Minireview:

Graeme Milligan

G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
Mol Pharmacol 2004 66: 1-7. Published online May 21, 2004; 10.1124/mol.104.000497 [Abstract] [Full Text] [PDF]  

Perspectives:

Myles H. Akabas

Na⁺/Ca²⁺ Exchange Inhibitors: Potential Drugs to Mitigate the Severity of Ischemic Injury
Mol Pharmacol 2004 66: 8-10. [Full Text] [PDF]  

Thomas M. Lincoln

Cyclic GMP and Phosphodiesterase 5 Inhibitor Therapies: What's on the Horizon?
Mol Pharmacol 2004 66: 11-13. [Full Text] [PDF]  

Articles:

Clare Stokes, Julia Kay Porter Papke, Nicole A. Horenstein, William R. Kem, Thomas J. McCormack, and Roger L. Papke

The Structural Basis for GTS-21 Selectivity between Human and Rat Nicotinic 7 Receptors
Mol Pharmacol 2004 66: 14-24. [Abstract] [Full Text] [PDF]  

Goli Samimi, Kuniyuki Katano, Alison K. Holzer, Roohangiz Safaei, and Stephen B. Howell

Modulation of the Cellular Pharmacology of Cisplatin and Its Analogs by the Copper Exporters ATP7A and ATP7B
Mol Pharmacol 2004 66: 25-32. [Abstract] [Full Text] [PDF]  

Eckhard Ficker, Yuri A. Kuryshev, Adrienne T. Dennis, Carlos Obejero-Paz, Lu Wang, Peter Hawryluk, Barbara A. Wible, and Arthur M. Brown

Mechanisms of Arsenic-Induced Prolongation of Cardiac Repolarization
Mol Pharmacol 2004 66: 33-44. [Abstract] [Full Text] [PDF]  

Takahiro Iwamoto, Yutaka Inoue, Kazuhiko Ito, Takahiro Sakaue, Satomi Kita, and Takeshi Katsuragi

The Exchanger Inhibitory Peptide Region-Dependent Inhibition of Na⁺/Ca²⁺ Exchange by SN-6 [2-[4-(4-Nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic Acid Ethyl Ester], a Novel Benzyloxyphenyl Derivative
Mol Pharmacol 2004 66: 45-55. [Abstract] [Full Text] [PDF]  

Kendall D. W. Morris and Jahanshah Amin

Insight into the Mechanism of Action of Neuroactive Steroids
Mol Pharmacol 2004 66: 56-69. [Abstract] [Full Text] [PDF]  

Myong-Hee Sung and Richard Simon

In Silico Simulation of Inhibitor Drug Effects on Nuclear Factor-B Pathway Dynamics
Mol Pharmacol 2004 66: 70-75. [Abstract] [Full Text] [PDF]  

Chaya Brodie, Rivka Steinhart, Gila Kazimirsky, Hadara Rubinfeld, Tehila Hyman, Jolene N. Ayres, Gang Min Hur, Attila Toth, Dazhi Yang, Susan H. Garfield, James C. Stone, and Peter M. Blumberg

PKC Associates with and Is Involved in the Phosphorylation of RasGRP3 in Response to Phorbol Esters
Mol Pharmacol 2004 66: 76-84. [Abstract] [Full Text] [PDF]  

Milena Moretti, Silvia Vailati, Michele Zoli, Giordano Lippi, Loredana Riganti, Renato Longhi, Alessandro Viegi, Francesco Clementi, and Cecilia Gotti

Nicotinic Acetylcholine Receptor Subtypes Expression during Rat Retina Development and Their Regulation by Visual Experience
Mol Pharmacol 2004 66: 85-96. [Abstract] [Full Text] [PDF]  

Elaine A. Gay, Jonathan D. Urban, David E. Nichols, Gerry S. Oxford, and Richard B. Mailman

Functional Selectivity of D₂ Receptor Ligands in a Chinese Hamster Ovary hD_2L Cell Line: Evidence for Induction of Ligand-Specific Receptor States
Mol Pharmacol 2004 66: 97-105. [Abstract] [Full Text] [PDF]  

L. M. Bohn, L. A. Dykstra, R. J. Lefkowitz, M. G. Caron, and L. S. Barak

Relative Opioid Efficacy Is Determined by the Complements of the G Protein-Coupled Receptor Desensitization Machinery
Mol Pharmacol 2004 66: 106-112. [Abstract] [Full Text] [PDF]  

Eric J. Gapud, Ruoli Bai, Arun K. Ghosh, and Ernest Hamel

Laulimalide and Paclitaxel: A Comparison of Their Effects on Tubulin Assembly and Their Synergistic Action When Present Simultaneously
Mol Pharmacol 2004 66: 113-121. [Abstract] [Full Text] [PDF]  

Hyun-Ock Pae, Byung-Min Choi, Gi-Su Oh, Myeong-Su Lee, Do-Gon Ryu, Hyun-Yul Rhew, Yung-Myung Kim, and Hun-Taeg Chung

Roles of Heme Oxygenase-1 in the Antiproliferative and Antiapoptotic Effects of Nitric Oxide on Jurkat T Cells
Mol Pharmacol 2004 66: 122-128. [Abstract] [Full Text] [PDF]  

Preeti Ramadoss and Gary H. Perdew

Use of 2-Azido-3-[¹²⁵I]iodo-7,8-dibromodibenzo-p-dioxin as a Probe to Determine the Relative Ligand Affinity of Human versus Mouse Aryl Hydrocarbon Receptor in Cultured Cells
Mol Pharmacol 2004 66: 129-136. [Abstract] [Full Text] [PDF]  

Margaret E. Gnegy, Habibeh Khoshbouei, Kelly A. Berg, Jonathan A. Javitch, William P. Clarke, Minjia Zhang, and Aurelio Galli

Intracellular Ca²⁺ Regulates Amphetamine-Induced Dopamine Efflux and Currents Mediated by the Human Dopamine Transporter
Mol Pharmacol 2004 66: 137-143. [Abstract] [Full Text] [PDF]  

Mitsi A. Blount, Alfreda Beasley, Roya Zoraghi, Konjeti R. Sekhar, Emmanuel P. Bessay, Sharron H. Francis, and Jackie D. Corbin

Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation
Mol Pharmacol 2004 66: 144-152. [Abstract] [Full Text] [PDF]  

Ming-Biao Yin, Zhan-Rong Li, Shousong Cao, Farukh A. Durrani, Rami G. Azrak, Cheryl Frank, and Youcef M. Rustum

Enhanced 7-Ethyl-10-hydroxycamptothecin (SN-38) Lethality by Methylselenocysteine Is Associated with Chk2 Phosphorylation at Threonine-68 and Down-Regulation of Cdc6 Expression
Mol Pharmacol 2004 66: 153-160. [Abstract] [Full Text] [PDF] NOTICE OF RETRACTION  

Juha-Matti I. Alakoskela, Tim Söderlund, Juha M. Holopainen, and Paavo K. J. Kinnunen

Dipole Potential and Head-Group Spacing Are Determinants for the Membrane Partitioning of Pregnanolone
Mol Pharmacol 2004 66: 161-168. Published online May 21, 2004; 10.1124/mol.104.000075 [Abstract] [Full Text] [PDF]  

Andon N. Placzek, Francesca Grassi, Thaddeus Papke, Edwin M. Meyer, and Roger L. Papke

A Single Point Mutation Confers Properties of the Muscle-Type Nicotinic Acetylcholine Receptor to Homomeric 7 Receptors
Mol Pharmacol 2004 66: 169-177. [Abstract] [Full Text] [PDF]  

Jing Fang, Zongxian Cao, Yi Charlie Chen, Eddie Reed, and Bing-Hua Jiang

9--D-Arabinofuranosyl-2-fluoroadenine Inhibits Expression of Vascular Endothelial Growth Factor through Hypoxia-Inducible Factor-1 in Human Ovarian Cancer Cells
Mol Pharmacol 2004 66: 178-186. [Abstract] [Full Text] [PDF]  

Meei Ling Sheu, Feng Ming Ho, Kuo Fang Chao, Ming Liang Kuo, and Shing Hwa Liu

Activation of Phosphoinositide 3-kinase in Response to High Glucose Leads to Regulation of Reactive Oxygen Species-Related Nuclear Factor-B Activation and Cyclooxygenase-2 Expression in Mesangial Cells
Mol Pharmacol 2004 66: 187-196. [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Characterization of human 42-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells"
Mol Pharmacol 2004 66: 197. [Full Text] [PDF]  

Correction to "Probing receptor structure/function with chimeric G-protein-coupled receptors"
Mol Pharmacol 2004 66: 198. [Full Text] [PDF]  

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