Perspectives:

Myron L. Toews

Adenosine Receptors Find a New Partner and Move Out
Mol Pharmacol 2006 69: 1075-1078. Published online January 18, 2006; 10.1124/mol.106.022699 [Abstract] [Full Text] [PDF] [Related Article]   

John D. Hildebrandt

Bring Your Own G Protein
Mol Pharmacol 2006 69: 1079-1082. Published online January 25, 2006; 10.1124/mol.106.022921 [Abstract] [Full Text] [PDF] [Data Supplement] [Related Article]   

Articles:

Tetyana Milojevic, Veronika Reiterer, Eduard Stefan, Vladimir M. Korkhov, Mario M. Dorostkar, Eszter Ducza, Egon Ogris, Stefan Boehm, Michael Freissmuth, and Christian Nanoff

The Ubiquitin-Specific Protease Usp4 Regulates the Cell Surface Level of the A_2a Receptor
Mol Pharmacol 2006 69: 1083-1094. Published online December 9, 2005; 10.1124/mol.105.015818 [Abstract] [Full Text] [PDF]  

F. Hosseinpour, R. Moore, M. Negishi, and T. Sueyoshi

Serine 202 Regulates the Nuclear Translocation of Constitutive Active/Androstane Receptor
Mol Pharmacol 2006 69: 1095-1102. Published online December 23, 2005; 10.1124/mol.105.019505 [Abstract] [Full Text] [PDF]  

Shigeyuki Uno, Timothy P. Dalton, Nadine Dragin, Christine P. Curran, Sandrine Derkenne, Marian L. Miller, Howard G. Shertzer, Frank J. Gonzalez, and Daniel W. Nebert

Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines: CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate
Mol Pharmacol 2006 69: 1103-1114. Published online December 23, 2005; 10.1124/mol.105.021501 [Abstract] [Full Text] [PDF]  

Julien Guergnon, Frédéric Dessauge, Victoria Dominguez, Jean Viallet, Serge Bonnefoy, Victor J. Yuste, Odile Mercereau-Puijalon, Xavier Cayla, Angelita Rebollo, Santos A. Susin, Pierre-Etienne Bost, and Alphonse Garcia

Use of Penetrating Peptides Interacting with PP1/PP2A Proteins As a General Approach for a Drug Phosphatase Technology
Mol Pharmacol 2006 69: 1115-1124. Published online December 30, 2005; 10.1124/mol.105.019364 [Abstract] [Full Text] [PDF]  

John J. Shacka, Barbara J. Klocke, Masahiro Shibata, Yasuo Uchiyama, Geeta Datta, Robert E. Schmidt, and Kevin A. Roth

Bafilomycin A1 Inhibits Chloroquine-Induced Death of Cerebellar Granule Neurons
Mol Pharmacol 2006 69: 1125-1136. Published online January 3, 2006; 10.1124/mol.105.018408 [Abstract] [Full Text] [PDF]  

Junyi Ma, Yong Zhang, Alex E. Kalyuzhny, and Zhizhong Z. Pan

Emergence of Functional -Opioid Receptors Induced by Long-Term Treatment with Morphine
Mol Pharmacol 2006 69: 1137-1145. Published online January 6, 2006; 10.1124/mol.105.019109 [Abstract] [Full Text] [PDF]  

Jean-Philippe Fortin, Edward K. Dziadulewicz, Lajos Gera, and François Marceau

A Nonpeptide Antagonist Reveals a Highly Glycosylated State of the Rabbit Kinin B₁ Receptor
Mol Pharmacol 2006 69: 1146-1157. Published online January 11, 2006; 10.1124/mol.105.019976 [Abstract] [Full Text] [PDF]  

Robin D. Couch, Neil J. Ganem, Ming Zhou, Veljko M. Popov, Tadashi Honda, Timothy D. Veenstra, Michael B. Sporn, and Amy C. Anderson

2-Cyano-3,12-dioxooleana-1,9(11)-diene-28-oic Acid Disrupts Microtubule Polymerization: A Possible Mechanism Contributing to Apoptosis
Mol Pharmacol 2006 69: 1158-1165. Published online January 11, 2006; 10.1124/mol.105.018572 [Abstract] [Full Text] [PDF]  

Jozsef Lazar, Derek C. Braun, Attila Tóth, Yun Wang, Larry V. Pearce, Vladimir A. Pavlyukovets, Peter M. Blumberg, Susan H. Garfield, Stephen Wincovitch, Hyun-Kyung Choi, and Jeewoo Lee

Kinetics of Penetration Influence the Apparent Potency of Vanilloids on TRPV1
Mol Pharmacol 2006 69: 1166-1173. Published online January 17, 2006; 10.1124/mol.105.019158 [Abstract] [Full Text] [PDF]  

Anna Planavila, Ricardo Rodríguez-Calvo, Alberto Fernández de Arriba, Rosa M. Sánchez, Juan C. Laguna, Manuel Merlos, and Manuel Vazquez-Carrera

Inhibition of Cardiac Hypertrophy by Triflusal (4-Trifluoromethyl Derivative of Salicylate) and Its Active Metabolite
Mol Pharmacol 2006 69: 1174-1181. Published online January 18, 2006; 10.1124/mol.105.016345 [Abstract] [Full Text] [PDF]  

Ismael Samudio, Marina Konopleva, Helene Pelicano, Peng Huang, Olga Frolova, William Bornmann, Yunming Ying, Randall Evans, Rooha Contractor, and Michael Andreeff

A Novel Mechanism of Action of Methyl-2-cyano-3,12 Dioxoolean-1,9 Diene-28-oate: Direct Permeabilization of the Inner Mitochondrial Membrane to Inhibit Electron Transport and Induce Apoptosis
Mol Pharmacol 2006 69: 1182-1193. Published online January 12, 2006; 10.1124/mol.105.018051 [Abstract] [Full Text] [PDF]  

Remko A. Bakker, Adrian Flores Lozada, André van Marle, Fiona C. Shenton, Guillaume Drutel, Kaj Karlstedt, Marcel Hoffmann, Minnamaija Lintunen, Yumiko Yamamoto, Richard M. van Rijn, Paul L. Chazot, Pertti Panula, and Rob Leurs

Discovery of Naturally Occurring Splice Variants of the Rat Histamine H₃ Receptor That Act as Dominant-Negative Isoforms
Mol Pharmacol 2006 69: 1194-1206. Published online January 13, 2006; 10.1124/mol.105.019299 [Abstract] [Full Text] [PDF]  

Haiyan Lu, Janice Murtagh, and Edward L. Schwartz

The Microtubule Binding Drug Laulimalide Inhibits Vascular Endothelial Growth Factor-Induced Human Endothelial Cell Migration and Is Synergistic when Combined with Docetaxel (Taxotere)
Mol Pharmacol 2006 69: 1207-1215. Published online January 13, 2006; 10.1124/mol.105.019075 [Abstract] [Full Text] [PDF]  

Yuri A. Kuryshev, Lu Wang, Barbara A. Wible, Xiaoping Wan, and Eckhard Ficker

Antimony-Based Antileishmanial Compounds Prolong the Cardiac Action Potential by an Increase in Cardiac Calcium Currents
Mol Pharmacol 2006 69: 1216-1225. Published online January 17, 2006; 10.1124/mol.105.019281 [Abstract] [Full Text] [PDF] [Data Supplement]   

Yun-Guang Tong, Xiong-Wen Zhang, Mei-Yu Geng, Jian-Ming Yue, Xian-Liang Xin, Fang Tian, Xu Shen, Lin-Jiang Tong, Mei-Hong Li, Chao Zhang, Wei-Hong Li, Li-Ping Lin, and Jian Ding

Pseudolarix Acid B, a New Tubulin-Binding Agent, Inhibits Angiogenesis by Interacting with a Novel Binding Site on Tubulin
Mol Pharmacol 2006 69: 1226-1233. Published online January 19, 2006; 10.1124/mol.105.020537 [Abstract] [Full Text] [PDF]  

Marianna Storto, Loredana Capobianco, Giuseppe Battaglia, Gemma Molinaro, Roberto Gradini, Barbara Riozzi, Alessandra Di Mambro, Kathryn J. Mitchell, Valeria Bruno, Maria P. Vairetti, Guy A. Rutter, and Ferdinando Nicoletti

Insulin Secretion Is Controlled by mGlu5 Metabotropic Glutamate Receptors
Mol Pharmacol 2006 69: 1234-1241. Published online January 19, 2006; 10.1124/mol.105.018390 [Abstract] [Full Text] [PDF]  

Henrik Amtoft Neubauer, Carsten Gram Hansen, and Ove Wiborg

Dissection of an Allosteric Mechanism on the Serotonin Transporter: A Cross-Species Study
Mol Pharmacol 2006 69: 1242-1250. Published online January 24, 2006; 10.1124/mol.105.018507 [Abstract] [Full Text] [PDF]  

C. M. Tigaret, A. Thalhammer, G. F. Rast, C. G. Specht, Y. P. Auberson, M. G. Stewart, and R. Schoepfer

Subunit Dependencies of N-Methyl-D-aspartate (NMDA) Receptor-Induced -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Internalization
Mol Pharmacol 2006 69: 1251-1259. Published online January 25, 2006; 10.1124/mol.105.018580 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ursula Schindler, Hartmut Strobel, Karl Schönafinger, Wolfgang Linz, Matthias Löhn, Piero A. Martorana, Hartmut Rütten, Peter W. Schindler, Andreas E. Busch, Michael Sohn, Andrea Töpfer, Astrid Pistorius, Christoph Jannek, and Alexander Mülsch

Biochemistry and Pharmacology of Novel Anthranilic Acid Derivatives Activating Heme-Oxidized Soluble Guanylyl Cyclase
Mol Pharmacol 2006 69: 1260-1268. Published online December 6, 2005; 10.1124/mol.105.018747 [Abstract] [Full Text] [PDF]  

Yun Ding, Mika Li, Jinwu Zhang, Ningli Li, Zongqin Xia, Yaer Hu, Sunxin Wang, and Guo-Huang Fan

The 73-kDa Heat Shock Cognate Protein Is a CXCR4 Binding Protein that Regulates the Receptor Endocytosis and the Receptor-Mediated Chemotaxis
Mol Pharmacol 2006 69: 1269-1279. Published online December 19, 2005; 10.1124/mol.105.020271 [Abstract] [Full Text] [PDF]  

Michael A. Clark and Nevin A. Lambert

Endogenous Regulator of G-Protein Signaling Proteins Regulate the Kinetics of G_q/11-Mediated Modulation of Ion Channels in Central Nervous System Neurons
Mol Pharmacol 2006 69: 1280-1287. Published online December 20, 2005; 10.1124/mol.105.019059 [Abstract] [Full Text] [PDF]  

Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki, Kazuyo Nakamura, Katsunori Takashima, Tsukasa Seya, Osamu Hazeki, Tomoyuki Kitazaki, and Yuji Iizawa

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling
Mol Pharmacol 2006 69: 1288-1295. Published online December 22, 2005; 10.1124/mol.105.019695 [Abstract] [Full Text] [PDF]  

Christopher G. Thomas, Johannes J. Krupp, Elena E. Bagley, Reginald Bauzon, Stephen F. Heinemann, Bryce Vissel, and Gary L. Westbrook

Probing N-Methyl-D-aspartate Receptor Desensitization with the Substituted-Cysteine Accessibility Method
Mol Pharmacol 2006 69: 1296-1303. Published online December 23, 2005; 10.1124/mol.105.017350 [Abstract] [Full Text] [PDF]  

Ericka N. Defoort, Perry M. Kim, and Louise M. Winn

Valproic Acid Increases Conservative Homologous Recombination Frequency and Reactive Oxygen Species Formation: A Potential Mechanism for Valproic Acid-Induced Neural Tube Defects
Mol Pharmacol 2006 69: 1304-1310. Published online December 23, 2005; 10.1124/mol.105.017855 [Abstract] [Full Text] [PDF]  

Nguyen D. Khoa, Michael Postow, Jennifer Danielsson, and Bruce N. Cronstein

Tumor Necrosis Factor- Prevents Desensitization of G_s-Coupled Receptors by Regulating GRK2 Association with the Plasma Membrane
Mol Pharmacol 2006 69: 1311-1319. Published online December 29, 2005; 10.1124/mol.105.016857 [Abstract] [Full Text] [PDF]  

Yixuan Gong, Gary L. Firestone, and Leonard F. Bjeldanes

3,3'-Diindolylmethane Is a Novel Topoisomerase II Catalytic Inhibitor That Induces S-Phase Retardation and Mitotic Delay in Human Hepatoma HepG2 Cells
Mol Pharmacol 2006 69: 1320-1327. Published online December 29, 2005; 10.1124/mol.105.018978 [Abstract] [Full Text] [PDF]  

Juliane Stieber, Karen Wieland, Georg Stöckl, Andreas Ludwig, and Franz Hofmann

Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors
Mol Pharmacol 2006 69: 1328-1337. Published online December 30, 2005; 10.1124/mol.105.020701 [Abstract] [Full Text] [PDF]  

Patrick Augereau, Eric Badia, Maryse Fuentes, Fanja Rabenoelina, Marine Corniou, Danièle Derocq, Patrick Balaguer, and Vincent Cavailles

Transcriptional Regulation of the Human NRIP1/RIP140 Gene by Estrogen Is Modulated by Dioxin Signalling
Mol Pharmacol 2006 69: 1338-1346. Published online January 3, 2006; 10.1124/mol.105.017376 [Abstract] [Full Text] [PDF]  

Cheng-Hsien Chen, Tzu-Hurng Cheng, Heng Lin, Neng-Lang Shih, Yen-Ling Chen, Yee-Shiuan Chen, Ching-Feng Cheng, Wei-Shiung Lian, Tzu-Ching Meng, Wen-Ta Chiu, and Jin-Jer Chen

Reactive Oxygen Species Generation Is Involved in Epidermal Growth Factor Receptor Transactivation through the Transient Oxidization of Src Homology 2-Containing Tyrosine Phosphatase in Endothelin-1 Signaling Pathway in Rat Cardiac Fibroblasts
Mol Pharmacol 2006 69: 1347-1355. Published online January 3, 2006; 10.1124/mol.105.017558 [Abstract] [Full Text] [PDF]  

Alexei Rossokhin, Georgeta Teodorescu, Stephan Grissmer, and Boris S. Zhorov

Interaction of d-Tubocurarine with Potassium Channels: Molecular Modeling and Ligand Binding
Mol Pharmacol 2006 69: 1356-1365. Published online January 3, 2006; 10.1124/mol.105.017970 [Abstract] [Full Text] [PDF]  

Fabio Fumagalli, Angelisa Frasca, Maria Spartà, Filippo Drago, Giorgio Racagni, and Marco Andrea Riva

Long-Term Exposure to the Atypical Antipsychotic Olanzapine Differently Up-Regulates Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylation in Subcellular Compartments of Rat Prefrontal Cortex
Mol Pharmacol 2006 69: 1366-1372. Published online January 3, 2006; 10.1124/mol.105.019828 [Abstract] [Full Text] [PDF]  

Nieves Márquez, Luciano De Petrocellis, Francisco J. Caballero, Antonio Macho, Aniello Schiano-Moriello, Alberto Minassi, Giovanni Appendino, Eduardo Muñoz, and Vincenzo Di Marzo

Iodinated N-Acylvanillamines: Potential "Multiple-Target" Anti-Inflammatory Agents Acting via the Inhibition of T-Cell Activation and Antagonism at Vanilloid TRPV1 Channels
Mol Pharmacol 2006 69: 1373-1382. Published online January 4, 2006; 10.1124/mol.105.019786 [Abstract] [Full Text] [PDF]  

Ding-Wu Shen, Xing-Jie Liang, Toshihiro Suzuki, and Michael M. Gottesman

Identification by Functional Cloning from a Retroviral cDNA Library of cDNAs for Ribosomal Protein L36 and the 10-kDa Heat Shock Protein that Confer Cisplatin Resistance
Mol Pharmacol 2006 69: 1383-1388. Published online January 4, 2006; 10.1124/mol.105.017525 [Abstract] [Full Text] [PDF]  

Laxiang Wan, Deliang Cao, Jianmin Zeng, Ruilan Yan, and Giuseppe Pizzorno

Modulation of Uridine Phosphorylase Gene Expression by Tumor Necrosis Factor- Enhances the Antiproliferative Activity of the Capecitabine Intermediate 5'-Deoxy-5-fluorouridine in Breast Cancer Cells
Mol Pharmacol 2006 69: 1389-1395. Published online January 5, 2006; 10.1124/mol.105.018515 [Abstract] [Full Text] [PDF]  

Martin A. Lewis, Lisa Hunihan, Diana Franco, Barbara Robertson, Jane Palmer, Denis R. St. Laurent, Balu N. Balasubramanian, Yi Li, and Ryan S. Westphal

Identification and Characterization of Compounds That Potentiate NT-3-Mediated Trk Receptor Activity
Mol Pharmacol 2006 69: 1396-1404. Published online January 6, 2006; 10.1124/mol.105.020255 [Abstract] [Full Text] [PDF]  

Heejung Kim, Hyunchu Jeon, Hyesik Kong, Youngwook Yang, Boim Choi, Young Mi Kim, Len Neckers, and Yunjin Jung

A Molecular Mechanism for the Anti-Inflammatory Effect of Taurine-Conjugated 5-Aminosalicylic Acid in Inflamed Colon
Mol Pharmacol 2006 69: 1405-1412. Published online January 11, 2006; 10.1124/mol.105.020578 [Abstract] [Full Text] [PDF]  

Ryuichi Takezawa, Henrique Cheng, Andreas Beck, Jun Ishikawa, Pierre Launay, Hirokazu Kubota, Jean-Pierre Kinet, Andrea Fleig, Toshimitsu Yamada, and Reinhold Penner

A Pyrazole Derivative Potently Inhibits Lymphocyte Ca²⁺ Influx and Cytokine Production by Facilitating Transient Receptor Potential Melastatin 4 Channel Activity
Mol Pharmacol 2006 69: 1413-1420. Published online January 11, 2006; 10.1124/mol.105.021154 [Abstract] [Full Text] [PDF]  

Hui Zhao, Horace H. Loh, and P. Y. Law

Adenylyl Cyclase Superactivation Induced by Long-Term Treatment with Opioid Agonist Is Dependent on Receptor Localized within Lipid Rafts and Is Independent of Receptor Internalization
Mol Pharmacol 2006 69: 1421-1432. Published online January 13, 2006; 10.1124/mol.105.020024 [Abstract] [Full Text] [PDF]  

Li Zhang, Cherisse DiLizio, David Kim, Emer M. Smyth, and David R. Manning

The G₁₂ Family of G Proteins as a Reporter of Thromboxane A₂ Receptor Activity
Mol Pharmacol 2006 69: 1433-1440. Published online January 17, 2006; 10.1124/mol.105.019703 [Abstract] [Full Text] [PDF]  

Jesper Mosolff Mathiesen, Arthur Christopoulos, Trond Ulven, Julia F. Royer, Mercedes Campillo, Akos Heinemann, Leonardo Pardo, and Evi Kostenis

On the Mechanism of Interaction of Potent Surmountable and Insurmountable Antagonists with the Prostaglandin D2 Receptor CRTH2
Mol Pharmacol 2006 69: 1441-1453. Published online January 17, 2006; 10.1124/mol.105.017681 [Abstract] [Full Text] [PDF] [Data Supplement]   

Elena A. Semenova, Allison A. Johnson, Christophe Marchand, David A. Davis, Robert Yarchoan, and Yves Pommier

Preferential Inhibition of the Magnesium-Dependent Strand Transfer Reaction of HIV-1 Integrase by -Hydroxytropolones
Mol Pharmacol 2006 69: 1454-1460. Published online January 17, 2006; 10.1124/mol.105.020321 [Abstract] [Full Text] [PDF]  

Pieter Leyssen, Erik De Clercq, and Johan Neyts

The Anti-Yellow Fever Virus Activity of Ribavirin Is Independent of Error-Prone Replication
Mol Pharmacol 2006 69: 1461-1467. Published online January 18, 2006; 10.1124/mol.105.020057 [Abstract] [Full Text] [PDF]  

Sven G. Meuth, M. Isabel Aller, Thomas Munsch, Thekla Schuhmacher, Thomas Seidenbecher, Patrick Meuth, Christoph Kleinschnitz, Hans-Christian Pape, Heinz Wiendl, William Wisden, and Thomas Budde

The Contribution of TWIK-Related Acid-Sensitive K⁺-Containing Channels to the Function of Dorsal Lateral Geniculate Thalamocortical Relay Neurons
Mol Pharmacol 2006 69: 1468-1476. Published online January 19, 2006; 10.1124/mol.105.020594 [Abstract] [Full Text] [PDF]  

Yoko Otake, Alice Mims, and Daniel J. Fernandes

Merbarone Induces Activation of Caspase-Activated DNase and Excision of Chromosomal DNA Loops from the Nuclear Matrix
Mol Pharmacol 2006 69: 1477-1485. Published online January 24, 2006; 10.1124/mol.105.018036 [Abstract] [Full Text] [PDF]  

Christine Börner, Volker Höllt, and Jürgen Kraus

Cannabinoid Receptor Type 2 Agonists Induce Transcription of the µ-Opioid Receptor Gene in Jurkat T Cells
Mol Pharmacol 2006 69: 1486-1491. Published online January 24, 2006; 10.1124/mol.105.018325 [Abstract] [Full Text] [PDF]  

Myreille D'Astous, Pablo Mendez, Marc Morissette, Luis Miguel Garcia-Segura, and Thérèse Di Paolo

Implication of the Phosphatidylinositol-3 Kinase/Protein Kinase B Signaling Pathway in the Neuroprotective Effect of Estradiol in the Striatum of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice
Mol Pharmacol 2006 69: 1492-1498. Published online January 24, 2006; 10.1124/mol.105.018671 [Abstract] [Full Text] [PDF]  

Charles S. Morrow, Christina Peklak-Scott, Bimjhana Bishwokarma, Timothy E. Kute, Pamela K. Smitherman, and Alan J. Townsend

Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediates Resistance to Mitoxantrone via Glutathione-Dependent Drug Efflux
Mol Pharmacol 2006 69: 1499-1505. Published online January 24, 2006; 10.1124/mol.105.017988 [Abstract] [Full Text] [PDF]  

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