Perspectives:

Olivier Civelli

An Orphan Receptor Adopted by a Family of Transmitters
Mol Pharmacol 2005 67: 583-584. Published online December 16, 2004; 10.1124/mol.104.010348 [Abstract] [Full Text] [PDF] Related Article  

Guiscard Seebohm

Activators of Cation Channels: Potential in Treatment of Channelopathies
Mol Pharmacol 2005 67: 585-588. Published online December 17, 2004; 10.1124/mol.104.010173 [Abstract] [Full Text] [PDF] Related Article  

Accelerated Communications:

Petrine Wellendorph, Kasper B. Hansen, Anders Balsgaard, Jeremy R. Greenwood, Jan Egebjerg, and Hans Bräuner-Osborne

Deorphanization of GPRC6A: A Promiscuous L--Amino Acid Receptor with Preference for Basic Amino Acids
Mol Pharmacol 2005 67: 589-597. Published online December 2, 2004; 10.1124/mol.104.007559 [Abstract] [Full Text] [PDF] data supplement  

Takaaki Hiragun, Ze Peng, and Michael A. Beaven

Dexamethasone Up-Regulates the Inhibitory Adaptor Protein Dok-1 and Suppresses Downstream Activation of the Mitogen-Activated Protein Kinase Pathway in Antigen-Stimulated RBL-2H3 Mast Cells
Mol Pharmacol 2005 67: 598-603. Published online December 17, 2004; 10.1124/mol.104.008607 [Abstract] [Full Text] [PDF]  

Monika Niehof and Jürgen Borlak

RSK4 and PAK5 Are Novel Candidate Genes in Diabetic Rat Kidney and Brain
Mol Pharmacol 2005 67: 604-611. Published online December 22, 2004; 10.1124/mol.104.008672 [Abstract] [Full Text] [PDF]  

Articles:

Kyung-Tae Park, Kristen A. Mitchell, Gengming Huang, and Cornelis J. Elferink

The Aryl Hydrocarbon Receptor Predisposes Hepatocytes to Fas-Mediated Apoptosis
Mol Pharmacol 2005 67: 612-622. Published online November 18, 2004; 10.1124/mol.104.005223 [Abstract] [Full Text] [PDF]  

Jun Gu, Huadong Cui, Melissa Behr, Li Zhang, Qing-Yu Zhang, Weizhu Yang, Jack A. Hinson, and Xinxin Ding

In Vivo Mechanisms of Tissue-Selective Drug Toxicity: Effects of Liver-Specific Knockout of the NADPH-Cytochrome P450 Reductase Gene on Acetaminophen Toxicity in Kidney, Lung, and Nasal Mucosa
Mol Pharmacol 2005 67: 623-630. Published online November 18, 2004; 10.1124/mol.104.007898 [Abstract] [Full Text] [PDF]  

Xiaoguang Sun, Kevin M. Kaltenbronn, Thomas H. Steinberg, and Kendall J. Blumer

RGS2 Is a Mediator of Nitric Oxide Action on Blood Pressure and Vasoconstrictor Signaling
Mol Pharmacol 2005 67: 631-639. Published online November 24, 2004; 10.1124/mol.104.007724 [Abstract] [Full Text] [PDF]  

Aaron N. Hata, Terry P. Lybrand, Lawrence J. Marnett, and Richard M. Breyer

Structural Determinants of Arylacetic Acid Nonsteroidal Anti-Inflammatory Drugs Necessary for Binding and Activation of the Prostaglandin D₂ Receptor CRTH2
Mol Pharmacol 2005 67: 640-647. Published online November 24, 2004; 10.1124/mol.104.007971 [Abstract] [Full Text] [PDF]  

Amal Robay, Gilles Toumaniantz, Véronique Leblais, and Chantal Gauthier

Transfected 3- but Not 2-Adrenergic Receptors Regulate Cystic Fibrosis Transmembrane Conductance Regulator Activity via a New Pathway Involving the Mitogen-Activated Protein Kinases Extracellular Signal-Regulated Kinases
Mol Pharmacol 2005 67: 648-654. Published online November 24, 2004; 10.1124/mol.104.002097 [Abstract] [Full Text] [PDF]  

Nicholas D. Holliday, Chi-Wing Lam, Iain R. Tough, and Helen M. Cox

Role of the C Terminus in Neuropeptide Y Y Receptor Desensitization and Internalization
Mol Pharmacol 2005 67: 655-664. Published online December 2, 2004; 10.1124/mol.104.006114 [Abstract] [Full Text] [PDF] Data Supplement  

Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri, and Hideyuki Yamada

Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4
Mol Pharmacol 2005 67: 665-672. Published online December 20, 2004; 10.1124/mol.104.007641 [Abstract] [Full Text] [PDF]  

Ken-Ichiro Inoue, Hirohisa Takano, Akinori Shimada, Rie Yanagisawa, Miho Sakurai, Shin Yoshino, Hiroyuki Sato, and Toshikazu Yoshikawa

Urinary Trypsin Inhibitor Protects against Systemic Inflammation Induced by Lipopolysaccharide
Mol Pharmacol 2005 67: 673-680. Published online December 2, 2004; 10.1124/mol.104.005967 [Abstract] [Full Text] [PDF]  

Anja J. Stauber, Holly Brown-Borg, Jie Liu, Michael P. Waalkes, Ashley Laughter, Rebecca A. Staben, Jaqueline C. Coley, Cynthia Swanson, Kenneth A. Voss, John J. Kopchick, and J. Christopher Corton

Constitutive Expression of Peroxisome Proliferator-Activated Receptor -Regulated Genes in Dwarf Mice
Mol Pharmacol 2005 67: 681-694. Published online December 2, 2004; 10.1124/mol.104.007278 [Abstract] [Full Text] [PDF]  

Hiroko Nakata and Tohru Kozasa

Functional Characterization of Go Signaling through G Protein-Regulated Inducer of Neurite Outgrowth 1
Mol Pharmacol 2005 67: 695-702. Published online December 7, 2004; 10.1124/mol.104.003913 [Abstract] [Full Text] [PDF]  

Anne Frandsen, Darryl S. Pickering, Bente Vestergaard, Christina Kasper, Bettina Bryde Nielsen, Jeremy R. Greenwood, Giuseppe Campiani, Caterina Fattorusso, Michael Gajhede, Arne Schousboe, and Jette Sandholm Kastrup

Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
Mol Pharmacol 2005 67: 703-713. Published online December 9, 2004; 10.1124/mol.104.002931 [Abstract] [Full Text] [PDF]  

Garet P. Lahvis, Robert W. Pyzalski, Edward Glover, Henry C. Pitot, Matthew K. McElwee, and Christopher A. Bradfield

The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse
Mol Pharmacol 2005 67: 714-720. Published online December 8, 2004; 10.1124/mol.104.008888 [Abstract] [Full Text] [PDF] Data Supplement  

Anthony Baurand, Anita Eckly, Béatrice Hechler, Gilles Kauffenstein, Jean-Luc Galzi, Jean-Pierre Cazenave, Catherine Léon, and Christian Gachet

Differential Regulation and Relocalization of the Platelet P2Y Receptors after Activation: A Way to Avoid Loss of Hemostatic Properties?
Mol Pharmacol 2005 67: 721-733. Published online December 15, 2004; 10.1124/mol.104.004846 [Abstract] [Full Text] [PDF] Data Supplement  

Yukio Kato, Yoshimichi Sai, Kazuhiro Yoshida, Chizuru Watanabe, Tadayoshi Hirata, and Akira Tsuji

PDZK1 Directly Regulates the Function of Organic Cation/Carnitine Transporter OCTN2
Mol Pharmacol 2005 67: 734-743. Published online November 2, 2004; 10.1124/mol.104.002212 [Abstract] [Full Text] [PDF]  

V. Krishnan, H. A. Bullock, B. C. Yaden, M. Liu, R. J. Barr, C. Montrose-Rafizadeh, K. Chen, J. A. Dodge, and H. U. Bryant

The Nongenotropic Synthetic Ligand 4-Estren-317-diol Is a High-Affinity Genotropic Androgen Receptor Agonist
Mol Pharmacol 2005 67: 744-748. Published online November 22, 2004; 10.1124/mol.104.005272 [Abstract] [Full Text] [PDF]  

Masuo Kondoh, Akane Masuyama, Azusa Takahashi, Nagayoshi Asano, Hiroyuki Mizuguchi, Naoya Koizumi, Makiko Fujii, Takao Hayakawa, Yasuhiko Horiguchi, and Yoshiteru Watanbe

A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator
Mol Pharmacol 2005 67: 749-756. Published online December 15, 2004; 10.1124/mol.104.008375 [Abstract] [Full Text] [PDF]  

Kurt Watson and Guo-Huang Fan

Macrophage Inflammatory Protein 2 Inhibits -Amyloid Peptide (1-42)-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Signaling Pathways
Mol Pharmacol 2005 67: 757-765. Published online December 17, 2004; 10.1124/mol.104.004812 [Abstract] [Full Text] [PDF]  

Tomohiko Kanayama, Naoki Kobayashi, Satoru Mamiya, Tsuyoshi Nakanishi, and Jun-ichi Nishikawa

Organotin Compounds Promote Adipocyte Differentiation as Agonists of the Peroxisome Proliferator-Activated Receptor /Retinoid X Receptor Pathway
Mol Pharmacol 2005 67: 766-774. Published online December 20, 2004; 10.1124/mol.104.008409 [Abstract] [Full Text] [PDF]  

Patrick S. Mangan, Chengsan Sun, Mackenzie Carpenter, Howard P. Goodkin, Werner Sieghart, and Jaideep Kapur

Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABA_A Receptors
Mol Pharmacol 2005 67: 775-788. Published online December 21, 2004; 10.1124/mol.104.007385 [Abstract] [Full Text] [PDF]  

Nathan Sandbo, Yimin Qin, Sebastien Taurin, D. Kyle Hogarth, Barry Kreutz, and Nickolai O. Dulin

Regulation of Serum Response Factor-Dependent Gene Expression by Proteasome Inhibitors
Mol Pharmacol 2005 67: 789-797. Published online November 18, 2004; 10.1124/mol.104.006874 [Abstract] [Full Text] [PDF]  

Christian Grimm, Robert Kraft, Günter Schultz, and Christian Harteneck

Activation of the Melastatin-Related Cation Channel TRPM3 by D-erythro-Sphingosine
Mol Pharmacol 2005 67: 798-805. Published online November 18, 2004; 10.1124/mol.104.006734 [Abstract] [Full Text] [PDF] Erratum  

Chih-Hung Hsu, Jieh-Yuan Liou, Ginger E. Dutschman, and Yung-Chi Cheng

Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium
Mol Pharmacol 2005 67: 806-814. Published online November 18, 2004; 10.1124/mol.104.006098 [Abstract] [Full Text] [PDF]  

Lars-Göran Bladh, Johan Lidén, Karin Dahlman-Wright, Mark Reimers, Stefan Nilsson, and Sam Okret

Identification of Endogenous Glucocorticoid Repressed Genes Differentially Regulated by a Glucocorticoid Receptor Mutant Able to Separate between Nuclear Factor-B and Activator Protein-1 Repression
Mol Pharmacol 2005 67: 815-826. Published online November 18, 2004; 10.1124/mol.104.005801 [Abstract] [Full Text] [PDF]  

Jiesheng Kang, Xiao-Liang Chen, Hongge Wang, Junzhi Ji, Hsien Cheng, Josephine Incardona, William Reynolds, Fabrice Viviani, Michel Tabart, and David Rampe

Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K⁺ Channel
Mol Pharmacol 2005 67: 827-836. Published online November 17, 2004; 10.1124/mol.104.006577 [Abstract] [Full Text] [PDF]  

Christopher J. Endres and Jashvant D. Unadkat

Residues Met89 and Ser160 in the Human Equilibrative Nucleoside Transporter 1 Affect Its Affinity for Adenosine, Guanosine, S⁶-(4-Nitrobenzyl)-mercaptopurine Riboside, and Dipyridamole
Mol Pharmacol 2005 67: 837-844. Published online November 19, 2004; 10.1124/mol.104.008102 [Abstract] [Full Text] [PDF]  

Junko Sugatani, Shinichi Nishitani, Kasumi Yamakawa, Kouichi Yoshinari, Tatsuya Sueyoshi, Masahiko Negishi, and Masao Miwa

Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting Protein 1
Mol Pharmacol 2005 67: 845-855. Published online November 22, 2004; 10.1124/mol.104.007161 [Abstract] [Full Text] [PDF]  

Cornelia Poulopoulou, Ioannis Markakis, Panagiota Davaki, Chryssoula Nikolaou, Alexandros Poulopoulos, Euclides Raptis, and Dimitrios Vassilopoulos

Modulation of Voltage-Gated Potassium Channels in Human T Lymphocytes by Extracellular Glutamate
Mol Pharmacol 2005 67: 856-867. [Abstract] [Full Text] [PDF]  

Fanfan Zhou, Wen Xu, Mei Hong, Zui Pan, Patrick J. Sinko, Jianjie Ma, and Guofeng You

The Role of N-Linked Glycosylation in Protein Folding, Membrane Targeting, and Substrate Binding of Human Organic Anion Transporter hOAT4
Mol Pharmacol 2005 67: 868-876. Published online December 2, 2004; 10.1124/mol.104.007583 [Abstract] [Full Text] [PDF]  

Brian J. Philips, Aileen Y. Chang, Peter B. Dervan, and Terry A. Beerman

DNA Damage Effects of a Polyamide-CBI Conjugate in SV40 Virions
Mol Pharmacol 2005 67: 877-882. Published online December 2, 2004; 10.1124/mol.104.006254 [Abstract] [Full Text] [PDF]  

Martin Bartsch, Alida H. Weeke-Klimp, Henriëtte W. M. Morselt, Andrea Kimpfler, Sigridur A. Ásgeirsdóttir, Rolf Schubert, Dirk K. F. Meijer, Gerrit L. Scherphof, and Jan A. A. M. Kamps

Optimized Targeting of Polyethylene Glycol-Stabilized Anti-Intercellular Adhesion Molecule 1 Oligonucleotide/Lipid Particles to Liver Sinusoidal Endothelial Cells
Mol Pharmacol 2005 67: 883-890. Published online December 14, 2004; 10.1124/mol.104.004523 [Abstract] [Full Text] [PDF]  

Ashish S. Verma, Ravindra N. Dhir, and Bernard H. Shapiro

Inadequacy of the Janus Kinase 2/Signal Transducer and Activator of Transcription Signal Transduction Pathway to Mediate Episodic Growth Hormone-Dependent Regulation of Hepatic CYP2C11
Mol Pharmacol 2005 67: 891-901. Published online December 9, 2004; 10.1124/mol.104.005454 [Abstract] [Full Text] [PDF]  

Karin F. K. Ejendal and Christine A. Hrycyna

Differential Sensitivities of the Human ATP-Binding Cassette Transporters ABCG2 and P-Glycoprotein to Cyclosporin A
Mol Pharmacol 2005 67: 902-911. Published online December 14, 2004; 10.1124/mol.104.001701 [Abstract] [Full Text] [PDF]  

Chihiro Hosoda, Taka-aki Koshimizu, Akito Tanoue, Yoshihisa Nasa, Ryo Oikawa, Takashi Tomabechi, Shinya Fukuda, Hitomi Shinoura, Sayuri Oshikawa, Satoshi Takeo, Tadaichi Kitamura, Susanna Cotecchia, and Gozoh Tsujimoto

Two ₁-Adrenergic Receptor Subtypes Regulating the Vasopressor Response Have Differential Roles in Blood Pressure Regulation
Mol Pharmacol 2005 67: 912-922. Published online December 14, 2004; 10.1124/mol.104.007500 [Abstract] [Full Text] [PDF]  

Yasuhisa Adachi, Hiroshi Suzuki, Alfred H. Schinkel, and Yuichi Sugiyama

Role of Breast Cancer Resistance Protein (Bcrp1/Abcg2) in the Extrusion of Glucuronide and Sulfate Conjugates from Enterocytes to Intestinal Lumen
Mol Pharmacol 2005 67: 923-928. Published online December 14, 2004; 10.1124/mol.104.007393 [Abstract] [Full Text] [PDF]  

Peter Kometiani, Lijun Liu, and Amir Askari

Digitalis-Induced Signaling by Na⁺/K⁺-ATPase in Human Breast Cancer Cells
Mol Pharmacol 2005 67: 929-936. Published online December 15, 2004; 10.1124/mol.104.007302 [Abstract] [Full Text] [PDF]  

Brian B. Hasinoff, Xing Wu, Oleg V. Krokhin, Werner Ens, Kenneth G. Standing, John L. Nitiss, Tejomoortula Sivaram, Angela Giorgianni, Shaohua Yang, Yu Jiang, and Jack C. Yalowich

Biochemical and Proteomics Approaches to Characterize Topoisomerase II Cysteines and DNA as Targets Responsible for Cisplatin-Induced Inhibition of Topoisomerase II
Mol Pharmacol 2005 67: 937-947. Published online December 15, 2004; 10.1124/mol.104.004416 [Abstract] [Full Text] [PDF]  

Thomas P. Burris, Chahrzad Montrose, Keith A. Houck, Harold E. Osborne, Wayne P. Bocchinfuso, Benjamin C. Yaden, Christine C. Cheng, Richard W. Zink, Robert J. Barr, Christoper D. Hepler, Venkatesh Krishnan, Heather A. Bullock, Lorri L. Burris, Rachelle J. Galvin, Kelli Bramlett, and Keith R. Stayrook

The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand
Mol Pharmacol 2005 67: 948-954. Published online December 15, 2004; 10.1124/mol.104.007054 [Abstract] [Full Text] [PDF]  

Simone Gorzalka, Sauro Vittori, Rosaria Volpini, Gloria Cristalli, Ivar von Kügelgen, and Christa E. Müller

Evidence for the Functional Expression and Pharmacological Characterization of Adenine Receptors in Native Cells and Tissues
Mol Pharmacol 2005 67: 955-964. Published online December 16, 2004; 10.1124/mol.104.006601 [Abstract] [Full Text] [PDF]  

Catherine Mollereau, Honoré Mazarguil, Jean-Marie Zajac, and Michel Roumy

Neuropeptide FF (NPFF) Analogs Functionally Antagonize Opioid Activities in NPFF₂ Receptor-Transfected SH-SY5Y Neuroblastoma Cells
Mol Pharmacol 2005 67: 965-975. Published online December 17, 2004; 10.1124/mol.104.004614 [Abstract] [Full Text] [PDF]  

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