Minireview:

Qingdong Ke and Max Costa

Hypoxia-Inducible Factor-1 (HIF-1)
Mol Pharmacol 2006 70: 1469-1480. Published online August 3, 2006; 10.1124/mol.106.027029 [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Yolanda R. Dale and Sakina E. Eltom

Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor
Mol Pharmacol 2006 70: 1481-1487. Published online August 4, 2006; 10.1124/mol.106.027474 [Abstract] [Full Text] [PDF]  

Natalya Belousova, Raymond Harris, Kurt Zinn, Mary Ann Rhodes-Selser, Alexander Kotov, Olga Kotova, Minghui Wang, Rosemarie Aurigemma, Zeng B. Zhu, David T. Curiel, and Ronald D. Alvarez

Circumventing Recombination Events Encountered with Production of a Clinical-Grade Adenoviral Vector with a Double-Expression Cassette
Mol Pharmacol 2006 70: 1488-1493. Published online August 8, 2006; 10.1124/mol.106.025619 [Abstract] [Full Text] [PDF]  

Articles:

Mala M. Shah, Mazyar Javadzadeh-Tabatabaie, David C. H. Benton, C. Robin Ganellin, and Dennis G. Haylett

Enhancement of Hippocampal Pyramidal Cell Excitability by the Novel Selective Slow-Afterhyperpolarization Channel Blocker 3-(Triphenylmethylaminomethyl)pyridine (UCL2077)
Mol Pharmacol 2006 70: 1494-1502. Published online July 28, 2006; 10.1124/mol.106.026625 [Abstract] [Full Text] [PDF]  

Lars H. Jensen, Hong Liang, Robert Shoemaker, Morten Grauslund, Maxwell Sehested, and Brian B. Hasinoff

A Three-Dimensional Quantitative Structure-Activity Relationship Study of the Inhibition of the ATPase Activity and the Strand Passing Catalytic Activity of Topoisomerase II by Substituted Purine Analogs
Mol Pharmacol 2006 70: 1503-1513. Published online July 31, 2006; 10.1124/mol.106.026856 [Abstract] [Full Text] [PDF] [Data Supplement]   

Megan M. McNulty, John W. Kyle, Gregory M. Lipkind, and Dorothy A. Hanck

An Inner Pore Residue (Asn406) in the Na_v1.5 Channel Controls Slow Inactivation and Enhances Mibefradil Block to T-Type Ca²⁺ Channel Levels
Mol Pharmacol 2006 70: 1514-1523. Published online August 2, 2006; 10.1124/mol.106.027177 [Abstract] [Full Text] [PDF]  

Christian Grommes, Gary E. Landreth, Magdalena Sastre, Martina Beck, Douglas L. Feinstein, Andreas H. Jacobs, Uwe Schlegel, and Michael T. Heneka

Inhibition of in Vivo Glioma Growth and Invasion by Peroxisome Proliferator-Activated Receptor Agonist Treatment
Mol Pharmacol 2006 70: 1524-1533. Published online August 3, 2006; 10.1124/mol.106.022194 [Abstract] [Full Text] [PDF]  

Ping-Hui Tseng, Yu-Chieh Wang, Shu-Chuan Weng, Jing-Ru Weng, Chang-Shi Chen, Robert W. Brueggemeier, Charles L. Shapiro, Ching-Yu Chen, Sandra E. Dunn, Michael Pollak, and Ching-Shih Chen

Overcoming Trastuzumab Resistance in HER2-Overexpressing Breast Cancer Cells by Using a Novel Celecoxib-Derived Phosphoinositide-Dependent Kinase-1 Inhibitor
Mol Pharmacol 2006 70: 1534-1541. Published online August 3, 2006; 10.1124/mol.106.023911 [Abstract] [Full Text] [PDF]  

Aditya Bhattacharji, Benjamin Kaplan, Thanawath Harris, Xiaoguang Qu, Markus W. Germann, and Manuel Covarrubias

The Concerted Contribution of the S4-S5 Linker and the S6 Segment to the Modulation of a K_v Channel by 1-Alkanols
Mol Pharmacol 2006 70: 1542-1554. Published online August 3, 2006; 10.1124/mol.106.026187 [Abstract] [Full Text] [PDF]  

Ernest Hamel, Billy W. Day, John H. Miller, M. Katherine Jung, Peter T. Northcote, Arun K. Ghosh, Dennis P. Curran, Mark Cushman, K. C. Nicolaou, Ian Paterson, and Erik J. Sorensen

Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly
Mol Pharmacol 2006 70: 1555-1564. Published online August 3, 2006; 10.1124/mol.106.027847 [Abstract] [Full Text] [PDF]  

Naissan Hussainzada, Antara Banerjee, and Peter W. Swaan

Transmembrane Domain VII of the Human Apical Sodium-Dependent Bile Acid Transporter ASBT (SLC10A2) Lines the Substrate Translocation Pathway
Mol Pharmacol 2006 70: 1565-1574. Published online August 9, 2006; 10.1124/mol.106.028647 [Abstract] [Full Text] [PDF]  

Ségolène Galandrin and Michel Bouvier

Distinct Signaling Profiles of ₁ and ₂ Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy
Mol Pharmacol 2006 70: 1575-1584. Published online August 10, 2006; 10.1124/mol.106.026716 [Abstract] [Full Text] [PDF]  

Charlotte A. Lanteri, Mhairi L. Stewart, Janice M. Brock, Vincent P. Alibu, Steven R. Meshnick, Richard R. Tidwell, and Michael P. Barrett

Roles for the Trypanosoma brucei P2 Transporter in DB75 Uptake and Resistance
Mol Pharmacol 2006 70: 1585-1592. Published online August 15, 2006; 10.1124/mol.106.024653 [Abstract] [Full Text] [PDF] [Data supplement]   

Chao-Xin Hu, Zhi-Li Zuo, Bing Xiong, Jin-Gui Ma, Mei-Yu Geng, Li-Ping Lin, Hua-Liang Jiang, and Jian Ding

Salvicine Functions as Novel Topoisomerase II Poison by Binding to ATP Pocket
Mol Pharmacol 2006 70: 1593-1601. Published online August 16, 2006; 10.1124/mol.106.027714 [Abstract] [Full Text] [PDF]  

Thomas J. Urban, Renata C. Gallagher, Chaline Brown, Richard A. Castro, Leah L. Lagpacan, Claire M. Brett, Travis R. Taylor, Elaine J. Carlson, Thomas E. Ferrin, Esteban G. Burchard, Seymour Packman, and Kathleen M. Giacomini

Functional Genetic Diversity in the High-Affinity Carnitine Transporter OCTN2 (SLC22A5)
Mol Pharmacol 2006 70: 1602-1611. Published online August 24, 2006; 10.1124/mol.106.028126 [Abstract] [Full Text] [PDF]  

Kristin Gustafsson, Birger Christensson, Birgitta Sander, and Jenny Flygare

Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
Mol Pharmacol 2006 70: 1612-1620. Published online August 25, 2006; 10.1124/mol.106.025981 [Abstract] [Full Text] [PDF] [Data Supplement]   

Huanhuan Gao, Jiening Xiao, Qiang Sun, Huixian Lin, Yunlong Bai, Long Yang, Baofeng Yang, Huizhen Wang, and Zhiguo Wang

A Single Decoy Oligodeoxynucleotides Targeting Multiple Oncoproteins Produces Strong Anticancer Effects
Mol Pharmacol 2006 70: 1621-1629. Published online August 25, 2006; 10.1124/mol.106.024273 [Abstract] [Full Text] [PDF]  

Thijs Beuming, Lei Shi, Jonathan A. Javitch, and Harel Weinstein

A Comprehensive Structure-Based Alignment of Prokaryotic and Eukaryotic Neurotransmitter/Na⁺ Symporters (NSS) Aids in the Use of the LeuT Structure to Probe NSS Structure and Function
Mol Pharmacol 2006 70: 1630-1642. Published online July 31, 2006; 10.1124/mol.106.026120 [Abstract] [Full Text] [PDF]  

Negin P. Martin, Robert P. Mohney, Sara Dunn, Margaret Das, Erica Scappini, and John P. O'Bryan

Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling
Mol Pharmacol 2006 70: 1643-1653. Published online August 16, 2006; 10.1124/mol.106.028274 [Abstract] [Full Text] [PDF] [Data Supplement]   

Yajaira Suárez, Laura González-Santiago, Natasha Zarich, Alberto Dávalos, Juan F. Aranda, Miguel A. Alonso, Miguel A. Lasunción, José María Rojas, and Alberto Muñoz

Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content
Mol Pharmacol 2006 70: 1654-1663. Published online August 23, 2006; 10.1124/mol.106.025569 [Abstract] [Full Text] [PDF] [Data Supplement]   

Hyunsung Choi, Yang-Sook Chun, Seung-Won Kim, Myung-Suk Kim, and Jong-Wan Park

Curcumin Inhibits Hypoxia-Inducible Factor-1 by Degrading Aryl Hydrocarbon Receptor Nuclear Translocator: A Mechanism of Tumor Growth Inhibition
Mol Pharmacol 2006 70: 1664-1671. Published online July 31, 2006; 10.1124/mol.106.025817 [Abstract] [Full Text] [PDF]  

Giancarlo Aldini, Federica Pirrone, Mariangela Albertini, Marica Orioli, Angela Piccoli, Silvia Mazzola, Maria Giovanna Clement, and Marina Carini

Electron Spin Resonance and Chemiluminescence Analyses to Elucidate the Vasodilating Mechanism of Sodium Nitroprusside
Mol Pharmacol 2006 70: 1672-1680. Published online August 1, 2006; 10.1124/mol.106.027870 [Abstract] [Full Text] [PDF]  

Celia P. Martínez-Jiménez, José V. Castell, M. José Gómez-Lechón, and Ramiro Jover

Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4 Requires Coactivators Peroxisomal Proliferator Activated Receptor- Coactivator 1 and Steroid Receptor Coactivator 1
Mol Pharmacol 2006 70: 1681-1692. Published online August 1, 2006; 10.1124/mol.106.025403 [Abstract] [Full Text] [PDF] [Data Supplement]   

Danyan Mao, Robert P. Yasuda, Hong Fan, Barry B. Wolfe, and Kenneth J. Kellar

Heterogeneity of Nicotinic Cholinergic Receptors in Rat Superior Cervical and Nodose Ganglia
Mol Pharmacol 2006 70: 1693-1699. Published online August 1, 2006; 10.1124/mol.106.027458 [Abstract] [Full Text] [PDF]  

Richard A. Bundey and Paul A. Insel

Adenylyl Cyclase 6 Overexpression Decreases the Permeability of Endothelial Monolayers via Preferential Enhancement of Prostacyclin Receptor Function
Mol Pharmacol 2006 70: 1700-1707. Published online August 2, 2006; 10.1124/mol.106.028035 [Abstract] [Full Text] [PDF] [Data Supplement]   

Jana Kaspárková, Olga Nováková, Oldrich Vrána, Francesco Intini, Giovanni Natile, and Viktor Brabec

Molecular Aspects of Antitumor Effects of a New Platinum(IV) Drug
Mol Pharmacol 2006 70: 1708-1719. Published online August 8, 2006; 10.1124/mol.106.027730 [Abstract] [Full Text] [PDF] [Erratum]   

Mina Ito, Taku Nagai, Hiroyuki Kamei, Noritaka Nakamichi, Toshitaka Nabeshima, Kazuhiro Takuma, and Kiyofumi Yamada

Involvement of Tissue Plasminogen Activator-Plasmin System in Depolarization-Evoked Dopamine Release in the Nucleus Accumbens of Mice
Mol Pharmacol 2006 70: 1720-1725. Published online August 14, 2006; 10.1124/mol.106.022467 [Abstract] [Full Text] [PDF]  

Fabio Fumagalli, Francesco Bedogni, Angelisa Frasca, Laura Di Pasquale, Giorgio Racagni, and Marco Andrea Riva

Corticostriatal Up-Regulation of Activity-Regulated Cytoskeletal-Associated Protein Expression after Repeated Exposure to Cocaine
Mol Pharmacol 2006 70: 1726-1734. Published online August 14, 2006; 10.1124/mol.106.026302 [Abstract] [Full Text] [PDF]  

Markus Grube, Kathleen Köck, Susanne Karner, Sebastian Reuther, Christoph A. Ritter, Gabriele Jedlitschky, and Heyo K. Kroemer

Modification of OATP2B1-Mediated Transport by Steroid Hormones
Mol Pharmacol 2006 70: 1735-1741. Published online August 14, 2006; 10.1124/mol.106.026450 [Abstract] [Full Text] [PDF]  

Shuang Li, Michael L. Lee, Michael R. Bruchas, Guy C. Chan, Daniel R. Storm, and Charles Chavkin

Calmodulin-Stimulated Adenylyl Cyclase Gene Deletion Affects Morphine Responses
Mol Pharmacol 2006 70: 1742-1749. Published online August 16, 2006; 10.1124/mol.106.025783 [Abstract] [Full Text] [PDF]  

Madhara Udawela, George Christopoulos, Maria Morfis, Arthur Christopoulos, Siying Ye, Nanda Tilakaratne, and Patrick M. Sexton

A Critical Role for the Short Intracellular C Terminus in Receptor Activity-Modifying Protein Function
Mol Pharmacol 2006 70: 1750-1760. Published online August 15, 2006; 10.1124/mol.106.024257 [Abstract] [Full Text] [PDF]  

Changhai Cui, Ming Xu, and Marco Atzori

Voltage-Dependent Block of N-Methyl-D-aspartate Receptors by Dopamine D1 Receptor Ligands
Mol Pharmacol 2006 70: 1761-1770. Published online August 18, 2006; 10.1124/mol.106.028332 [Abstract] [Full Text] [PDF]  

Dorte Strøbæk, Charlotte Hougaard, Tina H. Johansen, Ulrik S. Sørensen, Elsebet Ø. Nielsen, Karin S. Nielsen, Ruth D. T. Taylor, Paola Pedarzani, and Palle Christophersen

Inhibitory Gating Modulation of Small Conductance Ca²⁺-Activated K⁺ Channels by the Synthetic Compound (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) Reduces Afterhyperpolarizing Current in Hippocampal CA1 Neurons
Mol Pharmacol 2006 70: 1771-1782. Published online August 22, 2006; 10.1124/mol.106.027110 [Abstract] [Full Text] [PDF]  

Laura Albizu, Marie-Noëlle Balestre, Christophe Breton, Jean-Philippe Pin, Maurice Manning, Bernard Mouillac, Claude Barberis, and Thierry Durroux

Probing the Existence of G Protein-Coupled Receptor Dimers by Positive and Negative Ligand-Dependent Cooperative Binding
Mol Pharmacol 2006 70: 1783-1791. Published online August 22, 2006; 10.1124/mol.106.025684 [Abstract] [Full Text] [PDF]  

T. C. Tai, David C. Wong-Faull, Robert Claycomb, and Dona L. Wong

Nerve Growth Factor Regulates Adrenergic Expression
Mol Pharmacol 2006 70: 1792-1801. Published online August 22, 2006; 10.1124/mol.106.026237 [Abstract] [Full Text] [PDF]  

Christophe Blanquart, Carmen Gonzalez-Yanes, and Tarik Issad

Monitoring the Activation State of Insulin/Insulin-Like Growth Factor-1 Hybrid Receptors Using Bioluminescence Resonance Energy Transfer
Mol Pharmacol 2006 70: 1802-1811. Published online August 22, 2006; 10.1124/mol.106.026989 [Abstract] [Full Text] [PDF]  

Alessandra Ciucci, Patrizia Gianferretti, Roberto Piva, Thierry Guyot, Timothy J. Snape, Stanley M. Roberts, and M. Gabriella Santoro

Induction of Apoptosis in Estrogen Receptor-Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the IB Kinase/Nuclear Factor-B Pathway
Mol Pharmacol 2006 70: 1812-1821. Published online August 14, 2006; 10.1124/mol.106.025759 [Abstract] [Full Text] [PDF]  

Mitsi A. Blount, Roya Zoraghi, Hengming Ke, Emmanuel P. Bessay, Jackie D. Corbin, and Sharron H. Francis

A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization
Mol Pharmacol 2006 70: 1822-1831. Published online August 22, 2006; 10.1124/mol.106.028688 [Abstract] [Full Text] [PDF]  

Hitoshi Uga, Chikanori Kuramori, Akiko Ohta, Yasunori Tsuboi, Hiroshi Tanaka, Mamoru Hatakeyama, Yuki Yamaguchi, Takashi Takahashi, Masahiro Kizaki, and Hiroshi Handa

A New Mechanism of Methotrexate Action Revealed by Target Screening with Affinity Beads
Mol Pharmacol 2006 70: 1832-1839. Published online August 25, 2006; 10.1124/mol.106.025866 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries"
Mol Pharmacol 2006 70: 1840. [Full Text] [PDF]  

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