Perspectives:

John S. Lazo

Live Long and Prosper
Mol Pharmacol 2005 68: 1193-1195. Published online August 12, 2005; 10.1124/mol.105.017723 [Abstract] [Full Text] [PDF] Related Article  

Articles:

Kwang-Mook Jung, Regina Mangieri, Christopher Stapleton, Janet Kim, Darren Fegley, Matthew Wallace, Ken Mackie, and Daniele Piomelli

Stimulation of Endocannabinoid Formation in Brain Slice Cultures through Activation of Group I Metabotropic Glutamate Receptors
Mol Pharmacol 2005 68: 1196-1202. Published online July 28, 2005; 10.1124/mol.105.013961 [Abstract] [Full Text] [PDF]  

Zhi Yi Chen and Chi-Chuan Tseng

15-Deoxy-^12,14 Prostaglandin J₂ Up-Regulates Krüppel-Like Factor 4 Expression Independently of Peroxisome Proliferator-Activated Receptor by Activating the Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signal Transduction Pathway in HT-29 Colon Cancer Cells
Mol Pharmacol 2005 68: 1203-1213. Published online August 2, 2005; 10.1124/mol.105.014944 [Abstract] [Full Text] [PDF]  

Bénédicte Salthun-Lassalle, Sabine Traver, Etienne C. Hirsch, and Patrick P. Michel

Substance P, Neurokinins A and B, and Synthetic Tachykinin Peptides Protect Mesencephalic Dopaminergic Neurons in Culture via an Activity-Dependent Mechanism
Mol Pharmacol 2005 68: 1214-1224. Published online August 2, 2005; 10.1124/mol.105.015453 [Abstract] [Full Text] [PDF]  

Leah M. Helvering, Riting Liu, Nalini H. Kulkarni, Tao Wei, Peining Chen, Shuguang Huang, Frank Lawrence, David L. Halladay, Rebecca R. Miles, Emily M. Ambrose, Masahiko Sato, Yanfei L. Ma, Charles A. Frolik, Ernst R. Dow, Henry U. Bryant, and Jude E. Onyia

Expression Profiling of Rat Femur Revealed Suppression of Bone Formation Genes by Treatment with Alendronate and Estrogen but Not Raloxifene
Mol Pharmacol 2005 68: 1225-1238. Published online August 3, 2005; 10.1124/mol.105.011478 [Abstract] [Full Text] [PDF] Data Supplement  

Scott S. Auerbach, Matthew A. Stoner, Shengzhong Su, and Curtis J. Omiecinski

Retinoid X Receptor--Dependent Transactivation by a Naturally Occurring Structural Variant of Human Constitutive Androstane Receptor (NR1I3)
Mol Pharmacol 2005 68: 1239-1253. Published online August 11, 2005; 10.1124/mol.105.013417 [Abstract] [Full Text] [PDF]  

Alexander Schmitz, Ananthakrishnan Sankaranarayanan, Philippe Azam, Kristina Schmidt-Lassen, Daniel Homerick, Wolfram Hänsel, and Heike Wulff

Design of PAP-1, a Selective Small Molecule Kv1.3 Blocker, for the Suppression of Effector Memory T Cells in Autoimmune Diseases
Mol Pharmacol 2005 68: 1254-1270. Published online August 11, 2005; 10.1124/mol.105.015669 [Abstract] [Full Text] [PDF]  

Sorin Tunaru, Jens Lättig, Jukka Kero, Gerd Krause, and Stefan Offermanns

Characterization of Determinants of Ligand Binding to the Nicotinic Acid Receptor GPR109A (HM74A/PUMA-G)
Mol Pharmacol 2005 68: 1271-1280. Published online August 11, 2005; 10.1124/mol.105.015750 [Abstract] [Full Text] [PDF]  

Kyung Sun Lee, Hee Sun Park, Seoung Ju Park, So Ri Kim, Kyung Hoon Min, Sun Mi Jin, Kwang-Hyun Park, Uh-Hyun Kim, Chan Young Kim, and Yong Chul Lee

A Prodrug of Cysteine, L-2-Oxothiazolidine-4-carboxylic Acid, Regulates Vascular Permeability by Reducing Vascular Endothelial Growth Factor Expression in Asthma
Mol Pharmacol 2005 68: 1281-1290. Published online August 15, 2005; 10.1124/mol.105.016055 [Abstract] [Full Text] [PDF]  

Margot Ernst, Stefan Bruckner, Stefan Boresch, and Werner Sieghart

Comparative Models of GABA_A Receptor Extracellular and Transmembrane Domains: Important Insights in Pharmacology and Function
Mol Pharmacol 2005 68: 1291-1300. Published online August 15, 2005; 10.1124/mol.105.015982 [Abstract] [Full Text] [PDF] Data Supplement  

Bruce S. Edwards, Cristian Bologa, Susan M. Young, Konstantin V. Balakin, Eric R. Prossnitz, Nikolay P. Savchuck, Larry A. Sklar, and Tudor I. Oprea

Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide Receptor Antagonists
Mol Pharmacol 2005 68: 1301-1310. Published online August 23, 2005; 10.1124/mol.105.014068 [Abstract] [Full Text] [PDF] Data Supplement  

Lisa N. Putral, Megan J. Bywater, Wenyi Gu, Nicholas A. Saunders, Brian G. Gabrielli, Graham R. Leggatt, and Nigel A. J. McMillan

RNA Interference against Human Papillomavirus Oncogenes in Cervical Cancer Cells Results in Increased Sensitivity to Cisplatin
Mol Pharmacol 2005 68: 1311-1319. Published online August 24, 2005; 10.1124/mol.105.014191 [Abstract] [Full Text] [PDF]  

Malcolm A. Meyn, III, Steven J. Schreiner, Teodora Pene Dumitrescu, Gerard J. Nau, and Thomas E. Smithgall

Src Family Kinase Activity Is Required for Murine Embryonic Stem Cell Growth and Differentiation
Mol Pharmacol 2005 68: 1320-1330. Published online June 28, 2005; 10.1124/mol.104.010231 [Abstract] [Full Text] [PDF]  

Edward A. Monaco, III and Mary Lou Vallano

Roscovitine Triggers Excitotoxicity in Cultured Granule Neurons by Enhancing Glutamate Release
Mol Pharmacol 2005 68: 1331-1342. Published online July 28, 2005; 10.1124/mol.105.012732 [Abstract] [Full Text] [PDF]  

Matthew J. Walters, Mark J. Paul-Clark, Shaun K. McMaster, Kazuhiro Ito, Ian M. Adcock, and Jane A. Mitchell

Cigarette Smoke Activates Human Monocytes by an Oxidant-AP-1 Signaling Pathway: Implications for Steroid Resistance
Mol Pharmacol 2005 68: 1343-1353. Published online August 1, 2005; 10.1124/mol.105.012591 [Abstract] [Full Text] [PDF]  

Anthony S. L. Chan and Yung H. Wong

G_q-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the G_s-Coupled Dopamine D₁ Receptor in COS-7 Cells
Mol Pharmacol 2005 68: 1354-1364. Published online August 1, 2005; 10.1124/mol.105.014548 [Abstract] [Full Text] [PDF]  

Karen Hellauer, Guillaume Lesage, Anne-Marie Sdicu, and Bernard Turcotte

Large-Scale Analysis of Genes that Alter Sensitivity to the Anticancer Drug Tirapazamine in Saccharomyces cerevisiae
Mol Pharmacol 2005 68: 1365-1375. Published online August 1, 2005; 10.1124/mol.105.012963 [Abstract] [Full Text] [PDF] Data Supplement  

C. L. Parish, J. Nunan, D. I. Finkelstein, F. N. McNamara, J. Y. Wong, J. L. Waddington, R. M. Brown, A. J. Lawrence, M. K. Horne, and J. Drago

Mice Lacking the 4 Nicotinic Receptor Subunit Fail to Modulate Dopaminergic Neuronal Arbors and Possess Impaired Dopamine Transporter Function
Mol Pharmacol 2005 68: 1376-1386. Published online August 2, 2005; 10.1124/mol.104.004820 [Abstract] [Full Text] [PDF]  

Stefan G. Lechner, Simon Hussl, Klaus W. Schicker, Helmut Drobny, and Stefan Boehm

Presynaptic Inhibition via a Phospholipase C- and Phosphatidylinositol Bisphosphate-Dependent Regulation of Neuronal Ca²⁺ Channels
Mol Pharmacol 2005 68: 1387-1396. Published online August 11, 2005; 10.1124/mol.105.014886 [Abstract] [Full Text] [PDF]  

Karen Engel and Joanne Wang

Interaction of Organic Cations with a Newly Identified Plasma Membrane Monoamine Transporter
Mol Pharmacol 2005 68: 1397-1407. Published online August 11, 2005; 10.1124/mol.105.016832 [Abstract] [Full Text] [PDF]  

Tsugunobu Andoh, P. Boon Chock, Dennis L. Murphy, and Chuang C. Chiueh

Role of the Redox Protein Thioredoxin in Cytoprotective Mechanism Evoked by (-)-Deprenyl
Mol Pharmacol 2005 68: 1408-1414. Published online August 12, 2005; 10.1124/mol.105.012302 [Abstract] [Full Text] [PDF]  

Bernadette Bouchon, Christophe Chambon, Emmanuelle Mounetou, Janine Papon, Elisabeth Miot-Noirault, René C. Gaudreault, Jean-Claude Madelmont, and Françoise Degoul

Alkylation of -Tubulin on Glu 198 by a Microtubule Disrupter
Mol Pharmacol 2005 68: 1415-1422. Published online August 12, 2005; 10.1124/mol.105.015586 [Abstract] [Full Text] [PDF]  

Michael J. Duryee, Thomas L. Freeman, Monte S. Willis, Carlos D. Hunter, Bartlett C. Hamilton, III, Hiroshi Suzuki, Dean J. Tuma, Lynell W. Klassen, and Geoffrey M. Thiele

Scavenger Receptors on Sinusoidal Liver Endothelial Cells Are Involved in the Uptake of Aldehyde-Modified Proteins
Mol Pharmacol 2005 68: 1423-1430. Published online August 16, 2005; 10.1124/mol.105.016121 [Abstract] [Full Text] [PDF]  

Stuart J. Lansdell, Veronica J. Gee, Patricia C. Harkness, Anne I. Doward, Elizabeth R. Baker, Alasdair J. Gibb, and Neil S. Millar

RIC-3 Enhances Functional Expression of Multiple Nicotinic Acetylcholine Receptor Subtypes in Mammalian Cells
Mol Pharmacol 2005 68: 1431-1438. Published online August 24, 2005; 10.1124/mol.105.017459 [Abstract] [Full Text] [PDF]  

Susanne Kubetzko, Casim A. Sarkar, and Andreas Plückthun

Protein PEGylation Decreases Observed Target Association Rates via a Dual Blocking Mechanism
Mol Pharmacol 2005 68: 1439-1454. Published online August 12, 2005; 10.1124/mol.105.014910 [Abstract] [Full Text] [PDF] Data Supplement  

Peng Wu, Curtis J. Oleschuk, Qingcheng Mao, Bernd O. Keller, Roger G. Deeley, and Susan P. C. Cole

Analysis of Human Multidrug Resistance Protein 1 (ABCC1) by Matrix-Assisted Laser Desorption Ionization/Time of Flight Mass Spectrometry: Toward Identification of Leukotriene C₄ Binding Sites
Mol Pharmacol 2005 68: 1455-1465. Published online August 16, 2005; 10.1124/mol.105.016576 [Abstract] [Full Text] [PDF]  

Jun Sugama, Satoko Ohkubo, Masanori Atsumi, and Norimichi Nakahata

Mastoparan Changes the Cellular Localization of G_q/11 and G through Its Binding to Ganglioside in Lipid Rafts
Mol Pharmacol 2005 68: 1466-1474. Published online August 23, 2005; 10.1124/mol.105.013524 [Abstract] [Full Text] [PDF]  

Diego Rayes, Guillermo Spitzmaul, Steven M. Sine, and Cecilia Bouzat

Single-Channel Kinetic Analysis of Chimeric 7–5HT_3A Receptors
Mol Pharmacol 2005 68: 1475-1483. Published online August 23, 2005; 10.1124/mol.105.015438 [Abstract] [Full Text] [PDF]  

Martin R. Price, Gemma L. Baillie, Adèle Thomas, Lesley A. Stevenson, Morag Easson, Richard Goodwin, Adèle McLean, Lorraine McIntosh, Gillian Goodwin, Glenn Walker, Paul Westwood, Julia Marrs, Fiona Thomson, Phillip Cowley, Arthur Christopoulos, Roger G. Pertwee, and Ruth A. Ross

Allosteric Modulation of the Cannabinoid CB₁ Receptor
Mol Pharmacol 2005 68: 1484-1495. Published online August 19, 2005; 10.1124/mol.105.016162 [Abstract] [Full Text] [PDF]  

Mario Minuzzo, Michele Ceribelli, Marià Pitarque-Martì, Serena Borrelli, Eugenio Erba, Alberto diSilvio, Maurizio D'Incalci, and Roberto Mantovani

Selective Effects of the Anticancer Drug Yondelis (ET-743) on Cell-Cycle Promoters
Mol Pharmacol 2005 68: 1496-1503. Published online June 16, 2005; 10.1124/mol.105.013615 [Abstract] [Full Text] [PDF]  

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