positively charge residues in rhodopsin. The Calpha trace of rhodopsin (yellow) is viewed perpendicular to the transmembrane domain axis, with the extracellular side on the top and the intracellular side on the bottom. The side chains of Arg and Lys are shownin blue sticks. To represent the membrane bilayer, several phospholipid molecules (phosphatidylcholines in the extracellular leaflet and negatively charged phosphatidylserines in the cytoplasmic leaflet) are shown. Mol Pharmacol 60:1-19.



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