Mol Pharm -- Table of Contents (62 [4])

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October 2002; 62 (4)   [Index by Author] [Cover Caption]

       Accelerated Communications

       Articles

       Errata

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Accelerated Communications:

Aslamuzzaman Kazi, David M. Smith, Qing Zhong, and Q. Ping Dou: Inhibition of Bcl-X_L Phosphorylation by Tea Polyphenols or Epigallocatechin-3-Gallate Is Associated with Prostate Cancer Cell Apoptosis
Mol Pharmacol 2002 62: 765-771. [Abstract] [Full Text] [PDF]

Ursula G. B. Haider, Dan Sorescu, Kathy K. Griendling, Angelika M. Vollmar, and Verena M. Dirsch: Resveratrol Suppresses Angiotensin II-Induced Akt/Protein Kinase B and p70 S6 Kinase Phosphorylation and Subsequent Hypertrophy in Rat Aortic Smooth Muscle Cells
Mol Pharmacol 2002 62: 772-777. [Abstract] [Full Text] [PDF]

Articles:

Hiroyasu Furukawa, Toshiyuki Hamada, Mariko K. Hayashi, Tatsuya Haga, Yutaka Muto, Hiroshi Hirota, Shigeyuki Yokoyama, Kazuo Nagasawa, and Masaji Ishiguro: Conformation of Ligands Bound to the Muscarinic Acetylcholine Receptor
Mol Pharmacol 2002 62: 778-787. [Abstract] [Full Text] [PDF]

Sami Väisänen, Sanna Ryhänen, Janne T. A. Saarela, Mikael Peräkylä, Teemu Andersin, and Pekka H. Mäenpää: Structurally and Functionally Important Amino Acids of the Agonistic Conformation of the Human Vitamin D Receptor
Mol Pharmacol 2002 62: 788-794. [Abstract] [Full Text] [PDF]

Maria João Bonifácio, Margarida Archer, Maria L. Rodrigues, Pedro M. Matias, David A. Learmonth, Maria Arménia Carrondo, and Patrício Soares-da-Silva: Kinetics and Crystal Structure of Catechol-O-Methyltransferase Complex with Co-Substrate and a Novel Inhibitor with Potential Therapeutic Application
Mol Pharmacol 2002 62: 795-805. [Abstract] [Full Text] [PDF]

Zhijuan Song and Richard S. Pollenz: Ligand-Dependent and Independent Modulation of Aryl Hydrocarbon Receptor Localization, Degradation, and Gene Regulation
Mol Pharmacol 2002 62: 806-816. [Abstract] [Full Text] [PDF]

Pascal Legendre, Emilie Muller, Carmen Ionela Badiu, Jochen Meier, Christian Vannier, and Antoine Triller: Desensitization of Homomeric $alpha$ 1 Glycine Receptor Increases with Receptor Density
Mol Pharmacol 2002 62: 817-827. [Abstract] [Full Text] [PDF]

Sophie Parmentier-Batteur, Kunlin Jin, Lin Xie, Xiao Ou Mao, and David A. Greenberg: DNA Microarray Analysis of Cannabinoid Signaling in Mouse Brain in Vivo
Mol Pharmacol 2002 62: 828-835. [Abstract] [Full Text] [PDF]

Yuji Imaizumi, Kazuho Sakamoto, Aki Yamada, Aya Hotta, Susumu Ohya, Katsuhiko Muraki, Masanobu Uchiyama, and Tomohiko Ohwada: Molecular Basis of Pimarane Compounds as Novel Activators of Large-Conductance Ca²⁺-Activated K⁺ Channel $alpha$ -Subunit
Mol Pharmacol 2002 62: 836-846. [Abstract] [Full Text] [PDF]

Tomokazu Saitoh, Toshihiko Yanagita, Seiji Shiraishi, Hiroki Yokoo, Hideyuki Kobayashi, Shin-ichi Minami, Toshio Onitsuka, and Akihiko Wada: Down-Regulation of Cell Surface Insulin Receptor and Insulin Receptor Substrate-1 Phosphorylation by Inhibitor of 90-kDa Heat-Shock Protein Family: Endoplasmic Reticulum Retention of Monomeric Insulin Receptor Precursor with Calnexin in Adrenal Chromaffin Cells
Mol Pharmacol 2002 62: 847-855. [Abstract] [Full Text] [PDF]

Martin Spiecker, Ioana Lorenz, Nikolaus Marx, and Harald Darius: Tranilast Inhibits Cytokine-Induced Nuclear Factor $kappa$ B Activation in Vascular Endothelial Cells
Mol Pharmacol 2002 62: 856-863. [Abstract] [Full Text] [PDF]

Yun-Long Tseng, Jun-Jen Liu, and Ruey-Long Hong: Translocation of Liposomes into Cancer Cells by Cell-Penetrating Peptides Penetratin and Tat: A Kinetic and Efficacy Study
Mol Pharmacol 2002 62: 864-872. [Abstract] [Full Text] [PDF]

Ken Umemura, Tomoko Mizushima, Hajime Katayama, Yoshimitsu Kiryu, Takao Yamori, and Toshiwo Andoh: Inhibition of DNA Topoisomerases II and/or I by Pyrazolo[1,5-a]indole Derivatives and Their Growth Inhibitory Activities
Mol Pharmacol 2002 62: 873-880. [Abstract] [Full Text] [PDF]

Xinli Hu, Jing Bi, Horace H. Loh, and Li-Na Wei: Regulation of Mouse $kappa$ Opioid Receptor Gene Expression by Different 3'-Untranslated Regions and the Effect of Retinoic Acid
Mol Pharmacol 2002 62: 881-887. [Abstract] [Full Text] [PDF]

Juliana C. Kwok and Des R. Richardson: Unexpected Anthracycline-Mediated Alterations in Iron-Regulatory Protein-RNA-Binding Activity: The Iron and Copper Complexes of Anthracyclines Decrease RNA-Binding Activity
Mol Pharmacol 2002 62: 888-900. [Abstract] [Full Text] [PDF]

Marco I. González, Marcelo G. Kazanietz, and Michael B. Robinson: Regulation of the Neuronal Glutamate Transporter Excitatory Amino Acid Carrier-1 (EAAC1) by Different Protein Kinase C Subtypes
Mol Pharmacol 2002 62: 901-910. [Abstract] [Full Text] [PDF]

Susanne F. Eisen and H. Alex Brown: Selective Estrogen Receptor (ER) Modulators Differentially Regulate Phospholipase D Catalytic Activity in ER-Negative Breast Cancer Cells
Mol Pharmacol 2002 62: 911-920. [Abstract] [Full Text] [PDF]

Albert S. Koh, Tracey A. Simmons-Willis, John B. Pritchard, Steven M. Grassl, and Nazzareno Ballatori: Identification of a Mechanism by Which the Methylmercury Antidotes N-Acetylcysteine and Dimercaptopropanesulfonate Enhance Urinary Metal Excretion: Transport by the Renal Organic Anion Transporter-1
Mol Pharmacol 2002 62: 921-926. [Abstract] [Full Text] [PDF]

Carlos Zaragoza, Estrella Soria, Esther López, Darren Browning, Milagros Balbín, Carlos López-Otín, and Santiago Lamas: Activation of the Mitogen Activated Protein Kinase Extracellular Signal-Regulated Kinase 1 and 2 by the Nitric Oxide-cGMP-cGMP-Dependent Protein Kinase Axis Regulates the Expression of Matrix Metalloproteinase 13 in Vascular Endothelial Cells
Mol Pharmacol 2002 62: 927-935. [Abstract] [Full Text] [PDF]

Christoph Viktor Suschek, Eckhard Bonmann, Anna Kapsokefalou, Karsten Hemmrich, Hartmut Kleinert, Ulrich Förstermann, Klaus-Dietrich Kröncke, Csaba Mahotka, and Victoria Kolb-Bachofen: Revisiting an Old Antimicrobial Drug: Amphotericin B Induces Interleukin-1-Converting Enzyme as the Main Factor for Inducible Nitric-Oxide Synthase Expression in Activated Endothelia
Mol Pharmacol 2002 62: 936-946. [Abstract] [Full Text] [PDF]

Yun Wang, Tamas Szabo, Jacqueline D. Welter, Attila Toth, Richard Tran, Jiyoun Lee, Sang Uk Kang, Young-Ger Suh, Peter M. Blumberg, and Jeewoo Lee: High Affinity Antagonists of the Vanilloid Receptor
Mol Pharmacol 2002 62: 947-956. [Abstract] [Full Text] [PDF]

Scott S. Wildman, Sean G. Brown, Mary Rahman, Carole A. Noel, Linda Churchill, Geoffrey Burnstock, Robert J. Unwin, and Brian F. King: Sensitization by Extracellular Ca²⁺ of Rat P2X₅ Receptor and Its Pharmacological Properties Compared with Rat P2X₁.
Mol Pharmacol 2002 62: 957-966. [Abstract] [Full Text] [PDF]

Errata:

: Correction to "Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G_i "
Mol Pharmacol 2002 62: 967. [Full Text] [PDF]

: Correction to "Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists "
Mol Pharmacol 2002 62: 968. [Full Text] [PDF]

Cover Caption:

About the cover: DAT TM3 electrostatic potential models. A, dot surface displays of electrostatic potentials in WT (left)and F154A (right) TM3 helices. Each TM3 was built as an $alpha$ -helixand energy-minimized. The 21 amino acids of TM3 cross the plasmamembrane from the lower (N-terminal, cytoplasmic) side to theupper (C-terminal, extracellular) side. F154A is indicated byarrows. Dot surfaces were displayed using Sybyl 6.6 "vdW Dot Surface"with red indicating electrostatic potential measures of "V" >24.9; orange, yellow or green 3.3 > V > 0, cyan 0 > V > $-$ 3.3 andblue, purple or white V < $-$ 24.9. "V" is defined as described previously[Weiner PA, Langridge R, Blaney JM, Scharfer R, and Kollman PK(1982) Electrostatic potential molecular surfaces. Proc Natl AcadSci USA 79:3754-3758] at an arbitrary distance of 1.4 Å.At the helical side important for cocaine binding, there are sevenresidues; three (42%) are decreased and another three increasedin electrostatic potentials. At the side for dopamine uptake,there are eight residues; seven of them (87%) are decreased andnone of them is increased in electrostatic potentials. Indicatedare amino acid residues visible on this graph to the reader andwhose electrostatic potentials are reduced by the F154A substitution.Italic lables denote residues hiding from the reader (locatedat the opposite side of the domain). #, increased electrostaticpotentials for asparagine 157 (above the arrow) and phenylalanine150 (below the arrow). Scale bar, 5 Å. Mol Pharmacol 61:885-981.