Perspective:

Michael E. Wilhide and W. Keith Jones

Potential Therapeutic Gene for the Treatment of Ischemic Disease: Ad2/Hypoxia-Inducible Factor-1 (HIF-1)/VP16 Enhances B-Type Natriuretic Peptide Gene Expression via a HIF-1-Responsive Element
Mol Pharmacol 2006 69: 1773-1778. Published online March 27, 2006; 10.1124/mol.106.024968 [Abstract] [Full Text] [PDF] [Related Article]   

Accelerated Communication:

Wenjun Li, Douglas F. Covey, Juha-Matti Alakoskela, Paavo K. J. Kinnunen, and Joe Henry Steinbach

Enantiomers of Neuroactive Steroids Support a Specific Interaction with the GABA-C Receptor as the Mechanism of Steroid Action
Mol Pharmacol 2006 69: 1779-1782. Published online March 9, 2006; 10.1124/mol.106.022863 [Abstract] [Full Text] [PDF]  

Articles:

Jung-Hee Kim, Ji-Hye Jeong, Sung-Tak Jeon, Ho Kim, Jiyeon Ock, Kyoungho Suk, Sang-In Kim, Kyung-Sik Song, and Won-ha Lee

Decursin Inhibits Induction of Inflammatory Mediators by Blocking Nuclear Factor-B Activation in Macrophages
Mol Pharmacol 2006 69: 1783-1790. Published online March 1, 2006; 10.1124/mol.105.021048 [Abstract] [Full Text] [PDF] [Data Supplement]   

Mark A. Birrell, Sissie Wong, Elizabeth L. Hardaker, Matthew C. Catley, Kerryn McCluskie, Michael Collins, Saleem Haj-Yahia, and Maria G. Belvisi

IB Kinase-2-Independent and -Dependent Inflammation in Airway Disease Models: Relevance of IKK-2 Inhibition to the Clinic
Mol Pharmacol 2006 69: 1791-1800. Published online March 3, 2006; 10.1124/mol.105.019521 [Abstract] [Full Text] [PDF]  

Ritu Aneja, Surya N. Vangapandu, Manu Lopus, Ramesh Chandra, Dulal Panda, and Harish C. Joshi

Development of a Novel Nitro-Derivative of Noscapine for the Potential Treatment of Drug-Resistant Ovarian Cancer and T-Cell Lymphoma
Mol Pharmacol 2006 69: 1801-1809. Published online March 3, 2006; 10.1124/mol.105.021899 [Abstract] [Full Text] [PDF] [Erratum]   

Lei Zhang, Joan Tetrault, Wei Wang, Horace H. Loh, and Ping-Yee Law

Short- and Long-Term Regulation of Adenylyl Cyclase Activity by -Opioid Receptor Are Mediated by G_i2 in Neuroblastoma N₂A Cells
Mol Pharmacol 2006 69: 1810-1819. Published online March 8, 2006; 10.1124/mol.105.021352 [Abstract] [Full Text] [PDF]  

Naoyasu Umeda, Shu Kachi, Hideo Akiyama, Grit Zahn, Doerte Vossmeyer, Roland Stragies, and Peter A. Campochiaro

Suppression and Regression of Choroidal Neovascularization by Systemic Administration of an ₅₁ Integrin Antagonist
Mol Pharmacol 2006 69: 1820-1828. Published online March 9, 2006; 10.1124/mol.105.020941 [Abstract] [Full Text] [PDF]  

Kyung Sun Lee, So Ri Kim, Seoung Ju Park, Ho Kyung Lee, Hee Sun Park, Kyung Hoon Min, Sun Mi Jin, and Yong Chul Lee

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Reduces Vascular Endothelial Growth Factor Expression in Allergen-Induced Airway Inflammation
Mol Pharmacol 2006 69: 1829-1839. Published online March 9, 2006; 10.1124/mol.106.022228 [Abstract] [Full Text] [PDF]  

Hong Jin Lee, Andrew Wislocki, Catherine Goodman, Yan Ji, Rongrong Ge, Hubert Maehr, Milan Uskokovic, Michael Reiss, and Nanjoo Suh

A Novel Vitamin D Derivative Activates Bone Morphogenetic Protein Signaling in MCF10 Breast Epithelial Cells
Mol Pharmacol 2006 69: 1840-1848. Published online March 13, 2006; 10.1124/mol.105.022079 [Abstract] [Full Text] [PDF]  

James M. Sanders, Olli T. Pentikäinen, Luca Settimo, Ulla Pentikäinen, Muneo Shoji, Makoto Sasaki, Ryuichi Sakai, Mark S. Johnson, and Geoffrey T. Swanson

Determination of Binding Site Residues Responsible for the Subunit Selectivity of Novel Marine-Derived Compounds on Kainate Receptors
Mol Pharmacol 2006 69: 1849-1860. Published online March 14, 2006; 10.1124/mol.106.022772 [Abstract] [Full Text] [PDF]  

Hannu Kankaanranta, Pinja Ilmarinen, Xianzhi Zhang, Erkki Nissinen, and Eeva Moilanen

Antieosinophilic Activity of Orazipone
Mol Pharmacol 2006 69: 1861-1870. Published online March 15, 2006; 10.1124/mol.105.021170 [Abstract] [Full Text] [PDF] [Data Supplement]   

Sun-Hee Kim, Ellen C. Henry, Dong-Kyu Kim, Yun-Hee Kim, Kum Joo Shin, Myoung Sook Han, Taehoon G. Lee, Jong-Ku Kang, Thomas A. Gasiewicz, Sung Ho Ryu, and Pann-Ghill Suh

Novel Compound 2-Methyl-2H-pyrazole-3-carboxylic Acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) Prevents 2,3,7,8-TCDD-Induced Toxicity by Antagonizing the Aryl Hydrocarbon Receptor
Mol Pharmacol 2006 69: 1871-1878. Published online March 15, 2006; 10.1124/mol.105.021832 [Abstract] [Full Text] [PDF]  

Monica Ambrose, Aideen Ryan, Gerald C. O'Sullivan, Colum Dunne, and Orla P. Barry

Induction of Apoptosis in Renal Cell Carcinoma by Reactive Oxygen Species: Involvement of Extracellular Signal-Regulated Kinase 1/2, p38/, Cyclooxygenase-2 Down-Regulation, and Translocation of Apoptosis-Inducing Factor
Mol Pharmacol 2006 69: 1879-1890. Published online March 16, 2006; 10.1124/mol.105.020875 [Abstract] [Full Text] [PDF]  

Kamel El Omari, Sandra Liekens, Louise E. Bird, Jan Balzarini, and David K. Stammers

Mutations Distal to the Substrate Site Can Affect Varicella Zoster Virus Thymidine Kinase Activity: Implications for Drug Design
Mol Pharmacol 2006 69: 1891-1896. Published online March 23, 2006; 10.1124/mol.106.023002 [Abstract] [Full Text] [PDF]  

Mingxiang Liao, Saadia Faouzi, Andrey Karyakin, and Maria Almira Correia

Endoplasmic Reticulum-Associated Degradation of Cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: Further Characterization of Cellular Participants and Structural Determinants
Mol Pharmacol 2006 69: 1897-1904. Published online March 23, 2006; 10.1124/mol.105.021816 [Abstract] [Full Text] [PDF]  

Rafael Franco, Vicent Casadó, Josefa Mallol, Carla Ferrada, Sergi Ferré, Kjell Fuxe, Antoni Cortés, Francisco Ciruela, Carmen Lluis, and Enric I. Canela

The Two-State Dimer Receptor Model: A General Model for Receptor Dimers
Mol Pharmacol 2006 69: 1905-1912. Published online February 24, 2006; 10.1124/mol.105.020685 [Abstract] [Full Text] [PDF] [Data Supplement]   

Xianghai Chen, Frank Chen, Shanjun Liu, Hartmut Glaeser, Paul A. Dawson, Alan F. Hofmann, Richard B. Kim, Benjamin L. Shneider, and K. Sandy Pang

Transactivation of Rat Apical Sodium-Dependent Bile Acid Transporter and Increased Bile Acid Transport by 1,25-Dihydroxyvitamin D₃ via the Vitamin D Receptor
Mol Pharmacol 2006 69: 1913-1923. Published online February 15, 2006; 10.1124/mol.105.020792 [Abstract] [Full Text] [PDF]  

Rika Ueda, Hiromi Iketaki, Kiyoshi Nagata, Shioko Kimura, Frank J. Gonzalez, Kazutomi Kusano, Tsutomu Yoshimura, and Yasushi Yamazoe

A Common Regulatory Region Functions Bidirectionally in Transcriptional Activation of the Human CYP1A1 and CYP1A2 Genes
Mol Pharmacol 2006 69: 1924-1930. Published online February 27, 2006; 10.1124/mol.105.021220 [Abstract] [Full Text] [PDF]  

Nicole Martin-Moutot, Pascal Mansuelle, Gisèle Alcaraz, Raquel Gouvêa Dos Santos, Marta N. Cordeiro, Maria Elena De Lima, Michael Seagar, and Catherine Van Renterghem

Phoneutria nigriventer Toxin 1: A Novel, State-Dependent Inhibitor of Neuronal Sodium Channels That Interacts with µ Conotoxin Binding Sites
Mol Pharmacol 2006 69: 1931-1937. Published online February 27, 2006; 10.1124/mol.105.021147 [Abstract] [Full Text] [PDF] [Erratum]   

Qin Hao, Stacey A. Rutherford, Brad Low, and Hua Tang

Suppression of the Phosphorylation of Receptor Tyrosine Phosphatase- on the Src-Independent Site Tyrosine 789 by Reactive Oxygen Species
Mol Pharmacol 2006 69: 1938-1944. Published online February 27, 2006; 10.1124/mol.105.020115 [Abstract] [Full Text] [PDF]  

Galya R. Abdrakhmanova, M. Imad Damaj, F. Ivy Carroll, and Billy R. Martin

2-Fluoro-3-(4-nitro-phenyl)deschloroepibatidine Is a Novel Potent Competitive Antagonist of Human Neuronal 42 nAChRs
Mol Pharmacol 2006 69: 1945-1952. Published online February 27, 2006; 10.1124/mol.105.021782 [Abstract] [Full Text] [PDF]  

Yuxia Luo, Canwen Jiang, Adam J. Belanger, Geoffrey Y. Akita, Samuel C. Wadsworth, Richard J. Gregory, and Karen A. Vincent

A Constitutively Active Hypoxia-Inducible Factor-1/VP16 Hybrid Factor Activates Expression of the Human B-Type Natriuretic Peptide Gene
Mol Pharmacol 2006 69: 1953-1962. Published online February 28, 2006; 10.1124/mol.105.017905 [Abstract] [Full Text] [PDF]  

Achraf Traboulsie, Jean Chemin, Elodie Kupfer, Joël Nargeot, and Philippe Lory

T-Type Calcium Channels Are Inhibited by Fluoxetine and Its Metabolite Norfluoxetine
Mol Pharmacol 2006 69: 1963-1968. Published online March 1, 2006; 10.1124/mol.105.020842 [Abstract] [Full Text] [PDF]  

Florian Mullershausen, Alexander Lange, Evanthia Mergia, Andreas Friebe, and Doris Koesling

Desensitization of NO/cGMP Signaling in Smooth Muscle: Blood Vessels Versus Airways
Mol Pharmacol 2006 69: 1969-1974. Published online March 1, 2006; 10.1124/mol.105.020909 [Abstract] [Full Text] [PDF]  

Susanna Alloisio, Rita Aiello, Stefano Ferroni, and Mario Nobile

Potentiation of Native and Recombinant P2X7-Mediated Calcium Signaling by Arachidonic Acid in Cultured Cortical Astrocytes and Human Embryonic Kidney 293 Cells
Mol Pharmacol 2006 69: 1975-1983. Published online March 1, 2006; 10.1124/mol.105.020164 [Abstract] [Full Text] [PDF]  

Madhara Udawela, George Christopoulos, Nanda Tilakaratne, Arthur Christopoulos, Anthony Albiston, and Patrick M. Sexton

Distinct Receptor Activity-Modifying Protein Domains Differentially Modulate Interaction with Calcitonin Receptors
Mol Pharmacol 2006 69: 1984-1989. Published online March 10, 2006; 10.1124/mol.105.021915 [Abstract] [Full Text] [PDF]  

Bhavna Tanna, William Welch, Luc Ruest, John L. Sutko, and Alan J. Williams

The Interaction of an Impermeant Cation with the Sheep Cardiac RyR Channel Alters Ryanoid Association
Mol Pharmacol 2006 69: 1990-1997. Published online March 15, 2006; 10.1124/mol.105.021659 [Abstract] [Full Text] [PDF]  

Renê Oliveira Beleboni, Renato Guizzo, Andréia Cristina Karklin Fontana, Andrea Baldocchi Pizzo, Ruither Oliveira Gomes Carolino, Leonardo Gobbo-Neto, Norberto Peporine Lopes, Joaquim Coutinho-Netto, and Wagner Ferreira dos Santos

Neurochemical Characterization of a Neuroprotective Compound from Parawixia bistriata Spider Venom That Inhibits Synaptosomal Uptake of GABA and Glycine
Mol Pharmacol 2006 69: 1998-2006. Published online March 21, 2006; 10.1124/mol.105.017319 [Abstract] [Full Text] [PDF] [Data Supplement]   

Zhong-Liu Wu, Christal D. Sohl, Tsutomu Shimada, and F. Peter Guengerich

Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1
Mol Pharmacol 2006 69: 2007-2014. Published online March 21, 2006; 10.1124/mol.106.023648 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ping Li, Douglas F. Covey, Joe Henry Steinbach, and Gustav Akk

Dual Potentiating and Inhibitory Actions of a Benz[e]indene Neurosteroid Analog on Recombinant 122 GABA_A Receptors
Mol Pharmacol 2006 69: 2015-2026. Published online March 22, 2006; 10.1124/mol.106.022590 [Abstract] [Full Text] [PDF]  

Tamás Letoha, Erzsébet Kusz, Gábor Pápai, Annamária Szabolcs, József Kaszaki, Ilona Varga, Tamás Takács, Botond Penke, and Erno Duda

In Vitro and in Vivo Nuclear Factor-B Inhibitory Effects of the Cell-Penetrating Penetratin Peptide
Mol Pharmacol 2006 69: 2027-2036. Published online February 27, 2006; 10.1124/mol.105.019653 [Abstract] [Full Text] [PDF]  

Stéphanie Pochet, Séverine Tandel, Stéphanie Querriére, Marie Tre-Hardy, Mikel Garcia-Marcos, Manuela De Lorenzi, Michel Vandenbranden, Aida Marino, Michel Devleeschouwer, and Jean-Paul Dehaye

Modulation by LL-37 of the Responses of Salivary Glands to Purinergic Agonists
Mol Pharmacol 2006 69: 2037-2046. Published online March 2, 2006; 10.1124/mol.105.021444 [Abstract] [Full Text] [PDF]  

Chih-Hsin Tang, Rong-Sen Yang, Tsang-Hai Huang, Dah-Yuu Lu, Woei-Jer Chuang, Tur-Fu Huang, and Wen-Mei Fu

Ultrasound Stimulates Cyclooxygenase-2 Expression and Increases Bone Formation through Integrin, Focal Adhesion Kinase, Phosphatidylinositol 3-Kinase, and Akt Pathway in Osteoblasts
Mol Pharmacol 2006 69: 2047-2057. Published online March 15, 2006; 10.1124/mol.105.022160 [Abstract] [Full Text] [PDF]  

Ralf Hausmann, Jürgen Rettinger, Zoltan Gerevich, Sabine Meis, Matthias U. Kassack, Peter Illes, Günter Lambrecht, and Günther Schmalzing

The Suramin Analog 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic Acid (NF110) Potently Blocks P2X₃ Receptors: Subtype Selectivity Is Determined by Location of Sulfonic Acid Groups
Mol Pharmacol 2006 69: 2058-2067. Published online March 21, 2006; 10.1124/mol.106.022665 [Abstract] [Full Text] [PDF]  

Melinda D. Hains, Michele R. Wing, Savitri Maddileti, David P. Siderovski, and T. Kendall Harden

G_12/13- and Rho-Dependent Activation of Phospholipase C- by Lysophosphatidic Acid and Thrombin Receptors
Mol Pharmacol 2006 69: 2068-2075. Published online March 22, 2006; 10.1124/mol.105.017921 [Abstract] [Full Text] [PDF]  

Russell W. Garrett and Thomas A. Gasiewicz

The Aryl Hydrocarbon Receptor Agonist 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Circadian Rhythms, Quiescence, and Expression of Clock Genes in Murine Hematopoietic Stem and Progenitor Cells
Mol Pharmacol 2006 69: 2076-2083. Published online March 23, 2006; 10.1124/mol.105.021006 [Abstract] [Full Text] [PDF]  

Swati Nagar, Susan Walther, and Rebecca L. Blanchard

Sulfotransferase (SULT) 1A1 Polymorphic Variants ^*1, ^*2, and ^*3 Are Associated with Altered Enzymatic Activity, Cellular Phenotype, and Protein Degradation
Mol Pharmacol 2006 69: 2084-2092. Published online March 3, 2006; 10.1124/mol.105.019240 [Abstract] [Full Text] [PDF]  

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