Perspectives:

James A. McCubrey, Michelle M. LaHair, and Richard A. Franklin

OSU-03012 in the Treatment of Glioblastoma
Mol Pharmacol 2006 70: 437-439. Published online May 4, 2006; 10.1124/mol.106.026252 [Abstract] [Full Text] [PDF] [Related Article]   

Samuel S. Newton and Ronald S. Duman

Chromatin Remodeling: A Novel Mechanism of Psychotropic Drug Action
Mol Pharmacol 2006 70: 440-443. Published online May 25, 2006; 10.1124/mol.106.027078 [Abstract] [Full Text] [PDF] [Related Article]   

Ronald W. Holz

Pharmacology Meets Vesicular Trafficking at a Central Nervous System Synapse: Pregabalin Effects on Synaptic Vesicle Cycling in Hippocampal Neurons
Mol Pharmacol 2006 70: 444-446. Published online May 25, 2006; 10.1124/mol.106.026914 [Abstract] [Full Text] [PDF] [Related Article]   

Ingrid Gsandtner and Michael Freissmuth

A Tail of Two Signals: The C Terminus of the A_2A-Adenosine Receptor Recruits Alternative Signaling Pathways
Mol Pharmacol 2006 70: 447-449. Published online May 17, 2006; 10.1124/mol.106.026757 [Abstract] [Full Text] [PDF] [Related Article]   

Accelerated Communications:

Hideo Kohka Takahashi, Takeshi Watanabe, Akira Yokoyama, Hiromi Iwagaki, Tadashi Yoshino, Noriaki Tanaka, and Masahiro Nishibori

Cimetidine Induces Interleukin-18 Production through H2-Agonist Activity in Monocytes
Mol Pharmacol 2006 70: 450-453. Published online May 24, 2006; 10.1124/mol.106.025890 [Abstract] [Full Text] [PDF]  

Articles:

Chung-Nan Sun, Hsiao-Chun Cheng, Jui-ling Chou, Shen-Yang Lee, Ya-Wen Lin, Hsing-Lin Lai, Hui-Mei Chen, and Yijuang Chern

Rescue of p53 Blockage by the A_2A Adenosine Receptor via a Novel Interacting Protein, Translin-Associated Protein X
Mol Pharmacol 2006 70: 454-466. Published online April 14, 2006; 10.1124/mol.105.021261 [Abstract] [Full Text] [PDF]  

Kristina D. Micheva, Charles P. Taylor, and Stephen J Smith

Pregabalin Reduces the Release of Synaptic Vesicles from Cultured Hippocampal Neurons
Mol Pharmacol 2006 70: 467-476. Published online April 26, 2006; 10.1124/mol.106.023309 [Abstract] [Full Text] [PDF]  

Yasuhiro Uno, Hideki Fujino, Go Kito, Tetsuya Kamataki, and Ryoichi Nagata

CYP2C76, a Novel Cytochrome P450 in Cynomolgus Monkey, Is a Major CYP2C in Liver, Metabolizing Tolbutamide and Testosterone
Mol Pharmacol 2006 70: 477-486. Published online April 28, 2006; 10.1124/mol.106.022673 [Abstract] [Full Text] [PDF]  

Suzanne Cassel, Delphine Carouge, Claire Gensburger, Patrick Anglard, Claude Burgun, Jean-Bernard Dietrich, Dominique Aunis, and Jean Zwiller

Fluoxetine and Cocaine Induce the Epigenetic Factors MeCP2 and MBD1 in Adult Rat Brain
Mol Pharmacol 2006 70: 487-492. Published online May 2, 2006; 10.1124/mol.106.022301 [Abstract] [Full Text] [PDF]  

Dong-Chan Kim, Se-Young Choi, Sun-Hee Kim, Bong-Sik Yun, Ick-Dong Yoo, Nanga. Ravi Prakash Reddy, Ho Sup Yoon, and Kyong-Tai Kim

Isoliquiritigenin Selectively Inhibits H₂ Histamine Receptor Signaling
Mol Pharmacol 2006 70: 493-500. Published online May 4, 2006; 10.1124/mol.106.023226 [Abstract] [Full Text] [PDF] [Data Supplement]   

Sandra Liekens, Annelies Bronckaers, Ana-Isabel Hernández, Eva-María Priego, Elena Casanova, Maria-José Camarasa, Maria-Jesus Pérez-Pérez, and Jan Balzarini

5'-O-Tritylated Nucleoside Derivatives: Inhibition of Thymidine Phosphorylase and Angiogenesis
Mol Pharmacol 2006 70: 501-509. Published online May 4, 2006; 10.1124/mol.105.021188 [Abstract] [Full Text] [PDF]  

Chia-Ling Chen, Chiou-Feng Lin, Chi-Wu Chiang, Ming-Shiou Jan, and Yee-Shin Lin

Lithium Inhibits Ceramide- and Etoposide-Induced Protein Phosphatase 2A Methylation, Bcl-2 Dephosphorylation, Caspase-2 Activation, and Apoptosis
Mol Pharmacol 2006 70: 510-517. Published online May 8, 2006; 10.1124/mol.106.024059 [Abstract] [Full Text] [PDF]  

Ann M. Kapoun, Nicholas J. Gaspar, Ying Wang, Debby Damm, Yu-Wang Liu, Gilbert O'Young, Diana Quon, Andrew Lam, Kimberly Munson, Thomas-Toan Tran, Jing Ying Ma, Alison Murphy, Sundeep Dugar, Sarvajit Chakravarty, Andrew A. Protter, Fu-Qiang Wen, Xiangde Liu, Stephen I. Rennard, and Linda Slanec Higgins

Transforming Growth Factor- Receptor Type 1 (TGFRI) Kinase Activity but Not p38 Activation Is Required for TGFRI-Induced Myofibroblast Differentiation and Profibrotic Gene Expression
Mol Pharmacol 2006 70: 518-531. Published online May 17, 2006; 10.1124/mol.105.021600 [Abstract] [Full Text] [PDF] [Data Supplement]   

Qi Xu, Ning Xu, Tan Zhang, Hui Zhang, Zijian Li, Feng Yin, Zhizhen Lu, Qide Han, and Youyi Zhang

Mammalian Tolloid Alters Subcellular Localization, Internalization, and Signaling of _1a-Adrenergic Receptors
Mol Pharmacol 2006 70: 532-541. Published online May 11, 2006; 10.1124/mol.105.016451 [Abstract] [Full Text] [PDF] [Data Supplement]   

Kristopher M. Kahlig, Brandon J. Lute, Yuqiang Wei, Claus J. Loland, Ulrik Gether, Jonathan A. Javitch, and Aurelio Galli

Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine
Mol Pharmacol 2006 70: 542-548. Published online May 9, 2006; 10.1124/mol.106.023952 [Abstract] [Full Text] [PDF]  

Sara A. Carney, Jing Chen, C. Geoffrey Burns, Kong M. Xiong, Richard E. Peterson, and Warren Heideman

Aryl Hydrocarbon Receptor Activation Produces Heart-Specific Transcriptional and Toxic Responses in Developing Zebrafish
Mol Pharmacol 2006 70: 549-561. Published online May 19, 2006; 10.1124/mol.106.025304 [Abstract] [Full Text] [PDF] [Data Supplement]   

Liwei Chen, Shen-Shu Sung, M. L. Richard Yip, Harshani R. Lawrence, Yuan Ren, Wayne C. Guida, Said M. Sebti, Nicholas J. Lawrence, and Jie Wu

Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor
Mol Pharmacol 2006 70: 562-570. Published online May 22, 2006; 10.1124/mol.106.025536 [Abstract] [Full Text] [PDF]  

Dong Yan, Julia K. Meyer, and Michael M. White

Mapping Residues in the Ligand-Binding Domain of the 5-HT₃ Receptor onto d-Tubocurarine Structure
Mol Pharmacol 2006 70: 571-578. Published online May 24, 2006; 10.1124/mol.106.024075 [Abstract] [Full Text] [PDF]  

Guila Dayan, Mathieu Lupien, Anick Auger, Silvia I. Anghel, Walter Rocha, Sébastien Croisetière, John A. Katzenellenbogen, and Sylvie Mader

Tamoxifen and Raloxifene Differ in Their Functional Interactions with Aspartate 351 of Estrogen Receptor
Mol Pharmacol 2006 70: 579-588. Published online May 5, 2006; 10.1124/mol.105.021931 [Abstract] [Full Text] [PDF]  

Adly Yacoub, Margaret A. Park, David Hanna, Young Hong, Clint Mitchell, Aditi P. Pandya, Hisashi Harada, Garth Powis, Ching-Shih Chen, Costas Koumenis, Steven Grant, and Paul Dent

OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells
Mol Pharmacol 2006 70: 589-603. Published online April 18, 2006; 10.1124/mol.106.025007 [Abstract] [Full Text] [PDF]  

Richard M. van Rijn, Paul L. Chazot, Fiona C. Shenton, Kamonchanok Sansuk, Remko A. Bakker, and Rob Leurs

Oligomerization of Recombinant and Endogenously Expressed Human Histamine H₄ Receptors
Mol Pharmacol 2006 70: 604-615. Published online April 27, 2006; 10.1124/mol.105.020818 [Abstract] [Full Text] [PDF]  

Kamondanai Hemstapat, Tomas de Paulis, Yelin Chen, Ashley E. Brady, Vandana K. Grover, David Alagille, Gilles D. Tamagnan, and P. Jeffrey Conn

A Novel Class of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Interact with a Site Distinct from That of Negative Allosteric Modulators
Mol Pharmacol 2006 70: 616-626. Published online April 27, 2006; 10.1124/mol.105.021857 [Abstract] [Full Text] [PDF]  

Ishtiaq Qadri, Mieko Iwahashi, Gerd A. Kullak-Ublick, and Francis R. Simon

Hepatocyte Nuclear Factor (HNF) 1 and HNF4 Mediate Hepatic Multidrug Resistance Protein 2 Up-Regulation during Hepatitis C Virus Gene Expression
Mol Pharmacol 2006 70: 627-636. Published online May 2, 2006; 10.1124/mol.106.023499 [Abstract] [Full Text] [PDF]  

Yu-Li Lin, Shiuh-Sheng Lee, Shin-Miao Hou, and Bor-Luen Chiang

Polysaccharide Purified from Ganoderma lucidum Induces Gene Expression Changes in Human Dendritic Cells and Promotes T Helper 1 Immune Response in BALB/c Mice
Mol Pharmacol 2006 70: 637-644. Published online May 2, 2006; 10.1124/mol.106.022327 [Abstract] [Full Text] [PDF]  

Ning Gao, Lora Kramer, Mohamed Rahmani, Paul Dent, and Steven Grant

The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism
Mol Pharmacol 2006 70: 645-655. Published online May 3, 2006; 10.1124/mol.106.024505 [Abstract] [Full Text] [PDF]  

Jan Jakubík, Esam E. El-Fakahany, and Vladimír Dolezal

Differences in Kinetics of Xanomeline Binding and Selectivity of Activation of G Proteins at M₁ and M₂ Muscarinic Acetylcholine Receptors
Mol Pharmacol 2006 70: 656-666. Published online May 4, 2006; 10.1124/mol.106.023762 [Abstract] [Full Text] [PDF]  

Blaise Z. Peterson and William A. Catterall

Allosteric Interactions Required for High-Affinity Binding of Dihydropyridine Antagonists to Ca_V1.1 Channels Are Modulated by Calcium in the Pore
Mol Pharmacol 2006 70: 667-675. Published online May 4, 2006; 10.1124/mol.105.020644 [Abstract] [Full Text] [PDF]  

Elizabeth A. Johnson, Sue Oldfield, Ellen Braksator, Ana Gonzalez-Cuello, Daniel Couch, Kellie J. Hall, Stuart J. Mundell, Chris P. Bailey, Eamonn Kelly, and Graeme Henderson

Agonist-Selective Mechanisms of µ-Opioid Receptor Desensitization in Human Embryonic Kidney 293 Cells
Mol Pharmacol 2006 70: 676-685. Published online May 8, 2006; 10.1124/mol.106.022376 [Abstract] [Full Text] [PDF]  

Andreas Breit, Khatuna Gagnidze, Lakshmi A. Devi, Monique Lagacé, and Michel Bouvier

Simultaneous Activation of the Opioid Receptor (OR)/Sensory Neuron-Specific Receptor-4 (SNSR-4) Hetero-Oligomer by the Mixed Bivalent Agonist Bovine Adrenal Medulla Peptide 22 Activates SNSR-4 but Inhibits OR Signaling
Mol Pharmacol 2006 70: 686-696. Published online May 8, 2006; 10.1124/mol.106.022897 [Abstract] [Full Text] [PDF]  

Matthew C. Catley, Maria B. Sukkar, K. Fan Chung, Bruce Jaffee, Sha-Mei Liao, Anthony J. Coyle, El-Bdaoui Haddad, Peter J. Barnes, and Robert Newton

Validation of the Anti-Inflammatory Properties of Small-Molecule IB Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Negative IKK1 and IKK2 in Human Airways Smooth Muscle
Mol Pharmacol 2006 70: 697-705. Published online May 10, 2006; 10.1124/mol.106.023150 [Abstract] [Full Text] [PDF] [DataSupplement]   

Yulia Y. Tyurina, Vidisha Kini, Vladimir A. Tyurin, Irina I. Vlasova, Jianfei Jiang, Alexander A. Kapralov, Natalia A. Belikova, Jack C. Yalowich, Igor V. Kurnikov, and Valerian E. Kagan

Mechanisms of Cardiolipin Oxidation by Cytochrome c: Relevance to Pro- and Antiapoptotic Functions of Etoposide
Mol Pharmacol 2006 70: 706-717. Published online May 11, 2006; 10.1124/mol.106.022731 [Abstract] [Full Text] [PDF]  

Benjamin S. Freeze, Megan M. McNulty, and Dorothy A. Hanck

State-Dependent Verapamil Block of the Cloned Human Ca_v3.1 T-Type Ca²⁺ Channel
Mol Pharmacol 2006 70: 718-726. Published online May 12, 2006; 10.1124/mol.106.023473 [Abstract] [Full Text] [PDF]  

Sergey Ryzhov, Anna E. Goldstein, Italo Biaggioni, and Igor Feoktistov

Cross-Talk between G_s- and G_q-Coupled Pathways in Regulation of Interleukin-4 by A_2B Adenosine Receptors in Human Mast Cells
Mol Pharmacol 2006 70: 727-735. Published online May 17, 2006; 10.1124/mol.106.022780 [Abstract] [Full Text] [PDF]  

Alfred A. Lanzafame, Patrick M. Sexton, and Arthur Christopoulos

Interaction Studies of Multiple Binding Sites on M₄ Muscarinic Acetylcholine Receptors
Mol Pharmacol 2006 70: 736-746. Published online May 18, 2006; 10.1124/mol.106.024711 [Abstract] [Full Text] [PDF]  

Birgitta I. Eklund, My Moberg, Jonas Bergquist, and Bengt Mannervik

Divergent Activities of Human Glutathione Transferases in the Bioactivation of Azathioprine
Mol Pharmacol 2006 70: 747-754. Published online May 22, 2006; 10.1124/mol.106.025288 [Abstract] [Full Text] [PDF]  

Mirko Moroni, Ruud Zwart, Emanuele Sher, Bruce K. Cassels, and Isabel Bermudez

42 Nicotinic Receptors with High and Low Acetylcholine Sensitivity: Pharmacology, Stoichiometry, and Sensitivity to Long-Term Exposure to Nicotine
Mol Pharmacol 2006 70: 755-768. Published online May 23, 2006; 10.1124/mol.106.023044 [Abstract] [Full Text] [PDF]  

Agnes C. L. Martin and Dermot M. F. Cooper

Capacitative and 1-Oleyl-2-acetyl-sn-glycerol-Activated Ca²⁺ Entry Distinguished Using Adenylyl Cyclase Type 8
Mol Pharmacol 2006 70: 769-777. Published online May 24, 2006; 10.1124/mol.106.025213 [Abstract] [Full Text] [PDF]  

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