Editor's Note:

Paul A. Insel

Mol Pharmacol 2005 68: 1505. [Full Text] [PDF]  

Perspectives:

Jürgen Wess

Allosteric Binding Sites on Muscarinic Acetylcholine Receptors
Mol Pharmacol 2005 68: 1506-1509. Published online September 23, 2005; 10.1124/mol.105.019141 [Abstract] [Full Text] [PDF] Related Article  

Articles:

Kasper B. Hansen, Rasmus P. Clausen, Esben J. Bjerrum, Christian Bechmann, Jeremy R. Greenwood, Caspar Christensen, Jesper L. Kristensen, Jan Egebjerg, and Hans Bräuner-Osborne

Tweaking Agonist Efficacy at N-Methyl-D-aspartate Receptors by Site-Directed Mutagenesis
Mol Pharmacol 2005 68: 1510-1523. Published online August 30, 2005; 10.1124/mol.105.014795 [Abstract] [Full Text] [PDF] Data Supplement  

Narender R. Gavva, Rami Tamir, Lana Klionsky, Mark H. Norman, Jean-Claude Louis, Kenneth D. Wild, and James J. S. Treanor

Proton Activation Does Not Alter Antagonist Interaction with the Capsaicin-Binding Pocket of TRPV1
Mol Pharmacol 2005 68: 1524-1533. Published online August 31, 2005; 10.1124/mol.105.015727 [Abstract] [Full Text] [PDF] Data Supplement  

Qinghai Tian, Jing Li, Xin Xie, Meiling Sun, Hairong Sang, Caihong Zhou, Tianying An, Lihong Hu, Richard D. Ye, and Ming-Wei Wang

Stereospecific Induction of Nuclear Factor-B Activation by Isochamaejasmin
Mol Pharmacol 2005 68: 1534-1542. Published online September 1, 2005; 10.1124/mol.105.014720 [Abstract] [Full Text] [PDF]  

Hideo Akiyama, Khalid A. Mohamedali, Raquel Lima e Silva, Shu Kachi, JiKui Shen, Christina Hatara, Naoyasu Umeda, Sean F. Hackett, Sadia Aslam, Melissa Krause, Hong Lai, Michael G. Rosenblum, and Peter A. Campochiaro

Vascular Targeting of Ocular Neovascularization with a Vascular Endothelial Growth Factor₁₂₁/Gelonin Chimeric Protein
Mol Pharmacol 2005 68: 1543-1550. Published online September 8, 2005; 10.1124/mol.105.015628 [Abstract] [Full Text] [PDF]  

Jennifer C. Cookson, Fangping Dai, Victoria Smith, Robert A. Heald, Charles A. Laughton, Malcolm F. G. Stevens, and Angelika M. Burger

Pharmacodynamics of the G-Quadruplex-Stabilizing Telomerase Inhibitor 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in Vitro: Activity in Human Tumor Cells Correlates with Telomere Length and Can Be Enhanced, or Antagonized, with Cytotoxic Agents
Mol Pharmacol 2005 68: 1551-1558. Published online September 8, 2005; 10.1124/mol.105.013300 [Abstract] [Full Text] [PDF]  

Esther Marco and Federico Gago

DNA Structural Similarity in the 2:1 Complexes of the Antitumor Drugs Trabectedin (Yondelis) and Chromomycin A₃ with an Oligonucleotide Sequence Containing Two Adjacent TGG Binding Sites on Opposing Strands
Mol Pharmacol 2005 68: 1559-1567. Published online September 8, 2005; 10.1124/mol.105.015685 [Abstract] [Full Text] [PDF] Data Supplement  

So Ri Kim, Kyung Sun Lee, Hee Sun Park, Seoung Ju Park, Kyung Hoon Min, Sun Mi Jin, and Yong Chul Lee

Involvement of IL-10 in Peroxisome Proliferator-Activated Receptor -Mediated Anti-Inflammatory Response in Asthma
Mol Pharmacol 2005 68: 1568-1575. Published online September 8, 2005; 10.1124/mol.105.017160 [Abstract] [Full Text] [PDF]  

Guillaume Morissette, Emmanuel Moreau, René C.-Gaudreault, and François Marceau

N-Substituted 4-Aminobenzamides (Procainamide Analogs): An Assessment of Multiple Cellular Effects Concerning Ion Trapping
Mol Pharmacol 2005 68: 1576-1589. Published online September 23, 2005; 10.1124/mol.105.016527 [Abstract] [Full Text] [PDF] Data Supplement  

Guoli Dai, Nathan Chou, Lin He, Maxwell A. Gyamfi, Alphonse J. Mendy, Angela L. Slitt, Curtis D. Klaassen, and Yu-Jui Y. Wan

Retinoid X Receptor Regulates the Expression of Glutathione S-transferase Genes and Modulates Acetaminophen-Glutathione Conjugation in Mouse Liver
Mol Pharmacol 2005 68: 1590-1596. Published online September 12, 2005; 10.1124/mol.105.013680 [Abstract] [Full Text] [PDF]  

Christian Tränkle, Andreas Dittmann, Uwe Schulz, Oliver Weyand, Stefan Buller, Kirstin Jöhren, Eberhard Heller, Nigel J. M. Birdsall, Ulrike Holzgrabe, John Ellis, Hans Dieter Höltje, and Klaus Mohr

Atypical Muscarinic Allosteric Modulation: Cooperativity between Modulators and Their Atypical Binding Topology in Muscarinic M₂ and M₂/M₅ Chimeric Receptors
Mol Pharmacol 2005 68: 1597-1610. Published online September 12, 2005; 10.1124/mol.105.017707 [Abstract] [Full Text] [PDF]  

Gregory M. Lipkind and Harry A. Fozzard

Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels
Mol Pharmacol 2005 68: 1611-1622. Published online September 20, 2005; 10.1124/mol.105.014803 [Abstract] [Full Text] [PDF] Data Supplement  

Robert P. Picone, Atmaram D. Khanolkar, Wei Xu, Lionel A. Ayotte, Ganesh A. Thakur, Dow P. Hurst, Mary E. Abood, Patricia H. Reggio, Donna J. Fournier, and Alexandros Makriyannis

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor
Mol Pharmacol 2005 68: 1623-1635. Published online September 12, 2005; 10.1124/mol.105.014407 [Abstract] [Full Text] [PDF]  

Larry M. Karnitz, Karen S. Flatten, Jill M. Wagner, David Loegering, Jennifer S. Hackbarth, Sonnet J. H. Arlander, Benjamin T. Vroman, M. Bijoy Thomas, Yong-Un Baek, Kevin M. Hopkins, Howard B. Lieberman, Junjie Chen, William A. Cliby, and Scott H. Kaufmann

Gemcitabine-Induced Activation of Checkpoint Signaling Pathways That Affect Tumor Cell Survival
Mol Pharmacol 2005 68: 1636-1644. Published online August 26, 2005; 10.1124/mol.105.012716 [Abstract] [Full Text] [PDF]  

Jillian G. Baker

Evidence for a Secondary State of the Human 3-Adrenoceptor
Mol Pharmacol 2005 68: 1645-1655. Published online August 29, 2005; 10.1124/mol.105.015461 [Abstract] [Full Text] [PDF]  

Andrea M. Marritt, Brandon C. Cox, Robert P. Yasuda, J. Michael McIntosh, Yingxian Xiao, Barry B. Wolfe, and Kenneth J. Kellar

Nicotinic Cholinergic Receptors in the Rat Retina: Simple and Mixed Heteromeric Subtypes
Mol Pharmacol 2005 68: 1656-1668. Published online August 29, 2005; 10.1124/mol.105.012369 [Abstract] [Full Text] [PDF]  

Manuel Criado, José Mulet, José A. Bernal, Susana Gerber, Salvador Sala, and Francisco Sala

Mutations of a Conserved Lysine Residue in the N-Terminal Domain of 7 Nicotinic Receptors Affect Gating and Binding of Nicotinic Agonists
Mol Pharmacol 2005 68: 1669-1677. Published online August 29, 2005; 10.1124/mol.105.015446 [Abstract] [Full Text] [PDF]  

Pascal Amireault and François Dubé

Intracellular cAMP and Calcium Signaling by Serotonin in Mouse Cumulus-Oocyte Complexes
Mol Pharmacol 2005 68: 1678-1687. Published online August 30, 2005; 10.1124/mol.104.010124 [Abstract] [Full Text] [PDF]  

Wendy Walwyn, Nigel T. Maidment, Matthew Sanders, Christopher J. Evans, Brigitte L. Kieffer, and Tim G. Hales

Induction of Opioid Receptor Function by Up-Regulation of Membrane Receptors in Mouse Primary Afferent Neurons
Mol Pharmacol 2005 68: 1688-1698. Published online August 31, 2005; 10.1124/mol.105.014829 [Abstract] [Full Text] [PDF]  

Miranda D. Gray, Melissa Mann, John L. Nitiss, and Linda M. Hendershot

Activation of the Unfolded Protein Response Is Necessary and Sufficient for Reducing Topoisomerase II Protein Levels and Decreasing Sensitivity to Topoisomerase-Targeted Drugs
Mol Pharmacol 2005 68: 1699-1707. Published online September 1, 2005; 10.1124/mol.105.014753 [Abstract] [Full Text] [PDF]  

EunJung Kim, Maggie Tam, William F. Siems, and ChulHee Kang

Effects of Drugs with Muscle-Related Side Effects and Affinity for Calsequestrin on the Calcium Regulatory Function of Sarcoplasmic Reticulum Microsomes
Mol Pharmacol 2005 68: 1708-1715. Published online September 1, 2005; 10.1124/mol.105.016253 [Abstract] [Full Text] [PDF]  

Benchun Miao, Jing Li, Xueyan Fu, Li Gan, Xianliang Xin, and Meiyu Geng

Sulfated Polymannuroguluronate, a Novel Anti-AIDS Drug Candidate, Inhibits T Cell Apoptosis by Combating Oxidative Damage of Mitochondria
Mol Pharmacol 2005 68: 1716-1727. Published online September 1, 2005; 10.1124/mol.105.015412 [Abstract] [Full Text] [PDF]  

Stephan Krause and Wolfgang Schwarz

Identification and Selective Inhibition of the Channel Mode of the Neuronal GABA Transporter 1
Mol Pharmacol 2005 68: 1728-1735. Published online September 8, 2005; 10.1124/mol.105.013870 [Abstract] [Full Text] [PDF]  

Nicoletta Pedemonte, Tullia Diena, Emanuela Caci, Erika Nieddu, Mauro Mazzei, Roberto Ravazzolo, Olga Zegarra-Moran, and Luis J. V. Galietta

Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations
Mol Pharmacol 2005 68: 1736-1746. Published online September 8, 2005; 10.1124/mol.105.015149 [Abstract] [Full Text] [PDF]  

Julia C. Mallory, Gerard Crudden, Amelia Oliva, Christopher Saunders, Arnold Stromberg, and Rolf J. Craven

A Novel Group of Genes Regulates Susceptibility to Antineoplastic Drugs in Highly Tumorigenic Breast Cancer Cells
Mol Pharmacol 2005 68: 1747-1756. Published online September 8, 2005; 10.1124/mol.105.016519 [Abstract] [Full Text] [PDF] Data Supplement  

Guanghua Tang, Lingyun Wu, Wenbin Liang, and Rui Wang

Direct Stimulation of K_ATP Channels by Exogenous and Endogenous Hydrogen Sulfide in Vascular Smooth Muscle Cells
Mol Pharmacol 2005 68: 1757-1764. Published online September 8, 2005; 10.1124/mol.105.017467 [Abstract] [Full Text] [PDF]  

Takeshi Enomoto, Yukihiro Noda, Akihiro Mouri, Eun-Joo Shin, Dayong Wang, Rina Murai, Kazuo Hotta, Hiroshi Furukawa, Atsumi Nitta, Hyoung-Chun Kim, and Toshitaka Nabeshima

Long-Lasting Impairment of Associative Learning Is Correlated with a Dysfunction of N-Methyl-D-aspartate-Extracellular Signaling-Regulated Kinase Signaling in Mice after Withdrawal from Repeated Administration of Phencyclidine
Mol Pharmacol 2005 68: 1765-1774. Published online September 8, 2005; 10.1124/mol.105.011304 [Abstract] [Full Text] [PDF]  

Frank Wunder, Adrian Tersteegen, Annegret Rebmann, Christina Erb, Thomas Fahrig, and Martin Hendrix

Characterization of the First Potent and Selective PDE9 Inhibitor Using a cGMP Reporter Cell Line
Mol Pharmacol 2005 68: 1775-1781. Published online September 8, 2005; 10.1124/mol.105.017608 [Abstract] [Full Text] [PDF]  

Sudhakar Chintharlapalli, Sabitha Papineni, Seung Joon Baek, Shengxi Liu, and Stephen Safe

1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes Are Peroxisome Proliferator-Activated Receptor Agonists but Decrease HCT-116 Colon Cancer Cell Survival through Receptor-Independent Activation of Early Growth Response-1 and Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1
Mol Pharmacol 2005 68: 1782-1792. Published online September 9, 2005; 10.1124/mol.105.017046 [Abstract] [Full Text] [PDF]  

Alice L. Rodriguez, Yi Nong, Nishant K. Sekaran, David Alagille, Gilles D. Tamagnan, and P. Jeffrey Conn

A Close Structural Analog of 2-Methyl-6-(phenylethynyl)-pyridine Acts as a Neutral Allosteric Site Ligand on Metabotropic Glutamate Receptor Subtype 5 and Blocks the Effects of Multiple Allosteric Modulators
Mol Pharmacol 2005 68: 1793-1802. Published online September 9, 2005; 10.1124/mol.105.016139 [Abstract] [Full Text] [PDF]  

Kyung-Ok Choi, Taekyong Lee, Naery Lee, Ji-Hyun Kim, Eun Gyeong Yang, Jung Min Yoon, Jin Hwan Kim, Tae Gyu Lee, and Hyunsung Park

Inhibition of the Catalytic Activity of Hypoxia-Inducible Factor-1-Prolyl-Hydroxylase 2 by a MYND-Type Zinc Finger
Mol Pharmacol 2005 68: 1803-1809. Published online September 9, 2005; 10.1124/mol.105.015271 [Abstract] [Full Text] [PDF]  

Marni Brisson, Theresa Nguyen, Peter Wipf, Beomjun Joo, Billy W. Day, John S. Skoko, Emanuel M. Schreiber, Caleb Foster, Pallavi Bansal, and John S. Lazo

Redox Regulation of Cdc25B by Cell-Active Quinolinediones
Mol Pharmacol 2005 68: 1810-1820. Published online September 9, 2005; 10.1124/mol.105.016360 [Abstract] [Full Text] [PDF]  

Richard J. Ward and Graeme Milligan

A Key Serine for the GTPase-Activating Protein Function of Regulator of G Protein Signaling Proteins Is Not a General Target for 14-3-3 Interactions
Mol Pharmacol 2005 68: 1821-1830. Published online September 13, 2005; 10.1124/mol.105.015073 [Abstract] [Full Text] [PDF]  

Jianbei Zhu, Lei Xiong, Biao Yu, and Jiarui Wu

Apoptosis Induced by a New Member of Saponin Family Is Mediated through Caspase-8-Dependent Cleavage of Bcl-2
Mol Pharmacol 2005 68: 1831-1838. Published online September 23, 2005; 10.1124/mol.105.015826 [Abstract] [Full Text] [PDF]  

A. Kuryatov, J. Luo, J. Cooper, and J. Lindstrom

Nicotine Acts as a Pharmacological Chaperone to Up-Regulate Human 42 Acetylcholine Receptors
Mol Pharmacol 2005 68: 1839-1851. Published online September 23, 2005; 10.1124/mol.105.012419 [Abstract] [Full Text] [PDF]  

Walter Rocha, Rocio Sanchez, Julie Deschênes, Anick Auger, Elise Hébert, John H. White, and Sylvie Mader

Opposite Effects of Histone Deacetylase Inhibitors on Glucocorticoid and Estrogen Signaling in Human Endometrial Ishikawa Cells
Mol Pharmacol 2005 68: 1852-1862. Published online September 26, 2005; 10.1124/mol.105.014514 [Abstract] [Full Text] [PDF]  

Andon N. Placzek, Francesca Grassi, Edwin M Meyer, and Roger L. Papke

An 7 Nicotinic Acetylcholine Receptor Gain-of-Function Mutant That Retains Pharmacological Fidelity
Mol Pharmacol 2005 68: 1863-1876. Published online September 26, 2005; 10.1124/mol.105.016402 [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.