Perspectives:

Thomas Wieland and Martin C. Michel

Can a GDP-Liganded G-Protein Be Active?
Mol Pharmacol 2005 68: 559-562. Published online June 24, 2005; 10.1124/mol.105.016071 [Abstract] [Full Text] [PDF] Related Article  

Miles D. Houslay

The Long and Short of Vascular Smooth Muscle Phosphodiesterase-4 As a Putative Therapeutic Target
Mol Pharmacol 2005 68: 563-567. Published online June 15, 2005; 10.1124/mol.105.015719 [Abstract] [Full Text] [PDF] Related Article  

Articles:

Christopher H. So, George Varghese, Kevin J. Curley, Michael M. C. Kong, Mohammed Alijaniaram, Xiaodong Ji, Tuan Nguyen, Brian F. O'Dowd, and Susan R. George

D1 and D2 Dopamine Receptors Form Heterooligomers and Cointernalize after Selective Activation of Either Receptor
Mol Pharmacol 2005 68: 568-578. Published online May 27, 2005; 10.1124/mol.105.012229 [Abstract] [Full Text] [PDF]  

Andreas Daiber, Matthias Oelze, Silke Sulyok, Meike Coldewey, Eberhard Schulz, Nicolai Treiber, Ulrich Hink, Alexander Mülsch, Karin Scharffetter-Kochanek, and Thomas Münzel

Heterozygous Deficiency of Manganese Superoxide Dismutase in Mice (Mn-SOD^+/-): A Novel Approach to Assess the Role of Oxidative Stress for the Development of Nitrate Tolerance
Mol Pharmacol 2005 68: 579-588. Published online June 2, 2005; 10.1124/mol.105.011585 [Abstract] [Full Text] [PDF]  

Federico Geiser, Alexandra Lüscher, Harry P. de Koning, Thomas Seebeck, and Pascal Mäser

Molecular Pharmacology of Adenosine Transport in Trypanosoma brucei: P1/P2 Revisited
Mol Pharmacol 2005 68: 589-595. Published online June 2, 2005; 10.1124/mol.104.010298 [Abstract] [Full Text] [PDF]  

Douglas G. Tilley and Donald H. Maurice

Vascular Smooth Muscle Cell Phenotype-Dependent Phosphodiesterase 4D Short Form Expression: Role of Differential Histone Acetylation on cAMP-Regulated Function
Mol Pharmacol 2005 68: 596-605. Published online June 3, 2005; 10.1124/mol.105.014126 [Abstract] [Full Text] [PDF]  

Gary K. Scott, Christian Atsriku, Patrick Kaminker, Jason Held, Brad Gibson, Michael A. Baldwin, and Christopher C. Benz

Vitamin K3 (Menadione)-Induced Oncosis Associated with Keratin 8 Phosphorylation and Histone H3 Arylation
Mol Pharmacol 2005 68: 606-615. Published online June 6, 2005; 10.1124/mol.105.013474 [Abstract] [Full Text] [PDF]  

Lilah Rothem, Bluma Berman, Michal Stark, Gerrit Jansen, and Yehuda G. Assaraf

The Reduced Folate Carrier Gene Is a Novel Selectable Marker for Recombinant Protein Overexpression
Mol Pharmacol 2005 68: 616-624. Published online June 6, 2005; 10.1124/mol.105.013540 [Abstract] [Full Text] [PDF]  

Andrzej Skladanowski, Marie-George Côme, Michal Sabisz, Alexandre E. Escargueil, and Annette K. Larsen

Down-Regulation of DNA Topoisomerase II Leads to Prolonged Cell Cycle Transit in G₂ and Early M Phases and Increased Survival to Microtubule-Interacting Agents
Mol Pharmacol 2005 68: 625-634. Published online June 7, 2005; 10.1124/mol.105.013995 [Abstract] [Full Text] [PDF]  

Ling-Zhi Liu, Jing Fang, Qiong Zhou, Xiaowen Hu, Xianglin Shi, and Bing-Hua Jiang

Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer
Mol Pharmacol 2005 68: 635-643. Published online June 9, 2005; 10.1124/mol.105.011254 [Abstract] [Full Text] [PDF]  

Matthew A. Hummel, Charles W. Locuson, Peter M. Gannett, Dan A. Rock, Carrie M. Mosher, Allan E. Rettie, and Timothy S. Tracy

CYP2C9 Genotype-Dependent Effects on in Vitro Drug-Drug Interactions: Switching of Benzbromarone Effect from Inhibition to Activation in the CYP2C9.3 Variant
Mol Pharmacol 2005 68: 644-651. Published online June 13, 2005; 10.1124/mol.105.013763 [Abstract] [Full Text] [PDF]  

Joeri Auwerx, Fátima Rodríguez-Barrios, Francesca Ceccherini-Silberstein, Ana San-Félix, Sonsoles Velázquez, Erik De Clercq, María-José Camarasa, Carlo-Federico Perno, Federico Gago, and Jan Balzarini

The Role of Thr139 in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Sensitivity to (+)-Calanolide A
Mol Pharmacol 2005 68: 652-659. Published online June 16, 2005; 10.1124/mol.105.012351 [Abstract] [Full Text] [PDF]  

Eun Ju Bae and Sang Geon Kim

Enhanced CCAAT/Enhancer-Binding Protein -Liver-Enriched Inhibitory Protein Production by Oltipraz, Which Accompanies CUG Repeat-Binding Protein-1 (CUGBP1) RNA-Binding Protein Activation, Leads to Inhibition of Preadipocyte Differentiation
Mol Pharmacol 2005 68: 660-669. Published online June 16, 2005; 10.1124/mol.105.012997 [Abstract] [Full Text] [PDF] Data Supplement  

Yutaro Obara, Hitoshi Kurose, and Norimichi Nakahata

Thromboxane A₂ Promotes Interleukin-6 Biosynthesis Mediated by an Activation of Cyclic AMP-Response Element-Binding Protein in 1321N1 Human Astrocytoma Cells
Mol Pharmacol 2005 68: 670-679. Published online June 20, 2005; 10.1124/mol.105.012922 [Abstract] [Full Text] [PDF]  

J. A. Lundbæk, P. Birn, S. E. Tape, G. E. S. Toombes, R. Søgaard, Roger E. Koeppe, II, S. M. Gruner, A. J. Hansen, and O. S. Andersen

Capsaicin Regulates Voltage-Dependent Sodium Channels by Altering Lipid Bilayer Elasticity
Mol Pharmacol 2005 68: 680-689. Published online June 20, 2005; 10.1124/mol.105.013573 [Abstract] [Full Text] [PDF]  

Huiping Zhou, William M. Pandak, Jr., Vijay Lyall, Ramesh Natarajan, and Phillip B. Hylemon

HIV Protease Inhibitors Activate the Unfolded Protein Response in Macrophages: Implication for Atherosclerosis and Cardiovascular Disease
Mol Pharmacol 2005 68: 690-700. Published online June 23, 2005; 10.1124/mol.105.012898 [Abstract] [Full Text] [PDF]  

B. R. Jones, W. Li, J. Cao, T. A. Hoffman, P. M. Gerk, and M. Vore

The Role of Protein Synthesis and Degradation in the Post-Transcriptional Regulation of Rat Multidrug Resistance-Associated Protein 2 (Mrp2, Abcc2)
Mol Pharmacol 2005 68: 701-710. Published online May 25, 2005; 10.1124/mol.105.013144 [Abstract] [Full Text] [PDF]  

Monsheel S. K. Sodhi, David C. Airey, Warren Lambert, Philip W. J. Burnet, Paul J. Harrison, and Elaine Sanders-Bush

A Rapid New Assay to Detect RNA Editing Reveals Antipsychotic-Induced Changes in Serotonin-2C Transcripts
Mol Pharmacol 2005 68: 711-719. Published online May 25, 2005; 10.1124/mol.105.014134 [Abstract] [Full Text] [PDF]  

Özlem Ugur, Sükrü Sadik Oner, Paola Molinari, Caterina Ambrosio, Kemal Sayar, and H. Ongun Onaran

Guanine Nucleotide Exchange-Independent Activation of G_s Protein by ₂-Adrenoceptor
Mol Pharmacol 2005 68: 720-728. Published online June 2, 2005; 10.1124/mol.104.010306 [Abstract] [Full Text] [PDF]  

Sung-Su Kim, Krishan K. Pandey, Hack Sun Choi, Seong-Youl Kim, Ping-Yee Law, Li-Na Wei, and Horace H. Loh

Poly(C) Binding Protein Family Is a Transcription Factor in µ-Opioid Receptor Gene Expression
Mol Pharmacol 2005 68: 729-736. Published online June 2, 2005; 10.1124/mol.105.012245 [Abstract] [Full Text] [PDF]  

Sarah E. McCallum, Neeraja Parameswaran, Tanuja Bordia, J. Michael McIntosh, Sharon R. Grady, and Maryka Quik

Decrease in 3^*/6^* Nicotinic Receptors but Not Nicotine-Evoked Dopamine Release in Monkey Brain after Nigrostriatal Damage
Mol Pharmacol 2005 68: 737-746. Published online June 2, 2005; 10.1124/mol.105.012773 [Abstract] [Full Text] [PDF]  

Stephen S. Ferguson, Yuping Chen, Edward L. LeCluyse, Masahiko Negishi, and Joyce A. Goldstein

Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid Receptor, and Hepatic Nuclear Factor 4
Mol Pharmacol 2005 68: 747-757. Published online June 2, 2005; 10.1124/mol.105.013169 [Abstract] [Full Text] [PDF]  

Jean-Philippe Lievremont, Gary S. Bird, and James W. Putney, Jr.

Mechanism of Inhibition of TRPC Cation Channels by 2-Aminoethoxydiphenylborane
Mol Pharmacol 2005 68: 758-762. Published online June 2, 2005; 10.1124/mol.105.012856 [Abstract] [Full Text] [PDF]  

Jai Pal Singh, Raymond Kauffman, William Bensch, Guoming Wang, Pam McClelland, James Bean, Chahrzad Montrose, Nathan Mantlo, and Asavari Wagle

Identification of a Novel Selective Peroxisome Proliferator-Activated Receptor Agonist, 2-Methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl}phenoxy)propanoic Acid (LY518674), That Produces Marked Changes in Serum Lipids and Apolipoprotein A-1 Expression
Mol Pharmacol 2005 68: 763-768. Published online June 2, 2005; 10.1124/mol.105.010991 [Abstract] [Full Text] [PDF]  

Xi-Ping Huang, Stefanie Prilla, Klaus Mohr, and John Ellis

Critical Amino Acid Residues of the Common Allosteric Site on the M₂ Muscarinic Acetylcholine Receptor: More Similarities than Differences between the Structurally Divergent Agents Gallamine and Bis(ammonio)alkane-Type Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
Mol Pharmacol 2005 68: 769-778. Published online June 3, 2005; 10.1124/mol.105.014043 [Abstract] [Full Text] [PDF]  

Ryan J. Ward and Chantal Autexier

Pharmacological Telomerase Inhibition Can Sensitize Drug-Resistant and Drug-Sensitive Cells to Chemotherapeutic Treatment
Mol Pharmacol 2005 68: 779-786. Published online June 6, 2005; 10.1124/mol.105.011494 [Abstract] [Full Text] [PDF]  

Roland Baur, Urs Simmen, Martin Senn, Urs Séquin, and Erwin Sigel

Novel Plant Substances Acting as Subunit Isoform-Selective Positive Allosteric Modulators of GABA_A Receptors
Mol Pharmacol 2005 68: 787-792. Published online June 6, 2005; 10.1124/mol.105.011882 [Abstract] [Full Text] [PDF]  

Geneviève Tavernier, Maria Jimenez, Jean-Paul Giacobino, Nicolas Hulo, Max Lafontan, Patrick Muzzin, and Dominique Langin

Norepinephrine Induces Lipolysis in ₁/₂/₃-Adrenoceptor Knockout Mice
Mol Pharmacol 2005 68: 793-799. Published online June 6, 2005; 10.1124/mol.105.014670 [Abstract] [Full Text] [PDF]  

Masaru Hirano, Kazuya Maeda, Soichiro Matsushima, Yoshitane Nozaki, Hiroyuki Kusuhara, and Yuichi Sugiyama

Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin
Mol Pharmacol 2005 68: 800-807. Published online June 13, 2005; 10.1124/mol.105.014019 [Abstract] [Full Text] [PDF]  

Florent Busi and Thierry Cresteil

CYP3A5 mRNA Degradation by Nonsense-Mediated mRNA Decay
Mol Pharmacol 2005 68: 808-815. Published online June 13, 2005; 10.1124/mol.105.014225 [Abstract] [Full Text] [PDF]  

Laura Ghisolfi, Laura Papucci, Annamaria Bevilacqua, Gianfranco Canti, Giuseppe Tataranni, Andrea Lapucci, Nicola Schiavone, Sergio Capaccioli, and Angelo Nicolin

Increased Bcl2 Expression by Antisense Oligoribonucleotides Targeting the Adenine-Uridine-Rich Element Motif
Mol Pharmacol 2005 68: 816-821. Published online June 13, 2005; 10.1124/mol.105.014357 [Abstract] [Full Text] [PDF]  

Jimena A. Ballestero, Paola V. Plazas, Sebastian Kracun, María E. Gómez-Casati, Julián Taranda, Carla V. Rothlin, Eleonora Katz, Neil S. Millar, and A. Belén Elgoyhen

Effects of Quinine, Quinidine, and Chloroquine on 910 Nicotinic Cholinergic Receptors
Mol Pharmacol 2005 68: 822-829. Published online June 13, 2005; 10.1124/mol.105.014431 [Abstract] [Full Text] [PDF]  

Jing Zhang, Kyla M. Smith, Tracey Tackaberry, Frank Visser, Morris J. Robins, Lars P. C. Nielsen, Ireneusz Nowak, Edward Karpinski, Stephen A. Baldwin, James D. Young, and Carol E. Cass

Uridine Binding and Transportability Determinants of Human Concentrative Nucleoside Transporters
Mol Pharmacol 2005 68: 830-839. Published online June 14, 2005; 10.1124/mol.105.012187 [Abstract] [Full Text] [PDF]  

Kishani M. Ranatunga, Tracy M. Moreno-King, Bhavna Tanna, Ruiwu Wang, S. R. Wayne Chen, Luc Ruest, William Welch, and Alan J. Williams

The Gln⁴⁸⁶³Ala Mutation within a Putative, Pore-Lining Trans-Membrane Helix of the Cardiac Ryanodine Receptor Channel Alters Both the Kinetics of Ryanoid Interaction and the Subsequent Fractional Conductance
Mol Pharmacol 2005 68: 840-846. Published online June 14, 2005; 10.1124/mol.105.012807 [Abstract] [Full Text] [PDF]  

Chang-Xi Yu, Sheng Li, and A. Richard Whorton

Redox Regulation of PTEN by S-Nitrosothiols
Mol Pharmacol 2005 68: 847-854. Published online June 20, 2005; 10.1124/mol.104.010504 [Abstract] [Full Text] [PDF]  

Jijin Lin, Jun Guo, Hongying Gang, Peter Wojciechowski, Jeffrey T. Wigle, and Shetuan Zhang

Intracellular K⁺ Is Required for the Inactivation-Induced High-Affinity Binding of Cisapride to HERG Channels
Mol Pharmacol 2005 68: 855-865. Published online June 20, 2005; 10.1124/mol.105.012278 [Abstract] [Full Text] [PDF]  

Ying-Xian Pan, Jin Xu, Elizabeth Bolan, Howard S. Moskowitz, Mingming Xu, and Gavril W. Pasternak

Identification of Four Novel Exon 5 Splice Variants of the Mouse µ-Opioid Receptor Gene: Functional Consequences of C-Terminal Splicing
Mol Pharmacol 2005 68: 866-875. Published online June 6, 2005; 10.1124/mol.105.011858 [Abstract] [Full Text] [PDF]  

Jun Zhou, Corinne E. Augelli-Szafran, Jenifer A. Bradley, Xian Chen, Bryan J. Koci, Walter A. Volberg, Zhuoqian Sun, and Jason S. Cordes

Novel Potent Human Ether-à-Go-Go-Related Gene (hERG) Potassium Channel Enhancers and Their in Vitro Antiarrhythmic Activity
Mol Pharmacol 2005 68: 876-884. Published online June 23, 2005; 10.1124/mol.105.014035 [Abstract] [Full Text] [PDF]  

Christophe Blanquart, Nicolas Boute, Danièle Lacasa, and Tarik Issad

Monitoring the Activation State of the Insulin-Like Growth Factor-1 Receptor and Its Interaction with Protein Tyrosine Phosphatase 1B Using Bioluminescence Resonance Energy Transfer
Mol Pharmacol 2005 68: 885-894. Published online June 23, 2005; 10.1124/mol.105.013151 [Abstract] [Full Text] [PDF]  

Katalin Erdèlyi, Andrea Kiss, Edina Bakondi, Péter Bai, Csaba Szabó, Pál Gergely, Ferenc Erdödi, and László Virag

Gallotannin Inhibits the Expression of Chemokines and Inflammatory Cytokines in A549 Cells
Mol Pharmacol 2005 68: 895-904. Published online June 23, 2005; 10.1124/mol.105.012518 [Abstract] [Full Text] [PDF] Data Supplement  

Geraldine Pascal and Graeme Milligan

Functional Complementation and the Analysis of Opioid Receptor Homodimerization
Mol Pharmacol 2005 68: 905-915. Published online June 20, 2005; 10.1124/mol.105.013847 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Conservation of Functional and Pharmacological Properties in the Distantly Related Temperature Sensors TRVP1 and TRPM8"
Mol Pharmacol 2005 68: 916. [Full Text] [PDF]  

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