Minireview:

Satish A. Eraly, Kevin T. Bush, Rosemary V. Sampogna, Vibha Bhatnagar, and Sanjay K. Nigam

The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?
Mol Pharmacol 2004 65: 479-487. [Abstract] [Full Text] [PDF]  

Perspectives:

Morton P. Printz

The Confluence of Population Genetics with Molecular Pharmacology at the Angiotensin II Receptor: Dawn of a New Era or Just a New Wrinkle?
Mol Pharmacol 2004 65: 488-491. [Full Text] [PDF]  

Brian M. Cox and A. Tamara Crowder

Receptor Domains Regulating µ Opioid Receptor Uncoupling and Internalization: Relevance to Opioid Tolerance
Mol Pharmacol 2004 65: 492-495. [Full Text] [PDF]  

Articles:

Hideto Jinno, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Seiich Ishida, Mayumi Saeki, Akiko Soyama, Masaya Itoda, Tetsuji Nishimura, Yoshiro Saito, Shogo Ozawa, Masanori Ando, and Jun-ichi Sawada

Identification of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor and Characterization of Their Expression in the Liver
Mol Pharmacol 2004 65: 496-502. [Abstract] [Full Text] [PDF]  

James D. Brady, Thomas C. Rich, Xuan Le, Kimberlee Stafford, Cedar J. Fowler, Leatha Lynch, Jeffrey W. Karpen, R. Lane Brown, and Jeffrey R. Martens

Functional Role of Lipid Raft Microdomains in Cyclic Nucleotide-Gated Channel Activation
Mol Pharmacol 2004 65: 503-511. [Abstract] [Full Text] [PDF]  

Jennifer H. Gray, Lara M. Mangravite, Ryan P. Owen, Thomas J. Urban, Wendy Chan, Elaine J. Carlson, Conrad C. Huang, Michiko Kawamoto, Susan J. Johns, Douglas Stryke, Thomas E. Ferrin, and Kathleen M. Giacomini

Functional and Genetic Diversity in the Concentrative Nucleoside Transporter, CNT1, in Human Populations
Mol Pharmacol 2004 65: 512-519. [Abstract] [Full Text] [PDF]  

Martin Michaelis, U. Ruth Michaelis, Ingrid Fleming, Tatyana Suhan, Jaroslav Cinatl, Roman A. Blaheta, Katrin Hoffmann, Rouslan Kotchetkov, Rudi Busse, Heinz Nau, and Jindrich Cinatl, Jr.

Valproic Acid Inhibits Angiogenesis in Vitro and in Vivo
Mol Pharmacol 2004 65: 520-527. [Abstract] [Full Text] [PDF]  

Jeremy Celver, Mei Xu, Wenzhen Jin, Janet Lowe, and Charles Chavkin

Distinct Domains of the µ-Opioid Receptor Control Uncoupling and Internalization
Mol Pharmacol 2004 65: 528-537. [Abstract] [Full Text] [PDF]  

R. A. Bakker, D. M. Weiner, T. ter Laak, T. Beuming, O. P. Zuiderveld, M. Edelbroek, U. Hacksell, H. Timmerman, M. R. Brann, and R. Leurs

8R-Lisuride Is a Potent Stereospecific Histamine H₁-Receptor Partial Agonist
Mol Pharmacol 2004 65: 538-549. [Abstract] [Full Text] [PDF]  

Yong Wu, Xiaoxue Zhang, Fawzia Bardag-Gorce, Rose C. V. Robel, Jonathan Aguilo, Lixin Chen, Ying Zeng, Kelly Hwang, Samuel W. French, Shelly C. Lu, and Yu-Jui Y. Wan

Retinoid X Receptor Regulates Glutathione Homeostasis and Xenobiotic Detoxification Processes in Mouse Liver
Mol Pharmacol 2004 65: 550-557. [Abstract] [Full Text] [PDF]  

C. Chang, P. W. Swaan, L. Y. Ngo, P. Y. Lum, S. D. Patil, and J. D. Unadkat

Molecular Requirements of the Human Nucleoside Transporters hCNT1, hCNT2, and hENT1
Mol Pharmacol 2004 65: 558-570. [Abstract] [Full Text] [PDF]  

Roberto R. Rosato, Jorge A. Almenara, Chunrong Yu, and Steven Grant

Evidence of a Functional Role for p21^WAF1/CIP1 Down-Regulation in Synergistic Antileukemic Interactions between the Histone Deacetylase Inhibitor Sodium Butyrate and Flavopiridol
Mol Pharmacol 2004 65: 571-581. [Abstract] [Full Text] [PDF]  

Clayton M. Bullock, Jia-Da Li, and Qun-Yong Zhou

Structural Determinants Required for the Bioactivities of Prokineticins and Identification of Prokineticin Receptor Antagonists
Mol Pharmacol 2004 65: 582-588. [Abstract] [Full Text] [PDF]  

Ya-Jen Chang, Michael J. Holtzman, and Ching-Chow Chen

Differential Role of Janus Family Kinases (JAKs) in Interferon-–Induced Lung Epithelial ICAM-1 Expression: Involving Protein Interactions between JAKs, Phospholipase C, c-Src, and STAT1
Mol Pharmacol 2004 65: 589-598. [Abstract] [Full Text] [PDF]  

Sanjay Danthi, Judith A. Enyeart, and John J. Enyeart

Caffeic Acid Esters Activate TREK-1 Potassium Channels and Inhibit Depolarization-Dependent Secretion
Mol Pharmacol 2004 65: 599-610. [Abstract] [Full Text] [PDF]  

Steven L. Parker, Yitong Fu, Kathleen McAllen, Jianhong Luo, J. Michael McIntosh, Jon M. Lindstrom, and Burt M. Sharp

Up-Regulation of Brain Nicotinic Acetylcholine Receptors in the Rat during Long-Term Self-Administration of Nicotine: Disproportionate Increase of the 6 Subunit
Mol Pharmacol 2004 65: 611-622. [Abstract] [Full Text] [PDF]  

Sayuri Oshikawa, Akito Tanoue, Taka-aki Koshimizu, Yoko Kitagawa, and Gozoh Tsujimoto

Vasopressin Stimulates Insulin Release from Islet Cells through V1b Receptors: a Combined Pharmacological/Knockout Approach
Mol Pharmacol 2004 65: 623-629. [Abstract] [Full Text] [PDF]  

Heike Jäger, Tobias Dreker, Anita Buck, Klaudia Giehl, Thomas Gress, and Stephan Grissmer

Blockage of Intermediate-Conductance Ca²⁺-Activated K⁺ Channels Inhibit Human Pancreatic Cancer Cell Growth in Vitro
Mol Pharmacol 2004 65: 630-638. [Abstract] [Full Text] [PDF]  

Joost J. F. P. Luiken, Susan L. M. Coort, Jodil Willems, Will A. Coumans, Arend Bonen, and Jan F. C. Glatz

Dipyridamole Alters Cardiac Substrate Preference by Inducing Translocation of FAT/CD36, but Not That of GLUT4
Mol Pharmacol 2004 65: 639-645. [Abstract] [Full Text] [PDF]  

Ramin Raouf, Yassar Chakfe, Dominique Blais, Audrey Speelman, Eric Boué-Grabot, Duncan Henderson, and Philippe Séguéla

Selective Knock-Down of P2X₇ ATP Receptor Function by Dominant-Negative Subunits
Mol Pharmacol 2004 65: 646-654. [Abstract] [Full Text] [PDF]  

Philip C. Burcham, Frank R. Fontaine, Lisa M. Kaminskas, Dennis R. Petersen, and Simon M. Pyke

Protein Adduct-Trapping by Hydrazinophthalazine Drugs: Mechanisms of Cytoprotection Against Acrolein-Mediated Toxicity
Mol Pharmacol 2004 65: 655-664. [Abstract] [Full Text] [PDF]  

Juan Guo and Stephen R. Ikeda

Endocannabinoids Modulate N-Type Calcium Channels and G-Protein-Coupled Inwardly Rectifying Potassium Channels via CB1 Cannabinoid Receptors Heterologously Expressed in Mammalian Neurons
Mol Pharmacol 2004 65: 665-674. [Abstract] [Full Text] [PDF]  

Zuben E. Sauna, Xiang-Hong Peng, Krishnamachary Nandigama, Samrawit Tekle, and Suresh V. Ambudkar

The Molecular Basis of the Action of Disulfiram as a Modulator of the Multidrug Resistance-Linked ATP Binding Cassette Transporters MDR1 (ABCB1) and MRP1 (ABCC1)
Mol Pharmacol 2004 65: 675-684. [Abstract] [Full Text] [PDF]  

Enrico Leipold, Songqing Lu, Dalia Gordon, Alfred Hansel, and Stefan H. Heinemann

Combinatorial Interaction of Scorpion Toxins Lqh-2, Lqh-3, and LqhIT with Sodium Channel Receptor Sites-3
Mol Pharmacol 2004 65: 685-691. [Abstract] [Full Text] [PDF]  

Jon D. Gaffaney and Roxanne A. Vaughan

Uptake Inhibitors but not Substrates Induce Protease Resistance in Extracellular Loop Two of the Dopamine Transporter
Mol Pharmacol 2004 65: 692-701. [Abstract] [Full Text] [PDF]  

Margot W. Beukers, Joris van Oppenraaij, Patrick P. W. van der Hoorn, Clara C. Blad, Hans den Dulk, Jaap Brouwer, and Adriaan P. IJzerman

Random Mutagenesis of the Human Adenosine A_2B Receptor Followed by Growth Selection in Yeast. Identification of Constitutively Active and Gain of Function Mutations
Mol Pharmacol 2004 65: 702-710. [Abstract] [Full Text] [PDF]  

Stefania Gessi, Katia Varani, Stefania Merighi, Elena Cattabriga, Arianna Avitabile, Riccardo Gavioli, Cinzia Fortini, Edward Leung, Stephen Mac Lennan, and Pier Andrea Borea

Expression of A₃ Adenosine Receptors in Human Lymphocytes: Up-Regulation in T Cell Activation
Mol Pharmacol 2004 65: 711-719. [Abstract] [Full Text] [PDF]  

Ibtissam Echchgadda, Chung S. Song, Arun K. Roy, and Bandana Chatterjee

Dehydroepiandrosterone Sulfotransferase Is a Target for Transcriptional Induction by the Vitamin D Receptor
Mol Pharmacol 2004 65: 720-729. [Abstract] [Full Text] [PDF]  

Jixiang Ma, Joan Graves, J. Alyce Bradbury, Yun Zhao, Deborah L. Swope, Lorraine King, Wei Qu, James Clark, Page Myers, Vickie Walker, Jonathan Lindzey, Kenneth S. Korach, and Darryl C. Zeldin

Regulation of Mouse Renal CYP2J5 Expression by Sex Hormones
Mol Pharmacol 2004 65: 730-743. [Abstract] [Full Text] [PDF]  

Stacey DaCosta Byfield, Christopher Major, Nicholas J. Laping, and Anita B. Roberts

SB-505124 Is a Selective Inhibitor of Transforming Growth Factor- Type I Receptors ALK4, ALK5, and ALK7
Mol Pharmacol 2004 65: 744-752. [Abstract] [Full Text] [PDF]  

Martin Beinborn, Yong Ren, Michael Bläker, Ci Chen, and Alan S. Kopin

Ligand Function at Constitutively Active Receptor Mutants Is Affected by Two Distinct Yet Interacting Mechanisms
Mol Pharmacol 2004 65: 753-760. [Abstract] [Full Text] [PDF]  

D. Obradovic, M. Tirard, Zs. Némethy, O. Hirsch, H. Gronemeyer, and O. F. X. Almeida

DAXX, FLASH, and FAF-1 Modulate Mineralocorticoid and Glucocorticoid Receptor-Mediated Transcription in Hippocampal Cells—Toward a Basis for the Opposite Actions Elicited by Two Nuclear Receptors?
Mol Pharmacol 2004 65: 761-769. [Abstract] [Full Text] [PDF]  

Jakob Lerche Hansen, Stig Haunsø, Mark R. Brann, Søren P. Sheikh, and David M. Weiner

Loss-of-Function Polymorphic Variants of the Human Angiotensin II Type 1 Receptor
Mol Pharmacol 2004 65: 770-777. [Abstract] [Full Text] [PDF]  

Yoshikazu Takagi, Jun Du, Xiu-Yang Ma, Izumi Nakashima, and Fumihiko Nagase

Phorbol 12-Myristate 13-Acetate Protects Jurkat Cells from Methylglyoxal-Induced Apoptosis by Preventing c-Jun N-Terminal Kinase-Mediated Leakage of Cytochrome c in an Extracellular Signal-Regulated Kinase-Dependent Manner
Mol Pharmacol 2004 65: 778-787. [Abstract] [Full Text] [PDF]  

Oliver H. Wittekindt, Violeta Visan, Hiroaki Tomita, Faiqa Imtiaz, Jay J. Gargus, Frank Lehmann-Horn, Stephan Grissmer, and Deborah J. Morris-Rosendahl

An Apamin- and Scyllatoxin-Insensitive Isoform of the Human SK3 Channel
Mol Pharmacol 2004 65: 788-801. [Abstract] [Full Text] [PDF]  

Ron Bouchard, Alexander Omelchenko, Hoa Dinh Le, Platon Choptiany, Toshio Matsuda, Akemichi Baba, Kenzo Takahashi, Debora A. Nicoll, Kenneth D. Philipson, Mark Hnatowich, and Larry V. Hryshko

Effects of SEA0400 on Mutant NCX1.1 Na⁺-Ca²⁺ Exchangers with Altered Ionic Regulation
Mol Pharmacol 2004 65: 802-810. [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Agonist Binding and Gq-Stimulating Activities of the Purified Human P2Y₁ Receptor"
Mol Pharmacol 2004 65: 811. [Full Text] [PDF]  

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