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November 2003; 64 (5)   [Index by Author]  [Cover Caption]
       Minireview
       Perspective
       Articles
       Errata
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Minireview:

Paul A. Nguewa, Miguel A. Fuertes, Carlos Alonso, and José M. Peréz
Pharmacological Modulation of Poly(ADP-ribose) Polymerase-Mediated Cell Death: Exploitation in Cancer Chemotherapy
Mol Pharmacol 2003 64: 1007-1014. [Full Text] [PDF]  

Perspective:

Richard B. Clark and Thomas C. Rich
Probing the Roles of Protein Kinases in G-Protein-Coupled Receptor Desensitization
Mol Pharmacol 2003 64: 1015-1017. [Full Text] [PDF]  

Articles:

Ian R. Jowsey, Qing Jiang, Ken Itoh, Masayuki Yamamoto, and John D. Hayes
Expression of the Aflatoxin B1-8,9-Epoxide-Metabolizing Murine Glutathione S-Transferase A3 Subunit Is Regulated by the Nrf2 Transcription Factor through an Antioxidant Response Element
Mol Pharmacol 2003 64: 1018-1028. [Abstract] [Full Text] [PDF]  

Ming-Tsan Lin, Men-Luh Yen, Chia-Yi Lin, and Min-Liang Kuo
Inhibition of Vascular Endothelial Growth Factor-Induced Angiogenesis by Resveratrol through Interruption of Src-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation
Mol Pharmacol 2003 64: 1029-1036. [Abstract] [Full Text] [PDF]  

Christopher Volk, Valentin Gorboulev, Thomas Budiman, Georg Nagel, and Hermann Koepsell
Different Affinities of Inhibitors to the Outwardly and Inwardly Directed Substrate Binding Site of Organic Cation Transporter 2
Mol Pharmacol 2003 64: 1037-1047. [Abstract] [Full Text] [PDF]  

Khalid Chakir, Yang Xiang, Dongmei Yang, Sheng-Jun Zhang, Heping Cheng, Brian K. Kobilka, and Rui-Ping Xiao
The Third Intracellular Loop and the Carboxyl Terminus of {beta}2-Adrenergic Receptor Confer Spontaneous Activity of the Receptor
Mol Pharmacol 2003 64: 1048-1058. [Abstract] [Full Text] [PDF]  

Jonathon M. Willets, Rajendra Mistry, Stefan R. Nahorski, and R. A. John Challiss
Specificity of G Protein-Coupled Receptor Kinase 6-Mediated Phosphorylation and Regulation of Single-Cell M3 Muscarinic Acetylcholine Receptor Signaling
Mol Pharmacol 2003 64: 1059-1068. [Abstract] [Full Text] [PDF]  

Kaoru Kobayashi, Tatsuya Sueyoshi, Kaoru Inoue, Rick Moore, and Masahiko Negishi
Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells
Mol Pharmacol 2003 64: 1069-1075. [Abstract] [Full Text] [PDF]  

Shine-Gwo Shian, Yu-Rung Kao, Felicia Ying-Hsiueh Wu, and Cheng-Wen Wu
Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram
Mol Pharmacol 2003 64: 1076-1084. [Abstract] [Full Text] [PDF]  

Qi Zhao, Takeharu Kawano, Hiroko Nakata, Yasuko Nakajima, Shigehiro Nakajima, and Tohru Kozasa
Interaction of G Protein {beta} Subunit with Inward Rectifier K+ Channel Kir3
Mol Pharmacol 2003 64: 1085-1091. [Abstract] [Full Text] [PDF]  

Irma Onoprishvili, Matthew L. Andria, Hal K. Kramer, Natasa Ancevska-Taneva, Jacob M. Hiller, and Eric J. Simon
Interaction Between the µ Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking
Mol Pharmacol 2003 64: 1092-1100. [Abstract] [Full Text] [PDF]  

Christopher M. Incles, Christoph M. Schultes, Lloyd R. Kelland, and Stephen Neidle
Acquired Cellular Resistance to Flavopiridol in a Human Colon Carcinoma Cell Line Involves Up-Regulation of the Telomerase Catalytic Subunit and Telomere Elongation. Sensitivity of Resistant Cells to Combination Treatment with a Telomerase Inhibitor
Mol Pharmacol 2003 64: 1101-1108. [Abstract] [Full Text] [PDF]  

Jon DiFabio, Yanbin Ji, Vasilis Vasiliou, Gregory R. J. Thatcher, and Brian M. Bennett
Role of Mitochondrial Aldehyde Dehydrogenase in Nitrate Tolerance
Mol Pharmacol 2003 64: 1109-1116. [Abstract] [Full Text] [PDF]  

Catherine Pavoine, Niloufar Behforouz, Chantal Gauthier, Sabine Le Gouvello, Françoise Roudot-Thoraval, Catherine Rücker Martin, André Pawlak, Chloé Féral, Nicole Defer, Rémi Houel, Sandrine Magne, Aissata Amadou, Daniel Loisance, Philippe Duvaldestin, and Françoise Pecker
{beta}2-Adrenergic Signaling in Human Heart: Shift from the Cyclic AMP to the Arachidonic Acid Pathway
Mol Pharmacol 2003 64: 1117-1125. [Abstract] [Full Text] [PDF]  

Steven C. Prinster, Nancy A. Schulte, Megan R. Collins, and Myron L. Toews
Up-Regulation of {alpha}1B-Adrenergic Receptors with Defects in G Protein Coupling: Ligand-Induced Protection from Receptor Instability
Mol Pharmacol 2003 64: 1126-1135. [Abstract] [Full Text] [PDF]  

Derick Han, Raffaella Canali, Daniel Rettori, and Neil Kaplowitz
Effect of Glutathione Depletion on Sites and Topology of Superoxide and Hydrogen Peroxide Production in Mitochondria
Mol Pharmacol 2003 64: 1136-1144. [Abstract] [Full Text] [PDF]  

Heejeong Kim and Robert L. Macdonald
An N-Terminal Histidine Is the Primary Determinant of {alpha} Subunit-Dependent Cu2+ Sensitivity of {alpha}{beta}3{gamma}2L GABAA Receptors
Mol Pharmacol 2003 64: 1145-1152. [Abstract] [Full Text] [PDF]  

Ying Chen, Debora L. Kramer, Jason Jell, Slavoljub Vujcic, and Carl W. Porter
Small Interfering RNA Suppression of Polyamine Analog-Induced Spermidine/Spermine N1-Acetyltransferase
Mol Pharmacol 2003 64: 1153-1159. [Abstract] [Full Text] [PDF]  

Melissa A. Moss, Michael R. Nichols, Dana Kim Reed, Jan H. Hoh, and Terrone L. Rosenberry
The Peptide KLVFF-K6 Promotes {beta}-Amyloid(1–40) Protofibril Growth by Association but Does Not Alter Protofibril Effects on Cellular Reduction of 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide (MTT)
Mol Pharmacol 2003 64: 1160-1168. [Abstract] [Full Text] [PDF]  

Su Wol Chung, Bok Yun Kang, and Tae Sung Kim
Inhibition of Interleukin-4 Production in CD4+ T Cells by Peroxisome Proliferator-Activated Receptor-{gamma} (PPAR-{gamma}) Ligands: Involvement of Physical Association between PPAR-{gamma} and the Nuclear Factor of Activated T Cells Transcription Factor
Mol Pharmacol 2003 64: 1169-1179. [Abstract] [Full Text] [PDF]  

Song Her, Robert Claycomb, T. C. Tai, and Dona L. Wong
Regulation of the Rat Phenylethanolamine N-Methyltransferase Gene by Transcription Factors Sp1 and MAZ
Mol Pharmacol 2003 64: 1180-1188. [Abstract] [Full Text] [PDF]  

Robert Ramer, Ulrike Weinzierl, Bianca Schwind, Kay Brune, and Burkhard Hinz
Ceramide Is Involved in R(+)-Methanandamide-Induced Cyclooxygenase-2 Expression in Human Neuroglioma Cells
Mol Pharmacol 2003 64: 1189-1198. [Abstract] [Full Text] [PDF]  

Scott D. Sorensen, Olivier Nicole, Richard D. Peavy, Lisa M. Montoya, C. Justin Lee, T. J. Murphy, Stephen F. Traynelis, and John R. Hepler
Common Signaling Pathways Link Activation of Murine PAR-1, LPA, and S1P Receptors to Proliferation of Astrocytes
Mol Pharmacol 2003 64: 1199-1209. [Abstract] [Full Text] [PDF]  

Erik T. Bodor, Gary L. Waldo, Shelley B. Hooks, James Corbitt, Jose L. Boyer, and T. Kendall Harden
Purification and Functional Reconstitution of the Human P2Y12 Receptor
Mol Pharmacol 2003 64: 1210-1216. [Abstract] [Full Text] [PDF]  

Federico A. Dajas-Bailador, Kaisa Heimala, and Susan Wonnacott
The Allosteric Potentiation of Nicotinic Acetylcholine Receptors by Galantamine Is Transduced into Cellular Responses in Neurons: Ca2+ Signals and Neurotransmitter Release.
Mol Pharmacol 2003 64: 1217-1226. [Abstract] [Full Text] [PDF]  

Peter C. Simons, Mei Shi, Terry Foutz, Daniel F. Cimino, Jeremy Lewis, Tione Buranda, William K. Lim, Richard R. Neubig, William E. McIntire, James Garrison, Eric Prossnitz, and Larry A. Sklar
Ligand-Receptor-G-Protein Molecular Assemblies on Beads for Mechanistic Studies and Screening by Flow Cytometry
Mol Pharmacol 2003 64: 1227-1238. [Abstract] [Full Text] [PDF]  

Derek N. Robertson, Melanie S. Johnson, Louise O. Moggach, Pamela J. Holland, Eve M. Lutz, and Rory Mitchell
Selective Interaction of ARF1 with the Carboxy-Terminal Tail Domain of the 5-HT2A Receptor
Mol Pharmacol 2003 64: 1239-1250. [Abstract] [Full Text] [PDF]  

Geng Hui Zhu and Edward L. Schwartz
Expression of the Angiogenic Factor Thymidine Phosphorylase in THP-1 Monocytes: Induction by Autocrine Tumor Necrosis Factor-{alpha} and Inhibition by Aspirin
Mol Pharmacol 2003 64: 1251-1258. [Abstract] [Full Text] [PDF]  

Mario Muredda, Ken-Ichi Nunoya, Ruth A. Burtch-Wright, Ebba U. Kurz, Susan P. C. Cole, and Roger G. Deeley
Cloning and Characterization of the Murine and Rat mrp1 Promoter Regions
Mol Pharmacol 2003 64: 1259-1269. [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Rescuing the traffic-deficient mutants of rat µ-opioid receptors with hydrophobic ligands"
Mol Pharmacol 2003 64: 1270. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: Structure of poly(ADP-ribose) polymerase-1 (PARP-1). Ribbon representation of chicken's PARP-1 catalytic fragment (C-terminal end, amino acids 662 to 1014), which was cocrystallized with the NAD analog carba-NAD. See the article by Nguewa et al. on page 1007 of this issue.


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