Perspectives:

Michael M. White

Pretty Subunits All in a Row: Using Concatenated Subunit Constructs to Force the Expression of Receptors with Defined Subunit Stoichiometry and Spatial Arrangement
Mol Pharmacol 2006 69: 407-410. Published online November 17, 2005; 10.1124/mol.105.020727 [Abstract] [Full Text] [PDF] [Related Article]   

Articles:

Louisa M. Brown, Rachel L. Cowen, Camille Debray, Amanda Eustace, Janine T. Erler, Freda C. D. Sheppard, Catriona A. Parker, Ian J. Stratford, and Kaye J. Williams

Reversing Hypoxic Cell Chemoresistance in Vitro Using Genetic and Small Molecule Approaches Targeting Hypoxia Inducible Factor-1
Mol Pharmacol 2006 69: 411-418. Published online October 27, 2005; 10.1124/mol.105.015743 [Abstract] [Full Text] [PDF]  

Frank Bosmans, Lachlan Rash, Shunyi Zhu, Sylvie Diochot, Michel Lazdunski, Pierre Escoubas, and Jan Tytgat

Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes
Mol Pharmacol 2006 69: 419-429. Published online November 2, 2005; 10.1124/mol.105.015941 [Abstract] [Full Text] [PDF] [Data Supplement]   

Jacques E. Riby, Ling Xue, Urmi Chatterji, Erik L. Bjeldanes, Gary L. Firestone, and Leonard F. Bjeldanes

Activation and Potentiation of Interferon- Signaling by 3,3'-Diindolylmethane in MCF-7 Breast Cancer Cells
Mol Pharmacol 2006 69: 430-439. Published online November 2, 2005; 10.1124/mol.105.017053 [Abstract] [Full Text] [PDF]  

Guei-Sheung Liu, Li-Fen Liu, Che-Jen Lin, Jui-Cheng Tseng, Ming-Ju Chuang, Hing-Chung Lam, Jenn-Kuen Lee, Lin-Cheng Yang, Julie Hwa Yu Chan, Shen-Long Howng, and Ming-Hong Tai

Gene Transfer of Pro-opiomelanocortin Prohormone Suppressed the Growth and Metastasis of Melanoma: Involvement of -Melanocyte-Stimulating Hormone-Mediated Inhibition of the Nuclear Factor B/Cyclooxygenase-2 Pathway
Mol Pharmacol 2006 69: 440-451. Published online November 3, 2005; 10.1124/mol.105.015404 [Abstract] [Full Text] [PDF] [Data Supplement]   

Alexandre Mourot, Jordi Rodrigo, Florence Kotzyba-Hibert, Sonia Bertrand, Daniel Bertrand, and Maurice Goeldner

Probing the Reorganization of the Nicotinic Acetylcholine Receptor during Desensitization by Time-Resolved Covalent Labeling Using [³H]AC5, a Photoactivatable Agonist
Mol Pharmacol 2006 69: 452-461. Published online November 3, 2005; 10.1124/mol.105.017566 [Abstract] [Full Text] [PDF]  

Anika M. S. Hartz, Björn Bauer, Gert Fricker, and David S. Miller

Rapid Modulation of P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier by Tumor Necrosis Factor- and Lipopolysaccharide
Mol Pharmacol 2006 69: 462-470. Published online November 8, 2005; 10.1124/mol.105.017954 [Abstract] [Full Text] [PDF]  

Magali Gary-Bobo, Ghizlane Elachouri, Bernard Scatton, Gérard Le Fur, Florence Oury-Donat, and Mohammed Bensaid

The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Cell Proliferation and Increases Markers of Adipocyte Maturation in Cultured Mouse 3T3 F442A Preadipocytes
Mol Pharmacol 2006 69: 471-478. Published online November 9, 2005; 10.1124/mol.105.015040 [Abstract] [Full Text] [PDF]  

Sandra Milasta, John Pediani, Shirley Appelbe, Steven Trim, Michael Wyatt, Peter Cox, Mark Fidock, and Graeme Milligan

Interactions between the Mas-Related Receptors MrgD and MrgE Alter Signalling and Trafficking of MrgD
Mol Pharmacol 2006 69: 479-491. Published online November 9, 2005; 10.1124/mol.105.018788 [Abstract] [Full Text] [PDF]  

Ruth S. Everett, Miriam K. Vanhook, Nadia Barozzi, Istvan Toth, and Larry G. Johnson

Specific Modulation of Airway Epithelial Tight Junctions by Apical Application of an Occludin Peptide
Mol Pharmacol 2006 69: 492-500. Published online November 15, 2005; 10.1124/mol.105.017251 [Abstract] [Full Text] [PDF]  

Danyelle M. Townsend, Victoria J. Findlay, Farit Fazilev, Molly Ogle, Jacob Fraser, Joseph E. Saavedra, Xinhua Ji, Larry K. Keefer, and Kenneth D. Tew

A Glutathione S-Transferase -Activated Prodrug Causes Kinase Activation Concurrent with S-Glutathionylation of Proteins
Mol Pharmacol 2006 69: 501-508. Published online November 15, 2005; 10.1124/mol.105.018523 [Abstract] [Full Text] [PDF]  

Matthew Perry, Phillip J. Stansfeld, Joanne Leaney, Claire Wood, Marcel J. de Groot, Derek Leishman, Michael J. Sutcliffe, and John S. Mitcheson

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs
Mol Pharmacol 2006 69: 509-519. Published online November 16, 2005; 10.1124/mol.105.016741 [Abstract] [Full Text] [PDF]  

Ping Sun, Hui Xiong, Tae Hoon Kim, Bing Ren, and Zhuohua Zhang

Positive Inter-Regulation between -Catenin/T Cell Factor-4 Signaling and Endothelin-1 Signaling Potentiates Proliferation and Survival of Prostate Cancer Cells
Mol Pharmacol 2006 69: 520-531. Published online November 16, 2005; 10.1124/mol.105.019620 [Abstract] [Full Text] [PDF] [Erratum]   

Tram Anh Ta, Wei Feng, Tadeusz F. Molinski, and Isaac N. Pessah

Hydroxylated Xestospongins Block Inositol-1,4,5-trisphosphate-Induced Ca²⁺ Release and Sensitize Ca²⁺-Induced Ca²⁺ Release Mediated by Ryanodine Receptors
Mol Pharmacol 2006 69: 532-538. Published online October 25, 2005; 10.1124/mol.105.019125 [Abstract] [Full Text] [PDF]  

Tullio Florio, Silvia Casagrande, Fabrizio Diana, Adriana Bajetto, Carola Porcile, Gianluigi Zona, Stefano Thellung, Sara Arena, Alessandra Pattarozzi, Alessandro Corsaro, Renato Spaziante, Mauro Robello, and Gennaro Schettini

Chemokine Stromal Cell-Derived Factor 1 Induces Proliferation and Growth Hormone Release in GH4C1 Rat Pituitary Adenoma Cell Line through Multiple Intracellular Signals
Mol Pharmacol 2006 69: 539-546. Published online October 28, 2005; 10.1124/mol.105.015255 [Abstract] [Full Text] [PDF]  

Alexis Bond, Zachary Reichert, and James T. Stivers

Novel and Specific Inhibitors of a Poxvirus Type I Topoisomerase
Mol Pharmacol 2006 69: 547-557. Published online November 2, 2005; 10.1124/mol.105.019067 [Abstract] [Full Text] [PDF]  

Paul J. Groot-Kormelink, Steven Broadbent, Marco Beato, and Lucia G. Sivilotti

Constraining the Expression of Nicotinic Acetylcholine Receptors by Using Pentameric Constructs
Mol Pharmacol 2006 69: 558-563. Published online November 3, 2005; 10.1124/mol.105.019356 [Abstract] [Full Text] [PDF]  

Zakaria Mtchedlishvili and Jaideep Kapur

High-Affinity, Slowly Desensitizing GABA_A Receptors Mediate Tonic Inhibition in Hippocampal Dentate Granule Cells
Mol Pharmacol 2006 69: 564-575. Published online November 10, 2005; 10.1124/mol.105.016683 [Abstract] [Full Text] [PDF]  

Estelle Toulmé, Florentina Soto, Maurice Garret, and Eric Boué-Grabot

Functional Properties of Internalization-Deficient P2X₄ Receptors Reveal a Novel Mechanism of Ligand-Gated Channel Facilitation by Ivermectin
Mol Pharmacol 2006 69: 576-587. Published online November 10, 2005; 10.1124/mol.105.018812 [Abstract] [Full Text] [PDF]  

Omar Tliba, John A. Cidlowski, and Yassine Amrani

CD38 Expression Is Insensitive to Steroid Action in Cells Treated with Tumor Necrosis Factor- and Interferon- by a Mechanism Involving the Up-Regulation of the Glucocorticoid Receptor Isoform
Mol Pharmacol 2006 69: 588-596. Published online November 16, 2005; 10.1124/mol.105.019679 [Abstract] [Full Text] [PDF]  

Masatoshi Jinnin, Hironobu Ihn, and Kunihiko Tamaki

Characterization of SIS3, a Novel Specific Inhibitor of Smad3, and Its Effect on Transforming Growth Factor-1-Induced Extracellular Matrix Expression
Mol Pharmacol 2006 69: 597-607. Published online November 15, 2005; 10.1124/mol.105.017483 [Abstract] [Full Text] [PDF]  

Andrew J. Crossthwaite, Antonio Ciruela, Timothy F. Rayner, and Dermot M. F. Cooper

A Direct Interaction between the N Terminus of Adenylyl Cyclase AC8 and the Catalytic Subunit of Protein Phosphatase 2A
Mol Pharmacol 2006 69: 608-617. Published online October 28, 2005; 10.1124/mol.105.018275 [Abstract] [Full Text] [PDF]  

Jacques Barik and Susan Wonnacott

Indirect Modulation by 7 Nicotinic Acetylcholine Receptors of Noradrenaline Release in Rat Hippocampal Slices: Interaction with Glutamate and GABA Systems and Effect of Nicotine Withdrawal
Mol Pharmacol 2006 69: 618-628. Published online November 3, 2005; 10.1124/mol.105.018184 [Abstract] [Full Text] [PDF]  

Elaine M. Leslie, Jie Liu, Curtis D. Klaassen, and Michael P. Waalkes

Acquired Cadmium Resistance in Metallothionein-I/II(–/–) Knockout Cells: Role of the T-Type Calcium Channel Cacn_1G in Cadmium Uptake
Mol Pharmacol 2006 69: 629-639. Published online November 10, 2005; 10.1124/mol.105.014241 [Abstract] [Full Text] [PDF]  

S. Khom, I. Baburin, E. N. Timin, A. Hohaus, W. Sieghart, and S. Hering

Pharmacological Properties of GABA_A Receptors Containing 1 Subunits
Mol Pharmacol 2006 69: 640-649. Published online November 4, 2005; 10.1124/mol.105.017236 [Abstract] [Full Text] [PDF] [Data Supplement]   

Anneke C. Blackburn, Klaus I. Matthaei, Cindy Lim, Matthew C. Taylor, Jean Y. Cappello, John D. Hayes, M. W. Anders, and Philip G. Board

Deficiency of Glutathione Transferase Zeta Causes Oxidative Stress and Activation of Antioxidant Response Pathways
Mol Pharmacol 2006 69: 650-657. Published online November 8, 2005; 10.1124/mol.105.018911 [Abstract] [Full Text] [PDF]  

Oscar Casis, Søren-Peter Olesen, and Michael C. Sanguinetti

Mechanism of Action of a Novel Human ether-a-go-go-Related Gene Channel Activator
Mol Pharmacol 2006 69: 658-665. Published online November 11, 2005; 10.1124/mol.105.019943 [Abstract] [Full Text] [PDF]  

Amanda L. Harris, John J. Ryan, and Nicholas Farrell

Biological Consequences of Trinuclear Platinum Complexes: Comparison of [{trans-PtCl(NH₃)₂}₂µ-(trans-Pt(NH₃)₂(H₂N(CH₂)₆-NH₂)₂)]⁴⁺ (BBR 3464) with Its Noncovalent Congeners
Mol Pharmacol 2006 69: 666-672. Published online November 7, 2005; 10.1124/mol.105.018762 [Abstract] [Full Text] [PDF]  

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