Minireview:

Iain L. O. Buxton

Regulation of Uterine Function: a Biochemical Conundrum in the Regulation of Smooth Muscle Relaxation
Mol Pharmacol 2004 65: 1051-1059. [Abstract] [Full Text] [PDF]  

Perspectives:

Brian Kobilka

Agonist Binding: A Multistep Process
Mol Pharmacol 2004 65: 1060-1062. [Full Text] [PDF]  

Articles:

Lo-Ti Tsao, Chun-Nan Lin, and Jih-Pyang Wang

Justicidin A Inhibits the Transport of Tumor Necrosis Factor- to Cell Surface in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages
Mol Pharmacol 2004 65: 1063-1069. [Abstract] [Full Text] [PDF]  

Victoria J. Findlay, Danyelle M. Townsend, Joseph E. Saavedra, Gregory S. Buzard, Michael L. Citro, Larry K. Keefer, Xinhua Ji, and Kenneth D. Tew

Tumor Cell Responses to a Novel Glutathione S-Transferase–Activated Nitric Oxide-Releasing Prodrug
Mol Pharmacol 2004 65: 1070-1079. [Abstract] [Full Text] [PDF]  

Shulamith H. Shafer and Carol L. Williams

Elevated Rac1 Activity Changes the M₃ Muscarinic Acetylcholine Receptor-Mediated Inhibition of Proliferation to Induction of Cell Death
Mol Pharmacol 2004 65: 1080-1091. [Abstract] [Full Text] [PDF]  

Sandra Bien, Christoph A. Ritter, Matthias Gratz, Bernhard Sperker, Jürgen Sonnemann, James F. Beck, and Heyo K. Kroemer

Nuclear Factor-B Mediates Up-Regulation of Cathepsin B by Doxorubicin in Tumor Cells
Mol Pharmacol 2004 65: 1092-1102. [Abstract] [Full Text] [PDF]  

L. Iacovelli, L. Capobianco, M. Iula, V. Di Giorgi Gerevini, A. Picascia, J. Blahos, D. Melchiorri, F. Nicoletti, and A. De Blasi

Regulation of mGlu4 Metabotropic Glutamate Receptor Signaling by Type-2 G-Protein Coupled Receptor Kinase (GRK2)
Mol Pharmacol 2004 65: 1103-1110. [Abstract] [Full Text] [PDF]  

Mark S. Taylor, Chris Okwuchukwuasanya, Christian K. Nickl, Werner Tegge, Joseph E. Brayden, and Wolfgang R. G. Dostmann

Inhibition of cGMP-Dependent Protein Kinase by the Cell-Permeable Peptide DT-2 Reveals a Novel Mechanism of Vasoregulation
Mol Pharmacol 2004 65: 1111-1119. [Abstract] [Full Text] [PDF]  

Guido Gessner, Martin Zacharias, Susanne Bechstedt, Roland Schönherr, and Stefan H. Heinemann

Molecular Determinants for High-Affinity Block of Human EAG Potassium Channels by Antiarrhythmic Agents
Mol Pharmacol 2004 65: 1120-1129. [Abstract] [Full Text] [PDF]  

Hsuan-Hsu Chen and Danny Ling Wang

Nitric Oxide Inhibits Matrix Metalloproteinase-2 Expression via the Induction of Activating Transcription Factor 3 in Endothelial Cells
Mol Pharmacol 2004 65: 1130-1140. [Abstract] [Full Text] [PDF]  

Fanfan Zhou, Kunihiko Tanaka, Zui Pan, Jianjie Ma, and Guofeng You

The Role of Glycine Residues in the Function of Human Organic Anion Transporter 4
Mol Pharmacol 2004 65: 1141-1147. [Abstract] [Full Text] [PDF]  

Hong Wang, Yun Zhao, J. Alyce Bradbury, Joan P. Graves, Julie Foley, Joyce A. Blaisdell, Joyce A. Goldstein, and Darryl C. Zeldin

Cloning, Expression, and Characterization of Three New Mouse Cytochrome P450 Enzymes and Partial Characterization of Their Fatty Acid Oxidation Activities
Mol Pharmacol 2004 65: 1148-1158. [Abstract] [Full Text] [PDF]  

Dylan P. Hartley, Xudong Dai, Yudong D. He, Edward J. Carlini, Bonnie Wang, Su-er W. Huskey, Roger G. Ulrich, Thomas H. Rushmore, Raymond Evers, and David C. Evans

Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal Gene Expression
Mol Pharmacol 2004 65: 1159-1171. [Abstract] [Full Text] [PDF]  

Shuqiu Zheng and Zhiyi Zuo

Isoflurane Preconditioning Induces Neuroprotection against Ischemia via Activation of P38 Mitogen-Activated Protein Kinases
Mol Pharmacol 2004 65: 1172-1180. [Abstract] [Full Text] [PDF]  

George Liapakis, Wai Chi Chan, Maria Papadokostaki, and Jonathan A. Javitch

Synergistic Contributions of the Functional Groups of Epinephrine to Its Affinity and Efficacy at the ₂ Adrenergic Receptor
Mol Pharmacol 2004 65: 1181-1190. [Abstract] [Full Text] [PDF]  

Steven Mennerick, Yejun He, Xin Jiang, Brad D. Manion, Mingde Wang, Amanda Shute, Ann Benz, Alex S. Evers, Douglas F. Covey, and Charles F. Zorumski

Selective Antagonism of 5-Reduced Neurosteroid Effects at GABA_A Receptors
Mol Pharmacol 2004 65: 1191-1197. [Abstract] [Full Text] [PDF]  

Mitsuhiko Yamada and Yoshihisa Kurachi

The Nucleotide-Binding Domains of Sulfonylurea Receptor 2A and 2B Play Different Functional Roles in Nicorandil-Induced Activation of ATP-Sensitive K⁺ Channels
Mol Pharmacol 2004 65: 1198-1207. [Abstract] [Full Text] [PDF]  

Shuzhong Zhang, Xinning Yang, and Marilyn E. Morris

Flavonoids Are Inhibitors of Breast Cancer Resistance Protein (ABCG2)-Mediated Transport
Mol Pharmacol 2004 65: 1208-1216. [Abstract] [Full Text] [PDF]  

Xing-Jie Liang, Ding-Wu Shen, and Michael M. Gottesman

Down-Regulation and Altered Localization of -Catenin in Cisplatin-Resistant Adenocarcinoma Cells
Mol Pharmacol 2004 65: 1217-1224. [Abstract] [Full Text] [PDF]  

Shigeyuki Uno, Timothy P. Dalton, Sandrine Derkenne, Christine P. Curran, Marian L. Miller, Howard G. Shertzer, and Daniel W. Nebert

Oral Exposure to Benzo[a]pyrene in the Mouse: Detoxication by Inducible Cytochrome P450 Is More Important Than Metabolic Activation
Mol Pharmacol 2004 65: 1225-1237. [Abstract] [Full Text] [PDF]  

David Siegel, Daniel L. Gustafson, Donna L. Dehn, Jin Yi Han, Preecha Boonchoong, Lawrence J. Berliner, and David Ross

NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger
Mol Pharmacol 2004 65: 1238-1247. [Abstract] [Full Text] [PDF]  

Isabel D. Alves, Scott M. Cowell, Zdzislaw Salamon, Savitha Devanathan, Gordon Tollin, and Victor J. Hruby

Different Structural States of the Proteolipid Membrane Are Produced by Ligand Binding to the Human -Opioid Receptor as Shown by Plasmon-Waveguide Resonance Spectroscopy
Mol Pharmacol 2004 65: 1248-1257. [Abstract] [Full Text] [PDF] Erratum  

Adam Parker Hill, Olivia Kingston, and Rebecca Sitsapesan

Functional Regulation of the Cardiac Ryanodine Receptor by Suramin and Calmodulin Involves Multiple Binding Sites
Mol Pharmacol 2004 65: 1258-1268. [Abstract] [Full Text] [PDF]  

Guohong Liu, Nathan Hilliard, and Gregory H. Hockerman

Ca_v1.3 Is Preferentially Coupled to Glucose-Induced [Ca²⁺]_i Oscillations in the Pancreatic Cell Line INS-1
Mol Pharmacol 2004 65: 1269-1277. [Abstract] [Full Text] [PDF]  

Chong-Sheng Chen, Jack T. Lin, Kendrick A. Goss, You-ai He, James R. Halpert, and David J. Waxman

Activation of the Anticancer Prodrugs Cyclophosphamide and Ifosfamide: Identification of Cytochrome P450 2B Enzymes and Site-Specific Mutants with Improved Enzyme Kinetics
Mol Pharmacol 2004 65: 1278-1285. [Abstract] [Full Text] [PDF]  

Shiu-Hwa Yeh, Chia-Ho Lin, and Po-Wu Gean

Acetylation of Nuclear Factor-B in Rat Amygdala Improves Long-Term but not Short-Term Retention of Fear Memory
Mol Pharmacol 2004 65: 1286-1292. [Abstract] [Full Text] [PDF]  

Hiroyuki Mizoguchi, Kiyofumi Yamada, Makoto Mizuno, Tomoko Mizuno, Atsumi Nitta, Yukihiro Noda, and Toshitaka Nabeshima

Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like Gene-1 Signaling Pathway via the Activation of Dopamine Receptors
Mol Pharmacol 2004 65: 1293-1301. [Abstract] [Full Text] [PDF]  

Sarita D. Shenoy, Thomas A. Spencer, Nancy A. Mercer-Haines, Masumeh Abdolalipour, William L. Wurster, Melissa Runge-Morris, and Thomas A. Kocarek

Induction of CYP3A by 2,3-Oxidosqualene:Lanosterol Cyclase Inhibitors Is Mediated by an Endogenous Squalene Metabolite in Primary Cultured Rat Hepatocytes
Mol Pharmacol 2004 65: 1302-1312. [Abstract] [Full Text] [PDF]  

Jürgen F. Heubach, Ursula Ravens, and Alberto J. Kaumann

Epinephrine Activates Both G_s and G_i Pathways, but Norepinephrine Activates Only the G_s Pathway through Human ₂-Adrenoceptors Overexpressed in Mouse Heart
Mol Pharmacol 2004 65: 1313-1322. [Abstract] [Full Text] [PDF]  

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