Perspectives:

William P. Clarke

What's for Lunch at the Conformational Cafeteria?
Mol Pharmacol 2005 67: 1819-1821. Published online March 22, 2005; 10.1124/mol.105.013060 [Abstract] [Full Text] [PDF] Related Article  

Accelerated Communications:

Joanna Lawrence, Stuart J. Mundell, Hongruo Yun, Eamonn Kelly, and Kanamarlapudi Venkateswarlu

Centaurin-₁, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits ₂-Adrenoceptor Internalization
Mol Pharmacol 2005 67: 1822-1828. Published online March 18, 2005; 10.1124/mol.105.011338 [Abstract] [Full Text] [PDF]  

O. Boijoux, C. Boutonnet, C. Giamarchi, G. Favre, S. Vagner, and J. C. Faye

Chemical-Based Translational Induction of Luciferase Expression: An Efficient Tool for in Vivo Screening of Protein Farnesylation Inhibitors
Mol Pharmacol 2005 67: 1829-1833. Published online March 22, 2005; 10.1124/mol.105.011163 [Abstract] [Full Text] [PDF]  

Articles:

François G. Gervais, Jean-Pierre Morello, Christian Beaulieu, Nicole Sawyer, Danielle Denis, Gillian Greig, A. Daniel Malebranche, and Gary P. O'Neill

Identification of a Potent and Selective Synthetic Agonist at the CRTH2 Receptor
Mol Pharmacol 2005 67: 1834-1839. Published online March 8, 2005; 10.1124/mol.104.009068 [Abstract] [Full Text] [PDF]  

Juan Guo and Stephen R. Ikeda

Coupling of Metabotropic Glutamate Receptor 8 to N-Type Ca²⁺ Channels in Rat Sympathetic Neurons
Mol Pharmacol 2005 67: 1840-1851. Published online March 8, 2005; 10.1124/mol.105.010975 [Abstract] [Full Text] [PDF]  

Tsuyoshi Okuda, Xinjian Lin, Julie Trang, and Stephen B. Howell

Suppression of hREV1 Expression Reduces the Rate at Which Human Ovarian Carcinoma Cells Acquire Resistance to Cisplatin
Mol Pharmacol 2005 67: 1852-1860. Published online March 9, 2005; 10.1124/mol.104.010579 [Abstract] [Full Text] [PDF]  

Qin M. Chen, Donnia Alexander, Haipeng Sun, Lifang Xie, Yan Lin, Jerome Terrand, Steve Morrissy, and Sally Purdom

Corticosteroids Inhibit Cell Death Induced by Doxorubicin in Cardiomyocytes: Induction of Antiapoptosis, Antioxidant, and Detoxification Genes
Mol Pharmacol 2005 67: 1861-1873. Published online March 8, 2005; 10.1124/mol.104.003814 [Abstract] [Full Text] [PDF]  

Michal Harel, Janice L. Hyatt, Boris Brumshtein, Christopher L. Morton, Kyoung Jin P. Yoon, Randy M. Wadkins, Israel Silman, Joel L. Sussman, and Philip M. Potter

The Crystal Structure of the Complex of the Anticancer Prodrug 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica Acetylcholinesterase Provides a Molecular Explanation for Its Cholinergic Action
Mol Pharmacol 2005 67: 1874-1881. Published online March 16, 2005; 10.1124/mol.104.009944 [Abstract] [Full Text] [PDF]  

Sabine Traver, Bénédicte Salthun-Lassalle, Marc Marien, Etienne C. Hirsch, Francis Colpaert, and Patrick P. Michel

The Neurotransmitter Noradrenaline Rescues Septal Cholinergic Neurons in Culture from Degeneration Caused by Low-Level Oxidative Stress
Mol Pharmacol 2005 67: 1882-1891. Published online March 22, 2005; 10.1124/mol.104.007864 [Abstract] [Full Text] [PDF]  

Maoqing Dong, Elizabeth M. Hadac, Delia I. Pinon, and Laurence J. Miller

Differential Spatial Approximation between Cholecystokinin Residue 30 and Receptor Residues in Active and Inactive Conformations
Mol Pharmacol 2005 67: 1892-1900. Published online March 17, 2005; 10.1124/mol.105.012179 [Abstract] [Full Text] [PDF]  

Dario Bonanomi, Maria Pennuto, Michela Rigoni, Ornella Rossetto, Cesare Montecucco, and Flavia Valtorta

Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the Interaction of Synaptophysin I with VAMP2
Mol Pharmacol 2005 67: 1901-1908. Published online February 4, 2005; 10.1124/mol.104.005678 [Abstract] [Full Text] [PDF]  

Rex A. Parker, Oliver P. Flint, Ruth Mulvey, Carolina Elosua, Faye Wang, William Fenderson, Shulin Wang, Wen-Pin Yang, and Mustafa A. Noor

Endoplasmic Reticulum Stress Links Dyslipidemia to Inhibition of Proteasome Activity and Glucose Transport by HIV Protease Inhibitors
Mol Pharmacol 2005 67: 1909-1919. Published online March 8, 2005; 10.1124/mol.104.010165 [Abstract] [Full Text] [PDF]  

Derek A. Wallace, Lee Ann Johnston, Elaine Huston, Douglas MacMaster, Thomas M. Houslay, York-Fong Cheung, Lachlan Campbell, Jenni E. Millen, Robin A. Smith, Irene Gall, Richard G. Knowles, Michael Sullivan, and Miles D. Houslay

Identification and Characterization of PDE4A11, a Novel, Widely Expressed Long Isoform Encoded by the Human PDE4A cAMP Phosphodiesterase Gene
Mol Pharmacol 2005 67: 1920-1934. Published online February 28, 2005; 10.1124/mol.104.009423 [Abstract] [Full Text] [PDF] Data Supplement  

Attila Szanto and Laszlo Nagy

Retinoids Potentiate Peroxisome Proliferator-Activated Receptor Action in Differentiation, Gene Expression, and Lipid Metabolic Processes in Developing Myeloid Cells
Mol Pharmacol 2005 67: 1935-1943. Published online March 1, 2005; 10.1124/mol.104.006445 [Abstract] [Full Text] [PDF] Data Supplement  

Lea Payen, Mian Gao, Christopher Westlake, Ashley Theis, Susan P. C. Cole, and Roger G. Deeley

Functional Interactions Between Nucleotide Binding Domains and Leukotriene C₄ Binding Sites of Multidrug Resistance Protein 1 (ABCC1)
Mol Pharmacol 2005 67: 1944-1953. Published online March 8, 2005; 10.1124/mol.104.007708 [Abstract] [Full Text] [PDF]  

Oliver Burk, Katja A. Arnold, Andreas K. Nussler, Elke Schaeffeler, Ekaterina Efimova, Bonnie A. Avery, Mitchell A. Avery, Martin F. Fromm, and Michel Eichelbaum

Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor
Mol Pharmacol 2005 67: 1954-1965. Published online March 10, 2005; 10.1124/mol.104.009019 [Abstract] [Full Text] [PDF]  

Bernard Lagane, Sébastien Ballet, Thierry Planchenault, Karl Balabanian, Emmanuel Le Poul, Cédric Blanpain, Yann Percherancier, Isabelle Staropoli, Gilbert Vassart, Martin Oppermann, Marc Parmentier, and Françoise Bachelerie

Mutation of the DRY Motif Reveals Different Structural Requirements for the CC Chemokine Receptor 5-Mediated Signaling and Receptor Endocytosis
Mol Pharmacol 2005 67: 1966-1976. Published online March 10, 2005; 10.1124/mol.104.009779 [Abstract] [Full Text] [PDF]  

Roger L. Papke, Joshua D. Buhr, Michael M. Francis, Kyung Il Choi, Jeffrey S. Thinschmidt, and Nicole A. Horenstein

The Effects of Subunit Composition on the Inhibition of Nicotinic Receptors by the Amphipathic Blocker 2,2,6,6-Tetramethylpiperidin-4-yl Heptanoate
Mol Pharmacol 2005 67: 1977-1990. Published online March 10, 2005; 10.1124/mol.105.011676 [Abstract] [Full Text] [PDF]  

María Gómez-Benito, Isabel Marzo, Alberto Anel, and Javier Naval

Farnesyltransferase Inhibitor BMS-214662 Induces Apoptosis in Myeloma Cells through PUMA Up-Regulation, Bax and Bak Activation, and Mcl-1 Elimination
Mol Pharmacol 2005 67: 1991-1998. Published online February 28, 2005; 10.1124/mol.104.007021 [Abstract] [Full Text] [PDF]  

Aloys L. A. Sesink, Ilja C. W. Arts, Vincent C. J. de Boer, Pauline Breedveld, Jan H. M. Schellens, Peter C. H. Hollman, and Frans G. M. Russel

Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Net Intestinal Uptake of Quercetin in Rats by Facilitating Apical Efflux of Glucuronides
Mol Pharmacol 2005 67: 1999-2006. Published online March 4, 2005; 10.1124/mol.104.009753 [Abstract] [Full Text] [PDF]  

Cecilia Gotti, Milena Moretti, Francesco Clementi, Loredana Riganti, J. Michael McIntosh, Allan C. Collins, Michael J. Marks, and Paul Whiteaker

Expression of Nigrostriatal 6-Containing Nicotinic Acetylcholine Receptors Is Selectively Reduced, but Not Eliminated, by 3 Subunit Gene Deletion
Mol Pharmacol 2005 67: 2007-2015. Published online March 4, 2005; 10.1124/mol.105.011940 [Abstract] [Full Text] [PDF]  

Somnath Mukhopadhyay and Allyn C. Howlett

Chemically Distinct Ligands Promote Differential CB₁ Cannabinoid Receptor-Gi Protein Interactions
Mol Pharmacol 2005 67: 2016-2024. Published online March 4, 2005; 10.1124/mol.104.003558 [Abstract] [Full Text] [PDF]  

Dezheng Zhao, Yanai Zhan, Huiyan Zeng, Hon-Wai Koon, Mary P. Moyer, and Charalabos Pothoulakis

Neurotensin Stimulates Interleukin-8 Expression through Modulation of IB Phosphorylation and p65 Transcriptional Activity: Involvement of Protein Kinase C
Mol Pharmacol 2005 67: 2025-2031. Published online March 8, 2005; 10.1124/mol.104.010801 [Abstract] [Full Text] [PDF]  

Guilin Wang, Tiancheng Liu, Li-Na Wei, Ping-Yee Law, and Horace H. Loh

DNA Methylation-Related Chromatin Modification in the Regulation of Mouse -Opioid Receptor Gene
Mol Pharmacol 2005 67: 2032-2039. Published online March 15, 2005; 10.1124/mol.105.011056 [Abstract] [Full Text] [PDF]  

R. Benjamin Free, Susan B. McKay, Paul D. Gottlieb, R. Thomas Boyd, and Dennis B. McKay

Expression of Native 34* Neuronal Nicotinic Receptors: Binding and Functional Studies Investigating Turnover of Surface and Intracellular Receptor Populations
Mol Pharmacol 2005 67: 2040-2048. Published online March 16, 2005; 10.1124/mol.104.009282 [Abstract] [Full Text] [PDF]  

Rangnath Mishra, Yuan Wang, and Michael S. Simonson

Cell Cycle Signaling by Endothelin-1 Requires Src Nonreceptor Protein Tyrosine Kinase
Mol Pharmacol 2005 67: 2049-2056. Published online March 16, 2005; 10.1124/mol.104.010546 [Abstract] [Full Text] [PDF]  

Lei-Chin Chen, Ben-Kuen Chen, and Wen-Chang Chang

Activating Protein 1-Mediated Cyclooxygenase-2 Expression Is Independent of N-Terminal Phosphorylation of c-Jun
Mol Pharmacol 2005 67: 2057-2069. Published online March 16, 2005; 10.1124/mol.104.010900 [Abstract] [Full Text] [PDF]  

Jingcai Chen, Chester Kuei, Steven Sutton, Sandy Wilson, Jingxue Yu, Fredrik Kamme, Curt Mazur, Timothy Lovenberg, and Changlu Liu

Identification and Pharmacological Characterization of Prokineticin 2 as a Selective Ligand for Prokineticin Receptor 1
Mol Pharmacol 2005 67: 2070-2076. Published online March 16, 2005; 10.1124/mol.105.011619 [Abstract] [Full Text] [PDF]  

Lankupalle D. Jayanthi, Devadoss J. Samuvel, Randy D. Blakely, and Sammanda Ramamoorthy

Evidence for Biphasic Effects of Protein Kinase C on Serotonin Transporter Function, Endocytosis, and Phosphorylation
Mol Pharmacol 2005 67: 2077-2087. Published online March 17, 2005; 10.1124/mol.104.009555 [Abstract] [Full Text] [PDF]  

Celia P. Martínez-Jiménez, M. José Gómez-Lechón, José V. Castell, and Ramiro Jover

Transcriptional Regulation of the Human Hepatic CYP3A4: Identification of a New Distal Enhancer Region Responsive to CCAAT/Enhancer-Binding Protein Isoforms (Liver Activating Protein and Liver Inhibitory Protein)
Mol Pharmacol 2005 67: 2088-2101. Published online March 18, 2005; 10.1124/mol.104.008169 [Abstract] [Full Text] [PDF]  

Richard D. Peavy, Katherine B. Hubbard, Anthony Lau, R. Brett Fields, Kaiming Xu, C. Justin Lee, Terri T. Lee, Kimberly Gernert, T. J. Murphy, and John R. Hepler

Differential Effects of Gq, G14, and G15 on Vascular Smooth Muscle Cell Survival and Gene Expression Profiles
Mol Pharmacol 2005 67: 2102-2114. Published online March 23, 2005; 10.1124/mol.104.007799 [Abstract] [Full Text] [PDF]  

Mei Qiang, C. S. Sheela Rani, and Maharaj K. Ticku

Neuron-Restrictive Silencer Factor Regulates the N-Methyl-D-aspartate Receptor 2B Subunit Gene in Basal and Ethanol-Induced Gene Expression in Fetal Cortical Neurons
Mol Pharmacol 2005 67: 2115-2125. Published online March 8, 2005; 10.1124/mol.104.010751 [Abstract] [Full Text] [PDF]  

C. S. Sheela Rani, Mei Qiang, and Maharaj K. Ticku

Potential Role of cAMP Response Element-Binding Protein in Ethanol-Induced N-Methyl-D-aspartate Receptor 2B Subunit Gene Transcription in Fetal Mouse Cortical Cells
Mol Pharmacol 2005 67: 2126-2136. Published online March 17, 2005; 10.1124/mol.104.007872 [Abstract] [Full Text] [PDF]  

Stefania Gessi, Katia Varani, Stefania Merighi, Elena Cattabriga, Cecilia Pancaldi, Youri Szabadkai, Rosario Rizzuto, Karl-Norbert Klotz, Edward Leung, Stephen Mac Lennan, Pier Giovanni Baraldi, and Pier Andrea Borea

Expression, Pharmacological Profile, and Functional Coupling of A_2B Receptors in a Recombinant System and in Peripheral Blood Cells Using a Novel Selective Antagonist Radioligand, [³H]MRE 2029-F20
Mol Pharmacol 2005 67: 2137-2147. Published online March 23, 2005; 10.1124/mol.104.009225 [Abstract] [Full Text] [PDF]  

Marcel Fechir, Katrin Linker, Andrea Pautz, Thomas Hubrich, Ulrich Förstermann, Fernando Rodriguez-Pascual, and Hartmut Kleinert

Tristetraprolin Regulates the Expression of the Human Inducible Nitric-Oxide Synthase Gene
Mol Pharmacol 2005 67: 2148-2161. Published online March 18, 2005; 10.1124/mol.104.008763 [Abstract] [Full Text] [PDF]  

Henrique Cheng, Justin A. Grodnitzky, Sirintorn Yibchok-anun, Jing Ding, and Walter H. Hsu

Somatostatin Increases Phospholipase D Activity and Phosphatidylinositol 4,5-bisphosphate Synthesis in Clonal Cells HIT-T15
Mol Pharmacol 2005 67: 2162-2172. Published online March 22, 2005; 10.1124/mol.104.010470 [Abstract] [Full Text] [PDF]  

Danxin Wang, Xiaochun Sun, Laura M. Bohn, and Wolfgang Sadée

Opioid Receptor Homo- and Heterodimerization in Living Cells by Quantitative Bioluminescence Resonance Energy Transfer
Mol Pharmacol 2005 67: 2173-2184. Published online March 18, 2005; 10.1124/mol.104.010272 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "From Plants to Man: The GPCR `Tree of Life'"
Mol Pharmacol 2005 67: 2185. [Full Text] [PDF]  

Correction to "Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of Mammalian Endoplasmic Reticulum P450 Proteins"
Mol Pharmacol 2005 67: 2186. [Full Text] [PDF]  

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