Perspective:

Gonzalo E. Torres and Marc G. Caron

Center Stage for the Serotonin Transporter: A Gain-of-Function Polymorphism in Persons with Obsessive-Compulsive Disorder
Mol Pharmacol 2003 64: 196-198. [Full Text] [PDF]  

John S. Lazo, Alexander P. Ducruet, and Radosevda P. Koldamova

Sleuthful Pharmacology
Mol Pharmacol 2003 64: 199-201. [Full Text] [PDF]  

Articles:

C. Zöllner, M. A. Shaqura, C. P. Bopaiah, S. Mousa, C. Stein, and M. Schäfer

Painful Inflammation-Induced Increase in µ-Opioid Receptor Binding and G-Protein Coupling in Primary Afferent Neurons
Mol Pharmacol 2003 64: 202-210. [Abstract] [Full Text] [PDF]  

Qiang Ma, Krista Kinneer, Jianping Ye, and Bruce J. Chen

Inhibition of Nuclear Factor B by Phenolic Antioxidants: Interplay between Antioxidant Signaling and Inflammatory Cytokine Expression
Mol Pharmacol 2003 64: 211-219. [Abstract] [Full Text] [PDF]  

Michal Stark, Lilah Rothem, Gerrit Jansen, George L. Scheffer, I. David Goldman, and Yehuda G. Assaraf

Antifolate Resistance Associated with Loss of MRP1 Expression and Function in Chinese Hamster Ovary Cells with Markedly Impaired Export of Folate and Cholate
Mol Pharmacol 2003 64: 220-227. [Abstract] [Full Text] [PDF]  

Hyo Jung Kang, Jai Sung Noh, Yun Soo Bae, and Byoung Joo Gwag

Calcium-Dependent Prevention of Neuronal Apoptosis by Lithium Ion: Essential Role of Phosphoinositide 3-Kinase and Phospholipase C
Mol Pharmacol 2003 64: 228-234. [Abstract] [Full Text] [PDF]  

Shinji Yamaguchi, Boris S. Zhorov, Katsuro Yoshioka, Taku Nagao, Hidenori Ichijo, and Satomi Adachi-Akahane

Key Roles of Phe¹¹¹² and Ser¹¹¹⁵ in the Pore-Forming IIIS5-S6 Linker of L-Type Ca²⁺ Channel _1C Subunit (Ca_V 1.2) in Binding of Dihydropyridines and Action of Ca²⁺ Channel Agonists
Mol Pharmacol 2003 64: 235-248. [Abstract] [Full Text] [PDF]  

Devashish Kothapalli, Sheryl A. Stewart, Emer M. Smyth, Ijeoma Azonobi, Daniel J. Rader, Ellen Puré, and Richard K. Assoian

Prostacylin Receptor Activation Inhibits Proliferation of Aortic Smooth Muscle Cells by Regulating cAMP Response Element-Binding Protein- and Pocket Protein-Dependent Cyclin A Gene Expression
Mol Pharmacol 2003 64: 249-258. [Abstract] [Full Text] [PDF]  

Paul W. Schenk, Mariël Brok, Antonius W. M. Boersma, Jourica A. Brandsma, Hans Den Dulk, Herman Burger, Gerrit Stoter, Jaap Brouwer, and Kees Nooter

Anticancer Drug Resistance Induced by Disruption of the Saccharomyces cerevisiae NPR2 Gene: a Novel Component Involved in Cisplatin- and Doxorubicin-Provoked Cell Kill
Mol Pharmacol 2003 64: 259-268. [Abstract] [Full Text] [PDF]  

J. Josh Lawrence, Stephan Brenowitz, and Laurence O. Trussell

The Mechanism of Action of Aniracetam at Synaptic -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors: Indirect and Direct Effects on Desensitization
Mol Pharmacol 2003 64: 269-278. [Abstract] [Full Text] [PDF]  

Monika Wierdl, Amelia Wall, Christopher L. Morton, Janardhan Sampath, Mary K. Danks, John D. Schuetz, and Philip M. Potter

Carboxylesterase-Mediated Sensitization of Human Tumor Cells to CPT-11 Cannot Override ABCG2-Mediated Drug Resistance
Mol Pharmacol 2003 64: 279-288. [Abstract] [Full Text] [PDF]  

Dong Xu, Deitmar Falke, and R. L. Juliano

P53-Dependent Cell-Killing by Selective Repression of Thymidine Kinase and Reduced Prodrug Activation
Mol Pharmacol 2003 64: 289-297. [Abstract] [Full Text] [PDF]  

Elizabeth A. Cowley

Isoprostane-Mediated Secretion from Human Airway Epithelial Cells
Mol Pharmacol 2003 64: 298-307. [Abstract] [Full Text] [PDF]  

Aleksi Lahti, Ulla Jalonen, Hannu Kankaanranta, and Eeva Moilanen

c-Jun NH₂-Terminal Kinase Inhibitor Anthra(1,9-cd)pyrazol-6(2H)-one Reduces Inducible Nitric-Oxide Synthase Expression by Destabilizing mRNA in Activated Macrophages
Mol Pharmacol 2003 64: 308-315. [Abstract] [Full Text] [PDF]  

Yuping Chen, Stephen S. Ferguson, Masahiko Negishi, and Joyce A. Goldstein

Identification of Constitutive Androstane Receptor and Glucocorticoid Receptor Binding Sites in the CYP2C19 Promoter
Mol Pharmacol 2003 64: 316-324. [Abstract] [Full Text] [PDF]  

Yun Wang, Attila Toth, Richard Tran, Tamas Szabo, Jacqueline D. Welter, Peter M. Blumberg, Jiyoun Lee, Sang-Uk Kang, Ju-Ok Lim, and Jeewoo Lee

High-Affinity Partial Agonists of the Vanilloid Receptor
Mol Pharmacol 2003 64: 325-333. [Abstract] [Full Text] [PDF]  

Lei Chen, Lucinda Smith, Zhi Wang, and Jeffrey B. Smith

Preservation of Caspase-3 Subunits from Degradation Contributes to Apoptosis Evoked by Lactacystin: Any Single Lysine or Lysine Pair of the Small Subunit Is Sufficient for Ubiquitination
Mol Pharmacol 2003 64: 334-345. [Abstract] [Full Text] [PDF]  

Weimin Miao, Lianggao Hu, Mustapha Kandouz, and Gerald Batist

Oltipraz Is a Bifunctional Inducer Activating Both Phase I and Phase II Drug-Metabolizing Enzymes via the Xenobiotic Responsive Element
Mol Pharmacol 2003 64: 346-354. [Abstract] [Full Text] [PDF]  

Jonathan M. Shipley and David J. Waxman

Down-Regulation of STAT5b Transcriptional Activity by Ligand-Activated Peroxisome Proliferator-Activated Receptor (PPAR) and PPAR
Mol Pharmacol 2003 64: 355-364. [Abstract] [Full Text] [PDF]  

John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

Cholesterol Antagonizes Ethanol Potentiation of Human Brain BK_Ca Channels Reconstituted into Phospholipid Bilayers
Mol Pharmacol 2003 64: 365-372. [Abstract] [Full Text] [PDF]  

Wei Ouyang, Gang Wang, and Hugh C. Hemmings, Jr

Isoflurane and Propofol Inhibit Voltage-Gated Sodium Channels in Isolated Rat Neurohypophysial Nerve Terminals
Mol Pharmacol 2003 64: 373-381. [Abstract] [Full Text] [PDF]  

Thomas Efferth, Axel Sauerbrey, Armin Olbrich, Erich Gebhart, Pia Rauch, H. Oliver Weber, Jan G. Hengstler, Marc-Eric Halatsch, Manfred Volm, Kenneth D. Tew, Douglas D. Ross, and Jens Oliver Funk

Molecular Modes of Action of Artesunate in Tumor Cell Lines
Mol Pharmacol 2003 64: 382-394. [Abstract] [Full Text] [PDF]  

Michael F. Jackson, Daisy T. Joo, Azza A. Al-Mahrouki, Beverley A. Orser, and John F. Macdonald

Desensitization of -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Facilitates Use-Dependent Inhibition by Pentobarbital
Mol Pharmacol 2003 64: 395-406. [Abstract] [Full Text] [PDF]  

Paolo Ricchi, Antonella Di Palma, Tiziana Di Matola, Anna Apicella, Rosaria Fortunato, Raffaele Zarrilli, and Angela Maria Acquaviva

Aspirin Protects Caco-2 Cells from Apoptosis after Serum Deprivation through the Activation of a Phosphatidylinositol 3-Kinase/AKT/p21^Cip/WAF1Pathway
Mol Pharmacol 2003 64: 407-414. [Abstract] [Full Text] [PDF]  

Liat Drucker, Orit Uziel, Tali Tohami, Hava Shapiro, Judith Radnay, Shai Yarkoni, Meir Lahav, and Michael Lishner

Thalidomide Down-Regulates Transcript Levels of GC-Rich Promoter Genes in Multiple Myeloma
Mol Pharmacol 2003 64: 415-420. [Abstract] [Full Text] [PDF]  

Delphine Skrzydelski, Anne-Marie Lhiaubet, Antony Lebeau, Patricia Forgez, Misa Yamada, Emmanuel Hermans, William Rostene, and Didier Pelaprat

Differential Involvement of Intracellular Domains of the Rat NTS1 Neurotensin Receptor in Coupling to G Proteins: A Molecular Basis for Agonist-Directed Trafficking of Receptor Stimulus
Mol Pharmacol 2003 64: 421-429. [Abstract] [Full Text] [PDF]  

Wenfei Wang, Mark S. Sonders, Okechukwu T. Ukairo, Helen Scott, Megan K. Kloetzel, and Christopher K. Surratt

Dissociation of High-Affinity Cocaine Analog Binding and Dopamine Uptake Inhibition at the Dopamine Transporter
Mol Pharmacol 2003 64: 430-439. [Abstract] [Full Text] [PDF]  

Fusun Kilic, Dennis L. Murphy, and Gary Rudnick

A Human Serotonin Transporter Mutation Causes Constitutive Activation of Transport Activity
Mol Pharmacol 2003 64: 440-446. [Abstract] [Full Text] [PDF]  

Ming Yang, Hongmei Zhang, Tatyana Voyno-Yasenetskaya, and Richard D. Ye

Requirement of G and c-Src in D2 Dopamine Receptor-Mediated Nuclear Factor-B Activation
Mol Pharmacol 2003 64: 447-455. [Abstract] [Full Text] [PDF]  

Natalia F. Krynetskaia, Timothy L. Brenner, Eugene Y. Krynetski, Weinan Du, John C. Panetta, Pui Ching-Hon, and William E. Evans

Msh2 Deficiency Attenuates But Does Not Abolish Thiopurine Hematopoietic Toxicity in Msh2^-/- Mice
Mol Pharmacol 2003 64: 456-465. [Abstract] [Full Text] [PDF]  

Kuniyuki Katano, Roohangiz Safaei, Goli Samimi, Alison Holzer, Myriam Rochdi, and Stephen B. Howell

The Copper Export Pump ATP7B Modulates the Cellular Pharmacology of Carboplatin in Ovarian Carcinoma Cells
Mol Pharmacol 2003 64: 466-473. [Abstract] [Full Text] [PDF]  

Michael E. Wyde, Erika Bartolucci, Akiko Ueda, He Zhang, Binfang Yan, Masahiko Negishi, and Li You

The Environmental Pollutant 1,1-Dichloro-2,2-bis (p-chlorophenyl)ethylene Induces Rat Hepatic Cytochrome P450 2B and 3A Expression through the Constitutive Androstane Receptor and Pregnane X Receptor
Mol Pharmacol 2003 64: 474-481. [Abstract] [Full Text] [PDF]  

Beata D. Przybyla-Zawislak, Punit K. Srivastava, Johana Vázquez-Matías, Harvey W. Mohrenweiser, Joseph E. Maxwell, Bruce D. Hammock, J. Alyce Bradbury, Ahmed E. Enayetallah, Darryl C. Zeldin, and David F. Grant

Polymorphisms in Human Soluble Epoxide Hydrolase
Mol Pharmacol 2003 64: 482-490. [Abstract] [Full Text] [PDF]  

Nejmi Dilmac, Nathan Hilliard, and Gregory H. Hockerman

Molecular Determinants of Ca²⁺ Potentiation of Diltiazem Block and Ca²⁺-Dependent Inactivation in the Pore Region of Ca_v1.2
Mol Pharmacol 2003 64: 491-501. [Abstract] [Full Text] [PDF]  

Belén Ramos, Jill M. Lahti, Enrique Claro, and Suzanne Jackowski

Prevalence of Necrosis in C₂-Ceramide–Induced Cytotoxicity in NB16 Neuroblastoma Cells
Mol Pharmacol 2003 64: 502-511. [Abstract] [Full Text] [PDF]  

Federico Monczor, Natalia Fernández, Bibiana Lemos Legnazzi, Maria Eugenia Riveiro, Alberto Baldi, Carina Shayo, and Carlos Davio

Tiotidine, a Histamine H2 Receptor Inverse Agonist That Binds with High Affinity to an Inactive G-Protein—Coupled Form of the Receptor. Experimental Support for the Cubic Ternary Complex Model
Mol Pharmacol 2003 64: 512-520. [Abstract] [Full Text] [PDF]  

Chiung-Chun Huang, Samuel H. H. Chan, and Kuei-Sen Hsu

cGMP/Protein Kinase G-Dependent Potentiation of Glutamatergic Transmission Induced by Nitric Oxide in Immature Rat Rostral Ventrolateral Medulla Neurons in Vitro
Mol Pharmacol 2003 64: 521-532. [Abstract] [Full Text] [PDF]  

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