Perspectives:

Martin Beinborn

Class B GPCRs: A Hidden Agonist Within?
Mol Pharmacol 2006 70: 1-4. Published online April 21, 2006; 10.1124/mol.106.025932 [Abstract] [Full Text] [PDF] [Related Article]   

Jon Lindstrom

Potentiation of Acetylcholine Receptors by Divalent Cations
Mol Pharmacol 2006 70: 5-7. Published online April 26, 2006; 10.1124/mol.106.025767 [Abstract] [Full Text] [PDF] [Related Article]   

Accelerated Communications:

Elizabeth E. Dunham, Emily A. Stevens, Edward Glover, and Christopher A. Bradfield

The Aryl Hydrocarbon Receptor Signaling Pathway Is Modified through Interactions with a Kelch Protein
Mol Pharmacol 2006 70: 8-15. Published online March 31, 2006; 10.1124/mol.106.024380 [Abstract] [Full Text] [PDF]  

Articles:

James T. McLaughlin, Jie Fu, Adrian D. Sproul, and Robert L. Rosenberg

Role of the Outer -Sheet in Divalent Cation Modulation of 7 Nicotinic Receptors
Mol Pharmacol 2006 70: 16-22. Published online March 13, 2006; 10.1124/mol.106.023259 [Abstract] [Full Text] [PDF]  

Jan Peter Thomas, Juergen Lautermann, Bernd Liedert, Frank Seiler, and Juergen Thomale

High Accumulation of Platinum-DNA Adducts in Strial Marginal Cells of the Cochlea Is an Early Event in Cisplatin but Not Carboplatin Ototoxicity
Mol Pharmacol 2006 70: 23-29. Published online March 28, 2006; 10.1124/mol.106.022244 [Abstract] [Full Text] [PDF]  

Sabine Traver, Marc Marien, Elodie Martin, Etienne C. Hirsch, and Patrick P. Michel

The Phenotypic Differentiation of Locus Ceruleus Noradrenergic Neurons Mediated by Brain-Derived Neurotrophic Factor Is Enhanced by Corticotropin Releasing Factor through the Activation of a cAMP-Dependent Signaling Pathway
Mol Pharmacol 2006 70: 30-40. Published online March 28, 2006; 10.1124/mol.106.022715 [Abstract] [Full Text] [PDF]  

Steven W. Paugh, Michael P. Cassidy, Hengjun He, Sheldon Milstien, Laura J. Sim-Selley, Sarah Spiegel, and Dana E. Selley

Sphingosine and Its Analog, the Immunosuppressant 2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, Interact with the CB₁ Cannabinoid Receptor
Mol Pharmacol 2006 70: 41-50. Published online March 29, 2006; 10.1124/mol.105.020552 [Abstract] [Full Text] [PDF]  

Natalya M. Kogan, Cristina Blázquez, Luis Álvarez, Ruth Gallily, Michael Schlesinger, Manuel Guzmán, and Raphael Mechoulam

A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells
Mol Pharmacol 2006 70: 51-59. Published online March 29, 2006; 10.1124/mol.105.021089 [Abstract] [Full Text] [PDF]  

Jude M. Mulligan, Lisa M. Greene, Suzanne Cloonan, Margaret M. Mc Gee, Valeria Onnis, Giuseppe Campiani, Caterina Fattorusso, Mark Lawler, D. Clive Williams, and Daniela M. Zisterer

Identification of Tubulin as the Molecular Target of Proapoptotic Pyrrolo-1,5-benzoxazepines
Mol Pharmacol 2006 70: 60-70. Published online March 29, 2006; 10.1124/mol.105.021204 [Abstract] [Full Text] [PDF]  

Amy K. Jassen, Hong Yang, Gregory M. Miller, Elizabeth Calder, and Bertha K. Madras

Receptor Regulation of Gene Expression of Axon Guidance Molecules: Implications for Adaptation
Mol Pharmacol 2006 70: 71-77. Published online April 4, 2006; 10.1124/mol.105.021998 [Abstract] [Full Text] [PDF]  

Michael M. C. Kong, Theresa Fan, George Varghese, Brian F. O'Dowd, and Susan R. George

Agonist-Induced Cell Surface Trafficking of an Intracellularly Sequestered D1 Dopamine Receptor Homo-Oligomer
Mol Pharmacol 2006 70: 78-89. Published online April 5, 2006; 10.1124/mol.105.021246 [Abstract] [Full Text] [PDF]  

John G. Partridge, Henry L. Puhl, III, and Stephen R. Ikeda

Phosducin and Phosducin-like Protein Attenuate G-Protein-Coupled Receptor-Mediated Inhibition of Voltage-Gated Calcium Channels in Rat Sympathetic Neurons
Mol Pharmacol 2006 70: 90-100. Published online April 11, 2006; 10.1124/mol.105.021394 [Abstract] [Full Text] [PDF]  

Cheryl E. Rockwell, Natasha T. Snider, Jerry T. Thompson, John P. Vanden Heuvel, and Norbert E. Kaminski

Interleukin-2 Suppression by 2-Arachidonyl Glycerol Is Mediated through Peroxisome Proliferator-Activated Receptor Independently of Cannabinoid Receptors 1 and 2
Mol Pharmacol 2006 70: 101-111. Published online April 12, 2006; 10.1124/mol.105.019117 [Abstract] [Full Text] [PDF]  

Sang-Ok Moon, Won Kim, Mi Jeong Sung, Sik Lee, Kyung Pyo Kang, Duk Hoon Kim, Sang Yong Lee, June-No So, and Sung Kwang Park

Resveratrol Suppresses Tumor Necrosis Factor--Induced Fractalkine Expression in Endothelial Cells
Mol Pharmacol 2006 70: 112-119. Published online April 13, 2006; 10.1124/mol.106.022392 [Abstract] [Full Text] [PDF]  

Hiromi Hamamoto, Tatsuya Kusudo, Naoko Urushino, Hiroyuki Masuno, Keiko Yamamoto, Sachiko Yamada, Masaki Kamakura, Miho Ohta, Kuniyo Inouye, and Toshiyuki Sakaki

Structure-Function Analysis of Vitamin D 24-Hydroxylase (CYP24A1) by Site-Directed Mutagenesis: Amino Acid Residues Responsible for Species-Based Difference of CYP24A1 between Humans and Rats
Mol Pharmacol 2006 70: 120-128. Published online April 14, 2006; 10.1124/mol.106.023275 [Abstract] [Full Text] [PDF]  

Ting Shi, Zhong-Hui Duan, Robert Papay, Elzbieta Pluskota, Robert J. Gaivin, Carol A. de la Motte, Edward F. Plow, and Dianne M. Perez

Novel ₁-Adrenergic Receptor Signaling Pathways: Secreted Factors and Interactions with the Extracellular Matrix
Mol Pharmacol 2006 70: 129-142. Published online April 14, 2006; 10.1124/mol.105.020735 [Abstract] [Full Text] [PDF] [Data Supplement]   

P. N. Palma, M. L. Rodrigues, M. Archer, M. J. Bonifácio, A. I. Loureiro, D. A. Learmonth, M. A. Carrondo, and P. Soares-da-Silva

Comparative Study of ortho- and meta-Nitrated Inhibitors of Catechol-O-methyltransferase: Interactions with the Active Site and Regioselectivity of O-Methylation
Mol Pharmacol 2006 70: 143-153. Published online April 17, 2006; 10.1124/mol.106.023119 [Abstract] [Full Text] [PDF]  

Aliesha González-Arenas, Beatriz Aguilar-Maldonado, S. Eréndira Avendaño-Vázquez, and J. Adolfo García-Sáinz

Estrogens Cross-Talk to _1b-Adrenergic Receptors
Mol Pharmacol 2006 70: 154-162. Published online April 25, 2006; 10.1124/mol.106.025064 [Abstract] [Full Text] [PDF] [Data Supplement]   

Kristen A. Mitchell, Courtney A. Lockhart, Gengming Huang, and Cornelis J. Elferink

Sustained Aryl Hydrocarbon Receptor Activity Attenuates Liver Regeneration
Mol Pharmacol 2006 70: 163-170. Published online April 24, 2006; 10.1124/mol.106.023465 [Abstract] [Full Text] [PDF]  

Lei He, Kuppuswami Girijashanker, Timothy P. Dalton, Jodie Reed, Hong Li, Manoocher Soleimani, and Daniel W. Nebert

ZIP8, Member of the Solute-Carrier-39 (SLC39) Metal-Transporter Family: Characterization of Transporter Properties
Mol Pharmacol 2006 70: 171-180. Published online April 25, 2006; 10.1124/mol.106.024521 [Abstract] [Full Text] [PDF]  

Stefanie Prilla, Jasmin Schrobang, John Ellis, Hans-Dieter Höltje, and Klaus Mohr

Allosteric Interactions with Muscarinic Acetylcholine Receptors: Complex Role of the Conserved Tryptophan M₂⁴²²Trp in a Critical Cluster of Amino Acids for Baseline Affinity, Subtype Selectivity, and Cooperativity
Mol Pharmacol 2006 70: 181-193. Published online April 26, 2006; 10.1124/mol.106.023481 [Abstract] [Full Text] [PDF] [Data Supplement]   

Stacy M. Mervine, Evan A. Yost, Jonathan L. Sabo, Thomas R. Hynes, and Catherine H. Berlot

Analysis of G Protein Dimer Formation in Live Cells Using Multicolor Bimolecular Fluorescence Complementation Demonstrates Preferences of ₁ for Particular Subunits
Mol Pharmacol 2006 70: 194-205. Published online April 26, 2006; 10.1124/mol.106.022616 [Abstract] [Full Text] [PDF]  

Maoqing Dong, Delia I. Pinon, Yan W. Asmann, and Laurence J. Miller

Possible Endogenous Agonist Mechanism for the Activation of Secretin Family G Protein-Coupled Receptors
Mol Pharmacol 2006 70: 206-213. Published online March 10, 2006; 10.1124/mol.105.021840 [Abstract] [Full Text] [PDF]  

Michelle L. Halls, Ross A. D. Bathgate, and Roger J. Summers

Relaxin Family Peptide Receptors RXFP1 and RXFP2 Modulate cAMP Signaling by Distinct Mechanisms
Mol Pharmacol 2006 70: 214-226. Published online March 28, 2006; 10.1124/mol.105.021691 [Abstract] [Full Text] [PDF]  

Clark A. Briggs, Earl J. Gubbins, Michael J. Marks, C. Brent Putman, Rama Thimmapaya, Michael D. Meyer, and Carol S. Surowy

Untranslated Region-Dependent Exclusive Expression of High-Sensitivity Subforms of 42 and 32 Nicotinic Acetylcholine Receptors
Mol Pharmacol 2006 70: 227-240. Published online March 28, 2006; 10.1124/mol.105.020198 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ha Young Lee, Mi-Kyoung Kim, Kyoung Sun Park, Eun Ha Shin, Seong Ho Jo, Sang Doo Kim, Eun Jin Jo, Youl-Nam Lee, Chuhee Lee, Suk-Hwan Baek, and Yoe-Sik Bae

Serum Amyloid A Induces Contrary Immune Responses via Formyl Peptide Receptor-Like 1 in Human Monocytes
Mol Pharmacol 2006 70: 241-248. Published online March 28, 2006; 10.1124/mol.105.022103 [Abstract] [Full Text] [PDF]  

Nan Wu, Rosemarie Macion-Dazard, Stanley Nithianantham, Zhen Xu, Susan M. Hanson, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, Marc Thibonnier, and Menachem Shoham

Soluble Mimics of the Cytoplasmic Face of the Human V1-Vascular Vasopressin Receptor Bind Arrestin2 and Calmodulin
Mol Pharmacol 2006 70: 249-258. Published online March 30, 2006; 10.1124/mol.105.018804 [Abstract] [Full Text] [PDF]  

Alan R. Jacobson, Scott T. Moe, P. D. Allen, and James D. Fessenden

Structural Determinants of 4-Chloro-m-cresol Required for Activation of Ryanodine Receptor Type 1
Mol Pharmacol 2006 70: 259-266. Published online April 6, 2006; 10.1124/mol.106.022491 [Abstract] [Full Text] [PDF]  

Baoshuang Wang, Soomun Ngoi, Jingbo Wang, Samuel S. Chong, and Caroline G. L. Lee

The Promoter Region of the MDR1 Gene Is Largely Invariant, but Different Single Nucleotide Polymorphism Haplotypes Affect MDR1 Promoter Activity Differently in Different Cell Lines
Mol Pharmacol 2006 70: 267-276. Published online April 11, 2006; 10.1124/mol.105.019810 [Abstract] [Full Text] [PDF]  

Laura Romero, Lorraine Ng, and Gordon M. Kirby

Chemical Inducers of Rodent Glutathione S-Transferases Down-Regulate Human GSTA1 Transcription through a Mechanism Involving Variant Hepatic Nuclear Factor 1-C
Mol Pharmacol 2006 70: 277-286. Published online April 11, 2006; 10.1124/mol.105.018622 [Abstract] [Full Text] [PDF]  

Ai Tamura, Masato Watanabe, Hikaru Saito, Hiroshi Nakagawa, Toshiaki Kamachi, Ichiro Okura, and Toshihisa Ishikawa

Functional Validation of the Genetic Polymorphisms of Human ATP-Binding Cassette (ABC) Transporter ABCG2: Identification of Alleles That Are Defective in Porphyrin Transport
Mol Pharmacol 2006 70: 287-296. Published online April 11, 2006; 10.1124/mol.106.023556 [Abstract] [Full Text] [PDF]  

Ying Wang, M. Claire Bartlett, Tip W. Loo, and David M. Clarke

Specific Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Processing Mutants Using Pharmacological Chaperones
Mol Pharmacol 2006 70: 297-302. Published online April 19, 2006; 10.1124/mol.106.023994 [Abstract] [Full Text] [PDF]  

Marilyn L. Clarke, Vijaya L. Damaraju, Jing Zhang, Delores Mowles, Tracey Tackaberry, Thach Lang, Kyla M. Smith, James D. Young, Blake Tomkinson, and Carol E. Cass

The Role of Human Nucleoside Transporters in Cellular Uptake of 4'-Thio--D-arabinofuranosylcytosine and -D-Arabinosylcytosine
Mol Pharmacol 2006 70: 303-310. Published online April 14, 2006; 10.1124/mol.105.021543 [Abstract] [Full Text] [PDF]  

A. M. Preininger, L. G. Henage, W. M. Oldham, E. J. Yoon, H. E. Hamm, and H. A. Brown

Direct Modulation of Phospholipase D Activity by G
Mol Pharmacol 2006 70: 311-318. Published online April 25, 2006; 10.1124/mol.105.021451 [Abstract] [Full Text] [PDF]  

Hidetoshi Tozaki-Saitoh, Schuichi Koizumi, Yoji Sato, Makoto Tsuda, Taku Nagao, and Kazuhide Inoue

Retinoic Acids Increase P2X₂ Receptor Expression through the 5'-Flanking Region of P2rx2 Gene in Rat Phaeochromocytoma PC-12 Cells
Mol Pharmacol 2006 70: 319-328. Published online April 25, 2006; 10.1124/mol.105.020511 [Abstract] [Full Text] [PDF]  

Cedric Duret, Martine Daujat-Chavanieu, Jean-Marc Pascussi, Lydiane Pichard-Garcia, Patrick Balaguer, Jean-Michel Fabre, Marie-José Vilarem, Patrick Maurel, and Sabine Gerbal-Chaloin

Ketoconazole and Miconazole Are Antagonists of the Human Glucocorticoid Receptor: Consequences on the Expression and Function of the Constitutive Androstane Receptor and the Pregnane X Receptor
Mol Pharmacol 2006 70: 329-339. Published online April 11, 2006; 10.1124/mol.105.022046 [Abstract] [Full Text] [PDF]  

Enrico Leipold, Alfred Hansel, Adolfo Borges, and Stefan H. Heinemann

Subtype Specificity of Scorpion -Toxin Tz1 Interaction with Voltage-Gated Sodium Channels Is Determined by the Pore Loop of Domain 3
Mol Pharmacol 2006 70: 340-347. Published online April 25, 2006; 10.1124/mol.106.024034 [Abstract] [Full Text] [PDF]  

Corey R. Centerwall, Kirk A. Tacka, Deborah J. Kerwood, Jerry Goodisman, Bonnie B. Toms, Ronald L. Dubowy, and James C. Dabrowiak

Modification and Uptake of a Cisplatin Carbonato Complex by Jurkat Cells
Mol Pharmacol 2006 70: 348-355. Published online April 21, 2006; 10.1124/mol.106.023184 [Abstract] [Full Text] [PDF] [Data Supplement]   

Daphné Anne Schmid, Jan Paul Heribert Depta, Michael Lüthi, and Werner Joseph Pichler

Transfection of Drug-Specific T-Cell Receptors into Hybridoma Cells: Tools to Monitor Drug Interaction with T-Cell Receptors and Evaluate Cross-Reactivity to Related Compounds
Mol Pharmacol 2006 70: 356-365. Published online April 14, 2006; 10.1124/mol.105.021576 [Abstract] [Full Text] [PDF] [Data Supplement]   

Zhiyong Liao, Laurent Thibaut, Andrew Jobson, and Yves Pommier

Inhibition of Human Tyrosyl-DNA Phosphodiesterase by Aminoglycoside Antibiotics and Ribosome Inhibitors
Mol Pharmacol 2006 70: 366-372. Published online April 17, 2006; 10.1124/mol.105.021865 [Abstract] [Full Text] [PDF]  

Elena Sokolova, Andrei Skorinkin, Igor Moiseev, Andrei Agrachev, Andrea Nistri, and Rashid Giniatullin

Experimental and Modeling Studies of Desensitization of P2X₃ Receptors
Mol Pharmacol 2006 70: 373-382. Published online April 20, 2006; 10.1124/mol.106.023564 [Abstract] [Full Text] [PDF] [Data Supplement]   

Klara Susankova, Karolina Tousova, Ladislav Vyklicky, Jan Teisinger, and Viktorie Vlachova

Reducing and Oxidizing Agents Sensitize Heat-Activated Vanilloid Receptor (TRPV1) Current
Mol Pharmacol 2006 70: 383-394. Published online April 13, 2006; 10.1124/mol.106.023069 [Abstract] [Full Text] [PDF]  

Xiaofei Wang, James A. Dykens, Evelyn Perez, Ran Liu, Shaohua Yang, Douglas F. Covey, and James W. Simpkins

Neuroprotective Effects of 17-Estradiol and Nonfeminizing Estrogens against H₂O₂ Toxicity in Human Neuroblastoma SK-N-SH Cells
Mol Pharmacol 2006 70: 395-404. Published online April 13, 2006; 10.1124/mol.106.022384 [Abstract] [Full Text] [PDF]  

Chantal Maertens, Eva Cuypers, Mehriar Amininasab, Amir Jalali, Hossein Vatanpour, and Jan Tytgat

Potent Modulation of the Voltage-Gated Sodium Channel Na_v1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae
Mol Pharmacol 2006 70: 405-414. Published online April 26, 2006; 10.1124/mol.106.022970 [Abstract] [Full Text] [PDF]  

Seung Jin Lee, Eun Kyoung Yang, and Sang Geon Kim

Peroxisome Proliferator-Activated Receptor- and Retinoic Acid X Receptor Represses the TGF1 Gene via PTEN-Mediated p70 Ribosomal S6 Kinase-1 Inhibition: Role for Zf9 Dephosphorylation
Mol Pharmacol 2006 70: 415-425. Published online April 12, 2006; 10.1124/mol.106.022954 [Abstract] [Full Text] [PDF] [Data Supplement]   

Geetha Achanta, Aneta Modzelewska, Li Feng, Saeed R. Khan, and Peng Huang

A Boronic-Chalcone Derivative Exhibits Potent Anticancer Activity through Inhibition of the Proteasome
Mol Pharmacol 2006 70: 426-433. Published online April 24, 2006; 10.1124/mol.105.021311 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "No Nitric Oxide for HO-1 from Sodium Nitroprusside"
Mol Pharmacol 2006 70: 434. [Full Text] [PDF]  

Correction to "Positive Inter-Regulation between -Catenin/T Cell Factor-4 Signaling and Endothelin-1 Signaling Potentiates Proliferation and Survival of Prostate Cancer Cells"
Mol Pharmacol 2006 70: 435. [Full Text] [PDF]  

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