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Pilar Blancafort, David J. Segal, and Carlos F. Barbas, III

Designing Transcription Factor Architectures for Drug Discovery
Mol Pharmacol 2004 66: 1361-1371. Published online August 31, 2004; 10.1124/mol.104.002758 [Abstract] [Full Text] [PDF]  

Articles:

Andreas Daiber, Matthias Oelze, Meike Coldewey, Markus Bachschmid, Philip Wenzel, Karsten Sydow, Maria Wendt, Andrei L. Kleschyov, Dirk Stalleicken, Volker Ullrich, Alexander Mülsch, and Thomas Münzel

Oxidative Stress and Mitochondrial Aldehyde Dehydrogenase Activity: A Comparison of Pentaerythritol Tetranitrate with Other Organic Nitrates
Mol Pharmacol 2004 66: 1372-1382. Published online August 26, 2004; 10.1124/mol.104.002600 [Abstract] [Full Text] [PDF]  

Won-Ho Kim, Won Bong Park, Bin Gao, and Myeong Ho Jung

Critical Role of Reactive Oxygen Species and Mitochondrial Membrane Potential in Korean Mistletoe Lectin-Induced Apoptosis in Human Hepatocarcinoma Cells
Mol Pharmacol 2004 66: 1383-1396. Published online August 31, 2004; 10.1124/mol.104.001347 [Abstract] [Full Text] [PDF]  

Jean-Philippe Annereau, Gergely Szakács, Charles J. Tucker, Angela Arciello, Carol Cardarelli, Jennifer Collins, Sherry Grissom, Barry R. Zeeberg, William Reinhold, John N. Weinstein, Yves Pommier, Richard S. Paules, and Michael M. Gottesman

Analysis of ATP-Binding Cassette Transporter Expression in Drug-Selected Cell Lines by a Microarray Dedicated to Multidrug Resistance
Mol Pharmacol 2004 66: 1397-1405. Published online September 1, 2004; 10.1124/mol.104.005009 [Abstract] [Full Text] [PDF] Data Supplements  

Chrystal M. Paulos, Joseph A. Reddy, Christopher P. Leamon, Mary Jo Turk, and Philip S. Low

Ligand Binding and Kinetics of Folate Receptor Recycling in Vivo: Impact on Receptor-Mediated Drug Delivery
Mol Pharmacol 2004 66: 1406-1414. Published online September 15, 2004; 10.1124/mol.104.003723 [Abstract] [Full Text] [PDF]  

Tomoki Yokochi and Keith D. Robertson

Doxorubicin Inhibits DNMT1, Resulting in Conditional Apoptosis
Mol Pharmacol 2004 66: 1415-1420. Published online August 31, 2004; 10.1124/mol.104.002634 [Abstract] [Full Text] [PDF]  

Louis Gendron, Amélie Perron, Marcel Daniel Payet, Nicole Gallo-Payet, Philippe Sarret, and Alain Beaudet

Low-Affinity Neurotensin Receptor (NTS2) Signaling: Internalization-Dependent Activation of Extracellular Signal-Regulated Kinases 1/2
Mol Pharmacol 2004 66: 1421-1430. Published online September 10, 2004; 10.1124/mol.104.002303 [Abstract] [Full Text] [PDF]  

Christopher N. Davis, Violetta Zujovic, and Jeffrey K. Harrison

Viral Macrophage Inflammatory Protein-II and Fractalkine (CX3CL1) Chimeras Identify Molecular Determinants of Affinity, Efficacy, and Selectivity at CX3CR1
Mol Pharmacol 2004 66: 1431-1439. Published online September 10, 2004; 10.1124/mol.104.003277 [Abstract] [Full Text] [PDF]  

Steven P. Anderson, Corrie Dunn, Ashley Laughter, Lawrence Yoon, Cynthia Swanson, Thomas M. Stulnig, Knut R. Steffensen, Roshantha A.S. Chandraratna, Jan-Åke Gustafsson, and J. Christopher Corton

Overlapping Transcriptional Programs Regulated by the Nuclear Receptors Peroxisome Proliferator-Activated Receptor , Retinoid X Receptor, and Liver X Receptor in Mouse Liver
Mol Pharmacol 2004 66: 1440-1452. Published online September 15, 2004; 10.1124/mol.104.005496 [Abstract] [Full Text] [PDF] Data Supplements  

Stephen C. Tovey and Gary B. Willars

Single-Cell Imaging of Intracellular Ca²⁺ and Phospholipase C Activity Reveals That RGS 2, 3, and 4 Differentially Regulate Signaling via the G_q/11-Linked Muscarinic M₃ Receptor
Mol Pharmacol 2004 66: 1453-1464. Published online September 21, 2004; 10.1124/mol.104.005827 [Abstract] [Full Text] [PDF]  

Ya Jen Chang, Ming Shiang Wu, Jaw Town Lin, Bor Shyang Sheu, Tatsushi Muta, Hiroyasu Inoue, and Ching-Chow Chen

Induction of Cyclooxygenase-2 Overexpression in Human Gastric Epithelial Cells by Helicobacter pylori Involves TLR2/TLR9 and c-Src-Dependent Nuclear Factor-B Activation
Mol Pharmacol 2004 66: 1465-1477. Published online September 29, 2004; 10.1124/mol.104.005199 [Abstract] [Full Text] [PDF]  

George W. Small, Yue Y. Shi, Natalie A. Edmund, Sivagurunathan Somasundaram, Dominic T. Moore, and Robert Z. Orlowski

Evidence That Mitogen-Activated Protein Kinase Phosphatase-1 Induction by Proteasome Inhibitors Plays an Antiapoptotic Role
Mol Pharmacol 2004 66: 1478-1490. Published online September 24, 2004; 10.1124/mol.104.003400 [Abstract] [Full Text] [PDF]  

Sandhya Kortagere, Peter Gmeiner, Harel Weinstein, and John A. Schetz

Certain 1,4-Disubstituted Aromatic Piperidines and Piperazines with Extreme Selectivity for the Dopamine D4 Receptor Interact with a Common Receptor Microdomain
Mol Pharmacol 2004 66: 1491-1499. Published online September 24, 2004; 10.1124/mol.104.001321 [Abstract] [Full Text] [PDF]  

Xuechu Zhen, Satindra Goswami, Syed Amir Abdali, Mara Gil, Kalindi Bakshi, and Eitan Friedman

Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain
Mol Pharmacol 2004 66: 1500-1507. Published online July 30, 2004; 10.1124/mol.104.002279 [Abstract] [Full Text] [PDF]  

Parmesh Dutt, Aron B. Jaffe, Keith D. Merdek, Alan Hall, and Deniz Toksoz

Gz Inhibits Serum Response Factor-Dependent Transcription by Inhibiting Rho Signaling
Mol Pharmacol 2004 66: 1508-1516. Published online August 23, 2004; 10.1124/mol.104.002949 [Abstract] [Full Text] [PDF]  

Hua-Jun Feng and Robert L. Macdonald

Multiple Actions of Propofol on and GABA_A Receptors
Mol Pharmacol 2004 66: 1517-1524. Published online August 26, 2004; 10.1124/mol.104.003426 [Abstract] [Full Text] [PDF]  

H. S. Mason, S. Bourke, and P. J. Kemp

Selective Modulation of Ligand-Gated P2X Purinoceptor Channels by Acute Hypoxia Is Mediated by Reactive Oxygen Species
Mol Pharmacol 2004 66: 1525-1535. Published online August 26, 2004; 10.1124/mol.104.000851 [Abstract] [Full Text] [PDF]  

Lilah Rothem, Michal Stark, and Yehuda G. Assaraf

Impaired CREB-1 Phosphorylation in Antifolate-Resistant Cell Lines with Down-Regulation of the Reduced Folate Carrier Gene
Mol Pharmacol 2004 66: 1536-1543. Published online August 31, 2004; 10.1124/mol.104.004135 [Abstract] [Full Text] [PDF]  

Paul J. Brighton, Philip G. Szekeres, Alan Wise, and Gary B. Willars

Signaling and Ligand Binding by Recombinant Neuromedin U Receptors: Evidence for Dual Coupling to G_q/11 and G_i and an Irreversible Ligand-Receptor Interaction
Mol Pharmacol 2004 66: 1544-1556. Published online August 26, 2004; 10.1124/mol.104.002337 [Abstract] [Full Text] [PDF]  

Alexander Kel, Susanne Reymann, Volker Matys, Paul Nettesheim, Edgar Wingender, and Jürgen Borlak

A Novel Computational Approach for the Prediction of Networked Transcription Factors of Aryl Hydrocarbon-Receptor-Regulated Genes
Mol Pharmacol 2004 66: 1557-1572. Published online September 1, 2004; 10.1124/mol.104.001677 [Abstract] [Full Text] [PDF]  

David J. Roberts, Hong Lin, and Philip G. Strange

Mechanisms of Agonist Action at D₂ Dopamine Receptors
Mol Pharmacol 2004 66: 1573-1579. Published online August 31, 2004; 10.1124/mol.104.004077 [Abstract] [Full Text] [PDF]  

Po-Wei Lee, Sally Wu, and Yu-May Lee

Differential Expression of µ-Opioid Receptor Gene in CXBK and B6 Mice by Sp1
Mol Pharmacol 2004 66: 1580-1584. [Abstract] [Full Text] [PDF]  

S. T. Safrany

Protocols for Regulation and Study of Diphosphoinositol Polyphosphates
Mol Pharmacol 2004 66: 1585-1591. Published online September 1, 2004; 10.1124/mol.104.002667 [Abstract] [Full Text] [PDF]  

Christopher P. Bailey, Eamonn Kelly, and Graeme Henderson

Protein Kinase C Activation Enhances Morphine-Induced Rapid Desensitization of µ-Opioid Receptors in Mature Rat Locus Ceruleus Neurons
Mol Pharmacol 2004 66: 1592-1598. Published online September 10, 2004; 10.1124/mol.104.004747 [Abstract] [Full Text] [PDF]  

Tomoko Kadowaki, Atsuyo Baba, Naoko Abe, Ryosuke Takii, Munetaka Hashimoto, Takayuki Tsukuba, Shinji Okazaki, Yoshimitsu Suda, Tetsuji Asao, and Kenji Yamamoto

Suppression of Pathogenicity of Porphyromonas gingivalis by Newly Developed Gingipain Inhibitors
Mol Pharmacol 2004 66: 1599-1606. Published online September 10, 2004; 10.1124/mol.104.004366 [Abstract] [Full Text] [PDF]  

Yong-Fu Xiao, Qingen Ke, John M. Seubert, J. Alyce Bradbury, Joan Graves, Laura M. DeGraff, John R. Falck, Kris Krausz, Harry V. Gelboin, James P. Morgan, and Darryl C. Zeldin

Enhancement of Cardiac L-Type Ca²⁺ Currents in Transgenic Mice with Cardiac-Specific Overexpression of CYP2J2
Mol Pharmacol 2004 66: 1607-1616. Published online September 10, 2004; 10.1124/mol.104.004150 [Abstract] [Full Text] [PDF]  

Timothy A. Vortherms, Chau H. Nguyen, Catherine H. Berlot, and Val J. Watts

Using Molecular Tools to Dissect the Role of G_s in Sensitization of AC1
Mol Pharmacol 2004 66: 1617-1624. Published online September 10, 2004; 10.1124/mol.104.000166 [Abstract] [Full Text] [PDF]  

Pei-Wen Chen and Glenn S. Kroog

Alterations in Receptor Expression or Agonist Concentration Change the Pathways Gastrin-Releasing Peptide Receptor Uses to Regulate Extracellular Signal-Regulated Kinase
Mol Pharmacol 2004 66: 1625-1634. Published online September 10, 2004; 10.1124/mol.104.001206 [Abstract] [Full Text] [PDF]  

Tara A. Macey, Vsevolod V. Gurevich, and Kim A. Neve

Preferential Interaction between the Dopamine D2 Receptor and Arrestin2 in Neostriatal Neurons
Mol Pharmacol 2004 66: 1635-1642. Published online September 10, 2004; 10.1124/mol.104.001495 [Abstract] [Full Text] [PDF]  

Burkhard Hinz, Robert Ramer, Karin Eichele, Ulrike Weinzierl, and Kay Brune

Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells
Mol Pharmacol 2004 66: 1643-1651. Published online September 10, 2004; 10.1124/mol.104.002618 [Abstract] [Full Text] [PDF]  

Megan M. McNulty and Dorothy A. Hanck

State-Dependent Mibefradil Block of Na⁺ Channels
Mol Pharmacol 2004 66: 1652-1661. [Abstract] [Full Text] [PDF]  

Darrell R. Boverhof, Elaine Tam, Allison S. Harney, Robert B. Crawford, Norbert E. Kaminski, and Timothy R. Zacharewski

2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Suppressor of Cytokine Signaling 2 in Murine B Cells
Mol Pharmacol 2004 66: 1662-1670. Published online September 15, 2004; 10.1124/mol.104.002915 [Abstract] [Full Text] [PDF]  

Gemma Triola, Gemma Fabrias, Mihaela Dragusin, Lars Niederhausen, Roland Broere, Amadeu Llebaria, and Gerhild van Echten-Deckert

Specificity of the Dihydroceramide Desaturase Inhibitor N-[(1R,2S)-2-Hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in Primary Cultured Cerebellar Neurons
Mol Pharmacol 2004 66: 1671-1678. Published online September 15, 2004; 10.1124/mol.104.003681 [Abstract] [Full Text] [PDF]  

Susan J. Smith, Lenora B. Cieslinski, Robert Newton, Louise E. Donnelly, Peter S. Fenwick, Andrew G. Nicholson, Peter J. Barnes, Mary S. Barnette, and Mark A. Giembycz

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8⁺ T-Lymphocytes
Mol Pharmacol 2004 66: 1679-1689. Published online September 15, 2004; 10.1124/mol.104.002246 [Abstract] [Full Text] [PDF]  

Nadine Hempel, Hongbing Wang, Edward L. LeCluyse, Michael E. McManus, and Masahiko Negishi

The Human Sulfotransferase SULT1A1 Gene Is Regulated in a Synergistic Manner by Sp1 and GA Binding Protein
Mol Pharmacol 2004 66: 1690-1701. Published online September 21, 2004; 10.1124/mol.104.003350 [Abstract] [Full Text] [PDF]  

Stephan Steckelbroeck, Yi Jin, Busola Oyesanmi, Helenius J. Kloosterboer, and Trevor M. Penning

Tibolone Is Metabolized by the 3/3-Hydroxysteroid Dehydrogenase Activities of the Four Human Isozymes of the Aldo-Keto Reductase 1C Subfamily: Inversion of Stereospecificity with a ⁵⁽¹⁰⁾-3-Ketosteroid
Mol Pharmacol 2004 66: 1702-1711. Published online September 21, 2004; 10.1124/mol.104.004515 [Abstract] [Full Text] [PDF]  

Anne Cormier, Yoav Paas, Roland Zini, Jean-Paul Tillement, Gilbert Lagrue, Jean-Pierre Changeux, and Régis Grailhe

Long-Term Exposure to Nicotine Modulates the Level and Activity of Acetylcholine Receptors in White Blood Cells of Smokers and Model Mice
Mol Pharmacol 2004 66: 1712-1718. Published online September 21, 2004; 10.1124/mol.104.000463 [Abstract] [Full Text] [PDF]  

Christine Börner, Jürgen Kraus, Helmut Schröder, Hermann Ammer, and Volker Höllt

Transcriptional Regulation of the Human µ-Opioid Receptor Gene by Interleukin-6
Mol Pharmacol 2004 66: 1719-1726. Published online September 24, 2004; 10.1124/mol.104.003806 [Abstract] [Full Text] [PDF]  

Andrew Yen, Robert Fenning, Roshantha Chandraratna, Patricia Walker, and Susi Varvayanis

A Retinoic Acid Receptor /-Selective Prodrug (tazarotene) Plus a Retinoid X Receptor Ligand Induces Extracellular Signal-Regulated Kinase Activation, Retinoblastoma Hypophosphorylation, G₀ Arrest, and Cell Differentiation
Mol Pharmacol 2004 66: 1727-1737. Published online September 21, 2004; 10.1124/mol.104.003475 [Abstract] [Full Text] [PDF]  

Erika Suzuki, Markus Kessler, Kyle Montgomery, and Amy C. Arai

Divergent Effects of the Purinoceptor Antagonists Suramin and Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) (PPNDS) on -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
Mol Pharmacol 2004 66: 1738-1747. Published online September 24, 2004; 10.1124/mol.104.003038 [Abstract] [Full Text] [PDF]  

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